csp2: CSP2/CSP2_env/env-d9b9114564458d9d-741b3de822f2aaca6c6caa4325c4afce/lib/python3.8/site-packages/pysam/libcfaidx.c comparison

comparison CSP2/CSP2_env/env-d9b9114564458d9d-741b3de822f2aaca6c6caa4325c4afce/lib/python3.8/site-packages/pysam/libcfaidx.c @ 68:5028fdace37b

planemo upload commit 2e9511a184a1ca667c7be0c6321a36dc4e3d116d

author	jpayne
date	Tue, 18 Mar 2025 16:23:26 -0400
parents
children

comparison

equal deleted inserted replaced

-:0e9998148a16
+:5028fdace37b
+/* Generated by Cython 3.0.11 */
+/* BEGIN: Cython Metadata
+{
+"distutils": {
+"define_macros": [
+[
+"BUILDING_WHEEL",
+null
+]
+],
+"depends": [
+"/project/htslib/htslib/bgzf.h",
+"/project/htslib/htslib/cram.h",
+"/project/htslib/htslib/faidx.h",
+"/project/htslib/htslib/hfile.h",
+"/project/htslib/htslib/hts.h",
+"/project/htslib/htslib/kstring.h",
+"/project/htslib/htslib/sam.h",
+"/project/htslib/htslib/tbx.h",
+"/project/htslib/htslib/vcf.h",
+"/project/htslib/htslib/vcfutils.h",
+"/project/pysam/htslib_util.h",
+"/project/pysam/pysam_stream.h"
+],
+"extra_compile_args": [
+"-Wno-unused",
+"-Wno-strict-prototypes",
+"-Wno-sign-compare",
+"-Wno-error=declaration-after-statement"
+],
+"extra_link_args": [
+"-Wl,-rpath,$ORIGIN"
+],
+"include_dirs": [
+"pysam",
+"/project/pysam",
+"/project/htslib",
+"/project/samtools",
+"/project/samtools/lz4",
+"/project/bcftools",
+"/project"
+],
+"language": "c",
+"libraries": [
+"z",
+"lzma",
+"bz2",
+"z",
+"m",
+"curl",
+"crypto",
+"chtslib.cpython-37m-x86_64-linux-gnu",
+"cutils.cpython-37m-x86_64-linux-gnu"
+],
+"library_dirs": [
+"/project/pysam",
+"/project",
+"build/lib.linux-x86_64-cpython-37/pysam",
+"build/lib.linux-x86_64-cpython-37/pysam",
+"build/lib.linux-x86_64-cpython-37/pysam",
+"build/lib.linux-x86_64-cpython-37/pysam",
+"build/lib.linux-x86_64-cpython-37/pysam",
+"build/lib.linux-x86_64-cpython-37/pysam",
+"build/lib.linux-x86_64-cpython-37/pysam",
+"build/lib.linux-x86_64-cpython-37/pysam",
+"build/lib.linux-x86_64-cpython-37/pysam"
+],
+"name": "pysam.libcfaidx",
+"sources": [
+"pysam/libcfaidx.pyx"
+]
+},
+"module_name": "pysam.libcfaidx"
+}
+END: Cython Metadata */
+#ifndef PY_SSIZE_T_CLEAN
+#define PY_SSIZE_T_CLEAN
+#endif /* PY_SSIZE_T_CLEAN */
+#if defined(CYTHON_LIMITED_API) && 0
+#ifndef Py_LIMITED_API
+#if CYTHON_LIMITED_API+0 > 0x03030000
+#define Py_LIMITED_API CYTHON_LIMITED_API
+#else
+#define Py_LIMITED_API 0x03030000
+#endif
+#endif
+#endif
+#include "Python.h"
+#if PY_MAJOR_VERSION >= 3
+#define __Pyx_PyFloat_FromString(obj)  PyFloat_FromString(obj)
+#else
+#define __Pyx_PyFloat_FromString(obj)  PyFloat_FromString(obj, NULL)
+#endif
+#if PY_MAJOR_VERSION <= 2
+#define PyDict_GetItemWithError _PyDict_GetItemWithError
+#endif
+#if (PY_VERSION_HEX < 0x030700b1 || (CYTHON_COMPILING_IN_PYPY && PYPY_VERSION_NUM < 0x07030600)) && !defined(PyContextVar_Get)
+#define PyContextVar_Get(var, d, v)         ((d) ?             ((void)(var), Py_INCREF(d), (v)[0] = (d), 0) :             ((v)[0] = NULL, 0)         )
+#endif
+#ifndef Py_PYTHON_H
+#error Python headers needed to compile C extensions, please install development version of Python.
+#elif PY_VERSION_HEX < 0x02070000 || (0x03000000 <= PY_VERSION_HEX && PY_VERSION_HEX < 0x03030000)
+#error Cython requires Python 2.7+ or Python 3.3+.
+#else
+#if defined(CYTHON_LIMITED_API) && CYTHON_LIMITED_API
+#define __PYX_EXTRA_ABI_MODULE_NAME "limited"
+#else
+#define __PYX_EXTRA_ABI_MODULE_NAME ""
+#endif
+#define CYTHON_ABI "3_0_11" __PYX_EXTRA_ABI_MODULE_NAME
+#define __PYX_ABI_MODULE_NAME "_cython_" CYTHON_ABI
+#define __PYX_TYPE_MODULE_PREFIX __PYX_ABI_MODULE_NAME "."
+#define CYTHON_HEX_VERSION 0x03000BF0
+#define CYTHON_FUTURE_DIVISION 1
+#include <stddef.h>
+#ifndef offsetof
+#define offsetof(type, member) ( (size_t) & ((type*)0) -> member )
+#endif
+#if !defined(_WIN32) && !defined(WIN32) && !defined(MS_WINDOWS)
+#ifndef __stdcall
+#define __stdcall
+#endif
+#ifndef __cdecl
+#define __cdecl
+#endif
+#ifndef __fastcall
+#define __fastcall
+#endif
+#endif
+#ifndef DL_IMPORT
+#define DL_IMPORT(t) t
+#endif
+#ifndef DL_EXPORT
+#define DL_EXPORT(t) t
+#endif
+#define __PYX_COMMA ,
+#ifndef HAVE_LONG_LONG
+#define HAVE_LONG_LONG
+#endif
+#ifndef PY_LONG_LONG
+#define PY_LONG_LONG LONG_LONG
+#endif
+#ifndef Py_HUGE_VAL
+#define Py_HUGE_VAL HUGE_VAL
+#endif
+#define __PYX_LIMITED_VERSION_HEX PY_VERSION_HEX
+#if defined(GRAALVM_PYTHON)
+/* For very preliminary testing purposes. Most variables are set the same as PyPy.
+The existence of this section does not imply that anything works or is even tested */
+#define CYTHON_COMPILING_IN_PYPY 0
+#define CYTHON_COMPILING_IN_CPYTHON 0
+#define CYTHON_COMPILING_IN_LIMITED_API 0
+#define CYTHON_COMPILING_IN_GRAAL 1
+#define CYTHON_COMPILING_IN_NOGIL 0
+#undef CYTHON_USE_TYPE_SLOTS
+#define CYTHON_USE_TYPE_SLOTS 0
+#undef CYTHON_USE_TYPE_SPECS
+#define CYTHON_USE_TYPE_SPECS 0
+#undef CYTHON_USE_PYTYPE_LOOKUP
+#define CYTHON_USE_PYTYPE_LOOKUP 0
+#if PY_VERSION_HEX < 0x03050000
+#undef CYTHON_USE_ASYNC_SLOTS
+#define CYTHON_USE_ASYNC_SLOTS 0
+#elif !defined(CYTHON_USE_ASYNC_SLOTS)
+#define CYTHON_USE_ASYNC_SLOTS 1
+#endif
+#undef CYTHON_USE_PYLIST_INTERNALS
+#define CYTHON_USE_PYLIST_INTERNALS 0
+#undef CYTHON_USE_UNICODE_INTERNALS
+#define CYTHON_USE_UNICODE_INTERNALS 0
+#undef CYTHON_USE_UNICODE_WRITER
+#define CYTHON_USE_UNICODE_WRITER 0
+#undef CYTHON_USE_PYLONG_INTERNALS
+#define CYTHON_USE_PYLONG_INTERNALS 0
+#undef CYTHON_AVOID_BORROWED_REFS
+#define CYTHON_AVOID_BORROWED_REFS 1
+#undef CYTHON_ASSUME_SAFE_MACROS
+#define CYTHON_ASSUME_SAFE_MACROS 0
+#undef CYTHON_UNPACK_METHODS
+#define CYTHON_UNPACK_METHODS 0
+#undef CYTHON_FAST_THREAD_STATE
+#define CYTHON_FAST_THREAD_STATE 0
+#undef CYTHON_FAST_GIL
+#define CYTHON_FAST_GIL 0
+#undef CYTHON_METH_FASTCALL
+#define CYTHON_METH_FASTCALL 0
+#undef CYTHON_FAST_PYCALL
+#define CYTHON_FAST_PYCALL 0
+#ifndef CYTHON_PEP487_INIT_SUBCLASS
+#define CYTHON_PEP487_INIT_SUBCLASS (PY_MAJOR_VERSION >= 3)
+#endif
+#undef CYTHON_PEP489_MULTI_PHASE_INIT
+#define CYTHON_PEP489_MULTI_PHASE_INIT 1
+#undef CYTHON_USE_MODULE_STATE
+#define CYTHON_USE_MODULE_STATE 0
+#undef CYTHON_USE_TP_FINALIZE
+#define CYTHON_USE_TP_FINALIZE 0
+#undef CYTHON_USE_DICT_VERSIONS
+#define CYTHON_USE_DICT_VERSIONS 0
+#undef CYTHON_USE_EXC_INFO_STACK
+#define CYTHON_USE_EXC_INFO_STACK 0
+#ifndef CYTHON_UPDATE_DESCRIPTOR_DOC
+#define CYTHON_UPDATE_DESCRIPTOR_DOC 0
+#endif
+#undef CYTHON_USE_FREELISTS
+#define CYTHON_USE_FREELISTS 0
+#elif defined(PYPY_VERSION)
+#define CYTHON_COMPILING_IN_PYPY 1
+#define CYTHON_COMPILING_IN_CPYTHON 0
+#define CYTHON_COMPILING_IN_LIMITED_API 0
+#define CYTHON_COMPILING_IN_GRAAL 0
+#define CYTHON_COMPILING_IN_NOGIL 0
+#undef CYTHON_USE_TYPE_SLOTS
+#define CYTHON_USE_TYPE_SLOTS 0
+#ifndef CYTHON_USE_TYPE_SPECS
+#define CYTHON_USE_TYPE_SPECS 0
+#endif
+#undef CYTHON_USE_PYTYPE_LOOKUP
+#define CYTHON_USE_PYTYPE_LOOKUP 0
+#if PY_VERSION_HEX < 0x03050000
+#undef CYTHON_USE_ASYNC_SLOTS
+#define CYTHON_USE_ASYNC_SLOTS 0
+#elif !defined(CYTHON_USE_ASYNC_SLOTS)
+#define CYTHON_USE_ASYNC_SLOTS 1
+#endif
+#undef CYTHON_USE_PYLIST_INTERNALS
+#define CYTHON_USE_PYLIST_INTERNALS 0
+#undef CYTHON_USE_UNICODE_INTERNALS
+#define CYTHON_USE_UNICODE_INTERNALS 0
+#undef CYTHON_USE_UNICODE_WRITER
+#define CYTHON_USE_UNICODE_WRITER 0
+#undef CYTHON_USE_PYLONG_INTERNALS
+#define CYTHON_USE_PYLONG_INTERNALS 0
+#undef CYTHON_AVOID_BORROWED_REFS
+#define CYTHON_AVOID_BORROWED_REFS 1
+#undef CYTHON_ASSUME_SAFE_MACROS
+#define CYTHON_ASSUME_SAFE_MACROS 0
+#undef CYTHON_UNPACK_METHODS
+#define CYTHON_UNPACK_METHODS 0
+#undef CYTHON_FAST_THREAD_STATE
+#define CYTHON_FAST_THREAD_STATE 0
+#undef CYTHON_FAST_GIL
+#define CYTHON_FAST_GIL 0
+#undef CYTHON_METH_FASTCALL
+#define CYTHON_METH_FASTCALL 0
+#undef CYTHON_FAST_PYCALL
+#define CYTHON_FAST_PYCALL 0
+#ifndef CYTHON_PEP487_INIT_SUBCLASS
+#define CYTHON_PEP487_INIT_SUBCLASS (PY_MAJOR_VERSION >= 3)
+#endif
+#if PY_VERSION_HEX < 0x03090000
+#undef CYTHON_PEP489_MULTI_PHASE_INIT
+#define CYTHON_PEP489_MULTI_PHASE_INIT 0
+#elif !defined(CYTHON_PEP489_MULTI_PHASE_INIT)
+#define CYTHON_PEP489_MULTI_PHASE_INIT 1
+#endif
+#undef CYTHON_USE_MODULE_STATE
+#define CYTHON_USE_MODULE_STATE 0
+#undef CYTHON_USE_TP_FINALIZE
+#define CYTHON_USE_TP_FINALIZE (PY_VERSION_HEX >= 0x030400a1 && PYPY_VERSION_NUM >= 0x07030C00)
+#undef CYTHON_USE_DICT_VERSIONS
+#define CYTHON_USE_DICT_VERSIONS 0
+#undef CYTHON_USE_EXC_INFO_STACK
+#define CYTHON_USE_EXC_INFO_STACK 0
+#ifndef CYTHON_UPDATE_DESCRIPTOR_DOC
+#define CYTHON_UPDATE_DESCRIPTOR_DOC 0
+#endif
+#undef CYTHON_USE_FREELISTS
+#define CYTHON_USE_FREELISTS 0
+#elif defined(CYTHON_LIMITED_API)
+#ifdef Py_LIMITED_API
+#undef __PYX_LIMITED_VERSION_HEX
+#define __PYX_LIMITED_VERSION_HEX Py_LIMITED_API
+#endif
+#define CYTHON_COMPILING_IN_PYPY 0
+#define CYTHON_COMPILING_IN_CPYTHON 0
+#define CYTHON_COMPILING_IN_LIMITED_API 1
+#define CYTHON_COMPILING_IN_GRAAL 0
+#define CYTHON_COMPILING_IN_NOGIL 0
+#undef CYTHON_CLINE_IN_TRACEBACK
+#define CYTHON_CLINE_IN_TRACEBACK 0
+#undef CYTHON_USE_TYPE_SLOTS
+#define CYTHON_USE_TYPE_SLOTS 0
+#undef CYTHON_USE_TYPE_SPECS
+#define CYTHON_USE_TYPE_SPECS 1
+#undef CYTHON_USE_PYTYPE_LOOKUP
+#define CYTHON_USE_PYTYPE_LOOKUP 0
+#undef CYTHON_USE_ASYNC_SLOTS
+#define CYTHON_USE_ASYNC_SLOTS 0
+#undef CYTHON_USE_PYLIST_INTERNALS
+#define CYTHON_USE_PYLIST_INTERNALS 0
+#undef CYTHON_USE_UNICODE_INTERNALS
+#define CYTHON_USE_UNICODE_INTERNALS 0
+#ifndef CYTHON_USE_UNICODE_WRITER
+#define CYTHON_USE_UNICODE_WRITER 0
+#endif
+#undef CYTHON_USE_PYLONG_INTERNALS
+#define CYTHON_USE_PYLONG_INTERNALS 0
+#ifndef CYTHON_AVOID_BORROWED_REFS
+#define CYTHON_AVOID_BORROWED_REFS 0
+#endif
+#undef CYTHON_ASSUME_SAFE_MACROS
+#define CYTHON_ASSUME_SAFE_MACROS 0
+#undef CYTHON_UNPACK_METHODS
+#define CYTHON_UNPACK_METHODS 0
+#undef CYTHON_FAST_THREAD_STATE
+#define CYTHON_FAST_THREAD_STATE 0
+#undef CYTHON_FAST_GIL
+#define CYTHON_FAST_GIL 0
+#undef CYTHON_METH_FASTCALL
+#define CYTHON_METH_FASTCALL 0
+#undef CYTHON_FAST_PYCALL
+#define CYTHON_FAST_PYCALL 0
+#ifndef CYTHON_PEP487_INIT_SUBCLASS
+#define CYTHON_PEP487_INIT_SUBCLASS 1
+#endif
+#undef CYTHON_PEP489_MULTI_PHASE_INIT
+#define CYTHON_PEP489_MULTI_PHASE_INIT 0
+#undef CYTHON_USE_MODULE_STATE
+#define CYTHON_USE_MODULE_STATE 1
+#ifndef CYTHON_USE_TP_FINALIZE
+#define CYTHON_USE_TP_FINALIZE 0
+#endif
+#undef CYTHON_USE_DICT_VERSIONS
+#define CYTHON_USE_DICT_VERSIONS 0
+#undef CYTHON_USE_EXC_INFO_STACK
+#define CYTHON_USE_EXC_INFO_STACK 0
+#ifndef CYTHON_UPDATE_DESCRIPTOR_DOC
+#define CYTHON_UPDATE_DESCRIPTOR_DOC 0
+#endif
+#undef CYTHON_USE_FREELISTS
+#define CYTHON_USE_FREELISTS 0
+#elif defined(Py_GIL_DISABLED) || defined(Py_NOGIL)
+#define CYTHON_COMPILING_IN_PYPY 0
+#define CYTHON_COMPILING_IN_CPYTHON 0
+#define CYTHON_COMPILING_IN_LIMITED_API 0
+#define CYTHON_COMPILING_IN_GRAAL 0
+#define CYTHON_COMPILING_IN_NOGIL 1
+#ifndef CYTHON_USE_TYPE_SLOTS
+#define CYTHON_USE_TYPE_SLOTS 1
+#endif
+#ifndef CYTHON_USE_TYPE_SPECS
+#define CYTHON_USE_TYPE_SPECS 0
+#endif
+#undef CYTHON_USE_PYTYPE_LOOKUP
+#define CYTHON_USE_PYTYPE_LOOKUP 0
+#ifndef CYTHON_USE_ASYNC_SLOTS
+#define CYTHON_USE_ASYNC_SLOTS 1
+#endif
+#ifndef CYTHON_USE_PYLONG_INTERNALS
+#define CYTHON_USE_PYLONG_INTERNALS 0
+#endif
+#undef CYTHON_USE_PYLIST_INTERNALS
+#define CYTHON_USE_PYLIST_INTERNALS 0
+#ifndef CYTHON_USE_UNICODE_INTERNALS
+#define CYTHON_USE_UNICODE_INTERNALS 1
+#endif
+#undef CYTHON_USE_UNICODE_WRITER
+#define CYTHON_USE_UNICODE_WRITER 0
+#ifndef CYTHON_AVOID_BORROWED_REFS
+#define CYTHON_AVOID_BORROWED_REFS 0
+#endif
+#ifndef CYTHON_ASSUME_SAFE_MACROS
+#define CYTHON_ASSUME_SAFE_MACROS 1
+#endif
+#ifndef CYTHON_UNPACK_METHODS
+#define CYTHON_UNPACK_METHODS 1
+#endif
+#undef CYTHON_FAST_THREAD_STATE
+#define CYTHON_FAST_THREAD_STATE 0
+#undef CYTHON_FAST_GIL
+#define CYTHON_FAST_GIL 0
+#ifndef CYTHON_METH_FASTCALL
+#define CYTHON_METH_FASTCALL 1
+#endif
+#undef CYTHON_FAST_PYCALL
+#define CYTHON_FAST_PYCALL 0
+#ifndef CYTHON_PEP487_INIT_SUBCLASS
+#define CYTHON_PEP487_INIT_SUBCLASS 1
+#endif
+#ifndef CYTHON_PEP489_MULTI_PHASE_INIT
+#define CYTHON_PEP489_MULTI_PHASE_INIT 1
+#endif
+#ifndef CYTHON_USE_MODULE_STATE
+#define CYTHON_USE_MODULE_STATE 0
+#endif
+#ifndef CYTHON_USE_TP_FINALIZE
+#define CYTHON_USE_TP_FINALIZE 1
+#endif
+#undef CYTHON_USE_DICT_VERSIONS
+#define CYTHON_USE_DICT_VERSIONS 0
+#undef CYTHON_USE_EXC_INFO_STACK
+#define CYTHON_USE_EXC_INFO_STACK 0
+#ifndef CYTHON_UPDATE_DESCRIPTOR_DOC
+#define CYTHON_UPDATE_DESCRIPTOR_DOC 1
+#endif
+#ifndef CYTHON_USE_FREELISTS
+#define CYTHON_USE_FREELISTS 0
+#endif
+#else
+#define CYTHON_COMPILING_IN_PYPY 0
+#define CYTHON_COMPILING_IN_CPYTHON 1
+#define CYTHON_COMPILING_IN_LIMITED_API 0
+#define CYTHON_COMPILING_IN_GRAAL 0
+#define CYTHON_COMPILING_IN_NOGIL 0
+#ifndef CYTHON_USE_TYPE_SLOTS
+#define CYTHON_USE_TYPE_SLOTS 1
+#endif
+#ifndef CYTHON_USE_TYPE_SPECS
+#define CYTHON_USE_TYPE_SPECS 0
+#endif
+#ifndef CYTHON_USE_PYTYPE_LOOKUP
+#define CYTHON_USE_PYTYPE_LOOKUP 1
+#endif
+#if PY_MAJOR_VERSION < 3
+#undef CYTHON_USE_ASYNC_SLOTS
+#define CYTHON_USE_ASYNC_SLOTS 0
+#elif !defined(CYTHON_USE_ASYNC_SLOTS)
+#define CYTHON_USE_ASYNC_SLOTS 1
+#endif
+#ifndef CYTHON_USE_PYLONG_INTERNALS
+#define CYTHON_USE_PYLONG_INTERNALS 1
+#endif
+#ifndef CYTHON_USE_PYLIST_INTERNALS
+#define CYTHON_USE_PYLIST_INTERNALS 1
+#endif
+#ifndef CYTHON_USE_UNICODE_INTERNALS
+#define CYTHON_USE_UNICODE_INTERNALS 1
+#endif
+#if PY_VERSION_HEX < 0x030300F0 || PY_VERSION_HEX >= 0x030B00A2
+#undef CYTHON_USE_UNICODE_WRITER
+#define CYTHON_USE_UNICODE_WRITER 0
+#elif !defined(CYTHON_USE_UNICODE_WRITER)
+#define CYTHON_USE_UNICODE_WRITER 1
+#endif
+#ifndef CYTHON_AVOID_BORROWED_REFS
+#define CYTHON_AVOID_BORROWED_REFS 0
+#endif
+#ifndef CYTHON_ASSUME_SAFE_MACROS
+#define CYTHON_ASSUME_SAFE_MACROS 1
+#endif
+#ifndef CYTHON_UNPACK_METHODS
+#define CYTHON_UNPACK_METHODS 1
+#endif
+#ifndef CYTHON_FAST_THREAD_STATE
+#define CYTHON_FAST_THREAD_STATE 1
+#endif
+#ifndef CYTHON_FAST_GIL
+#define CYTHON_FAST_GIL (PY_MAJOR_VERSION < 3 || PY_VERSION_HEX >= 0x03060000 && PY_VERSION_HEX < 0x030C00A6)
+#endif
+#ifndef CYTHON_METH_FASTCALL
+#define CYTHON_METH_FASTCALL (PY_VERSION_HEX >= 0x030700A1)
+#endif
+#ifndef CYTHON_FAST_PYCALL
+#define CYTHON_FAST_PYCALL 1
+#endif
+#ifndef CYTHON_PEP487_INIT_SUBCLASS
+#define CYTHON_PEP487_INIT_SUBCLASS 1
+#endif
+#if PY_VERSION_HEX < 0x03050000
+#undef CYTHON_PEP489_MULTI_PHASE_INIT
+#define CYTHON_PEP489_MULTI_PHASE_INIT 0
+#elif !defined(CYTHON_PEP489_MULTI_PHASE_INIT)
+#define CYTHON_PEP489_MULTI_PHASE_INIT 1
+#endif
+#ifndef CYTHON_USE_MODULE_STATE
+#define CYTHON_USE_MODULE_STATE 0
+#endif
+#if PY_VERSION_HEX < 0x030400a1
+#undef CYTHON_USE_TP_FINALIZE
+#define CYTHON_USE_TP_FINALIZE 0
+#elif !defined(CYTHON_USE_TP_FINALIZE)
+#define CYTHON_USE_TP_FINALIZE 1
+#endif
+#if PY_VERSION_HEX < 0x030600B1
+#undef CYTHON_USE_DICT_VERSIONS
+#define CYTHON_USE_DICT_VERSIONS 0
+#elif !defined(CYTHON_USE_DICT_VERSIONS)
+#define CYTHON_USE_DICT_VERSIONS  (PY_VERSION_HEX < 0x030C00A5)
+#endif
+#if PY_VERSION_HEX < 0x030700A3
+#undef CYTHON_USE_EXC_INFO_STACK
+#define CYTHON_USE_EXC_INFO_STACK 0
+#elif !defined(CYTHON_USE_EXC_INFO_STACK)
+#define CYTHON_USE_EXC_INFO_STACK 1
+#endif
+#ifndef CYTHON_UPDATE_DESCRIPTOR_DOC
+#define CYTHON_UPDATE_DESCRIPTOR_DOC 1
+#endif
+#ifndef CYTHON_USE_FREELISTS
+#define CYTHON_USE_FREELISTS 1
+#endif
+#endif
+#if !defined(CYTHON_FAST_PYCCALL)
+#define CYTHON_FAST_PYCCALL  (CYTHON_FAST_PYCALL && PY_VERSION_HEX >= 0x030600B1)
+#endif
+#if !defined(CYTHON_VECTORCALL)
+#define CYTHON_VECTORCALL  (CYTHON_FAST_PYCCALL && PY_VERSION_HEX >= 0x030800B1)
+#endif
+#define CYTHON_BACKPORT_VECTORCALL (CYTHON_METH_FASTCALL && PY_VERSION_HEX < 0x030800B1)
+#if CYTHON_USE_PYLONG_INTERNALS
+#if PY_MAJOR_VERSION < 3
+#include "longintrepr.h"
+#endif
+#undef SHIFT
+#undef BASE
+#undef MASK
+#ifdef SIZEOF_VOID_P
+enum { __pyx_check_sizeof_voidp = 1 / (int)(SIZEOF_VOID_P == sizeof(void*)) };
+#endif
+#endif
+#ifndef __has_attribute
+#define __has_attribute(x) 0
+#endif
+#ifndef __has_cpp_attribute
+#define __has_cpp_attribute(x) 0
+#endif
+#ifndef CYTHON_RESTRICT
+#if defined(__GNUC__)
+#define CYTHON_RESTRICT __restrict__
+#elif defined(_MSC_VER) && _MSC_VER >= 1400
+#define CYTHON_RESTRICT __restrict
+#elif defined (__STDC_VERSION__) && __STDC_VERSION__ >= 199901L
+#define CYTHON_RESTRICT restrict
+#else
+#define CYTHON_RESTRICT
+#endif
+#endif
+#ifndef CYTHON_UNUSED
+#if defined(__cplusplus)
+/* for clang __has_cpp_attribute(maybe_unused) is true even before C++17
+* but leads to warnings with -pedantic, since it is a C++17 feature */
+#if ((defined(_MSVC_LANG) && _MSVC_LANG >= 201703L) || __cplusplus >= 201703L)
+#if __has_cpp_attribute(maybe_unused)
+#define CYTHON_UNUSED [[maybe_unused]]
+#endif
+#endif
+#endif
+#endif
+#ifndef CYTHON_UNUSED
+# if defined(__GNUC__)
+#   if !(defined(__cplusplus)) || (__GNUC__ > 3 || (__GNUC__ == 3 && __GNUC_MINOR__ >= 4))
+#     define CYTHON_UNUSED __attribute__ ((__unused__))
+#   else
+#     define CYTHON_UNUSED
+#   endif
+# elif defined(__ICC) || (defined(__INTEL_COMPILER) && !defined(_MSC_VER))
+#   define CYTHON_UNUSED __attribute__ ((__unused__))
+# else
+#   define CYTHON_UNUSED
+# endif
+#endif
+#ifndef CYTHON_UNUSED_VAR
+#  if defined(__cplusplus)
+template<class T> void CYTHON_UNUSED_VAR( const T& ) { }
+#  else
+#    define CYTHON_UNUSED_VAR(x) (void)(x)
+#  endif
+#endif
+#ifndef CYTHON_MAYBE_UNUSED_VAR
+#define CYTHON_MAYBE_UNUSED_VAR(x) CYTHON_UNUSED_VAR(x)
+#endif
+#ifndef CYTHON_NCP_UNUSED
+# if CYTHON_COMPILING_IN_CPYTHON
+#  define CYTHON_NCP_UNUSED
+# else
+#  define CYTHON_NCP_UNUSED CYTHON_UNUSED
+# endif
+#endif
+#ifndef CYTHON_USE_CPP_STD_MOVE
+#if defined(__cplusplus) && (\
+__cplusplus >= 201103L || (defined(_MSC_VER) && _MSC_VER >= 1600))
+#define CYTHON_USE_CPP_STD_MOVE 1
+#else
+#define CYTHON_USE_CPP_STD_MOVE 0
+#endif
+#endif
+#define __Pyx_void_to_None(void_result) ((void)(void_result), Py_INCREF(Py_None), Py_None)
+#ifdef _MSC_VER
+#ifndef _MSC_STDINT_H_
+#if _MSC_VER < 1300
+typedef unsigned char     uint8_t;
+typedef unsigned short    uint16_t;
+typedef unsigned int      uint32_t;
+#else
+typedef unsigned __int8   uint8_t;
+typedef unsigned __int16  uint16_t;
+typedef unsigned __int32  uint32_t;
+#endif
+#endif
+#if _MSC_VER < 1300
+#ifdef _WIN64
+typedef unsigned long long  __pyx_uintptr_t;
+#else
+typedef unsigned int        __pyx_uintptr_t;
+#endif
+#else
+#ifdef _WIN64
+typedef unsigned __int64    __pyx_uintptr_t;
+#else
+typedef unsigned __int32    __pyx_uintptr_t;
+#endif
+#endif
+#else
+#include <stdint.h>
+typedef uintptr_t  __pyx_uintptr_t;
+#endif
+#ifndef CYTHON_FALLTHROUGH
+#if defined(__cplusplus)
+/* for clang __has_cpp_attribute(fallthrough) is true even before C++17
+* but leads to warnings with -pedantic, since it is a C++17 feature */
+#if ((defined(_MSVC_LANG) && _MSVC_LANG >= 201703L) || __cplusplus >= 201703L)
+#if __has_cpp_attribute(fallthrough)
+#define CYTHON_FALLTHROUGH [[fallthrough]]
+#endif
+#endif
+#ifndef CYTHON_FALLTHROUGH
+#if __has_cpp_attribute(clang::fallthrough)
+#define CYTHON_FALLTHROUGH [[clang::fallthrough]]
+#elif __has_cpp_attribute(gnu::fallthrough)
+#define CYTHON_FALLTHROUGH [[gnu::fallthrough]]
+#endif
+#endif
+#endif
+#ifndef CYTHON_FALLTHROUGH
+#if __has_attribute(fallthrough)
+#define CYTHON_FALLTHROUGH __attribute__((fallthrough))
+#else
+#define CYTHON_FALLTHROUGH
+#endif
+#endif
+#if defined(__clang__) && defined(__apple_build_version__)
+#if __apple_build_version__ < 7000000
+#undef  CYTHON_FALLTHROUGH
+#define CYTHON_FALLTHROUGH
+#endif
+#endif
+#endif
+#ifdef __cplusplus
+template <typename T>
+struct __PYX_IS_UNSIGNED_IMPL {static const bool value = T(0) < T(-1);};
+#define __PYX_IS_UNSIGNED(type) (__PYX_IS_UNSIGNED_IMPL<type>::value)
+#else
+#define __PYX_IS_UNSIGNED(type) (((type)-1) > 0)
+#endif
+#if CYTHON_COMPILING_IN_PYPY == 1
+#define __PYX_NEED_TP_PRINT_SLOT  (PY_VERSION_HEX >= 0x030800b4 && PY_VERSION_HEX < 0x030A0000)
+#else
+#define __PYX_NEED_TP_PRINT_SLOT  (PY_VERSION_HEX >= 0x030800b4 && PY_VERSION_HEX < 0x03090000)
+#endif
+#define __PYX_REINTERPRET_FUNCION(func_pointer, other_pointer) ((func_pointer)(void(*)(void))(other_pointer))
+#ifndef CYTHON_INLINE
+#if defined(__clang__)
+#define CYTHON_INLINE __inline__ __attribute__ ((__unused__))
+#elif defined(__GNUC__)
+#define CYTHON_INLINE __inline__
+#elif defined(_MSC_VER)
+#define CYTHON_INLINE __inline
+#elif defined (__STDC_VERSION__) && __STDC_VERSION__ >= 199901L
+#define CYTHON_INLINE inline
+#else
+#define CYTHON_INLINE
+#endif
+#endif
+#define __PYX_BUILD_PY_SSIZE_T "n"
+#define CYTHON_FORMAT_SSIZE_T "z"
+#if PY_MAJOR_VERSION < 3
+#define __Pyx_BUILTIN_MODULE_NAME "__builtin__"
+#define __Pyx_DefaultClassType PyClass_Type
+#define __Pyx_PyCode_New(a, p, k, l, s, f, code, c, n, v, fv, cell, fn, name, fline, lnos)\
+PyCode_New(a+k, l, s, f, code, c, n, v, fv, cell, fn, name, fline, lnos)
+#else
+#define __Pyx_BUILTIN_MODULE_NAME "builtins"
+#define __Pyx_DefaultClassType PyType_Type
+#if CYTHON_COMPILING_IN_LIMITED_API
+static CYTHON_INLINE PyObject* __Pyx_PyCode_New(int a, int p, int k, int l, int s, int f,
+PyObject *code, PyObject *c, PyObject* n, PyObject *v,
+PyObject *fv, PyObject *cell, PyObject* fn,
+PyObject *name, int fline, PyObject *lnos) {
+PyObject *exception_table = NULL;
+PyObject *types_module=NULL, *code_type=NULL, *result=NULL;
+#if __PYX_LIMITED_VERSION_HEX < 0x030B0000
+PyObject *version_info;
+PyObject *py_minor_version = NULL;
+#endif
+long minor_version = 0;
+PyObject *type, *value, *traceback;
+PyErr_Fetch(&type, &value, &traceback);
+#if __PYX_LIMITED_VERSION_HEX >= 0x030B0000
+minor_version = 11;
+#else
+if (!(version_info = PySys_GetObject("version_info"))) goto end;
+if (!(py_minor_version = PySequence_GetItem(version_info, 1))) goto end;
+minor_version = PyLong_AsLong(py_minor_version);
+Py_DECREF(py_minor_version);
+if (minor_version == -1 && PyErr_Occurred()) goto end;
+#endif
+if (!(types_module = PyImport_ImportModule("types"))) goto end;
+if (!(code_type = PyObject_GetAttrString(types_module, "CodeType"))) goto end;
+if (minor_version <= 7) {
+(void)p;
+result = PyObject_CallFunction(code_type, "iiiiiOOOOOOiOO", a, k, l, s, f, code,
+c, n, v, fn, name, fline, lnos, fv, cell);
+} else if (minor_version <= 10) {
+result = PyObject_CallFunction(code_type, "iiiiiiOOOOOOiOO", a,p, k, l, s, f, code,
+c, n, v, fn, name, fline, lnos, fv, cell);
+} else {
+if (!(exception_table = PyBytes_FromStringAndSize(NULL, 0))) goto end;
+result = PyObject_CallFunction(code_type, "iiiiiiOOOOOOOiOO", a,p, k, l, s, f, code,
+c, n, v, fn, name, name, fline, lnos, exception_table, fv, cell);
+}
+end:
+Py_XDECREF(code_type);
+Py_XDECREF(exception_table);
+Py_XDECREF(types_module);
+if (type) {
+PyErr_Restore(type, value, traceback);
+}
+return result;
+}
+#ifndef CO_OPTIMIZED
+#define CO_OPTIMIZED 0x0001
+#endif
+#ifndef CO_NEWLOCALS
+#define CO_NEWLOCALS 0x0002
+#endif
+#ifndef CO_VARARGS
+#define CO_VARARGS 0x0004
+#endif
+#ifndef CO_VARKEYWORDS
+#define CO_VARKEYWORDS 0x0008
+#endif
+#ifndef CO_ASYNC_GENERATOR
+#define CO_ASYNC_GENERATOR 0x0200
+#endif
+#ifndef CO_GENERATOR
+#define CO_GENERATOR 0x0020
+#endif
+#ifndef CO_COROUTINE
+#define CO_COROUTINE 0x0080
+#endif
+#elif PY_VERSION_HEX >= 0x030B0000
+static CYTHON_INLINE PyCodeObject* __Pyx_PyCode_New(int a, int p, int k, int l, int s, int f,
+PyObject *code, PyObject *c, PyObject* n, PyObject *v,
+PyObject *fv, PyObject *cell, PyObject* fn,
+PyObject *name, int fline, PyObject *lnos) {
+PyCodeObject *result;
+PyObject *empty_bytes = PyBytes_FromStringAndSize("", 0);
+if (!empty_bytes) return NULL;
+result =
+#if PY_VERSION_HEX >= 0x030C0000
+PyUnstable_Code_NewWithPosOnlyArgs
+#else
+PyCode_NewWithPosOnlyArgs
+#endif
+(a, p, k, l, s, f, code, c, n, v, fv, cell, fn, name, name, fline, lnos, empty_bytes);
+Py_DECREF(empty_bytes);
+return result;
+}
+#elif PY_VERSION_HEX >= 0x030800B2 && !CYTHON_COMPILING_IN_PYPY
+#define __Pyx_PyCode_New(a, p, k, l, s, f, code, c, n, v, fv, cell, fn, name, fline, lnos)\
+PyCode_NewWithPosOnlyArgs(a, p, k, l, s, f, code, c, n, v, fv, cell, fn, name, fline, lnos)
+#else
+#define __Pyx_PyCode_New(a, p, k, l, s, f, code, c, n, v, fv, cell, fn, name, fline, lnos)\
+PyCode_New(a, k, l, s, f, code, c, n, v, fv, cell, fn, name, fline, lnos)
+#endif
+#endif
+#if PY_VERSION_HEX >= 0x030900A4 || defined(Py_IS_TYPE)
+#define __Pyx_IS_TYPE(ob, type) Py_IS_TYPE(ob, type)
+#else
+#define __Pyx_IS_TYPE(ob, type) (((const PyObject*)ob)->ob_type == (type))
+#endif
+#if PY_VERSION_HEX >= 0x030A00B1 || defined(Py_Is)
+#define __Pyx_Py_Is(x, y)  Py_Is(x, y)
+#else
+#define __Pyx_Py_Is(x, y) ((x) == (y))
+#endif
+#if PY_VERSION_HEX >= 0x030A00B1 || defined(Py_IsNone)
+#define __Pyx_Py_IsNone(ob) Py_IsNone(ob)
+#else
+#define __Pyx_Py_IsNone(ob) __Pyx_Py_Is((ob), Py_None)
+#endif
+#if PY_VERSION_HEX >= 0x030A00B1 || defined(Py_IsTrue)
+#define __Pyx_Py_IsTrue(ob) Py_IsTrue(ob)
+#else
+#define __Pyx_Py_IsTrue(ob) __Pyx_Py_Is((ob), Py_True)
+#endif
+#if PY_VERSION_HEX >= 0x030A00B1 || defined(Py_IsFalse)
+#define __Pyx_Py_IsFalse(ob) Py_IsFalse(ob)
+#else
+#define __Pyx_Py_IsFalse(ob) __Pyx_Py_Is((ob), Py_False)
+#endif
+#define __Pyx_NoneAsNull(obj)  (__Pyx_Py_IsNone(obj) ? NULL : (obj))
+#if PY_VERSION_HEX >= 0x030900F0 && !CYTHON_COMPILING_IN_PYPY
+#define __Pyx_PyObject_GC_IsFinalized(o) PyObject_GC_IsFinalized(o)
+#else
+#define __Pyx_PyObject_GC_IsFinalized(o) _PyGC_FINALIZED(o)
+#endif
+#ifndef CO_COROUTINE
+#define CO_COROUTINE 0x80
+#endif
+#ifndef CO_ASYNC_GENERATOR
+#define CO_ASYNC_GENERATOR 0x200
+#endif
+#ifndef Py_TPFLAGS_CHECKTYPES
+#define Py_TPFLAGS_CHECKTYPES 0
+#endif
+#ifndef Py_TPFLAGS_HAVE_INDEX
+#define Py_TPFLAGS_HAVE_INDEX 0
+#endif
+#ifndef Py_TPFLAGS_HAVE_NEWBUFFER
+#define Py_TPFLAGS_HAVE_NEWBUFFER 0
+#endif
+#ifndef Py_TPFLAGS_HAVE_FINALIZE
+#define Py_TPFLAGS_HAVE_FINALIZE 0
+#endif
+#ifndef Py_TPFLAGS_SEQUENCE
+#define Py_TPFLAGS_SEQUENCE 0
+#endif
+#ifndef Py_TPFLAGS_MAPPING
+#define Py_TPFLAGS_MAPPING 0
+#endif
+#ifndef METH_STACKLESS
+#define METH_STACKLESS 0
+#endif
+#if PY_VERSION_HEX <= 0x030700A3 || !defined(METH_FASTCALL)
+#ifndef METH_FASTCALL
+#define METH_FASTCALL 0x80
+#endif
+typedef PyObject *(*__Pyx_PyCFunctionFast) (PyObject *self, PyObject *const *args, Py_ssize_t nargs);
+typedef PyObject *(*__Pyx_PyCFunctionFastWithKeywords) (PyObject *self, PyObject *const *args,
+Py_ssize_t nargs, PyObject *kwnames);
+#else
+#if PY_VERSION_HEX >= 0x030d00A4
+#  define __Pyx_PyCFunctionFast PyCFunctionFast
+#  define __Pyx_PyCFunctionFastWithKeywords PyCFunctionFastWithKeywords
+#else
+#  define __Pyx_PyCFunctionFast _PyCFunctionFast
+#  define __Pyx_PyCFunctionFastWithKeywords _PyCFunctionFastWithKeywords
+#endif
+#endif
+#if CYTHON_METH_FASTCALL
+#define __Pyx_METH_FASTCALL METH_FASTCALL
+#define __Pyx_PyCFunction_FastCall __Pyx_PyCFunctionFast
+#define __Pyx_PyCFunction_FastCallWithKeywords __Pyx_PyCFunctionFastWithKeywords
+#else
+#define __Pyx_METH_FASTCALL METH_VARARGS
+#define __Pyx_PyCFunction_FastCall PyCFunction
+#define __Pyx_PyCFunction_FastCallWithKeywords PyCFunctionWithKeywords
+#endif
+#if CYTHON_VECTORCALL
+#define __pyx_vectorcallfunc vectorcallfunc
+#define __Pyx_PY_VECTORCALL_ARGUMENTS_OFFSET  PY_VECTORCALL_ARGUMENTS_OFFSET
+#define __Pyx_PyVectorcall_NARGS(n)  PyVectorcall_NARGS((size_t)(n))
+#elif CYTHON_BACKPORT_VECTORCALL
+typedef PyObject *(*__pyx_vectorcallfunc)(PyObject *callable, PyObject *const *args,
+size_t nargsf, PyObject *kwnames);
+#define __Pyx_PY_VECTORCALL_ARGUMENTS_OFFSET  ((size_t)1 << (8 * sizeof(size_t) - 1))
+#define __Pyx_PyVectorcall_NARGS(n)  ((Py_ssize_t)(((size_t)(n)) & ~__Pyx_PY_VECTORCALL_ARGUMENTS_OFFSET))
+#else
+#define __Pyx_PY_VECTORCALL_ARGUMENTS_OFFSET  0
+#define __Pyx_PyVectorcall_NARGS(n)  ((Py_ssize_t)(n))
+#endif
+#if PY_MAJOR_VERSION >= 0x030900B1
+#define __Pyx_PyCFunction_CheckExact(func)  PyCFunction_CheckExact(func)
+#else
+#define __Pyx_PyCFunction_CheckExact(func)  PyCFunction_Check(func)
+#endif
+#define __Pyx_CyOrPyCFunction_Check(func)  PyCFunction_Check(func)
+#if CYTHON_COMPILING_IN_CPYTHON
+#define __Pyx_CyOrPyCFunction_GET_FUNCTION(func)  (((PyCFunctionObject*)(func))->m_ml->ml_meth)
+#elif !CYTHON_COMPILING_IN_LIMITED_API
+#define __Pyx_CyOrPyCFunction_GET_FUNCTION(func)  PyCFunction_GET_FUNCTION(func)
+#endif
+#if CYTHON_COMPILING_IN_CPYTHON
+#define __Pyx_CyOrPyCFunction_GET_FLAGS(func)  (((PyCFunctionObject*)(func))->m_ml->ml_flags)
+static CYTHON_INLINE PyObject* __Pyx_CyOrPyCFunction_GET_SELF(PyObject *func) {
+return (__Pyx_CyOrPyCFunction_GET_FLAGS(func) & METH_STATIC) ? NULL : ((PyCFunctionObject*)func)->m_self;
+}
+#endif
+static CYTHON_INLINE int __Pyx__IsSameCFunction(PyObject *func, void *cfunc) {
+#if CYTHON_COMPILING_IN_LIMITED_API
+return PyCFunction_Check(func) && PyCFunction_GetFunction(func) == (PyCFunction) cfunc;
+#else
+return PyCFunction_Check(func) && PyCFunction_GET_FUNCTION(func) == (PyCFunction) cfunc;
+#endif
+}
+#define __Pyx_IsSameCFunction(func, cfunc)   __Pyx__IsSameCFunction(func, cfunc)
+#if __PYX_LIMITED_VERSION_HEX < 0x030900B1
+#define __Pyx_PyType_FromModuleAndSpec(m, s, b)  ((void)m, PyType_FromSpecWithBases(s, b))
+typedef PyObject *(*__Pyx_PyCMethod)(PyObject *, PyTypeObject *, PyObject *const *, size_t, PyObject *);
+#else
+#define __Pyx_PyType_FromModuleAndSpec(m, s, b)  PyType_FromModuleAndSpec(m, s, b)
+#define __Pyx_PyCMethod  PyCMethod
+#endif
+#ifndef METH_METHOD
+#define METH_METHOD 0x200
+#endif
+#if CYTHON_COMPILING_IN_PYPY && !defined(PyObject_Malloc)
+#define PyObject_Malloc(s)   PyMem_Malloc(s)
+#define PyObject_Free(p)     PyMem_Free(p)
+#define PyObject_Realloc(p)  PyMem_Realloc(p)
+#endif
+#if CYTHON_COMPILING_IN_LIMITED_API
+#define __Pyx_PyCode_HasFreeVars(co)  (PyCode_GetNumFree(co) > 0)
+#define __Pyx_PyFrame_SetLineNumber(frame, lineno)
+#else
+#define __Pyx_PyCode_HasFreeVars(co)  (PyCode_GetNumFree(co) > 0)
+#define __Pyx_PyFrame_SetLineNumber(frame, lineno)  (frame)->f_lineno = (lineno)
+#endif
+#if CYTHON_COMPILING_IN_LIMITED_API
+#define __Pyx_PyThreadState_Current PyThreadState_Get()
+#elif !CYTHON_FAST_THREAD_STATE
+#define __Pyx_PyThreadState_Current PyThreadState_GET()
+#elif PY_VERSION_HEX >= 0x030d00A1
+#define __Pyx_PyThreadState_Current PyThreadState_GetUnchecked()
+#elif PY_VERSION_HEX >= 0x03060000
+#define __Pyx_PyThreadState_Current _PyThreadState_UncheckedGet()
+#elif PY_VERSION_HEX >= 0x03000000
+#define __Pyx_PyThreadState_Current PyThreadState_GET()
+#else
+#define __Pyx_PyThreadState_Current _PyThreadState_Current
+#endif
+#if CYTHON_COMPILING_IN_LIMITED_API
+static CYTHON_INLINE void *__Pyx_PyModule_GetState(PyObject *op)
+{
+void *result;
+result = PyModule_GetState(op);
+if (!result)
+Py_FatalError("Couldn't find the module state");
+return result;
+}
+#endif
+#define __Pyx_PyObject_GetSlot(obj, name, func_ctype)  __Pyx_PyType_GetSlot(Py_TYPE(obj), name, func_ctype)
+#if CYTHON_COMPILING_IN_LIMITED_API
+#define __Pyx_PyType_GetSlot(type, name, func_ctype)  ((func_ctype) PyType_GetSlot((type), Py_##name))
+#else
+#define __Pyx_PyType_GetSlot(type, name, func_ctype)  ((type)->name)
+#endif
+#if PY_VERSION_HEX < 0x030700A2 && !defined(PyThread_tss_create) && !defined(Py_tss_NEEDS_INIT)
+#include "pythread.h"
+#define Py_tss_NEEDS_INIT 0
+typedef int Py_tss_t;
+static CYTHON_INLINE int PyThread_tss_create(Py_tss_t *key) {
+*key = PyThread_create_key();
+return 0;
+}
+static CYTHON_INLINE Py_tss_t * PyThread_tss_alloc(void) {
+Py_tss_t *key = (Py_tss_t *)PyObject_Malloc(sizeof(Py_tss_t));
+*key = Py_tss_NEEDS_INIT;
+return key;
+}
+static CYTHON_INLINE void PyThread_tss_free(Py_tss_t *key) {
+PyObject_Free(key);
+}
+static CYTHON_INLINE int PyThread_tss_is_created(Py_tss_t *key) {
+return *key != Py_tss_NEEDS_INIT;
+}
+static CYTHON_INLINE void PyThread_tss_delete(Py_tss_t *key) {
+PyThread_delete_key(*key);
+*key = Py_tss_NEEDS_INIT;
+}
+static CYTHON_INLINE int PyThread_tss_set(Py_tss_t *key, void *value) {
+return PyThread_set_key_value(*key, value);
+}
+static CYTHON_INLINE void * PyThread_tss_get(Py_tss_t *key) {
+return PyThread_get_key_value(*key);
+}
+#endif
+#if PY_MAJOR_VERSION < 3
+#if CYTHON_COMPILING_IN_PYPY
+#if PYPY_VERSION_NUM < 0x07030600
+#if defined(__cplusplus) && __cplusplus >= 201402L
+[[deprecated("`with nogil:` inside a nogil function will not release the GIL in PyPy2 < 7.3.6")]]
+#elif defined(__GNUC__) || defined(__clang__)
+__attribute__ ((__deprecated__("`with nogil:` inside a nogil function will not release the GIL in PyPy2 < 7.3.6")))
+#elif defined(_MSC_VER)
+__declspec(deprecated("`with nogil:` inside a nogil function will not release the GIL in PyPy2 < 7.3.6"))
+#endif
+static CYTHON_INLINE int PyGILState_Check(void) {
+return 0;
+}
+#else  // PYPY_VERSION_NUM < 0x07030600
+#endif  // PYPY_VERSION_NUM < 0x07030600
+#else
+static CYTHON_INLINE int PyGILState_Check(void) {
+PyThreadState * tstate = _PyThreadState_Current;
+return tstate && (tstate == PyGILState_GetThisThreadState());
+}
+#endif
+#endif
+#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX < 0x030d0000 || defined(_PyDict_NewPresized)
+#define __Pyx_PyDict_NewPresized(n)  ((n <= 8) ? PyDict_New() : _PyDict_NewPresized(n))
+#else
+#define __Pyx_PyDict_NewPresized(n)  PyDict_New()
+#endif
+#if PY_MAJOR_VERSION >= 3 || CYTHON_FUTURE_DIVISION
+#define __Pyx_PyNumber_Divide(x,y)         PyNumber_TrueDivide(x,y)
+#define __Pyx_PyNumber_InPlaceDivide(x,y)  PyNumber_InPlaceTrueDivide(x,y)
+#else
+#define __Pyx_PyNumber_Divide(x,y)         PyNumber_Divide(x,y)
+#define __Pyx_PyNumber_InPlaceDivide(x,y)  PyNumber_InPlaceDivide(x,y)
+#endif
+#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX > 0x030600B4 && PY_VERSION_HEX < 0x030d0000 && CYTHON_USE_UNICODE_INTERNALS
+#define __Pyx_PyDict_GetItemStrWithError(dict, name)  _PyDict_GetItem_KnownHash(dict, name, ((PyASCIIObject *) name)->hash)
+static CYTHON_INLINE PyObject * __Pyx_PyDict_GetItemStr(PyObject *dict, PyObject *name) {
+PyObject *res = __Pyx_PyDict_GetItemStrWithError(dict, name);
+if (res == NULL) PyErr_Clear();
+return res;
+}
+#elif PY_MAJOR_VERSION >= 3 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07020000)
+#define __Pyx_PyDict_GetItemStrWithError  PyDict_GetItemWithError
+#define __Pyx_PyDict_GetItemStr           PyDict_GetItem
+#else
+static CYTHON_INLINE PyObject * __Pyx_PyDict_GetItemStrWithError(PyObject *dict, PyObject *name) {
+#if CYTHON_COMPILING_IN_PYPY
+return PyDict_GetItem(dict, name);
+#else
+PyDictEntry *ep;
+PyDictObject *mp = (PyDictObject*) dict;
+long hash = ((PyStringObject *) name)->ob_shash;
+assert(hash != -1);
+ep = (mp->ma_lookup)(mp, name, hash);
+if (ep == NULL) {
+return NULL;
+}
+return ep->me_value;
+#endif
+}
+#define __Pyx_PyDict_GetItemStr           PyDict_GetItem
+#endif
+#if CYTHON_USE_TYPE_SLOTS
+#define __Pyx_PyType_GetFlags(tp)   (((PyTypeObject *)tp)->tp_flags)
+#define __Pyx_PyType_HasFeature(type, feature)  ((__Pyx_PyType_GetFlags(type) & (feature)) != 0)
+#define __Pyx_PyObject_GetIterNextFunc(obj)  (Py_TYPE(obj)->tp_iternext)
+#else
+#define __Pyx_PyType_GetFlags(tp)   (PyType_GetFlags((PyTypeObject *)tp))
+#define __Pyx_PyType_HasFeature(type, feature)  PyType_HasFeature(type, feature)
+#define __Pyx_PyObject_GetIterNextFunc(obj)  PyIter_Next
+#endif
+#if CYTHON_COMPILING_IN_LIMITED_API
+#define __Pyx_SetItemOnTypeDict(tp, k, v) PyObject_GenericSetAttr((PyObject*)tp, k, v)
+#else
+#define __Pyx_SetItemOnTypeDict(tp, k, v) PyDict_SetItem(tp->tp_dict, k, v)
+#endif
+#if CYTHON_USE_TYPE_SPECS && PY_VERSION_HEX >= 0x03080000
+#define __Pyx_PyHeapTypeObject_GC_Del(obj)  {\
+PyTypeObject *type = Py_TYPE((PyObject*)obj);\
+assert(__Pyx_PyType_HasFeature(type, Py_TPFLAGS_HEAPTYPE));\
+PyObject_GC_Del(obj);\
+Py_DECREF(type);\
+}
+#else
+#define __Pyx_PyHeapTypeObject_GC_Del(obj)  PyObject_GC_Del(obj)
+#endif
+#if CYTHON_COMPILING_IN_LIMITED_API
+#define CYTHON_PEP393_ENABLED 1
+#define __Pyx_PyUnicode_READY(op)       (0)
+#define __Pyx_PyUnicode_GET_LENGTH(u)   PyUnicode_GetLength(u)
+#define __Pyx_PyUnicode_READ_CHAR(u, i) PyUnicode_ReadChar(u, i)
+#define __Pyx_PyUnicode_MAX_CHAR_VALUE(u)   ((void)u, 1114111U)
+#define __Pyx_PyUnicode_KIND(u)         ((void)u, (0))
+#define __Pyx_PyUnicode_DATA(u)         ((void*)u)
+#define __Pyx_PyUnicode_READ(k, d, i)   ((void)k, PyUnicode_ReadChar((PyObject*)(d), i))
+#define __Pyx_PyUnicode_IS_TRUE(u)      (0 != PyUnicode_GetLength(u))
+#elif PY_VERSION_HEX > 0x03030000 && defined(PyUnicode_KIND)
+#define CYTHON_PEP393_ENABLED 1
+#if PY_VERSION_HEX >= 0x030C0000
+#define __Pyx_PyUnicode_READY(op)       (0)
+#else
+#define __Pyx_PyUnicode_READY(op)       (likely(PyUnicode_IS_READY(op)) ?\
+0 : _PyUnicode_Ready((PyObject *)(op)))
+#endif
+#define __Pyx_PyUnicode_GET_LENGTH(u)   PyUnicode_GET_LENGTH(u)
+#define __Pyx_PyUnicode_READ_CHAR(u, i) PyUnicode_READ_CHAR(u, i)
+#define __Pyx_PyUnicode_MAX_CHAR_VALUE(u)   PyUnicode_MAX_CHAR_VALUE(u)
+#define __Pyx_PyUnicode_KIND(u)         ((int)PyUnicode_KIND(u))
+#define __Pyx_PyUnicode_DATA(u)         PyUnicode_DATA(u)
+#define __Pyx_PyUnicode_READ(k, d, i)   PyUnicode_READ(k, d, i)
+#define __Pyx_PyUnicode_WRITE(k, d, i, ch)  PyUnicode_WRITE(k, d, i, (Py_UCS4) ch)
+#if PY_VERSION_HEX >= 0x030C0000
+#define __Pyx_PyUnicode_IS_TRUE(u)      (0 != PyUnicode_GET_LENGTH(u))
+#else
+#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX >= 0x03090000
+#define __Pyx_PyUnicode_IS_TRUE(u)      (0 != (likely(PyUnicode_IS_READY(u)) ? PyUnicode_GET_LENGTH(u) : ((PyCompactUnicodeObject *)(u))->wstr_length))
+#else
+#define __Pyx_PyUnicode_IS_TRUE(u)      (0 != (likely(PyUnicode_IS_READY(u)) ? PyUnicode_GET_LENGTH(u) : PyUnicode_GET_SIZE(u)))
+#endif
+#endif
+#else
+#define CYTHON_PEP393_ENABLED 0
+#define PyUnicode_1BYTE_KIND  1
+#define PyUnicode_2BYTE_KIND  2
+#define PyUnicode_4BYTE_KIND  4
+#define __Pyx_PyUnicode_READY(op)       (0)
+#define __Pyx_PyUnicode_GET_LENGTH(u)   PyUnicode_GET_SIZE(u)
+#define __Pyx_PyUnicode_READ_CHAR(u, i) ((Py_UCS4)(PyUnicode_AS_UNICODE(u)[i]))
+#define __Pyx_PyUnicode_MAX_CHAR_VALUE(u)   ((sizeof(Py_UNICODE) == 2) ? 65535U : 1114111U)
+#define __Pyx_PyUnicode_KIND(u)         ((int)sizeof(Py_UNICODE))
+#define __Pyx_PyUnicode_DATA(u)         ((void*)PyUnicode_AS_UNICODE(u))
+#define __Pyx_PyUnicode_READ(k, d, i)   ((void)(k), (Py_UCS4)(((Py_UNICODE*)d)[i]))
+#define __Pyx_PyUnicode_WRITE(k, d, i, ch)  (((void)(k)), ((Py_UNICODE*)d)[i] = (Py_UNICODE) ch)
+#define __Pyx_PyUnicode_IS_TRUE(u)      (0 != PyUnicode_GET_SIZE(u))
+#endif
+#if CYTHON_COMPILING_IN_PYPY
+#define __Pyx_PyUnicode_Concat(a, b)      PyNumber_Add(a, b)
+#define __Pyx_PyUnicode_ConcatSafe(a, b)  PyNumber_Add(a, b)
+#else
+#define __Pyx_PyUnicode_Concat(a, b)      PyUnicode_Concat(a, b)
+#define __Pyx_PyUnicode_ConcatSafe(a, b)  ((unlikely((a) == Py_None) || unlikely((b) == Py_None)) ?\
+PyNumber_Add(a, b) : __Pyx_PyUnicode_Concat(a, b))
+#endif
+#if CYTHON_COMPILING_IN_PYPY
+#if !defined(PyUnicode_DecodeUnicodeEscape)
+#define PyUnicode_DecodeUnicodeEscape(s, size, errors)  PyUnicode_Decode(s, size, "unicode_escape", errors)
+#endif
+#if !defined(PyUnicode_Contains) || (PY_MAJOR_VERSION == 2 && PYPY_VERSION_NUM < 0x07030500)
+#undef PyUnicode_Contains
+#define PyUnicode_Contains(u, s)  PySequence_Contains(u, s)
+#endif
+#if !defined(PyByteArray_Check)
+#define PyByteArray_Check(obj)  PyObject_TypeCheck(obj, &PyByteArray_Type)
+#endif
+#if !defined(PyObject_Format)
+#define PyObject_Format(obj, fmt)  PyObject_CallMethod(obj, "__format__", "O", fmt)
+#endif
+#endif
+#define __Pyx_PyString_FormatSafe(a, b)   ((unlikely((a) == Py_None || (PyString_Check(b) && !PyString_CheckExact(b)))) ? PyNumber_Remainder(a, b) : __Pyx_PyString_Format(a, b))
+#define __Pyx_PyUnicode_FormatSafe(a, b)  ((unlikely((a) == Py_None || (PyUnicode_Check(b) && !PyUnicode_CheckExact(b)))) ? PyNumber_Remainder(a, b) : PyUnicode_Format(a, b))
+#if PY_MAJOR_VERSION >= 3
+#define __Pyx_PyString_Format(a, b)  PyUnicode_Format(a, b)
+#else
+#define __Pyx_PyString_Format(a, b)  PyString_Format(a, b)
+#endif
+#if PY_MAJOR_VERSION < 3 && !defined(PyObject_ASCII)
+#define PyObject_ASCII(o)            PyObject_Repr(o)
+#endif
+#if PY_MAJOR_VERSION >= 3
+#define PyBaseString_Type            PyUnicode_Type
+#define PyStringObject               PyUnicodeObject
+#define PyString_Type                PyUnicode_Type
+#define PyString_Check               PyUnicode_Check
+#define PyString_CheckExact          PyUnicode_CheckExact
+#ifndef PyObject_Unicode
+#define PyObject_Unicode             PyObject_Str
+#endif
+#endif
+#if PY_MAJOR_VERSION >= 3
+#define __Pyx_PyBaseString_Check(obj) PyUnicode_Check(obj)
+#define __Pyx_PyBaseString_CheckExact(obj) PyUnicode_CheckExact(obj)
+#else
+#define __Pyx_PyBaseString_Check(obj) (PyString_Check(obj) || PyUnicode_Check(obj))
+#define __Pyx_PyBaseString_CheckExact(obj) (PyString_CheckExact(obj) || PyUnicode_CheckExact(obj))
+#endif
+#if CYTHON_COMPILING_IN_CPYTHON
+#define __Pyx_PySequence_ListKeepNew(obj)\
+(likely(PyList_CheckExact(obj) && Py_REFCNT(obj) == 1) ? __Pyx_NewRef(obj) : PySequence_List(obj))
+#else
+#define __Pyx_PySequence_ListKeepNew(obj)  PySequence_List(obj)
+#endif
+#ifndef PySet_CheckExact
+#define PySet_CheckExact(obj)        __Pyx_IS_TYPE(obj, &PySet_Type)
+#endif
+#if PY_VERSION_HEX >= 0x030900A4
+#define __Pyx_SET_REFCNT(obj, refcnt) Py_SET_REFCNT(obj, refcnt)
+#define __Pyx_SET_SIZE(obj, size) Py_SET_SIZE(obj, size)
+#else
+#define __Pyx_SET_REFCNT(obj, refcnt) Py_REFCNT(obj) = (refcnt)
+#define __Pyx_SET_SIZE(obj, size) Py_SIZE(obj) = (size)
+#endif
+#if CYTHON_ASSUME_SAFE_MACROS
+#define __Pyx_PySequence_ITEM(o, i) PySequence_ITEM(o, i)
+#define __Pyx_PySequence_SIZE(seq)  Py_SIZE(seq)
+#define __Pyx_PyTuple_SET_ITEM(o, i, v) (PyTuple_SET_ITEM(o, i, v), (0))
+#define __Pyx_PyList_SET_ITEM(o, i, v) (PyList_SET_ITEM(o, i, v), (0))
+#define __Pyx_PyTuple_GET_SIZE(o) PyTuple_GET_SIZE(o)
+#define __Pyx_PyList_GET_SIZE(o) PyList_GET_SIZE(o)
+#define __Pyx_PySet_GET_SIZE(o) PySet_GET_SIZE(o)
+#define __Pyx_PyBytes_GET_SIZE(o) PyBytes_GET_SIZE(o)
+#define __Pyx_PyByteArray_GET_SIZE(o) PyByteArray_GET_SIZE(o)
+#else
+#define __Pyx_PySequence_ITEM(o, i) PySequence_GetItem(o, i)
+#define __Pyx_PySequence_SIZE(seq)  PySequence_Size(seq)
+#define __Pyx_PyTuple_SET_ITEM(o, i, v) PyTuple_SetItem(o, i, v)
+#define __Pyx_PyList_SET_ITEM(o, i, v) PyList_SetItem(o, i, v)
+#define __Pyx_PyTuple_GET_SIZE(o) PyTuple_Size(o)
+#define __Pyx_PyList_GET_SIZE(o) PyList_Size(o)
+#define __Pyx_PySet_GET_SIZE(o) PySet_Size(o)
+#define __Pyx_PyBytes_GET_SIZE(o) PyBytes_Size(o)
+#define __Pyx_PyByteArray_GET_SIZE(o) PyByteArray_Size(o)
+#endif
+#if __PYX_LIMITED_VERSION_HEX >= 0x030d00A1
+#define __Pyx_PyImport_AddModuleRef(name) PyImport_AddModuleRef(name)
+#else
+static CYTHON_INLINE PyObject *__Pyx_PyImport_AddModuleRef(const char *name) {
+PyObject *module = PyImport_AddModule(name);
+Py_XINCREF(module);
+return module;
+}
+#endif
+#if PY_MAJOR_VERSION >= 3
+#define PyIntObject                  PyLongObject
+#define PyInt_Type                   PyLong_Type
+#define PyInt_Check(op)              PyLong_Check(op)
+#define PyInt_CheckExact(op)         PyLong_CheckExact(op)
+#define __Pyx_Py3Int_Check(op)       PyLong_Check(op)
+#define __Pyx_Py3Int_CheckExact(op)  PyLong_CheckExact(op)
+#define PyInt_FromString             PyLong_FromString
+#define PyInt_FromUnicode            PyLong_FromUnicode
+#define PyInt_FromLong               PyLong_FromLong
+#define PyInt_FromSize_t             PyLong_FromSize_t
+#define PyInt_FromSsize_t            PyLong_FromSsize_t
+#define PyInt_AsLong                 PyLong_AsLong
+#define PyInt_AS_LONG                PyLong_AS_LONG
+#define PyInt_AsSsize_t              PyLong_AsSsize_t
+#define PyInt_AsUnsignedLongMask     PyLong_AsUnsignedLongMask
+#define PyInt_AsUnsignedLongLongMask PyLong_AsUnsignedLongLongMask
+#define PyNumber_Int                 PyNumber_Long
+#else
+#define __Pyx_Py3Int_Check(op)       (PyLong_Check(op) || PyInt_Check(op))
+#define __Pyx_Py3Int_CheckExact(op)  (PyLong_CheckExact(op) || PyInt_CheckExact(op))
+#endif
+#if PY_MAJOR_VERSION >= 3
+#define PyBoolObject                 PyLongObject
+#endif
+#if PY_MAJOR_VERSION >= 3 && CYTHON_COMPILING_IN_PYPY
+#ifndef PyUnicode_InternFromString
+#define PyUnicode_InternFromString(s) PyUnicode_FromString(s)
+#endif
+#endif
+#if PY_VERSION_HEX < 0x030200A4
+typedef long Py_hash_t;
+#define __Pyx_PyInt_FromHash_t PyInt_FromLong
+#define __Pyx_PyInt_AsHash_t   __Pyx_PyIndex_AsHash_t
+#else
+#define __Pyx_PyInt_FromHash_t PyInt_FromSsize_t
+#define __Pyx_PyInt_AsHash_t   __Pyx_PyIndex_AsSsize_t
+#endif
+#if CYTHON_USE_ASYNC_SLOTS
+#if PY_VERSION_HEX >= 0x030500B1
+#define __Pyx_PyAsyncMethodsStruct PyAsyncMethods
+#define __Pyx_PyType_AsAsync(obj) (Py_TYPE(obj)->tp_as_async)
+#else
+#define __Pyx_PyType_AsAsync(obj) ((__Pyx_PyAsyncMethodsStruct*) (Py_TYPE(obj)->tp_reserved))
+#endif
+#else
+#define __Pyx_PyType_AsAsync(obj) NULL
+#endif
+#ifndef __Pyx_PyAsyncMethodsStruct
+typedef struct {
+unaryfunc am_await;
+unaryfunc am_aiter;
+unaryfunc am_anext;
+} __Pyx_PyAsyncMethodsStruct;
+#endif
+#if defined(_WIN32) || defined(WIN32) || defined(MS_WINDOWS)
+#if !defined(_USE_MATH_DEFINES)
+#define _USE_MATH_DEFINES
+#endif
+#endif
+#include <math.h>
+#ifdef NAN
+#define __PYX_NAN() ((float) NAN)
+#else
+static CYTHON_INLINE float __PYX_NAN() {
+float value;
+memset(&value, 0xFF, sizeof(value));
+return value;
+}
+#endif
+#if defined(__CYGWIN__) && defined(_LDBL_EQ_DBL)
+#define __Pyx_truncl trunc
+#else
+#define __Pyx_truncl truncl
+#endif
+#define __PYX_MARK_ERR_POS(f_index, lineno) \
+{ __pyx_filename = __pyx_f[f_index]; (void)__pyx_filename; __pyx_lineno = lineno; (void)__pyx_lineno; __pyx_clineno = __LINE__;  (void)__pyx_clineno; }
+#define __PYX_ERR(f_index, lineno, Ln_error) \
+{ __PYX_MARK_ERR_POS(f_index, lineno) goto Ln_error; }
+#ifdef CYTHON_EXTERN_C
+#undef __PYX_EXTERN_C
+#define __PYX_EXTERN_C CYTHON_EXTERN_C
+#elif defined(__PYX_EXTERN_C)
+#ifdef _MSC_VER
+#pragma message ("Please do not define the '__PYX_EXTERN_C' macro externally. Use 'CYTHON_EXTERN_C' instead.")
+#else
+#warning Please do not define the '__PYX_EXTERN_C' macro externally. Use 'CYTHON_EXTERN_C' instead.
+#endif
+#else
+#ifdef __cplusplus
+#define __PYX_EXTERN_C extern "C"
+#else
+#define __PYX_EXTERN_C extern
+#endif
+#endif
+#define __PYX_HAVE__pysam__libcfaidx
+#define __PYX_HAVE_API__pysam__libcfaidx
+/* Early includes */
+#include <stdint.h>
+#include <string.h>
+#include <stdlib.h>
+#include <stdio.h>
+#include <stddef.h>
+#include "pythread.h"
+#if CYTHON_COMPILING_IN_PYPY
+#ifdef _MSC_VER
+#pragma message ("This module uses CPython specific internals of 'array.array', which are not available in PyPy.")
+#else
+#warning This module uses CPython specific internals of 'array.array', which are not available in PyPy.
+#endif
+#endif
+#include <sys/types.h>
+#include "stdarg.h"
+#include "htslib/kstring.h"
+#include "htslib_util.h"
+#include "htslib/hfile.h"
+#include "htslib/bgzf.h"
+#include "htslib/hts.h"
+#include "htslib/sam.h"
+#include "htslib/faidx.h"
+#include "htslib/tbx.h"
+#include "htslib/vcf.h"
+#include "htslib/vcfutils.h"
+#include "htslib/cram.h"
+#include "pysam_stream.h"
+#include <errno.h>
+#ifdef _OPENMP
+#include <omp.h>
+#endif /* _OPENMP */
+#if defined(PYREX_WITHOUT_ASSERTIONS) && !defined(CYTHON_WITHOUT_ASSERTIONS)
+#define CYTHON_WITHOUT_ASSERTIONS
+#endif
+typedef struct {PyObject **p; const char *s; const Py_ssize_t n; const char* encoding;
+const char is_unicode; const char is_str; const char intern; } __Pyx_StringTabEntry;
+#define __PYX_DEFAULT_STRING_ENCODING_IS_ASCII 0
+#define __PYX_DEFAULT_STRING_ENCODING_IS_UTF8 0
+#define __PYX_DEFAULT_STRING_ENCODING_IS_DEFAULT (PY_MAJOR_VERSION >= 3 && __PYX_DEFAULT_STRING_ENCODING_IS_UTF8)
+#define __PYX_DEFAULT_STRING_ENCODING ""
+#define __Pyx_PyObject_FromString __Pyx_PyBytes_FromString
+#define __Pyx_PyObject_FromStringAndSize __Pyx_PyBytes_FromStringAndSize
+#define __Pyx_uchar_cast(c) ((unsigned char)c)
+#define __Pyx_long_cast(x) ((long)x)
+#define __Pyx_fits_Py_ssize_t(v, type, is_signed)  (\
+(sizeof(type) < sizeof(Py_ssize_t))  ||\
+(sizeof(type) > sizeof(Py_ssize_t) &&\
+likely(v < (type)PY_SSIZE_T_MAX ||\
+v == (type)PY_SSIZE_T_MAX)  &&\
+(!is_signed || likely(v > (type)PY_SSIZE_T_MIN ||\
+v == (type)PY_SSIZE_T_MIN)))  ||\
+(sizeof(type) == sizeof(Py_ssize_t) &&\
+(is_signed || likely(v < (type)PY_SSIZE_T_MAX ||\
+v == (type)PY_SSIZE_T_MAX)))  )
+static CYTHON_INLINE int __Pyx_is_valid_index(Py_ssize_t i, Py_ssize_t limit) {
+return (size_t) i < (size_t) limit;
+}
+#if defined (__cplusplus) && __cplusplus >= 201103L
+#include <cstdlib>
+#define __Pyx_sst_abs(value) std::abs(value)
+#elif SIZEOF_INT >= SIZEOF_SIZE_T
+#define __Pyx_sst_abs(value) abs(value)
+#elif SIZEOF_LONG >= SIZEOF_SIZE_T
+#define __Pyx_sst_abs(value) labs(value)
+#elif defined (_MSC_VER)
+#define __Pyx_sst_abs(value) ((Py_ssize_t)_abs64(value))
+#elif defined (__STDC_VERSION__) && __STDC_VERSION__ >= 199901L
+#define __Pyx_sst_abs(value) llabs(value)
+#elif defined (__GNUC__)
+#define __Pyx_sst_abs(value) __builtin_llabs(value)
+#else
+#define __Pyx_sst_abs(value) ((value<0) ? -value : value)
+#endif
+static CYTHON_INLINE Py_ssize_t __Pyx_ssize_strlen(const char *s);
+static CYTHON_INLINE const char* __Pyx_PyObject_AsString(PyObject*);
+static CYTHON_INLINE const char* __Pyx_PyObject_AsStringAndSize(PyObject*, Py_ssize_t* length);
+static CYTHON_INLINE PyObject* __Pyx_PyByteArray_FromString(const char*);
+#define __Pyx_PyByteArray_FromStringAndSize(s, l) PyByteArray_FromStringAndSize((const char*)s, l)
+#define __Pyx_PyBytes_FromString        PyBytes_FromString
+#define __Pyx_PyBytes_FromStringAndSize PyBytes_FromStringAndSize
+static CYTHON_INLINE PyObject* __Pyx_PyUnicode_FromString(const char*);
+#if PY_MAJOR_VERSION < 3
+#define __Pyx_PyStr_FromString        __Pyx_PyBytes_FromString
+#define __Pyx_PyStr_FromStringAndSize __Pyx_PyBytes_FromStringAndSize
+#else
+#define __Pyx_PyStr_FromString        __Pyx_PyUnicode_FromString
+#define __Pyx_PyStr_FromStringAndSize __Pyx_PyUnicode_FromStringAndSize
+#endif
+#define __Pyx_PyBytes_AsWritableString(s)     ((char*) PyBytes_AS_STRING(s))
+#define __Pyx_PyBytes_AsWritableSString(s)    ((signed char*) PyBytes_AS_STRING(s))
+#define __Pyx_PyBytes_AsWritableUString(s)    ((unsigned char*) PyBytes_AS_STRING(s))
+#define __Pyx_PyBytes_AsString(s)     ((const char*) PyBytes_AS_STRING(s))
+#define __Pyx_PyBytes_AsSString(s)    ((const signed char*) PyBytes_AS_STRING(s))
+#define __Pyx_PyBytes_AsUString(s)    ((const unsigned char*) PyBytes_AS_STRING(s))
+#define __Pyx_PyObject_AsWritableString(s)    ((char*)(__pyx_uintptr_t) __Pyx_PyObject_AsString(s))
+#define __Pyx_PyObject_AsWritableSString(s)    ((signed char*)(__pyx_uintptr_t) __Pyx_PyObject_AsString(s))
+#define __Pyx_PyObject_AsWritableUString(s)    ((unsigned char*)(__pyx_uintptr_t) __Pyx_PyObject_AsString(s))
+#define __Pyx_PyObject_AsSString(s)    ((const signed char*) __Pyx_PyObject_AsString(s))
+#define __Pyx_PyObject_AsUString(s)    ((const unsigned char*) __Pyx_PyObject_AsString(s))
+#define __Pyx_PyObject_FromCString(s)  __Pyx_PyObject_FromString((const char*)s)
+#define __Pyx_PyBytes_FromCString(s)   __Pyx_PyBytes_FromString((const char*)s)
+#define __Pyx_PyByteArray_FromCString(s)   __Pyx_PyByteArray_FromString((const char*)s)
+#define __Pyx_PyStr_FromCString(s)     __Pyx_PyStr_FromString((const char*)s)
+#define __Pyx_PyUnicode_FromCString(s) __Pyx_PyUnicode_FromString((const char*)s)
+#define __Pyx_PyUnicode_FromOrdinal(o)       PyUnicode_FromOrdinal((int)o)
+#define __Pyx_PyUnicode_AsUnicode            PyUnicode_AsUnicode
+#define __Pyx_NewRef(obj) (Py_INCREF(obj), obj)
+#define __Pyx_Owned_Py_None(b) __Pyx_NewRef(Py_None)
+static CYTHON_INLINE PyObject * __Pyx_PyBool_FromLong(long b);
+static CYTHON_INLINE int __Pyx_PyObject_IsTrue(PyObject*);
+static CYTHON_INLINE int __Pyx_PyObject_IsTrueAndDecref(PyObject*);
+static CYTHON_INLINE PyObject* __Pyx_PyNumber_IntOrLong(PyObject* x);
+#define __Pyx_PySequence_Tuple(obj)\
+(likely(PyTuple_CheckExact(obj)) ? __Pyx_NewRef(obj) : PySequence_Tuple(obj))
+static CYTHON_INLINE Py_ssize_t __Pyx_PyIndex_AsSsize_t(PyObject*);
+static CYTHON_INLINE PyObject * __Pyx_PyInt_FromSize_t(size_t);
+static CYTHON_INLINE Py_hash_t __Pyx_PyIndex_AsHash_t(PyObject*);
+#if CYTHON_ASSUME_SAFE_MACROS
+#define __pyx_PyFloat_AsDouble(x) (PyFloat_CheckExact(x) ? PyFloat_AS_DOUBLE(x) : PyFloat_AsDouble(x))
+#else
+#define __pyx_PyFloat_AsDouble(x) PyFloat_AsDouble(x)
+#endif
+#define __pyx_PyFloat_AsFloat(x) ((float) __pyx_PyFloat_AsDouble(x))
+#if PY_MAJOR_VERSION >= 3
+#define __Pyx_PyNumber_Int(x) (PyLong_CheckExact(x) ? __Pyx_NewRef(x) : PyNumber_Long(x))
+#else
+#define __Pyx_PyNumber_Int(x) (PyInt_CheckExact(x) ? __Pyx_NewRef(x) : PyNumber_Int(x))
+#endif
+#if CYTHON_USE_PYLONG_INTERNALS
+#if PY_VERSION_HEX >= 0x030C00A7
+#ifndef _PyLong_SIGN_MASK
+#define _PyLong_SIGN_MASK 3
+#endif
+#ifndef _PyLong_NON_SIZE_BITS
+#define _PyLong_NON_SIZE_BITS 3
+#endif
+#define __Pyx_PyLong_Sign(x)  (((PyLongObject*)x)->long_value.lv_tag & _PyLong_SIGN_MASK)
+#define __Pyx_PyLong_IsNeg(x)  ((__Pyx_PyLong_Sign(x) & 2) != 0)
+#define __Pyx_PyLong_IsNonNeg(x)  (!__Pyx_PyLong_IsNeg(x))
+#define __Pyx_PyLong_IsZero(x)  (__Pyx_PyLong_Sign(x) & 1)
+#define __Pyx_PyLong_IsPos(x)  (__Pyx_PyLong_Sign(x) == 0)
+#define __Pyx_PyLong_CompactValueUnsigned(x)  (__Pyx_PyLong_Digits(x)[0])
+#define __Pyx_PyLong_DigitCount(x)  ((Py_ssize_t) (((PyLongObject*)x)->long_value.lv_tag >> _PyLong_NON_SIZE_BITS))
+#define __Pyx_PyLong_SignedDigitCount(x)\
+((1 - (Py_ssize_t) __Pyx_PyLong_Sign(x)) * __Pyx_PyLong_DigitCount(x))
+#if defined(PyUnstable_Long_IsCompact) && defined(PyUnstable_Long_CompactValue)
+#define __Pyx_PyLong_IsCompact(x)     PyUnstable_Long_IsCompact((PyLongObject*) x)
+#define __Pyx_PyLong_CompactValue(x)  PyUnstable_Long_CompactValue((PyLongObject*) x)
+#else
+#define __Pyx_PyLong_IsCompact(x)     (((PyLongObject*)x)->long_value.lv_tag < (2 << _PyLong_NON_SIZE_BITS))
+#define __Pyx_PyLong_CompactValue(x)  ((1 - (Py_ssize_t) __Pyx_PyLong_Sign(x)) * (Py_ssize_t) __Pyx_PyLong_Digits(x)[0])
+#endif
+typedef Py_ssize_t  __Pyx_compact_pylong;
+typedef size_t  __Pyx_compact_upylong;
+#else
+#define __Pyx_PyLong_IsNeg(x)  (Py_SIZE(x) < 0)
+#define __Pyx_PyLong_IsNonNeg(x)  (Py_SIZE(x) >= 0)
+#define __Pyx_PyLong_IsZero(x)  (Py_SIZE(x) == 0)
+#define __Pyx_PyLong_IsPos(x)  (Py_SIZE(x) > 0)
+#define __Pyx_PyLong_CompactValueUnsigned(x)  ((Py_SIZE(x) == 0) ? 0 : __Pyx_PyLong_Digits(x)[0])
+#define __Pyx_PyLong_DigitCount(x)  __Pyx_sst_abs(Py_SIZE(x))
+#define __Pyx_PyLong_SignedDigitCount(x)  Py_SIZE(x)
+#define __Pyx_PyLong_IsCompact(x)  (Py_SIZE(x) == 0 || Py_SIZE(x) == 1 || Py_SIZE(x) == -1)
+#define __Pyx_PyLong_CompactValue(x)\
+((Py_SIZE(x) == 0) ? (sdigit) 0 : ((Py_SIZE(x) < 0) ? -(sdigit)__Pyx_PyLong_Digits(x)[0] : (sdigit)__Pyx_PyLong_Digits(x)[0]))
+typedef sdigit  __Pyx_compact_pylong;
+typedef digit  __Pyx_compact_upylong;
+#endif
+#if PY_VERSION_HEX >= 0x030C00A5
+#define __Pyx_PyLong_Digits(x)  (((PyLongObject*)x)->long_value.ob_digit)
+#else
+#define __Pyx_PyLong_Digits(x)  (((PyLongObject*)x)->ob_digit)
+#endif
+#endif
+#if PY_MAJOR_VERSION < 3 && __PYX_DEFAULT_STRING_ENCODING_IS_ASCII
+#include <string.h>
+static int __Pyx_sys_getdefaultencoding_not_ascii;
+static int __Pyx_init_sys_getdefaultencoding_params(void) {
+PyObject* sys;
+PyObject* default_encoding = NULL;
+PyObject* ascii_chars_u = NULL;
+PyObject* ascii_chars_b = NULL;
+const char* default_encoding_c;
+sys = PyImport_ImportModule("sys");
+if (!sys) goto bad;
+default_encoding = PyObject_CallMethod(sys, (char*) "getdefaultencoding", NULL);
+Py_DECREF(sys);
+if (!default_encoding) goto bad;
+default_encoding_c = PyBytes_AsString(default_encoding);
+if (!default_encoding_c) goto bad;
+if (strcmp(default_encoding_c, "ascii") == 0) {
+__Pyx_sys_getdefaultencoding_not_ascii = 0;
+} else {
+char ascii_chars[128];
+int c;
+for (c = 0; c < 128; c++) {
+ascii_chars[c] = (char) c;
+}
+__Pyx_sys_getdefaultencoding_not_ascii = 1;
+ascii_chars_u = PyUnicode_DecodeASCII(ascii_chars, 128, NULL);
+if (!ascii_chars_u) goto bad;
+ascii_chars_b = PyUnicode_AsEncodedString(ascii_chars_u, default_encoding_c, NULL);
+if (!ascii_chars_b || !PyBytes_Check(ascii_chars_b) || memcmp(ascii_chars, PyBytes_AS_STRING(ascii_chars_b), 128) != 0) {
+PyErr_Format(
+PyExc_ValueError,
+"This module compiled with c_string_encoding=ascii, but default encoding '%.200s' is not a superset of ascii.",
+default_encoding_c);
+goto bad;
+}
+Py_DECREF(ascii_chars_u);
+Py_DECREF(ascii_chars_b);
+}
+Py_DECREF(default_encoding);
+return 0;
+bad:
+Py_XDECREF(default_encoding);
+Py_XDECREF(ascii_chars_u);
+Py_XDECREF(ascii_chars_b);
+return -1;
+}
+#endif
+#if __PYX_DEFAULT_STRING_ENCODING_IS_DEFAULT && PY_MAJOR_VERSION >= 3
+#define __Pyx_PyUnicode_FromStringAndSize(c_str, size) PyUnicode_DecodeUTF8(c_str, size, NULL)
+#else
+#define __Pyx_PyUnicode_FromStringAndSize(c_str, size) PyUnicode_Decode(c_str, size, __PYX_DEFAULT_STRING_ENCODING, NULL)
+#if __PYX_DEFAULT_STRING_ENCODING_IS_DEFAULT
+#include <string.h>
+static char* __PYX_DEFAULT_STRING_ENCODING;
+static int __Pyx_init_sys_getdefaultencoding_params(void) {
+PyObject* sys;
+PyObject* default_encoding = NULL;
+char* default_encoding_c;
+sys = PyImport_ImportModule("sys");
+if (!sys) goto bad;
+default_encoding = PyObject_CallMethod(sys, (char*) (const char*) "getdefaultencoding", NULL);
+Py_DECREF(sys);
+if (!default_encoding) goto bad;
+default_encoding_c = PyBytes_AsString(default_encoding);
+if (!default_encoding_c) goto bad;
+__PYX_DEFAULT_STRING_ENCODING = (char*) malloc(strlen(default_encoding_c) + 1);
+if (!__PYX_DEFAULT_STRING_ENCODING) goto bad;
+strcpy(__PYX_DEFAULT_STRING_ENCODING, default_encoding_c);
+Py_DECREF(default_encoding);
+return 0;
+bad:
+Py_XDECREF(default_encoding);
+return -1;
+}
+#endif
+#endif
+/* Test for GCC > 2.95 */
+#if defined(__GNUC__)     && (__GNUC__ > 2 || (__GNUC__ == 2 && (__GNUC_MINOR__ > 95)))
+#define likely(x)   __builtin_expect(!!(x), 1)
+#define unlikely(x) __builtin_expect(!!(x), 0)
+#else /* !__GNUC__ or GCC < 2.95 */
+#define likely(x)   (x)
+#define unlikely(x) (x)
+#endif /* __GNUC__ */
+static CYTHON_INLINE void __Pyx_pretend_to_initialize(void* ptr) { (void)ptr; }
+#if !CYTHON_USE_MODULE_STATE
+static PyObject *__pyx_m = NULL;
+#endif
+static int __pyx_lineno;
+static int __pyx_clineno = 0;
+static const char * __pyx_cfilenm = __FILE__;
+static const char *__pyx_filename;
+/* #### Code section: filename_table ### */
+static const char *__pyx_f[] = {
+"pysam/libcfaidx.pyx",
+"<stringsource>",
+"contextvars.pxd",
+"array.pxd",
+"pysam/libcfaidx.pxd",
+"type.pxd",
+"bool.pxd",
+"complex.pxd",
+"pysam/libchtslib.pxd",
+};
+/* #### Code section: utility_code_proto_before_types ### */
+/* ForceInitThreads.proto */
+#ifndef __PYX_FORCE_INIT_THREADS
+#define __PYX_FORCE_INIT_THREADS 0
+#endif
+/* NoFastGil.proto */
+#define __Pyx_PyGILState_Ensure PyGILState_Ensure
+#define __Pyx_PyGILState_Release PyGILState_Release
+#define __Pyx_FastGIL_Remember()
+#define __Pyx_FastGIL_Forget()
+#define __Pyx_FastGilFuncInit()
+/* #### Code section: numeric_typedefs ### */
+/* #### Code section: complex_type_declarations ### */
+/* #### Code section: type_declarations ### */
+/*--- Type declarations ---*/
+#ifndef _ARRAYARRAY_H
+struct arrayobject;
+typedef struct arrayobject arrayobject;
+#endif
+struct __pyx_obj_5pysam_10libchtslib_HTSFile;
+struct __pyx_obj_5pysam_9libcfaidx_FastaFile;
+struct __pyx_obj_5pysam_9libcfaidx_FastqProxy;
+struct __pyx_obj_5pysam_9libcfaidx_FastxRecord;
+struct __pyx_obj_5pysam_9libcfaidx_FastxFile;
+struct __pyx_obj_5pysam_9libcfaidx_FastqFile;
+struct __pyx_obj_5pysam_9libcfaidx_Fastafile;
+struct __pyx_opt_args_7cpython_11contextvars_get_value;
+struct __pyx_opt_args_7cpython_11contextvars_get_value_no_default;
+/* "cpython/contextvars.pxd":112
+*
+*
+* cdef inline object get_value(var, default_value=None):             # <<<<<<<<<<<<<<
+*     """Return a new reference to the value of the context variable,
+*     or the default value of the context variable,
+*/
+struct __pyx_opt_args_7cpython_11contextvars_get_value {
+int __pyx_n;
+PyObject *default_value;
+};
+/* "cpython/contextvars.pxd":129
+*
+*
+* cdef inline object get_value_no_default(var, default_value=None):             # <<<<<<<<<<<<<<
+*     """Return a new reference to the value of the context variable,
+*     or the provided default value if no such value was found.
+*/
+struct __pyx_opt_args_7cpython_11contextvars_get_value_no_default {
+int __pyx_n;
+PyObject *default_value;
+};
+struct __pyx_opt_args_5pysam_9libcutils_parse_region;
+struct __pyx_opt_args_5pysam_9libcutils_qualitystring_to_array;
+struct __pyx_opt_args_5pysam_9libcutils_array_to_qualitystring;
+struct __pyx_opt_args_5pysam_9libcutils_qualities_to_qualitystring;
+struct __pyx_opt_args_5pysam_9libcutils_charptr_to_str;
+struct __pyx_opt_args_5pysam_9libcutils_charptr_to_bytes;
+struct __pyx_opt_args_5pysam_9libcutils_charptr_to_str_w_len;
+struct __pyx_opt_args_5pysam_9libcutils_force_str;
+struct __pyx_opt_args_5pysam_9libcutils_force_bytes;
+struct __pyx_opt_args_5pysam_9libcutils_decode_bytes;
+/* "pysam/libcutils.pxd":8
+* from cpython cimport array as c_array
+*
+* cpdef parse_region(contig=*, start=*, stop=*, region=*, reference=*, end=*)             # <<<<<<<<<<<<<<
+*
+* cdef int libc_whence_from_io(int whence)
+*/
+struct __pyx_opt_args_5pysam_9libcutils_parse_region {
+int __pyx_n;
+PyObject *contig;
+PyObject *start;
+PyObject *stop;
+PyObject *region;
+PyObject *reference;
+PyObject *end;
+};
+/* "pysam/libcutils.pxd":15
+* # Utility functions for quality string conversions
+*
+* cpdef c_array.array qualitystring_to_array(input_str, int offset=*)             # <<<<<<<<<<<<<<
+* cpdef array_to_qualitystring(c_array.array arr, int offset=*)
+* cpdef qualities_to_qualitystring(qualities, int offset=*)
+*/
+struct __pyx_opt_args_5pysam_9libcutils_qualitystring_to_array {
+int __pyx_n;
+int offset;
+};
+/* "pysam/libcutils.pxd":16
+*
+* cpdef c_array.array qualitystring_to_array(input_str, int offset=*)
+* cpdef array_to_qualitystring(c_array.array arr, int offset=*)             # <<<<<<<<<<<<<<
+* cpdef qualities_to_qualitystring(qualities, int offset=*)
+*
+*/
+struct __pyx_opt_args_5pysam_9libcutils_array_to_qualitystring {
+int __pyx_n;
+int offset;
+};
+/* "pysam/libcutils.pxd":17
+* cpdef c_array.array qualitystring_to_array(input_str, int offset=*)
+* cpdef array_to_qualitystring(c_array.array arr, int offset=*)
+* cpdef qualities_to_qualitystring(qualities, int offset=*)             # <<<<<<<<<<<<<<
+*
+* ########################################################################
+*/
+struct __pyx_opt_args_5pysam_9libcutils_qualities_to_qualitystring {
+int __pyx_n;
+int offset;
+};
+/* "pysam/libcutils.pxd":29
+* ## Python 3 compatibility functions
+* ########################################################################
+* cdef charptr_to_str(const char *s, encoding=*, errors=*)             # <<<<<<<<<<<<<<
+* cdef bytes charptr_to_bytes(const char *s, encoding=*, errors=*)
+* cdef charptr_to_str_w_len(const char* s, size_t n, encoding=*, errors=*)
+*/
+struct __pyx_opt_args_5pysam_9libcutils_charptr_to_str {
+int __pyx_n;
+PyObject *encoding;
+PyObject *errors;
+};
+/* "pysam/libcutils.pxd":30
+* ########################################################################
+* cdef charptr_to_str(const char *s, encoding=*, errors=*)
+* cdef bytes charptr_to_bytes(const char *s, encoding=*, errors=*)             # <<<<<<<<<<<<<<
+* cdef charptr_to_str_w_len(const char* s, size_t n, encoding=*, errors=*)
+* cdef force_str(object s, encoding=*, errors=*)
+*/
+struct __pyx_opt_args_5pysam_9libcutils_charptr_to_bytes {
+int __pyx_n;
+PyObject *encoding;
+PyObject *errors;
+};
+/* "pysam/libcutils.pxd":31
+* cdef charptr_to_str(const char *s, encoding=*, errors=*)
+* cdef bytes charptr_to_bytes(const char *s, encoding=*, errors=*)
+* cdef charptr_to_str_w_len(const char* s, size_t n, encoding=*, errors=*)             # <<<<<<<<<<<<<<
+* cdef force_str(object s, encoding=*, errors=*)
+* cdef bytes force_bytes(object s, encoding=*, errors=*)
+*/
+struct __pyx_opt_args_5pysam_9libcutils_charptr_to_str_w_len {
+int __pyx_n;
+PyObject *encoding;
+PyObject *errors;
+};
+/* "pysam/libcutils.pxd":32
+* cdef bytes charptr_to_bytes(const char *s, encoding=*, errors=*)
+* cdef charptr_to_str_w_len(const char* s, size_t n, encoding=*, errors=*)
+* cdef force_str(object s, encoding=*, errors=*)             # <<<<<<<<<<<<<<
+* cdef bytes force_bytes(object s, encoding=*, errors=*)
+* cdef decode_bytes(bytes s, encoding=*, errors=*)
+*/
+struct __pyx_opt_args_5pysam_9libcutils_force_str {
+int __pyx_n;
+PyObject *encoding;
+PyObject *errors;
+};
+/* "pysam/libcutils.pxd":33
+* cdef charptr_to_str_w_len(const char* s, size_t n, encoding=*, errors=*)
+* cdef force_str(object s, encoding=*, errors=*)
+* cdef bytes force_bytes(object s, encoding=*, errors=*)             # <<<<<<<<<<<<<<
+* cdef decode_bytes(bytes s, encoding=*, errors=*)
+* cdef bytes encode_filename(object filename)
+*/
+struct __pyx_opt_args_5pysam_9libcutils_force_bytes {
+int __pyx_n;
+PyObject *encoding;
+PyObject *errors;
+};
+/* "pysam/libcutils.pxd":34
+* cdef force_str(object s, encoding=*, errors=*)
+* cdef bytes force_bytes(object s, encoding=*, errors=*)
+* cdef decode_bytes(bytes s, encoding=*, errors=*)             # <<<<<<<<<<<<<<
+* cdef bytes encode_filename(object filename)
+* cdef from_string_and_size(const char *s, size_t length)
+*/
+struct __pyx_opt_args_5pysam_9libcutils_decode_bytes {
+int __pyx_n;
+PyObject *encoding;
+PyObject *errors;
+};
+struct __pyx_opt_args_5pysam_9libcfaidx_10FastqProxy_get_quality_array;
+struct __pyx_opt_args_5pysam_9libcfaidx_11FastxRecord_get_quality_array;
+/* "pysam/libcfaidx.pxd":50
+*     cdef cython.str to_string(self)
+*     cdef cython.str tostring(self)
+*     cpdef array.array get_quality_array(self, int offset=*)             # <<<<<<<<<<<<<<
+*
+*
+*/
+struct __pyx_opt_args_5pysam_9libcfaidx_10FastqProxy_get_quality_array {
+int __pyx_n;
+int offset;
+};
+/* "pysam/libcfaidx.pxd":60
+*     cdef cython.str to_string(self)
+*     cdef cython.str tostring(self)
+*     cpdef array.array get_quality_array(self, int offset=*)             # <<<<<<<<<<<<<<
+*
+* cdef class FastxFile:
+*/
+struct __pyx_opt_args_5pysam_9libcfaidx_11FastxRecord_get_quality_array {
+int __pyx_n;
+int offset;
+};
+/* "pysam/libchtslib.pxd":2706
+*
+*
+* cdef class HTSFile(object):             # <<<<<<<<<<<<<<
+*     cdef          htsFile *htsfile       # pointer to htsFile structure
+*     cdef          int64_t start_offset   # BGZF offset of first record
+*/
+struct __pyx_obj_5pysam_10libchtslib_HTSFile {
+PyObject_HEAD
+struct __pyx_vtabstruct_5pysam_10libchtslib_HTSFile *__pyx_vtab;
+htsFile *htsfile;
+int64_t start_offset;
+PyObject *filename;
+PyObject *mode;
+PyObject *threads;
+PyObject *index_filename;
+int is_stream;
+int is_remote;
+int duplicate_filehandle;
+};
+/* "pysam/libcfaidx.pxd":38
+*                     int * dret)
+*
+* cdef class FastaFile:             # <<<<<<<<<<<<<<
+*     cdef bint is_remote
+*     cdef object _filename, _references, _lengths, reference2length
+*/
+struct __pyx_obj_5pysam_9libcfaidx_FastaFile {
+PyObject_HEAD
+struct __pyx_vtabstruct_5pysam_9libcfaidx_FastaFile *__pyx_vtab;
+int is_remote;
+PyObject *_filename;
+PyObject *_references;
+PyObject *_lengths;
+PyObject *reference2length;
+faidx_t *fastafile;
+};
+/* "pysam/libcfaidx.pxd":46
+*
+*
+* cdef class FastqProxy:             # <<<<<<<<<<<<<<
+*     cdef kseq_t * _delegate
+*     cdef cython.str to_string(self)
+*/
+struct __pyx_obj_5pysam_9libcfaidx_FastqProxy {
+PyObject_HEAD
+struct __pyx_vtabstruct_5pysam_9libcfaidx_FastqProxy *__pyx_vtab;
+kseq_t *_delegate;
+};
+/* "pysam/libcfaidx.pxd":53
+*
+*
+* cdef class FastxRecord:             # <<<<<<<<<<<<<<
+*     """
+*     Python container for pysam.libcfaidx.FastqProxy with persistence.
+*/
+struct __pyx_obj_5pysam_9libcfaidx_FastxRecord {
+PyObject_HEAD
+struct __pyx_vtabstruct_5pysam_9libcfaidx_FastxRecord *__pyx_vtab;
+PyObject *comment;
+PyObject *quality;
+PyObject *sequence;
+PyObject *name;
+};
+/* "pysam/libcfaidx.pxd":62
+*     cpdef array.array get_quality_array(self, int offset=*)
+*
+* cdef class FastxFile:             # <<<<<<<<<<<<<<
+*     cdef object _filename
+*     cdef BGZF * fastqfile
+*/
+struct __pyx_obj_5pysam_9libcfaidx_FastxFile {
+PyObject_HEAD
+struct __pyx_vtabstruct_5pysam_9libcfaidx_FastxFile *__pyx_vtab;
+PyObject *_filename;
+BGZF *fastqfile;
+kseq_t *entry;
+int persist;
+int is_remote;
+};
+/* "pysam/libcfaidx.pxd":74
+*
+* # Compatibility Layer for pysam 0.8.1
+* cdef class FastqFile(FastxFile):             # <<<<<<<<<<<<<<
+*     pass
+*
+*/
+struct __pyx_obj_5pysam_9libcfaidx_FastqFile {
+struct __pyx_obj_5pysam_9libcfaidx_FastxFile __pyx_base;
+};
+/* "pysam/libcfaidx.pxd":79
+*
+* # Compatibility Layer for pysam < 0.8
+* cdef class Fastafile(FastaFile):             # <<<<<<<<<<<<<<
+*     pass
+*
+*/
+struct __pyx_obj_5pysam_9libcfaidx_Fastafile {
+struct __pyx_obj_5pysam_9libcfaidx_FastaFile __pyx_base;
+};
+/* "pysam/libchtslib.pxd":2706
+*
+*
+* cdef class HTSFile(object):             # <<<<<<<<<<<<<<
+*     cdef          htsFile *htsfile       # pointer to htsFile structure
+*     cdef          int64_t start_offset   # BGZF offset of first record
+*/
+struct __pyx_vtabstruct_5pysam_10libchtslib_HTSFile {
+htsFile *(*_open_htsfile)(struct __pyx_obj_5pysam_10libchtslib_HTSFile *);
+};
+static struct __pyx_vtabstruct_5pysam_10libchtslib_HTSFile *__pyx_vtabptr_5pysam_10libchtslib_HTSFile;
+/* "pysam/libcfaidx.pyx":83
+* ##        add automatic indexing.
+* ##        add function to get sequence names.
+* cdef class FastaFile:             # <<<<<<<<<<<<<<
+*     """Random access to fasta formatted files that
+*     have been indexed by :term:`faidx`.
+*/
+struct __pyx_vtabstruct_5pysam_9libcfaidx_FastaFile {
+char *(*_fetch)(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *, char *, int, int, int *);
+};
+static struct __pyx_vtabstruct_5pysam_9libcfaidx_FastaFile *__pyx_vtabptr_5pysam_9libcfaidx_FastaFile;
+/* "pysam/libcfaidx.pyx":355
+*
+*
+* cdef class FastqProxy:             # <<<<<<<<<<<<<<
+*     """A single entry in a fastq file."""
+*     def __init__(self):
+*/
+struct __pyx_vtabstruct_5pysam_9libcfaidx_FastqProxy {
+PyObject *(*to_string)(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *);
+PyObject *(*tostring)(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *);
+arrayobject *(*get_quality_array)(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *, int __pyx_skip_dispatch, struct __pyx_opt_args_5pysam_9libcfaidx_10FastqProxy_get_quality_array *__pyx_optional_args);
+};
+static struct __pyx_vtabstruct_5pysam_9libcfaidx_FastqProxy *__pyx_vtabptr_5pysam_9libcfaidx_FastqProxy;
+/* "pysam/libcfaidx.pyx":411
+*                                       offset=offset)
+*
+* cdef class FastxRecord:             # <<<<<<<<<<<<<<
+*     """A fasta/fastq record.
+*
+*/
+struct __pyx_vtabstruct_5pysam_9libcfaidx_FastxRecord {
+PyObject *(*to_string)(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *);
+PyObject *(*tostring)(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *);
+arrayobject *(*get_quality_array)(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *, int __pyx_skip_dispatch, struct __pyx_opt_args_5pysam_9libcfaidx_11FastxRecord_get_quality_array *__pyx_optional_args);
+};
+static struct __pyx_vtabstruct_5pysam_9libcfaidx_FastxRecord *__pyx_vtabptr_5pysam_9libcfaidx_FastxRecord;
+/* "pysam/libcfaidx.pyx":496
+*
+*
+* cdef class FastxFile:             # <<<<<<<<<<<<<<
+*     r"""Stream access to :term:`fasta` or :term:`fastq` formatted files.
+*
+*/
+struct __pyx_vtabstruct_5pysam_9libcfaidx_FastxFile {
+kseq_t *(*getCurrent)(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *);
+int (*cnext)(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *);
+};
+static struct __pyx_vtabstruct_5pysam_9libcfaidx_FastxFile *__pyx_vtabptr_5pysam_9libcfaidx_FastxFile;
+/* "pysam/libcfaidx.pyx":658
+*
+* # Compatibility Layer for pysam 0.8.1
+* cdef class FastqFile(FastxFile):             # <<<<<<<<<<<<<<
+*     """FastqFile is deprecated: use FastxFile instead"""
+*     pass
+*/
+struct __pyx_vtabstruct_5pysam_9libcfaidx_FastqFile {
+struct __pyx_vtabstruct_5pysam_9libcfaidx_FastxFile __pyx_base;
+};
+static struct __pyx_vtabstruct_5pysam_9libcfaidx_FastqFile *__pyx_vtabptr_5pysam_9libcfaidx_FastqFile;
+/* "pysam/libcfaidx.pyx":663
+*
+* # Compatibility Layer for pysam < 0.8
+* cdef class Fastafile(FastaFile):             # <<<<<<<<<<<<<<
+*     """Fastafile is deprecated: use FastaFile instead"""
+*     pass
+*/
+struct __pyx_vtabstruct_5pysam_9libcfaidx_Fastafile {
+struct __pyx_vtabstruct_5pysam_9libcfaidx_FastaFile __pyx_base;
+};
+static struct __pyx_vtabstruct_5pysam_9libcfaidx_Fastafile *__pyx_vtabptr_5pysam_9libcfaidx_Fastafile;
+/* #### Code section: utility_code_proto ### */
+/* --- Runtime support code (head) --- */
+/* Refnanny.proto */
+#ifndef CYTHON_REFNANNY
+#define CYTHON_REFNANNY 0
+#endif
+#if CYTHON_REFNANNY
+typedef struct {
+void (*INCREF)(void*, PyObject*, Py_ssize_t);
+void (*DECREF)(void*, PyObject*, Py_ssize_t);
+void (*GOTREF)(void*, PyObject*, Py_ssize_t);
+void (*GIVEREF)(void*, PyObject*, Py_ssize_t);
+void* (*SetupContext)(const char*, Py_ssize_t, const char*);
+void (*FinishContext)(void**);
+} __Pyx_RefNannyAPIStruct;
+static __Pyx_RefNannyAPIStruct *__Pyx_RefNanny = NULL;
+static __Pyx_RefNannyAPIStruct *__Pyx_RefNannyImportAPI(const char *modname);
+#define __Pyx_RefNannyDeclarations void *__pyx_refnanny = NULL;
+#ifdef WITH_THREAD
+#define __Pyx_RefNannySetupContext(name, acquire_gil)\
+if (acquire_gil) {\
+PyGILState_STATE __pyx_gilstate_save = PyGILState_Ensure();\
+__pyx_refnanny = __Pyx_RefNanny->SetupContext((name), (__LINE__), (__FILE__));\
+PyGILState_Release(__pyx_gilstate_save);\
+} else {\
+__pyx_refnanny = __Pyx_RefNanny->SetupContext((name), (__LINE__), (__FILE__));\
+}
+#define __Pyx_RefNannyFinishContextNogil() {\
+PyGILState_STATE __pyx_gilstate_save = PyGILState_Ensure();\
+__Pyx_RefNannyFinishContext();\
+PyGILState_Release(__pyx_gilstate_save);\
+}
+#else
+#define __Pyx_RefNannySetupContext(name, acquire_gil)\
+__pyx_refnanny = __Pyx_RefNanny->SetupContext((name), (__LINE__), (__FILE__))
+#define __Pyx_RefNannyFinishContextNogil() __Pyx_RefNannyFinishContext()
+#endif
+#define __Pyx_RefNannyFinishContextNogil() {\
+PyGILState_STATE __pyx_gilstate_save = PyGILState_Ensure();\
+__Pyx_RefNannyFinishContext();\
+PyGILState_Release(__pyx_gilstate_save);\
+}
+#define __Pyx_RefNannyFinishContext()\
+__Pyx_RefNanny->FinishContext(&__pyx_refnanny)
+#define __Pyx_INCREF(r)  __Pyx_RefNanny->INCREF(__pyx_refnanny, (PyObject *)(r), (__LINE__))
+#define __Pyx_DECREF(r)  __Pyx_RefNanny->DECREF(__pyx_refnanny, (PyObject *)(r), (__LINE__))
+#define __Pyx_GOTREF(r)  __Pyx_RefNanny->GOTREF(__pyx_refnanny, (PyObject *)(r), (__LINE__))
+#define __Pyx_GIVEREF(r) __Pyx_RefNanny->GIVEREF(__pyx_refnanny, (PyObject *)(r), (__LINE__))
+#define __Pyx_XINCREF(r)  do { if((r) == NULL); else {__Pyx_INCREF(r); }} while(0)
+#define __Pyx_XDECREF(r)  do { if((r) == NULL); else {__Pyx_DECREF(r); }} while(0)
+#define __Pyx_XGOTREF(r)  do { if((r) == NULL); else {__Pyx_GOTREF(r); }} while(0)
+#define __Pyx_XGIVEREF(r) do { if((r) == NULL); else {__Pyx_GIVEREF(r);}} while(0)
+#else
+#define __Pyx_RefNannyDeclarations
+#define __Pyx_RefNannySetupContext(name, acquire_gil)
+#define __Pyx_RefNannyFinishContextNogil()
+#define __Pyx_RefNannyFinishContext()
+#define __Pyx_INCREF(r) Py_INCREF(r)
+#define __Pyx_DECREF(r) Py_DECREF(r)
+#define __Pyx_GOTREF(r)
+#define __Pyx_GIVEREF(r)
+#define __Pyx_XINCREF(r) Py_XINCREF(r)
+#define __Pyx_XDECREF(r) Py_XDECREF(r)
+#define __Pyx_XGOTREF(r)
+#define __Pyx_XGIVEREF(r)
+#endif
+#define __Pyx_Py_XDECREF_SET(r, v) do {\
+PyObject *tmp = (PyObject *) r;\
+r = v; Py_XDECREF(tmp);\
+} while (0)
+#define __Pyx_XDECREF_SET(r, v) do {\
+PyObject *tmp = (PyObject *) r;\
+r = v; __Pyx_XDECREF(tmp);\
+} while (0)
+#define __Pyx_DECREF_SET(r, v) do {\
+PyObject *tmp = (PyObject *) r;\
+r = v; __Pyx_DECREF(tmp);\
+} while (0)
+#define __Pyx_CLEAR(r)    do { PyObject* tmp = ((PyObject*)(r)); r = NULL; __Pyx_DECREF(tmp);} while(0)
+#define __Pyx_XCLEAR(r)   do { if((r) != NULL) {PyObject* tmp = ((PyObject*)(r)); r = NULL; __Pyx_DECREF(tmp);}} while(0)
+/* PyErrExceptionMatches.proto */
+#if CYTHON_FAST_THREAD_STATE
+#define __Pyx_PyErr_ExceptionMatches(err) __Pyx_PyErr_ExceptionMatchesInState(__pyx_tstate, err)
+static CYTHON_INLINE int __Pyx_PyErr_ExceptionMatchesInState(PyThreadState* tstate, PyObject* err);
+#else
+#define __Pyx_PyErr_ExceptionMatches(err)  PyErr_ExceptionMatches(err)
+#endif
+/* PyThreadStateGet.proto */
+#if CYTHON_FAST_THREAD_STATE
+#define __Pyx_PyThreadState_declare  PyThreadState *__pyx_tstate;
+#define __Pyx_PyThreadState_assign  __pyx_tstate = __Pyx_PyThreadState_Current;
+#if PY_VERSION_HEX >= 0x030C00A6
+#define __Pyx_PyErr_Occurred()  (__pyx_tstate->current_exception != NULL)
+#define __Pyx_PyErr_CurrentExceptionType()  (__pyx_tstate->current_exception ? (PyObject*) Py_TYPE(__pyx_tstate->current_exception) : (PyObject*) NULL)
+#else
+#define __Pyx_PyErr_Occurred()  (__pyx_tstate->curexc_type != NULL)
+#define __Pyx_PyErr_CurrentExceptionType()  (__pyx_tstate->curexc_type)
+#endif
+#else
+#define __Pyx_PyThreadState_declare
+#define __Pyx_PyThreadState_assign
+#define __Pyx_PyErr_Occurred()  (PyErr_Occurred() != NULL)
+#define __Pyx_PyErr_CurrentExceptionType()  PyErr_Occurred()
+#endif
+/* PyErrFetchRestore.proto */
+#if CYTHON_FAST_THREAD_STATE
+#define __Pyx_PyErr_Clear() __Pyx_ErrRestore(NULL, NULL, NULL)
+#define __Pyx_ErrRestoreWithState(type, value, tb)  __Pyx_ErrRestoreInState(PyThreadState_GET(), type, value, tb)
+#define __Pyx_ErrFetchWithState(type, value, tb)    __Pyx_ErrFetchInState(PyThreadState_GET(), type, value, tb)
+#define __Pyx_ErrRestore(type, value, tb)  __Pyx_ErrRestoreInState(__pyx_tstate, type, value, tb)
+#define __Pyx_ErrFetch(type, value, tb)    __Pyx_ErrFetchInState(__pyx_tstate, type, value, tb)
+static CYTHON_INLINE void __Pyx_ErrRestoreInState(PyThreadState *tstate, PyObject *type, PyObject *value, PyObject *tb);
+static CYTHON_INLINE void __Pyx_ErrFetchInState(PyThreadState *tstate, PyObject **type, PyObject **value, PyObject **tb);
+#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX < 0x030C00A6
+#define __Pyx_PyErr_SetNone(exc) (Py_INCREF(exc), __Pyx_ErrRestore((exc), NULL, NULL))
+#else
+#define __Pyx_PyErr_SetNone(exc) PyErr_SetNone(exc)
+#endif
+#else
+#define __Pyx_PyErr_Clear() PyErr_Clear()
+#define __Pyx_PyErr_SetNone(exc) PyErr_SetNone(exc)
+#define __Pyx_ErrRestoreWithState(type, value, tb)  PyErr_Restore(type, value, tb)
+#define __Pyx_ErrFetchWithState(type, value, tb)  PyErr_Fetch(type, value, tb)
+#define __Pyx_ErrRestoreInState(tstate, type, value, tb)  PyErr_Restore(type, value, tb)
+#define __Pyx_ErrFetchInState(tstate, type, value, tb)  PyErr_Fetch(type, value, tb)
+#define __Pyx_ErrRestore(type, value, tb)  PyErr_Restore(type, value, tb)
+#define __Pyx_ErrFetch(type, value, tb)  PyErr_Fetch(type, value, tb)
+#endif
+/* PyObjectGetAttrStr.proto */
+#if CYTHON_USE_TYPE_SLOTS
+static CYTHON_INLINE PyObject* __Pyx_PyObject_GetAttrStr(PyObject* obj, PyObject* attr_name);
+#else
+#define __Pyx_PyObject_GetAttrStr(o,n) PyObject_GetAttr(o,n)
+#endif
+/* PyObjectGetAttrStrNoError.proto */
+static CYTHON_INLINE PyObject* __Pyx_PyObject_GetAttrStrNoError(PyObject* obj, PyObject* attr_name);
+/* GetBuiltinName.proto */
+static PyObject *__Pyx_GetBuiltinName(PyObject *name);
+/* TupleAndListFromArray.proto */
+#if CYTHON_COMPILING_IN_CPYTHON
+static CYTHON_INLINE PyObject* __Pyx_PyList_FromArray(PyObject *const *src, Py_ssize_t n);
+static CYTHON_INLINE PyObject* __Pyx_PyTuple_FromArray(PyObject *const *src, Py_ssize_t n);
+#endif
+/* IncludeStringH.proto */
+#include <string.h>
+/* BytesEquals.proto */
+static CYTHON_INLINE int __Pyx_PyBytes_Equals(PyObject* s1, PyObject* s2, int equals);
+/* UnicodeEquals.proto */
+static CYTHON_INLINE int __Pyx_PyUnicode_Equals(PyObject* s1, PyObject* s2, int equals);
+/* fastcall.proto */
+#if CYTHON_AVOID_BORROWED_REFS
+#define __Pyx_Arg_VARARGS(args, i) PySequence_GetItem(args, i)
+#elif CYTHON_ASSUME_SAFE_MACROS
+#define __Pyx_Arg_VARARGS(args, i) PyTuple_GET_ITEM(args, i)
+#else
+#define __Pyx_Arg_VARARGS(args, i) PyTuple_GetItem(args, i)
+#endif
+#if CYTHON_AVOID_BORROWED_REFS
+#define __Pyx_Arg_NewRef_VARARGS(arg) __Pyx_NewRef(arg)
+#define __Pyx_Arg_XDECREF_VARARGS(arg) Py_XDECREF(arg)
+#else
+#define __Pyx_Arg_NewRef_VARARGS(arg) arg
+#define __Pyx_Arg_XDECREF_VARARGS(arg)
+#endif
+#define __Pyx_NumKwargs_VARARGS(kwds) PyDict_Size(kwds)
+#define __Pyx_KwValues_VARARGS(args, nargs) NULL
+#define __Pyx_GetKwValue_VARARGS(kw, kwvalues, s) __Pyx_PyDict_GetItemStrWithError(kw, s)
+#define __Pyx_KwargsAsDict_VARARGS(kw, kwvalues) PyDict_Copy(kw)
+#if CYTHON_METH_FASTCALL
+#define __Pyx_Arg_FASTCALL(args, i) args[i]
+#define __Pyx_NumKwargs_FASTCALL(kwds) PyTuple_GET_SIZE(kwds)
+#define __Pyx_KwValues_FASTCALL(args, nargs) ((args) + (nargs))
+static CYTHON_INLINE PyObject * __Pyx_GetKwValue_FASTCALL(PyObject *kwnames, PyObject *const *kwvalues, PyObject *s);
+#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX >= 0x030d0000
+CYTHON_UNUSED static PyObject *__Pyx_KwargsAsDict_FASTCALL(PyObject *kwnames, PyObject *const *kwvalues);
+#else
+#define __Pyx_KwargsAsDict_FASTCALL(kw, kwvalues) _PyStack_AsDict(kwvalues, kw)
+#endif
+#define __Pyx_Arg_NewRef_FASTCALL(arg) arg  /* no-op, __Pyx_Arg_FASTCALL is direct and this needs
+to have the same reference counting */
+#define __Pyx_Arg_XDECREF_FASTCALL(arg)
+#else
+#define __Pyx_Arg_FASTCALL __Pyx_Arg_VARARGS
+#define __Pyx_NumKwargs_FASTCALL __Pyx_NumKwargs_VARARGS
+#define __Pyx_KwValues_FASTCALL __Pyx_KwValues_VARARGS
+#define __Pyx_GetKwValue_FASTCALL __Pyx_GetKwValue_VARARGS
+#define __Pyx_KwargsAsDict_FASTCALL __Pyx_KwargsAsDict_VARARGS
+#define __Pyx_Arg_NewRef_FASTCALL(arg) __Pyx_Arg_NewRef_VARARGS(arg)
+#define __Pyx_Arg_XDECREF_FASTCALL(arg) __Pyx_Arg_XDECREF_VARARGS(arg)
+#endif
+#if CYTHON_COMPILING_IN_CPYTHON && CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
+#define __Pyx_ArgsSlice_VARARGS(args, start, stop) __Pyx_PyTuple_FromArray(&__Pyx_Arg_VARARGS(args, start), stop - start)
+#define __Pyx_ArgsSlice_FASTCALL(args, start, stop) __Pyx_PyTuple_FromArray(&__Pyx_Arg_FASTCALL(args, start), stop - start)
+#else
+#define __Pyx_ArgsSlice_VARARGS(args, start, stop) PyTuple_GetSlice(args, start, stop)
+#define __Pyx_ArgsSlice_FASTCALL(args, start, stop) PyTuple_GetSlice(args, start, stop)
+#endif
+/* Profile.proto */
+#ifndef CYTHON_PROFILE
+#if CYTHON_COMPILING_IN_LIMITED_API || CYTHON_COMPILING_IN_PYPY
+#define CYTHON_PROFILE 0
+#else
+#define CYTHON_PROFILE 1
+#endif
+#endif
+#ifndef CYTHON_TRACE_NOGIL
+#define CYTHON_TRACE_NOGIL 0
+#else
+#if CYTHON_TRACE_NOGIL && !defined(CYTHON_TRACE)
+#define CYTHON_TRACE 1
+#endif
+#endif
+#ifndef CYTHON_TRACE
+#define CYTHON_TRACE 0
+#endif
+#if CYTHON_TRACE
+#undef CYTHON_PROFILE_REUSE_FRAME
+#endif
+#ifndef CYTHON_PROFILE_REUSE_FRAME
+#define CYTHON_PROFILE_REUSE_FRAME 0
+#endif
+#if CYTHON_PROFILE || CYTHON_TRACE
+#include "compile.h"
+#include "frameobject.h"
+#include "traceback.h"
+#if PY_VERSION_HEX >= 0x030b00a6
+#ifndef Py_BUILD_CORE
+#define Py_BUILD_CORE 1
+#endif
+#include "internal/pycore_frame.h"
+#endif
+#if CYTHON_PROFILE_REUSE_FRAME
+#define CYTHON_FRAME_MODIFIER static
+#define CYTHON_FRAME_DEL(frame)
+#else
+#define CYTHON_FRAME_MODIFIER
+#define CYTHON_FRAME_DEL(frame) Py_CLEAR(frame)
+#endif
+#define __Pyx_TraceDeclarations\
+static PyCodeObject *__pyx_frame_code = NULL;\
+CYTHON_FRAME_MODIFIER PyFrameObject *__pyx_frame = NULL;\
+int __Pyx_use_tracing = 0;
+#define __Pyx_TraceFrameInit(codeobj)\
+if (codeobj) __pyx_frame_code = (PyCodeObject*) codeobj;
+#if PY_VERSION_HEX >= 0x030b00a2
+#if PY_VERSION_HEX >= 0x030C00b1
+#define __Pyx_IsTracing(tstate, check_tracing, check_funcs)\
+((!(check_tracing) || !(tstate)->tracing) &&\
+(!(check_funcs) || (tstate)->c_profilefunc || (CYTHON_TRACE && (tstate)->c_tracefunc)))
+#else
+#define __Pyx_IsTracing(tstate, check_tracing, check_funcs)\
+(unlikely((tstate)->cframe->use_tracing) &&\
+(!(check_tracing) || !(tstate)->tracing) &&\
+(!(check_funcs) || (tstate)->c_profilefunc || (CYTHON_TRACE && (tstate)->c_tracefunc)))
+#endif
+#define __Pyx_EnterTracing(tstate)  PyThreadState_EnterTracing(tstate)
+#define __Pyx_LeaveTracing(tstate)  PyThreadState_LeaveTracing(tstate)
+#elif PY_VERSION_HEX >= 0x030a00b1
+#define __Pyx_IsTracing(tstate, check_tracing, check_funcs)\
+(unlikely((tstate)->cframe->use_tracing) &&\
+(!(check_tracing) || !(tstate)->tracing) &&\
+(!(check_funcs) || (tstate)->c_profilefunc || (CYTHON_TRACE && (tstate)->c_tracefunc)))
+#define __Pyx_EnterTracing(tstate)\
+do { tstate->tracing++; tstate->cframe->use_tracing = 0; } while (0)
+#define __Pyx_LeaveTracing(tstate)\
+do {\
+tstate->tracing--;\
+tstate->cframe->use_tracing = ((CYTHON_TRACE && tstate->c_tracefunc != NULL)\
+|| tstate->c_profilefunc != NULL);\
+} while (0)
+#else
+#define __Pyx_IsTracing(tstate, check_tracing, check_funcs)\
+(unlikely((tstate)->use_tracing) &&\
+(!(check_tracing) || !(tstate)->tracing) &&\
+(!(check_funcs) || (tstate)->c_profilefunc || (CYTHON_TRACE && (tstate)->c_tracefunc)))
+#define __Pyx_EnterTracing(tstate)\
+do { tstate->tracing++; tstate->use_tracing = 0; } while (0)
+#define __Pyx_LeaveTracing(tstate)\
+do {\
+tstate->tracing--;\
+tstate->use_tracing = ((CYTHON_TRACE && tstate->c_tracefunc != NULL)\
+|| tstate->c_profilefunc != NULL);\
+} while (0)
+#endif
+#ifdef WITH_THREAD
+#define __Pyx_TraceCall(funcname, srcfile, firstlineno, nogil, goto_error)\
+if (nogil) {\
+if (CYTHON_TRACE_NOGIL) {\
+PyThreadState *tstate;\
+PyGILState_STATE state = PyGILState_Ensure();\
+tstate = __Pyx_PyThreadState_Current;\
+if (__Pyx_IsTracing(tstate, 1, 1)) {\
+__Pyx_use_tracing = __Pyx_TraceSetupAndCall(&__pyx_frame_code, &__pyx_frame, tstate, funcname, srcfile, firstlineno);\
+}\
+PyGILState_Release(state);\
+if (unlikely(__Pyx_use_tracing < 0)) goto_error;\
+}\
+} else {\
+PyThreadState* tstate = PyThreadState_GET();\
+if (__Pyx_IsTracing(tstate, 1, 1)) {\
+__Pyx_use_tracing = __Pyx_TraceSetupAndCall(&__pyx_frame_code, &__pyx_frame, tstate, funcname, srcfile, firstlineno);\
+if (unlikely(__Pyx_use_tracing < 0)) goto_error;\
+}\
+}
+#else
+#define __Pyx_TraceCall(funcname, srcfile, firstlineno, nogil, goto_error)\
+{   PyThreadState* tstate = PyThreadState_GET();\
+if (__Pyx_IsTracing(tstate, 1, 1)) {\
+__Pyx_use_tracing = __Pyx_TraceSetupAndCall(&__pyx_frame_code, &__pyx_frame, tstate, funcname, srcfile, firstlineno);\
+if (unlikely(__Pyx_use_tracing < 0)) goto_error;\
+}\
+}
+#endif
+#define __Pyx_TraceException()\
+if (likely(!__Pyx_use_tracing)); else {\
+PyThreadState* tstate = __Pyx_PyThreadState_Current;\
+if (__Pyx_IsTracing(tstate, 0, 1)) {\
+__Pyx_EnterTracing(tstate);\
+PyObject *exc_info = __Pyx_GetExceptionTuple(tstate);\
+if (exc_info) {\
+if (CYTHON_TRACE && tstate->c_tracefunc)\
+tstate->c_tracefunc(\
+tstate->c_traceobj, __pyx_frame, PyTrace_EXCEPTION, exc_info);\
+tstate->c_profilefunc(\
+tstate->c_profileobj, __pyx_frame, PyTrace_EXCEPTION, exc_info);\
+Py_DECREF(exc_info);\
+}\
+__Pyx_LeaveTracing(tstate);\
+}\
+}
+static void __Pyx_call_return_trace_func(PyThreadState *tstate, PyFrameObject *frame, PyObject *result) {
+PyObject *type, *value, *traceback;
+__Pyx_ErrFetchInState(tstate, &type, &value, &traceback);
+__Pyx_EnterTracing(tstate);
+if (CYTHON_TRACE && tstate->c_tracefunc)
+tstate->c_tracefunc(tstate->c_traceobj, frame, PyTrace_RETURN, result);
+if (tstate->c_profilefunc)
+tstate->c_profilefunc(tstate->c_profileobj, frame, PyTrace_RETURN, result);
+CYTHON_FRAME_DEL(frame);
+__Pyx_LeaveTracing(tstate);
+__Pyx_ErrRestoreInState(tstate, type, value, traceback);
+}
+#ifdef WITH_THREAD
+#define __Pyx_TraceReturn(result, nogil)\
+if (likely(!__Pyx_use_tracing)); else {\
+if (nogil) {\
+if (CYTHON_TRACE_NOGIL) {\
+PyThreadState *tstate;\
+PyGILState_STATE state = PyGILState_Ensure();\
+tstate = __Pyx_PyThreadState_Current;\
+if (__Pyx_IsTracing(tstate, 0, 0)) {\
+__Pyx_call_return_trace_func(tstate, __pyx_frame, (PyObject*)result);\
+}\
+PyGILState_Release(state);\
+}\
+} else {\
+PyThreadState* tstate = __Pyx_PyThreadState_Current;\
+if (__Pyx_IsTracing(tstate, 0, 0)) {\
+__Pyx_call_return_trace_func(tstate, __pyx_frame, (PyObject*)result);\
+}\
+}\
+}
+#else
+#define __Pyx_TraceReturn(result, nogil)\
+if (likely(!__Pyx_use_tracing)); else {\
+PyThreadState* tstate = __Pyx_PyThreadState_Current;\
+if (__Pyx_IsTracing(tstate, 0, 0)) {\
+__Pyx_call_return_trace_func(tstate, __pyx_frame, (PyObject*)result);\
+}\
+}
+#endif
+static PyCodeObject *__Pyx_createFrameCodeObject(const char *funcname, const char *srcfile, int firstlineno);
+static int __Pyx_TraceSetupAndCall(PyCodeObject** code, PyFrameObject** frame, PyThreadState* tstate, const char *funcname, const char *srcfile, int firstlineno);
+#else
+#define __Pyx_TraceDeclarations
+#define __Pyx_TraceFrameInit(codeobj)
+#define __Pyx_TraceCall(funcname, srcfile, firstlineno, nogil, goto_error)   if ((1)); else goto_error;
+#define __Pyx_TraceException()
+#define __Pyx_TraceReturn(result, nogil)
+#endif
+#if CYTHON_TRACE
+static int __Pyx_call_line_trace_func(PyThreadState *tstate, PyFrameObject *frame, int lineno) {
+int ret;
+PyObject *type, *value, *traceback;
+__Pyx_ErrFetchInState(tstate, &type, &value, &traceback);
+__Pyx_PyFrame_SetLineNumber(frame, lineno);
+__Pyx_EnterTracing(tstate);
+ret = tstate->c_tracefunc(tstate->c_traceobj, frame, PyTrace_LINE, NULL);
+__Pyx_LeaveTracing(tstate);
+if (likely(!ret)) {
+__Pyx_ErrRestoreInState(tstate, type, value, traceback);
+} else {
+Py_XDECREF(type);
+Py_XDECREF(value);
+Py_XDECREF(traceback);
+}
+return ret;
+}
+#ifdef WITH_THREAD
+#define __Pyx_TraceLine(lineno, nogil, goto_error)\
+if (likely(!__Pyx_use_tracing)); else {\
+if (nogil) {\
+if (CYTHON_TRACE_NOGIL) {\
+int ret = 0;\
+PyThreadState *tstate;\
+PyGILState_STATE state = __Pyx_PyGILState_Ensure();\
+tstate = __Pyx_PyThreadState_Current;\
+if (__Pyx_IsTracing(tstate, 0, 0) && tstate->c_tracefunc && __pyx_frame->f_trace) {\
+ret = __Pyx_call_line_trace_func(tstate, __pyx_frame, lineno);\
+}\
+__Pyx_PyGILState_Release(state);\
+if (unlikely(ret)) goto_error;\
+}\
+} else {\
+PyThreadState* tstate = __Pyx_PyThreadState_Current;\
+if (__Pyx_IsTracing(tstate, 0, 0) && tstate->c_tracefunc && __pyx_frame->f_trace) {\
+int ret = __Pyx_call_line_trace_func(tstate, __pyx_frame, lineno);\
+if (unlikely(ret)) goto_error;\
+}\
+}\
+}
+#else
+#define __Pyx_TraceLine(lineno, nogil, goto_error)\
+if (likely(!__Pyx_use_tracing)); else {\
+PyThreadState* tstate = __Pyx_PyThreadState_Current;\
+if (__Pyx_IsTracing(tstate, 0, 0) && tstate->c_tracefunc && __pyx_frame->f_trace) {\
+int ret = __Pyx_call_line_trace_func(tstate, __pyx_frame, lineno);\
+if (unlikely(ret)) goto_error;\
+}\
+}
+#endif
+#else
+#define __Pyx_TraceLine(lineno, nogil, goto_error)   if ((1)); else goto_error;
+#endif
+/* KeywordStringCheck.proto */
+static int __Pyx_CheckKeywordStrings(PyObject *kw, const char* function_name, int kw_allowed);
+/* PyObjectCall.proto */
+#if CYTHON_COMPILING_IN_CPYTHON
+static CYTHON_INLINE PyObject* __Pyx_PyObject_Call(PyObject *func, PyObject *arg, PyObject *kw);
+#else
+#define __Pyx_PyObject_Call(func, arg, kw) PyObject_Call(func, arg, kw)
+#endif
+/* RaiseArgTupleInvalid.proto */
+static void __Pyx_RaiseArgtupleInvalid(const char* func_name, int exact,
+Py_ssize_t num_min, Py_ssize_t num_max, Py_ssize_t num_found);
+/* RaiseException.proto */
+static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb, PyObject *cause);
+/* RaiseDoubleKeywords.proto */
+static void __Pyx_RaiseDoubleKeywordsError(const char* func_name, PyObject* kw_name);
+/* ParseKeywords.proto */
+static int __Pyx_ParseOptionalKeywords(PyObject *kwds, PyObject *const *kwvalues,
+PyObject **argnames[],
+PyObject *kwds2, PyObject *values[], Py_ssize_t num_pos_args,
+const char* function_name);
+/* PyFunctionFastCall.proto */
+#if CYTHON_FAST_PYCALL
+#if !CYTHON_VECTORCALL
+#define __Pyx_PyFunction_FastCall(func, args, nargs)\
+__Pyx_PyFunction_FastCallDict((func), (args), (nargs), NULL)
+static PyObject *__Pyx_PyFunction_FastCallDict(PyObject *func, PyObject **args, Py_ssize_t nargs, PyObject *kwargs);
+#endif
+#define __Pyx_BUILD_ASSERT_EXPR(cond)\
+(sizeof(char [1 - 2*!(cond)]) - 1)
+#ifndef Py_MEMBER_SIZE
+#define Py_MEMBER_SIZE(type, member) sizeof(((type *)0)->member)
+#endif
+#if !CYTHON_VECTORCALL
+#if PY_VERSION_HEX >= 0x03080000
+#include "frameobject.h"
+#if PY_VERSION_HEX >= 0x030b00a6 && !CYTHON_COMPILING_IN_LIMITED_API
+#ifndef Py_BUILD_CORE
+#define Py_BUILD_CORE 1
+#endif
+#include "internal/pycore_frame.h"
+#endif
+#define __Pxy_PyFrame_Initialize_Offsets()
+#define __Pyx_PyFrame_GetLocalsplus(frame)  ((frame)->f_localsplus)
+#else
+static size_t __pyx_pyframe_localsplus_offset = 0;
+#include "frameobject.h"
+#define __Pxy_PyFrame_Initialize_Offsets()\
+((void)__Pyx_BUILD_ASSERT_EXPR(sizeof(PyFrameObject) == offsetof(PyFrameObject, f_localsplus) + Py_MEMBER_SIZE(PyFrameObject, f_localsplus)),\
+(void)(__pyx_pyframe_localsplus_offset = ((size_t)PyFrame_Type.tp_basicsize) - Py_MEMBER_SIZE(PyFrameObject, f_localsplus)))
+#define __Pyx_PyFrame_GetLocalsplus(frame)\
+(assert(__pyx_pyframe_localsplus_offset), (PyObject **)(((char *)(frame)) + __pyx_pyframe_localsplus_offset))
+#endif
+#endif
+#endif
+/* PyObjectCallMethO.proto */
+#if CYTHON_COMPILING_IN_CPYTHON
+static CYTHON_INLINE PyObject* __Pyx_PyObject_CallMethO(PyObject *func, PyObject *arg);
+#endif
+/* PyObjectFastCall.proto */
+#define __Pyx_PyObject_FastCall(func, args, nargs)  __Pyx_PyObject_FastCallDict(func, args, (size_t)(nargs), NULL)
+static CYTHON_INLINE PyObject* __Pyx_PyObject_FastCallDict(PyObject *func, PyObject **args, size_t nargs, PyObject *kwargs);
+/* PyDictVersioning.proto */
+#if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_TYPE_SLOTS
+#define __PYX_DICT_VERSION_INIT  ((PY_UINT64_T) -1)
+#define __PYX_GET_DICT_VERSION(dict)  (((PyDictObject*)(dict))->ma_version_tag)
+#define __PYX_UPDATE_DICT_CACHE(dict, value, cache_var, version_var)\
+(version_var) = __PYX_GET_DICT_VERSION(dict);\
+(cache_var) = (value);
+#define __PYX_PY_DICT_LOOKUP_IF_MODIFIED(VAR, DICT, LOOKUP) {\
+static PY_UINT64_T __pyx_dict_version = 0;\
+static PyObject *__pyx_dict_cached_value = NULL;\
+if (likely(__PYX_GET_DICT_VERSION(DICT) == __pyx_dict_version)) {\
+(VAR) = __pyx_dict_cached_value;\
+} else {\
+(VAR) = __pyx_dict_cached_value = (LOOKUP);\
+__pyx_dict_version = __PYX_GET_DICT_VERSION(DICT);\
+}\
+}
+static CYTHON_INLINE PY_UINT64_T __Pyx_get_tp_dict_version(PyObject *obj);
+static CYTHON_INLINE PY_UINT64_T __Pyx_get_object_dict_version(PyObject *obj);
+static CYTHON_INLINE int __Pyx_object_dict_version_matches(PyObject* obj, PY_UINT64_T tp_dict_version, PY_UINT64_T obj_dict_version);
+#else
+#define __PYX_GET_DICT_VERSION(dict)  (0)
+#define __PYX_UPDATE_DICT_CACHE(dict, value, cache_var, version_var)
+#define __PYX_PY_DICT_LOOKUP_IF_MODIFIED(VAR, DICT, LOOKUP)  (VAR) = (LOOKUP);
+#endif
+/* GetModuleGlobalName.proto */
+#if CYTHON_USE_DICT_VERSIONS
+#define __Pyx_GetModuleGlobalName(var, name)  do {\
+static PY_UINT64_T __pyx_dict_version = 0;\
+static PyObject *__pyx_dict_cached_value = NULL;\
+(var) = (likely(__pyx_dict_version == __PYX_GET_DICT_VERSION(__pyx_d))) ?\
+(likely(__pyx_dict_cached_value) ? __Pyx_NewRef(__pyx_dict_cached_value) : __Pyx_GetBuiltinName(name)) :\
+__Pyx__GetModuleGlobalName(name, &__pyx_dict_version, &__pyx_dict_cached_value);\
+} while(0)
+#define __Pyx_GetModuleGlobalNameUncached(var, name)  do {\
+PY_UINT64_T __pyx_dict_version;\
+PyObject *__pyx_dict_cached_value;\
+(var) = __Pyx__GetModuleGlobalName(name, &__pyx_dict_version, &__pyx_dict_cached_value);\
+} while(0)
+static PyObject *__Pyx__GetModuleGlobalName(PyObject *name, PY_UINT64_T *dict_version, PyObject **dict_cached_value);
+#else
+#define __Pyx_GetModuleGlobalName(var, name)  (var) = __Pyx__GetModuleGlobalName(name)
+#define __Pyx_GetModuleGlobalNameUncached(var, name)  (var) = __Pyx__GetModuleGlobalName(name)
+static CYTHON_INLINE PyObject *__Pyx__GetModuleGlobalName(PyObject *name);
+#endif
+/* PyObjectCallOneArg.proto */
+static CYTHON_INLINE PyObject* __Pyx_PyObject_CallOneArg(PyObject *func, PyObject *arg);
+/* ListAppend.proto */
+#if CYTHON_USE_PYLIST_INTERNALS && CYTHON_ASSUME_SAFE_MACROS
+static CYTHON_INLINE int __Pyx_PyList_Append(PyObject* list, PyObject* x) {
+PyListObject* L = (PyListObject*) list;
+Py_ssize_t len = Py_SIZE(list);
+if (likely(L->allocated > len) & likely(len > (L->allocated >> 1))) {
+Py_INCREF(x);
+#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX >= 0x030d0000
+L->ob_item[len] = x;
+#else
+PyList_SET_ITEM(list, len, x);
+#endif
+__Pyx_SET_SIZE(list, len + 1);
+return 0;
+}
+return PyList_Append(list, x);
+}
+#else
+#define __Pyx_PyList_Append(L,x) PyList_Append(L,x)
+#endif
+/* PyObjectCall2Args.proto */
+static CYTHON_INLINE PyObject* __Pyx_PyObject_Call2Args(PyObject* function, PyObject* arg1, PyObject* arg2);
+/* PyObjectGetMethod.proto */
+static int __Pyx_PyObject_GetMethod(PyObject *obj, PyObject *name, PyObject **method);
+/* PyObjectCallMethod1.proto */
+static PyObject* __Pyx_PyObject_CallMethod1(PyObject* obj, PyObject* method_name, PyObject* arg);
+/* append.proto */
+static CYTHON_INLINE int __Pyx_PyObject_Append(PyObject* L, PyObject* x);
+/* WriteUnraisableException.proto */
+static void __Pyx_WriteUnraisable(const char *name, int clineno,
+int lineno, const char *filename,
+int full_traceback, int nogil);
+/* RaiseTooManyValuesToUnpack.proto */
+static CYTHON_INLINE void __Pyx_RaiseTooManyValuesError(Py_ssize_t expected);
+/* RaiseNeedMoreValuesToUnpack.proto */
+static CYTHON_INLINE void __Pyx_RaiseNeedMoreValuesError(Py_ssize_t index);
+/* IterFinish.proto */
+static CYTHON_INLINE int __Pyx_IterFinish(void);
+/* UnpackItemEndCheck.proto */
+static int __Pyx_IternextUnpackEndCheck(PyObject *retval, Py_ssize_t expected);
+/* GetException.proto */
+#if CYTHON_FAST_THREAD_STATE
+#define __Pyx_GetException(type, value, tb)  __Pyx__GetException(__pyx_tstate, type, value, tb)
+static int __Pyx__GetException(PyThreadState *tstate, PyObject **type, PyObject **value, PyObject **tb);
+#else
+static int __Pyx_GetException(PyObject **type, PyObject **value, PyObject **tb);
+#endif
+/* SwapException.proto */
+#if CYTHON_FAST_THREAD_STATE
+#define __Pyx_ExceptionSwap(type, value, tb)  __Pyx__ExceptionSwap(__pyx_tstate, type, value, tb)
+static CYTHON_INLINE void __Pyx__ExceptionSwap(PyThreadState *tstate, PyObject **type, PyObject **value, PyObject **tb);
+#else
+static CYTHON_INLINE void __Pyx_ExceptionSwap(PyObject **type, PyObject **value, PyObject **tb);
+#endif
+/* GetTopmostException.proto */
+#if CYTHON_USE_EXC_INFO_STACK && CYTHON_FAST_THREAD_STATE
+static _PyErr_StackItem * __Pyx_PyErr_GetTopmostException(PyThreadState *tstate);
+#endif
+/* SaveResetException.proto */
+#if CYTHON_FAST_THREAD_STATE
+#define __Pyx_ExceptionSave(type, value, tb)  __Pyx__ExceptionSave(__pyx_tstate, type, value, tb)
+static CYTHON_INLINE void __Pyx__ExceptionSave(PyThreadState *tstate, PyObject **type, PyObject **value, PyObject **tb);
+#define __Pyx_ExceptionReset(type, value, tb)  __Pyx__ExceptionReset(__pyx_tstate, type, value, tb)
+static CYTHON_INLINE void __Pyx__ExceptionReset(PyThreadState *tstate, PyObject *type, PyObject *value, PyObject *tb);
+#else
+#define __Pyx_ExceptionSave(type, value, tb)   PyErr_GetExcInfo(type, value, tb)
+#define __Pyx_ExceptionReset(type, value, tb)  PyErr_SetExcInfo(type, value, tb)
+#endif
+/* GetItemInt.proto */
+#define __Pyx_GetItemInt(o, i, type, is_signed, to_py_func, is_list, wraparound, boundscheck)\
+(__Pyx_fits_Py_ssize_t(i, type, is_signed) ?\
+__Pyx_GetItemInt_Fast(o, (Py_ssize_t)i, is_list, wraparound, boundscheck) :\
+(is_list ? (PyErr_SetString(PyExc_IndexError, "list index out of range"), (PyObject*)NULL) :\
+__Pyx_GetItemInt_Generic(o, to_py_func(i))))
+#define __Pyx_GetItemInt_List(o, i, type, is_signed, to_py_func, is_list, wraparound, boundscheck)\
+(__Pyx_fits_Py_ssize_t(i, type, is_signed) ?\
+__Pyx_GetItemInt_List_Fast(o, (Py_ssize_t)i, wraparound, boundscheck) :\
+(PyErr_SetString(PyExc_IndexError, "list index out of range"), (PyObject*)NULL))
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_List_Fast(PyObject *o, Py_ssize_t i,
+int wraparound, int boundscheck);
+#define __Pyx_GetItemInt_Tuple(o, i, type, is_signed, to_py_func, is_list, wraparound, boundscheck)\
+(__Pyx_fits_Py_ssize_t(i, type, is_signed) ?\
+__Pyx_GetItemInt_Tuple_Fast(o, (Py_ssize_t)i, wraparound, boundscheck) :\
+(PyErr_SetString(PyExc_IndexError, "tuple index out of range"), (PyObject*)NULL))
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Tuple_Fast(PyObject *o, Py_ssize_t i,
+int wraparound, int boundscheck);
+static PyObject *__Pyx_GetItemInt_Generic(PyObject *o, PyObject* j);
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Fast(PyObject *o, Py_ssize_t i,
+int is_list, int wraparound, int boundscheck);
+/* ObjectGetItem.proto */
+#if CYTHON_USE_TYPE_SLOTS
+static CYTHON_INLINE PyObject *__Pyx_PyObject_GetItem(PyObject *obj, PyObject *key);
+#else
+#define __Pyx_PyObject_GetItem(obj, key)  PyObject_GetItem(obj, key)
+#endif
+/* PySequenceContains.proto */
+static CYTHON_INLINE int __Pyx_PySequence_ContainsTF(PyObject* item, PyObject* seq, int eq) {
+int result = PySequence_Contains(seq, item);
+return unlikely(result < 0) ? result : (result == (eq == Py_EQ));
+}
+/* PyObjectFormatAndDecref.proto */
+static CYTHON_INLINE PyObject* __Pyx_PyObject_FormatSimpleAndDecref(PyObject* s, PyObject* f);
+static CYTHON_INLINE PyObject* __Pyx_PyObject_FormatAndDecref(PyObject* s, PyObject* f);
+/* JoinPyUnicode.proto */
+static PyObject* __Pyx_PyUnicode_Join(PyObject* value_tuple, Py_ssize_t value_count, Py_ssize_t result_ulength,
+Py_UCS4 max_char);
+/* ExtTypeTest.proto */
+static CYTHON_INLINE int __Pyx_TypeTest(PyObject *obj, PyTypeObject *type);
+/* ArgTypeTest.proto */
+#define __Pyx_ArgTypeTest(obj, type, none_allowed, name, exact)\
+((likely(__Pyx_IS_TYPE(obj, type) | (none_allowed && (obj == Py_None)))) ? 1 :\
+__Pyx__ArgTypeTest(obj, type, name, exact))
+static int __Pyx__ArgTypeTest(PyObject *obj, PyTypeObject *type, const char *name, int exact);
+/* RaiseUnexpectedTypeError.proto */
+static int __Pyx_RaiseUnexpectedTypeError(const char *expected, PyObject *obj);
+/* PyUnicode_Unicode.proto */
+static CYTHON_INLINE PyObject* __Pyx_PyUnicode_Unicode(PyObject *obj);
+/* GetAttr3.proto */
+static CYTHON_INLINE PyObject *__Pyx_GetAttr3(PyObject *, PyObject *, PyObject *);
+/* Import.proto */
+static PyObject *__Pyx_Import(PyObject *name, PyObject *from_list, int level);
+/* ImportFrom.proto */
+static PyObject* __Pyx_ImportFrom(PyObject* module, PyObject* name);
+/* GetAttr.proto */
+static CYTHON_INLINE PyObject *__Pyx_GetAttr(PyObject *, PyObject *);
+/* HasAttr.proto */
+static CYTHON_INLINE int __Pyx_HasAttr(PyObject *, PyObject *);
+/* IncludeStructmemberH.proto */
+#include <structmember.h>
+/* FixUpExtensionType.proto */
+#if CYTHON_USE_TYPE_SPECS
+static int __Pyx_fix_up_extension_type_from_spec(PyType_Spec *spec, PyTypeObject *type);
+#endif
+/* PyObjectCallNoArg.proto */
+static CYTHON_INLINE PyObject* __Pyx_PyObject_CallNoArg(PyObject *func);
+/* PyObjectCallMethod0.proto */
+static PyObject* __Pyx_PyObject_CallMethod0(PyObject* obj, PyObject* method_name);
+/* ValidateBasesTuple.proto */
+#if CYTHON_COMPILING_IN_CPYTHON || CYTHON_COMPILING_IN_LIMITED_API || CYTHON_USE_TYPE_SPECS
+static int __Pyx_validate_bases_tuple(const char *type_name, Py_ssize_t dictoffset, PyObject *bases);
+#endif
+/* PyType_Ready.proto */
+CYTHON_UNUSED static int __Pyx_PyType_Ready(PyTypeObject *t);
+/* PyObject_GenericGetAttrNoDict.proto */
+#if CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP && PY_VERSION_HEX < 0x03070000
+static CYTHON_INLINE PyObject* __Pyx_PyObject_GenericGetAttrNoDict(PyObject* obj, PyObject* attr_name);
+#else
+#define __Pyx_PyObject_GenericGetAttrNoDict PyObject_GenericGetAttr
+#endif
+/* PyObject_GenericGetAttr.proto */
+#if CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP && PY_VERSION_HEX < 0x03070000
+static PyObject* __Pyx_PyObject_GenericGetAttr(PyObject* obj, PyObject* attr_name);
+#else
+#define __Pyx_PyObject_GenericGetAttr PyObject_GenericGetAttr
+#endif
+/* SetVTable.proto */
+static int __Pyx_SetVtable(PyTypeObject* typeptr , void* vtable);
+/* GetVTable.proto */
+static void* __Pyx_GetVtable(PyTypeObject *type);
+/* MergeVTables.proto */
+#if !CYTHON_COMPILING_IN_LIMITED_API
+static int __Pyx_MergeVtables(PyTypeObject *type);
+#endif
+/* SetupReduce.proto */
+#if !CYTHON_COMPILING_IN_LIMITED_API
+static int __Pyx_setup_reduce(PyObject* type_obj);
+#endif
+/* TypeImport.proto */
+#ifndef __PYX_HAVE_RT_ImportType_proto_3_0_11
+#define __PYX_HAVE_RT_ImportType_proto_3_0_11
+#if defined (__STDC_VERSION__) && __STDC_VERSION__ >= 201112L
+#include <stdalign.h>
+#endif
+#if (defined (__STDC_VERSION__) && __STDC_VERSION__ >= 201112L) || __cplusplus >= 201103L
+#define __PYX_GET_STRUCT_ALIGNMENT_3_0_11(s) alignof(s)
+#else
+#define __PYX_GET_STRUCT_ALIGNMENT_3_0_11(s) sizeof(void*)
+#endif
+enum __Pyx_ImportType_CheckSize_3_0_11 {
+__Pyx_ImportType_CheckSize_Error_3_0_11 = 0,
+__Pyx_ImportType_CheckSize_Warn_3_0_11 = 1,
+__Pyx_ImportType_CheckSize_Ignore_3_0_11 = 2
+};
+static PyTypeObject *__Pyx_ImportType_3_0_11(PyObject* module, const char *module_name, const char *class_name, size_t size, size_t alignment, enum __Pyx_ImportType_CheckSize_3_0_11 check_size);
+#endif
+/* ImportDottedModule.proto */
+static PyObject *__Pyx_ImportDottedModule(PyObject *name, PyObject *parts_tuple);
+#if PY_MAJOR_VERSION >= 3
+static PyObject *__Pyx_ImportDottedModule_WalkParts(PyObject *module, PyObject *name, PyObject *parts_tuple);
+#endif
+/* FetchSharedCythonModule.proto */
+static PyObject *__Pyx_FetchSharedCythonABIModule(void);
+/* FetchCommonType.proto */
+#if !CYTHON_USE_TYPE_SPECS
+static PyTypeObject* __Pyx_FetchCommonType(PyTypeObject* type);
+#else
+static PyTypeObject* __Pyx_FetchCommonTypeFromSpec(PyObject *module, PyType_Spec *spec, PyObject *bases);
+#endif
+/* PyMethodNew.proto */
+#if CYTHON_COMPILING_IN_LIMITED_API
+static PyObject *__Pyx_PyMethod_New(PyObject *func, PyObject *self, PyObject *typ) {
+PyObject *typesModule=NULL, *methodType=NULL, *result=NULL;
+CYTHON_UNUSED_VAR(typ);
+if (!self)
+return __Pyx_NewRef(func);
+typesModule = PyImport_ImportModule("types");
+if (!typesModule) return NULL;
+methodType = PyObject_GetAttrString(typesModule, "MethodType");
+Py_DECREF(typesModule);
+if (!methodType) return NULL;
+result = PyObject_CallFunctionObjArgs(methodType, func, self, NULL);
+Py_DECREF(methodType);
+return result;
+}
+#elif PY_MAJOR_VERSION >= 3
+static PyObject *__Pyx_PyMethod_New(PyObject *func, PyObject *self, PyObject *typ) {
+CYTHON_UNUSED_VAR(typ);
+if (!self)
+return __Pyx_NewRef(func);
+return PyMethod_New(func, self);
+}
+#else
+#define __Pyx_PyMethod_New PyMethod_New
+#endif
+/* PyVectorcallFastCallDict.proto */
+#if CYTHON_METH_FASTCALL
+static CYTHON_INLINE PyObject *__Pyx_PyVectorcall_FastCallDict(PyObject *func, __pyx_vectorcallfunc vc, PyObject *const *args, size_t nargs, PyObject *kw);
+#endif
+/* CythonFunctionShared.proto */
+#define __Pyx_CyFunction_USED
+#define __Pyx_CYFUNCTION_STATICMETHOD  0x01
+#define __Pyx_CYFUNCTION_CLASSMETHOD   0x02
+#define __Pyx_CYFUNCTION_CCLASS        0x04
+#define __Pyx_CYFUNCTION_COROUTINE     0x08
+#define __Pyx_CyFunction_GetClosure(f)\
+(((__pyx_CyFunctionObject *) (f))->func_closure)
+#if PY_VERSION_HEX < 0x030900B1 || CYTHON_COMPILING_IN_LIMITED_API
+#define __Pyx_CyFunction_GetClassObj(f)\
+(((__pyx_CyFunctionObject *) (f))->func_classobj)
+#else
+#define __Pyx_CyFunction_GetClassObj(f)\
+((PyObject*) ((PyCMethodObject *) (f))->mm_class)
+#endif
+#define __Pyx_CyFunction_SetClassObj(f, classobj)\
+__Pyx__CyFunction_SetClassObj((__pyx_CyFunctionObject *) (f), (classobj))
+#define __Pyx_CyFunction_Defaults(type, f)\
+((type *)(((__pyx_CyFunctionObject *) (f))->defaults))
+#define __Pyx_CyFunction_SetDefaultsGetter(f, g)\
+((__pyx_CyFunctionObject *) (f))->defaults_getter = (g)
+typedef struct {
+#if CYTHON_COMPILING_IN_LIMITED_API
+PyObject_HEAD
+PyObject *func;
+#elif PY_VERSION_HEX < 0x030900B1
+PyCFunctionObject func;
+#else
+PyCMethodObject func;
+#endif
+#if CYTHON_BACKPORT_VECTORCALL
+__pyx_vectorcallfunc func_vectorcall;
+#endif
+#if PY_VERSION_HEX < 0x030500A0 || CYTHON_COMPILING_IN_LIMITED_API
+PyObject *func_weakreflist;
+#endif
+PyObject *func_dict;
+PyObject *func_name;
+PyObject *func_qualname;
+PyObject *func_doc;
+PyObject *func_globals;
+PyObject *func_code;
+PyObject *func_closure;
+#if PY_VERSION_HEX < 0x030900B1 || CYTHON_COMPILING_IN_LIMITED_API
+PyObject *func_classobj;
+#endif
+void *defaults;
+int defaults_pyobjects;
+size_t defaults_size;
+int flags;
+PyObject *defaults_tuple;
+PyObject *defaults_kwdict;
+PyObject *(*defaults_getter)(PyObject *);
+PyObject *func_annotations;
+PyObject *func_is_coroutine;
+} __pyx_CyFunctionObject;
+#undef __Pyx_CyOrPyCFunction_Check
+#define __Pyx_CyFunction_Check(obj)  __Pyx_TypeCheck(obj, __pyx_CyFunctionType)
+#define __Pyx_CyOrPyCFunction_Check(obj)  __Pyx_TypeCheck2(obj, __pyx_CyFunctionType, &PyCFunction_Type)
+#define __Pyx_CyFunction_CheckExact(obj)  __Pyx_IS_TYPE(obj, __pyx_CyFunctionType)
+static CYTHON_INLINE int __Pyx__IsSameCyOrCFunction(PyObject *func, void *cfunc);
+#undef __Pyx_IsSameCFunction
+#define __Pyx_IsSameCFunction(func, cfunc)   __Pyx__IsSameCyOrCFunction(func, cfunc)
+static PyObject *__Pyx_CyFunction_Init(__pyx_CyFunctionObject* op, PyMethodDef *ml,
+int flags, PyObject* qualname,
+PyObject *closure,
+PyObject *module, PyObject *globals,
+PyObject* code);
+static CYTHON_INLINE void __Pyx__CyFunction_SetClassObj(__pyx_CyFunctionObject* f, PyObject* classobj);
+static CYTHON_INLINE void *__Pyx_CyFunction_InitDefaults(PyObject *m,
+size_t size,
+int pyobjects);
+static CYTHON_INLINE void __Pyx_CyFunction_SetDefaultsTuple(PyObject *m,
+PyObject *tuple);
+static CYTHON_INLINE void __Pyx_CyFunction_SetDefaultsKwDict(PyObject *m,
+PyObject *dict);
+static CYTHON_INLINE void __Pyx_CyFunction_SetAnnotationsDict(PyObject *m,
+PyObject *dict);
+static int __pyx_CyFunction_init(PyObject *module);
+#if CYTHON_METH_FASTCALL
+static PyObject * __Pyx_CyFunction_Vectorcall_NOARGS(PyObject *func, PyObject *const *args, size_t nargsf, PyObject *kwnames);
+static PyObject * __Pyx_CyFunction_Vectorcall_O(PyObject *func, PyObject *const *args, size_t nargsf, PyObject *kwnames);
+static PyObject * __Pyx_CyFunction_Vectorcall_FASTCALL_KEYWORDS(PyObject *func, PyObject *const *args, size_t nargsf, PyObject *kwnames);
+static PyObject * __Pyx_CyFunction_Vectorcall_FASTCALL_KEYWORDS_METHOD(PyObject *func, PyObject *const *args, size_t nargsf, PyObject *kwnames);
+#if CYTHON_BACKPORT_VECTORCALL
+#define __Pyx_CyFunction_func_vectorcall(f) (((__pyx_CyFunctionObject*)f)->func_vectorcall)
+#else
+#define __Pyx_CyFunction_func_vectorcall(f) (((PyCFunctionObject*)f)->vectorcall)
+#endif
+#endif
+/* CythonFunction.proto */
+static PyObject *__Pyx_CyFunction_New(PyMethodDef *ml,
+int flags, PyObject* qualname,
+PyObject *closure,
+PyObject *module, PyObject *globals,
+PyObject* code);
+/* CLineInTraceback.proto */
+#ifdef CYTHON_CLINE_IN_TRACEBACK
+#define __Pyx_CLineForTraceback(tstate, c_line)  (((CYTHON_CLINE_IN_TRACEBACK)) ? c_line : 0)
+#else
+static int __Pyx_CLineForTraceback(PyThreadState *tstate, int c_line);
+#endif
+/* CodeObjectCache.proto */
+#if !CYTHON_COMPILING_IN_LIMITED_API
+typedef struct {
+PyCodeObject* code_object;
+int code_line;
+} __Pyx_CodeObjectCacheEntry;
+struct __Pyx_CodeObjectCache {
+int count;
+int max_count;
+__Pyx_CodeObjectCacheEntry* entries;
+};
+static struct __Pyx_CodeObjectCache __pyx_code_cache = {0,0,NULL};
+static int __pyx_bisect_code_objects(__Pyx_CodeObjectCacheEntry* entries, int count, int code_line);
+static PyCodeObject *__pyx_find_code_object(int code_line);
+static void __pyx_insert_code_object(int code_line, PyCodeObject* code_object);
+#endif
+/* AddTraceback.proto */
+static void __Pyx_AddTraceback(const char *funcname, int c_line,
+int py_line, const char *filename);
+/* ArrayAPI.proto */
+#ifndef _ARRAYARRAY_H
+#define _ARRAYARRAY_H
+typedef struct arraydescr {
+int typecode;
+int itemsize;
+PyObject * (*getitem)(struct arrayobject *, Py_ssize_t);
+int (*setitem)(struct arrayobject *, Py_ssize_t, PyObject *);
+#if PY_MAJOR_VERSION >= 3
+char *formats;
+#endif
+} arraydescr;
+struct arrayobject {
+PyObject_HEAD
+Py_ssize_t ob_size;
+union {
+char *ob_item;
+float *as_floats;
+double *as_doubles;
+int *as_ints;
+unsigned int *as_uints;
+unsigned char *as_uchars;
+signed char *as_schars;
+char *as_chars;
+unsigned long *as_ulongs;
+long *as_longs;
+#if PY_MAJOR_VERSION >= 3
+unsigned long long *as_ulonglongs;
+long long *as_longlongs;
+#endif
+short *as_shorts;
+unsigned short *as_ushorts;
+Py_UNICODE *as_pyunicodes;
+void *as_voidptr;
+} data;
+Py_ssize_t allocated;
+struct arraydescr *ob_descr;
+PyObject *weakreflist;
+#if PY_MAJOR_VERSION >= 3
+int ob_exports;
+#endif
+};
+#ifndef NO_NEWARRAY_INLINE
+static CYTHON_INLINE PyObject * newarrayobject(PyTypeObject *type, Py_ssize_t size,
+struct arraydescr *descr) {
+arrayobject *op;
+size_t nbytes;
+if (size < 0) {
+PyErr_BadInternalCall();
+return NULL;
+}
+nbytes = size * descr->itemsize;
+if (nbytes / descr->itemsize != (size_t)size) {
+return PyErr_NoMemory();
+}
+op = (arrayobject *) type->tp_alloc(type, 0);
+if (op == NULL) {
+return NULL;
+}
+op->ob_descr = descr;
+op->allocated = size;
+op->weakreflist = NULL;
+__Pyx_SET_SIZE(op, size);
+if (size <= 0) {
+op->data.ob_item = NULL;
+}
+else {
+op->data.ob_item = PyMem_NEW(char, nbytes);
+if (op->data.ob_item == NULL) {
+Py_DECREF(op);
+return PyErr_NoMemory();
+}
+}
+return (PyObject *) op;
+}
+#else
+PyObject* newarrayobject(PyTypeObject *type, Py_ssize_t size,
+struct arraydescr *descr);
+#endif
+static CYTHON_INLINE int resize(arrayobject *self, Py_ssize_t n) {
+void *items = (void*) self->data.ob_item;
+PyMem_Resize(items, char, (size_t)(n * self->ob_descr->itemsize));
+if (items == NULL) {
+PyErr_NoMemory();
+return -1;
+}
+self->data.ob_item = (char*) items;
+__Pyx_SET_SIZE(self, n);
+self->allocated = n;
+return 0;
+}
+static CYTHON_INLINE int resize_smart(arrayobject *self, Py_ssize_t n) {
+void *items = (void*) self->data.ob_item;
+Py_ssize_t newsize;
+if (n < self->allocated && n*4 > self->allocated) {
+__Pyx_SET_SIZE(self, n);
+return 0;
+}
+newsize = n + (n / 2) + 1;
+if (newsize <= n) {
+PyErr_NoMemory();
+return -1;
+}
+PyMem_Resize(items, char, (size_t)(newsize * self->ob_descr->itemsize));
+if (items == NULL) {
+PyErr_NoMemory();
+return -1;
+}
+self->data.ob_item = (char*) items;
+__Pyx_SET_SIZE(self, n);
+self->allocated = newsize;
+return 0;
+}
+#endif
+/* GCCDiagnostics.proto */
+#if !defined(__INTEL_COMPILER) && defined(__GNUC__) && (__GNUC__ > 4 || (__GNUC__ == 4 && __GNUC_MINOR__ >= 6))
+#define __Pyx_HAS_GCC_DIAGNOSTIC
+#endif
+/* CIntFromPy.proto */
+static CYTHON_INLINE int __Pyx_PyInt_As_int(PyObject *);
+/* CIntFromPy.proto */
+static CYTHON_INLINE long __Pyx_PyInt_As_long(PyObject *);
+/* CIntToPy.proto */
+static CYTHON_INLINE PyObject* __Pyx_PyInt_From_int(int value);
+/* CIntToPy.proto */
+static CYTHON_INLINE PyObject* __Pyx_PyInt_From_long(long value);
+/* FormatTypeName.proto */
+#if CYTHON_COMPILING_IN_LIMITED_API
+typedef PyObject *__Pyx_TypeName;
+#define __Pyx_FMT_TYPENAME "%U"
+static __Pyx_TypeName __Pyx_PyType_GetName(PyTypeObject* tp);
+#define __Pyx_DECREF_TypeName(obj) Py_XDECREF(obj)
+#else
+typedef const char *__Pyx_TypeName;
+#define __Pyx_FMT_TYPENAME "%.200s"
+#define __Pyx_PyType_GetName(tp) ((tp)->tp_name)
+#define __Pyx_DECREF_TypeName(obj)
+#endif
+/* FastTypeChecks.proto */
+#if CYTHON_COMPILING_IN_CPYTHON
+#define __Pyx_TypeCheck(obj, type) __Pyx_IsSubtype(Py_TYPE(obj), (PyTypeObject *)type)
+#define __Pyx_TypeCheck2(obj, type1, type2) __Pyx_IsAnySubtype2(Py_TYPE(obj), (PyTypeObject *)type1, (PyTypeObject *)type2)
+static CYTHON_INLINE int __Pyx_IsSubtype(PyTypeObject *a, PyTypeObject *b);
+static CYTHON_INLINE int __Pyx_IsAnySubtype2(PyTypeObject *cls, PyTypeObject *a, PyTypeObject *b);
+static CYTHON_INLINE int __Pyx_PyErr_GivenExceptionMatches(PyObject *err, PyObject *type);
+static CYTHON_INLINE int __Pyx_PyErr_GivenExceptionMatches2(PyObject *err, PyObject *type1, PyObject *type2);
+#else
+#define __Pyx_TypeCheck(obj, type) PyObject_TypeCheck(obj, (PyTypeObject *)type)
+#define __Pyx_TypeCheck2(obj, type1, type2) (PyObject_TypeCheck(obj, (PyTypeObject *)type1) || PyObject_TypeCheck(obj, (PyTypeObject *)type2))
+#define __Pyx_PyErr_GivenExceptionMatches(err, type) PyErr_GivenExceptionMatches(err, type)
+#define __Pyx_PyErr_GivenExceptionMatches2(err, type1, type2) (PyErr_GivenExceptionMatches(err, type1) || PyErr_GivenExceptionMatches(err, type2))
+#endif
+#define __Pyx_PyErr_ExceptionMatches2(err1, err2)  __Pyx_PyErr_GivenExceptionMatches2(__Pyx_PyErr_CurrentExceptionType(), err1, err2)
+#define __Pyx_PyException_Check(obj) __Pyx_TypeCheck(obj, PyExc_Exception)
+/* CheckBinaryVersion.proto */
+static unsigned long __Pyx_get_runtime_version(void);
+static int __Pyx_check_binary_version(unsigned long ct_version, unsigned long rt_version, int allow_newer);
+/* FunctionImport.proto */
+static int __Pyx_ImportFunction_3_0_11(PyObject *module, const char *funcname, void (**f)(void), const char *sig);
+/* InitStrings.proto */
+static int __Pyx_InitStrings(__Pyx_StringTabEntry *t);
+/* #### Code section: module_declarations ### */
+static CYTHON_INLINE double __pyx_f_7cpython_7complex_7complex_4real_real(PyComplexObject *__pyx_v_self); /* proto*/
+static CYTHON_INLINE double __pyx_f_7cpython_7complex_7complex_4imag_imag(PyComplexObject *__pyx_v_self); /* proto*/
+static char *__pyx_f_5pysam_9libcfaidx_9FastaFile__fetch(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self, char *__pyx_v_reference, int __pyx_v_start, int __pyx_v_end, int *__pyx_v_length); /* proto*/
+static PyObject *__pyx_f_5pysam_9libcfaidx_10FastqProxy_to_string(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self); /* proto*/
+static PyObject *__pyx_f_5pysam_9libcfaidx_10FastqProxy_tostring(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self); /* proto*/
+static arrayobject *__pyx_f_5pysam_9libcfaidx_10FastqProxy_get_quality_array(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self, int __pyx_skip_dispatch, struct __pyx_opt_args_5pysam_9libcfaidx_10FastqProxy_get_quality_array *__pyx_optional_args); /* proto*/
+static PyObject *__pyx_f_5pysam_9libcfaidx_11FastxRecord_to_string(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self); /* proto*/
+static PyObject *__pyx_f_5pysam_9libcfaidx_11FastxRecord_tostring(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self); /* proto*/
+static arrayobject *__pyx_f_5pysam_9libcfaidx_11FastxRecord_get_quality_array(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, int __pyx_skip_dispatch, struct __pyx_opt_args_5pysam_9libcfaidx_11FastxRecord_get_quality_array *__pyx_optional_args); /* proto*/
+static kseq_t *__pyx_f_5pysam_9libcfaidx_9FastxFile_getCurrent(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self); /* proto*/
+static int __pyx_f_5pysam_9libcfaidx_9FastxFile_cnext(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self); /* proto*/
+/* Module declarations from "libc.stdint" */
+/* Module declarations from "libc.string" */
+/* Module declarations from "libc.stdlib" */
+/* Module declarations from "libc.stdio" */
+/* Module declarations from "cython" */
+/* Module declarations from "cpython.version" */
+/* Module declarations from "__builtin__" */
+/* Module declarations from "cpython.type" */
+/* Module declarations from "cpython.object" */
+/* Module declarations from "cpython.ref" */
+/* Module declarations from "cpython.exc" */
+/* Module declarations from "cpython.module" */
+/* Module declarations from "cpython.mem" */
+/* Module declarations from "cpython.tuple" */
+/* Module declarations from "cpython.list" */
+/* Module declarations from "cpython.sequence" */
+/* Module declarations from "cpython.mapping" */
+/* Module declarations from "cpython.iterator" */
+/* Module declarations from "cpython.number" */
+/* Module declarations from "cpython.int" */
+/* Module declarations from "__builtin__" */
+/* Module declarations from "cpython.bool" */
+/* Module declarations from "cpython.long" */
+/* Module declarations from "cpython.float" */
+/* Module declarations from "__builtin__" */
+/* Module declarations from "cpython.complex" */
+/* Module declarations from "cpython.string" */
+/* Module declarations from "libc.stddef" */
+/* Module declarations from "cpython.unicode" */
+/* Module declarations from "cpython.pyport" */
+/* Module declarations from "cpython.dict" */
+/* Module declarations from "cpython.instance" */
+/* Module declarations from "cpython.function" */
+/* Module declarations from "cpython.method" */
+/* Module declarations from "cpython.weakref" */
+/* Module declarations from "cpython.getargs" */
+/* Module declarations from "cpython.pythread" */
+/* Module declarations from "cpython.pystate" */
+/* Module declarations from "cpython.cobject" */
+/* Module declarations from "cpython.oldbuffer" */
+/* Module declarations from "cpython.set" */
+/* Module declarations from "cpython.buffer" */
+/* Module declarations from "cpython.bytes" */
+/* Module declarations from "cpython.pycapsule" */
+/* Module declarations from "cpython.contextvars" */
+/* Module declarations from "cpython" */
+/* Module declarations from "array" */
+/* Module declarations from "cpython.array" */
+static CYTHON_INLINE int __pyx_f_7cpython_5array_extend_buffer(arrayobject *, char *, Py_ssize_t); /*proto*/
+/* Module declarations from "posix.types" */
+/* Module declarations from "pysam.libchtslib" */
+/* Module declarations from "libc.errno" */
+/* Module declarations from "pysam.libcutils" */
+static PyObject *(*__pyx_f_5pysam_9libcutils_parse_region)(int __pyx_skip_dispatch, struct __pyx_opt_args_5pysam_9libcutils_parse_region *__pyx_optional_args); /*proto*/
+static arrayobject *(*__pyx_f_5pysam_9libcutils_qualitystring_to_array)(PyObject *, int __pyx_skip_dispatch, struct __pyx_opt_args_5pysam_9libcutils_qualitystring_to_array *__pyx_optional_args); /*proto*/
+static PyObject *(*__pyx_f_5pysam_9libcutils_charptr_to_str)(char const *, struct __pyx_opt_args_5pysam_9libcutils_charptr_to_str *__pyx_optional_args); /*proto*/
+static PyObject *(*__pyx_f_5pysam_9libcutils_force_str)(PyObject *, struct __pyx_opt_args_5pysam_9libcutils_force_str *__pyx_optional_args); /*proto*/
+static PyObject *(*__pyx_f_5pysam_9libcutils_force_bytes)(PyObject *, struct __pyx_opt_args_5pysam_9libcutils_force_bytes *__pyx_optional_args); /*proto*/
+static PyObject *(*__pyx_f_5pysam_9libcutils_encode_filename)(PyObject *); /*proto*/
+static PyObject *(*__pyx_f_5pysam_9libcutils_from_string_and_size)(char const *, size_t); /*proto*/
+/* Module declarations from "pysam.libcfaidx" */
+static PyObject *__pyx_f_5pysam_9libcfaidx_makeFastqProxy(kseq_t *); /*proto*/
+static PyObject *__pyx_f_5pysam_9libcfaidx___pyx_unpickle_FastxRecord__set_state(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *, PyObject *); /*proto*/
+/* #### Code section: typeinfo ### */
+/* #### Code section: before_global_var ### */
+#define __Pyx_MODULE_NAME "pysam.libcfaidx"
+extern int __pyx_module_is_main_pysam__libcfaidx;
+int __pyx_module_is_main_pysam__libcfaidx = 0;
+/* Implementation of "pysam.libcfaidx" */
+/* #### Code section: global_var ### */
+static PyObject *__pyx_builtin_ValueError;
+static PyObject *__pyx_builtin_IOError;
+static PyObject *__pyx_builtin_zip;
+static PyObject *__pyx_builtin_KeyError;
+static PyObject *__pyx_builtin_TypeError;
+static PyObject *__pyx_builtin_StopIteration;
+static PyObject *__pyx_builtin_MemoryError;
+/* #### Code section: string_decls ### */
+static const char __pyx_k_s[] = " %s";
+static const char __pyx_k_x[] = "x";
+static const char __pyx_k__4[] = "-";
+static const char __pyx_k_gc[] = "gc";
+static const char __pyx_k_os[] = "os";
+static const char __pyx_k_re[] = "re";
+static const char __pyx_k_ss[] = "ss";
+static const char __pyx_k__11[] = "";
+static const char __pyx_k__16[] = ">";
+static const char __pyx_k__17[] = "\n";
+static const char __pyx_k__18[] = "@";
+static const char __pyx_k__19[] = "\n+\n";
+static const char __pyx_k__47[] = ".";
+static const char __pyx_k__48[] = "*";
+static const char __pyx_k__68[] = "?";
+static const char __pyx_k_all[] = "__all__";
+static const char __pyx_k_end[] = "end";
+static const char __pyx_k_new[] = "__new__";
+static const char __pyx_k_ref[] = "ref";
+static const char __pyx_k_s_2[] = "s";
+static const char __pyx_k_seq[] = "seq";
+static const char __pyx_k_sys[] = "sys";
+static const char __pyx_k_zip[] = "zip";
+static const char __pyx_k_None[] = "None";
+static const char __pyx_k_copy[] = "__copy__";
+static const char __pyx_k_dict[] = "__dict__";
+static const char __pyx_k_exit[] = "__exit__";
+static const char __pyx_k_main[] = "__main__";
+static const char __pyx_k_memo[] = "memo";
+static const char __pyx_k_name[] = "name";
+static const char __pyx_k_open[] = "_open";
+static const char __pyx_k_path[] = "path";
+static const char __pyx_k_rend[] = "rend";
+static const char __pyx_k_self[] = "self";
+static const char __pyx_k_spec[] = "__spec__";
+static const char __pyx_k_test[] = "__test__";
+static const char __pyx_k_close[] = "close";
+static const char __pyx_k_enter[] = "__enter__";
+static const char __pyx_k_fetch[] = "fetch";
+static const char __pyx_k_proxy[] = "proxy";
+static const char __pyx_k_start[] = "start";
+static const char __pyx_k_state[] = "state";
+static const char __pyx_k_append[] = "append";
+static const char __pyx_k_contig[] = "contig";
+static const char __pyx_k_dict_2[] = "_dict";
+static const char __pyx_k_enable[] = "enable";
+static const char __pyx_k_exists[] = "exists";
+static const char __pyx_k_format[] = "format";
+static const char __pyx_k_import[] = "__import__";
+static const char __pyx_k_length[] = "length";
+static const char __pyx_k_name_2[] = "__name__";
+static const char __pyx_k_offset[] = "offset";
+static const char __pyx_k_pickle[] = "pickle";
+static const char __pyx_k_reduce[] = "__reduce__";
+static const char __pyx_k_region[] = "region";
+static const char __pyx_k_rstart[] = "rstart";
+static const char __pyx_k_update[] = "update";
+static const char __pyx_k_IOError[] = "IOError";
+static const char __pyx_k_comment[] = "comment";
+static const char __pyx_k_disable[] = "disable";
+static const char __pyx_k_is_open[] = "is_open";
+static const char __pyx_k_persist[] = "persist";
+static const char __pyx_k_quality[] = "quality";
+static const char __pyx_k_KeyError[] = "KeyError";
+static const char __pyx_k_contig_b[] = "contig_b";
+static const char __pyx_k_deepcopy[] = "__deepcopy__";
+static const char __pyx_k_exc_type[] = "exc_type";
+static const char __pyx_k_filename[] = "filename";
+static const char __pyx_k_getstate[] = "__getstate__";
+static const char __pyx_k_pyx_type[] = "__pyx_type";
+static const char __pyx_k_sequence[] = "sequence";
+static const char __pyx_k_set_name[] = "set_name";
+static const char __pyx_k_setstate[] = "__setstate__";
+static const char __pyx_k_FastaFile[] = "FastaFile";
+static const char __pyx_k_Fastafile[] = "Fastafile";
+static const char __pyx_k_FastqFile[] = "FastqFile";
+static const char __pyx_k_FastxFile[] = "FastxFile";
+static const char __pyx_k_TypeError[] = "TypeError";
+static const char __pyx_k_cfilename[] = "cfilename";
+static const char __pyx_k_exc_value[] = "exc_value";
+static const char __pyx_k_isenabled[] = "isenabled";
+static const char __pyx_k_pyx_state[] = "__pyx_state";
+static const char __pyx_k_reduce_ex[] = "__reduce_ex__";
+static const char __pyx_k_reference[] = "reference";
+static const char __pyx_k_traceback[] = "traceback";
+static const char __pyx_k_FastqProxy[] = "FastqProxy";
+static const char __pyx_k_ValueError[] = "ValueError";
+static const char __pyx_k_cindexname[] = "cindexname";
+static const char __pyx_k_pyx_result[] = "__pyx_result";
+static const char __pyx_k_pyx_vtable[] = "__pyx_vtable__";
+static const char __pyx_k_references[] = "references";
+static const char __pyx_k_FastxRecord[] = "FastxRecord";
+static const char __pyx_k_MemoryError[] = "MemoryError";
+static const char __pyx_k_PickleError[] = "PickleError";
+static const char __pyx_k_nreferences[] = "nreferences";
+static const char __pyx_k_set_comment[] = "set_comment";
+static const char __pyx_k_initializing[] = "_initializing";
+static const char __pyx_k_is_coroutine[] = "_is_coroutine";
+static const char __pyx_k_pyx_checksum[] = "__pyx_checksum";
+static const char __pyx_k_set_sequence[] = "set_sequence";
+static const char __pyx_k_stringsource[] = "<stringsource>";
+static const char __pyx_k_use_setstate[] = "use_setstate";
+static const char __pyx_k_StopIteration[] = "StopIteration";
+static const char __pyx_k_class_getitem[] = "__class_getitem__";
+static const char __pyx_k_reduce_cython[] = "__reduce_cython__";
+static const char __pyx_k_filepath_index[] = "filepath_index";
+static const char __pyx_k_FastaFile__open[] = "FastaFile._open";
+static const char __pyx_k_FastaFile_close[] = "FastaFile.close";
+static const char __pyx_k_FastaFile_fetch[] = "FastaFile.fetch";
+static const char __pyx_k_FastxFile__open[] = "FastxFile._open";
+static const char __pyx_k_FastxFile_close[] = "FastxFile.close";
+static const char __pyx_k_bindex_filename[] = "bindex_filename";
+static const char __pyx_k_pysam_libcfaidx[] = "pysam.libcfaidx";
+static const char __pyx_k_pyx_PickleError[] = "__pyx_PickleError";
+static const char __pyx_k_setstate_cython[] = "__setstate_cython__";
+static const char __pyx_k_FastaFile___exit[] = "FastaFile.__exit__";
+static const char __pyx_k_FastxFile___exit[] = "FastxFile.__exit__";
+static const char __pyx_k_file_s_not_found[] = "file `%s` not found";
+static const char __pyx_k_FastaFile___enter[] = "FastaFile.__enter__";
+static const char __pyx_k_FastaFile_is_open[] = "FastaFile.is_open";
+static const char __pyx_k_FastxFile___enter[] = "FastxFile.__enter__";
+static const char __pyx_k_FastxFile_is_open[] = "FastxFile.is_open";
+static const char __pyx_k_get_quality_array[] = "get_quality_array";
+static const char __pyx_k_FastxRecord___copy[] = "FastxRecord.__copy__";
+static const char __pyx_k_asyncio_coroutines[] = "asyncio.coroutines";
+static const char __pyx_k_cline_in_traceback[] = "cline_in_traceback";
+static const char __pyx_k_pysam_libcfaidx_pyx[] = "pysam/libcfaidx.pyx";
+static const char __pyx_k_FastxRecord_set_name[] = "FastxRecord.set_name";
+static const char __pyx_k_get_reference_length[] = "get_reference_length";
+static const char __pyx_k_cindexname_compressed[] = "cindexname_compressed";
+static const char __pyx_k_FastxRecord___deepcopy[] = "FastxRecord.__deepcopy__";
+static const char __pyx_k_sequence_s_not_present[] = "sequence '%s' not present";
+static const char __pyx_k_FastxRecord_set_comment[] = "FastxRecord.set_comment";
+static const char __pyx_k_filename_does_not_exist[] = "filename {} does not exist";
+static const char __pyx_k_FastxRecord_set_sequence[] = "FastxRecord.set_sequence";
+static const char __pyx_k_pyx_unpickle_FastxRecord[] = "__pyx_unpickle_FastxRecord";
+static const char __pyx_k_FastaFile___reduce_cython[] = "FastaFile.__reduce_cython__";
+static const char __pyx_k_Fastafile___reduce_cython[] = "Fastafile.__reduce_cython__";
+static const char __pyx_k_FastqFile___reduce_cython[] = "FastqFile.__reduce_cython__";
+static const char __pyx_k_FastxFile___reduce_cython[] = "FastxFile.__reduce_cython__";
+static const char __pyx_k_error_when_opening_file_s[] = "error when opening file `%s`";
+static const char __pyx_k_filepath_index_compressed[] = "filepath_index_compressed";
+static const char __pyx_k_unknown_problem_parsing_0[] = "unknown problem parsing {0}";
+static const char __pyx_k_FastqProxy___reduce_cython[] = "FastqProxy.__reduce_cython__";
+static const char __pyx_k_bindex_filename_compressed[] = "bindex_filename_compressed";
+static const char __pyx_k_calling_len_on_closed_file[] = "calling len() on closed file";
+static const char __pyx_k_FastaFile___setstate_cython[] = "FastaFile.__setstate_cython__";
+static const char __pyx_k_Fastafile___setstate_cython[] = "Fastafile.__setstate_cython__";
+static const char __pyx_k_FastqFile___setstate_cython[] = "FastqFile.__setstate_cython__";
+static const char __pyx_k_FastxFile___setstate_cython[] = "FastxFile.__setstate_cython__";
+static const char __pyx_k_FastxRecord___reduce_cython[] = "FastxRecord.__reduce_cython__";
+static const char __pyx_k_no_sequence_region_supplied[] = "no sequence/region supplied.";
+static const char __pyx_k_FastqProxy___setstate_cython[] = "FastqProxy.__setstate_cython__";
+static const char __pyx_k_FastqProxy_get_quality_array[] = "FastqProxy.get_quality_array";
+static const char __pyx_k_I_O_operation_on_closed_file[] = "I/O operation on closed file";
+static const char __pyx_k_FastxRecord___setstate_cython[] = "FastxRecord.__setstate_cython__";
+static const char __pyx_k_FastxRecord_get_quality_array[] = "FastxRecord.get_quality_array";
+static const char __pyx_k_truncated_quality_string_in_0[] = "truncated quality string in {0}";
+static const char __pyx_k_FastaFile_get_reference_length[] = "FastaFile.get_reference_length";
+static const char __pyx_k_FastxRecord_must_have_a_name_and[] = "FastxRecord must have a name and not None";
+static const char __pyx_k_Incompatible_checksums_0x_x_vs_0[] = "Incompatible checksums (0x%x vs (0x1bdb611, 0xb688a86, 0x43fd151) = (comment, name, quality, sequence))";
+static const char __pyx_k_can_not_write_record_without_a_s[] = "can not write record without a sequence";
+static const char __pyx_k_can_not_write_record_without_nam[] = "can not write record without name";
+static const char __pyx_k_do_not_instantiate_FastqProxy_di[] = "do not instantiate FastqProxy directly";
+static const char __pyx_k_failure_when_retrieving_sequence[] = "failure when retrieving sequence on '%s'";
+static const char __pyx_k_no_default___reduce___due_to_non[] = "no default __reduce__ due to non-trivial __cinit__";
+static const char __pyx_k_self__delegate_cannot_be_convert[] = "self._delegate cannot be converted to a Python object for pickling";
+static const char __pyx_k_sequence_and_quality_length_do_n[] = "sequence and quality length do not match: {} vs {}";
+/* #### Code section: decls ### */
+static int __pyx_pf_7cpython_5array_5array___getbuffer__(arrayobject *__pyx_v_self, Py_buffer *__pyx_v_info, CYTHON_UNUSED int __pyx_v_flags); /* proto */
+static void __pyx_pf_7cpython_5array_5array_2__releasebuffer__(CYTHON_UNUSED arrayobject *__pyx_v_self, Py_buffer *__pyx_v_info); /* proto */
+static int __pyx_pf_5pysam_9libcfaidx_9FastaFile___cinit__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self, PyObject *__pyx_v_args, PyObject *__pyx_v_kwargs); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_2is_open(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self); /* proto */
+static Py_ssize_t __pyx_pf_5pysam_9libcfaidx_9FastaFile_4__len__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_6_open(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self, PyObject *__pyx_v_filename, PyObject *__pyx_v_filepath_index, PyObject *__pyx_v_filepath_index_compressed); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_8close(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self); /* proto */
+static void __pyx_pf_5pysam_9libcfaidx_9FastaFile_10__dealloc__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_12__enter__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_14__exit__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v_exc_type, CYTHON_UNUSED PyObject *__pyx_v_exc_value, CYTHON_UNUSED PyObject *__pyx_v_traceback); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_6closed___get__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_8filename___get__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_10references___get__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_11nreferences___get__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_7lengths___get__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_16fetch(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self, PyObject *__pyx_v_reference, PyObject *__pyx_v_start, PyObject *__pyx_v_end, PyObject *__pyx_v_region); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_18get_reference_length(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self, PyObject *__pyx_v_reference); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_20__getitem__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self, PyObject *__pyx_v_reference); /* proto */
+static int __pyx_pf_5pysam_9libcfaidx_9FastaFile_22__contains__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self, PyObject *__pyx_v_reference); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_24__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_26__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state); /* proto */
+static int __pyx_pf_5pysam_9libcfaidx_10FastqProxy___init__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_10FastqProxy_4name___get__(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_10FastqProxy_8sequence___get__(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_10FastqProxy_7comment___get__(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_10FastqProxy_7quality___get__(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_10FastqProxy_2__str__(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_10FastqProxy_4get_quality_array(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self, int __pyx_v_offset); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_10FastqProxy_6__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_10FastqProxy_8__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state); /* proto */
+static int __pyx_pf_5pysam_9libcfaidx_11FastxRecord___init__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, PyObject *__pyx_v_name, PyObject *__pyx_v_comment, PyObject *__pyx_v_sequence, PyObject *__pyx_v_quality, struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_proxy); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_2__copy__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_4__deepcopy__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v_memo); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_6set_name(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, PyObject *__pyx_v_name); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_8set_comment(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, PyObject *__pyx_v_comment); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_10set_sequence(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, PyObject *__pyx_v_sequence, PyObject *__pyx_v_quality); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_12__str__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_14get_quality_array(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, int __pyx_v_offset); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_7comment___get__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self); /* proto */
+static int __pyx_pf_5pysam_9libcfaidx_11FastxRecord_7comment_2__set__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, PyObject *__pyx_v_value); /* proto */
+static int __pyx_pf_5pysam_9libcfaidx_11FastxRecord_7comment_4__del__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_7quality___get__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self); /* proto */
+static int __pyx_pf_5pysam_9libcfaidx_11FastxRecord_7quality_2__set__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, PyObject *__pyx_v_value); /* proto */
+static int __pyx_pf_5pysam_9libcfaidx_11FastxRecord_7quality_4__del__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_8sequence___get__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self); /* proto */
+static int __pyx_pf_5pysam_9libcfaidx_11FastxRecord_8sequence_2__set__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, PyObject *__pyx_v_value); /* proto */
+static int __pyx_pf_5pysam_9libcfaidx_11FastxRecord_8sequence_4__del__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_4name___get__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self); /* proto */
+static int __pyx_pf_5pysam_9libcfaidx_11FastxRecord_4name_2__set__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, PyObject *__pyx_v_value); /* proto */
+static int __pyx_pf_5pysam_9libcfaidx_11FastxRecord_4name_4__del__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_16__reduce_cython__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_18__setstate_cython__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, PyObject *__pyx_v___pyx_state); /* proto */
+static int __pyx_pf_5pysam_9libcfaidx_9FastxFile___cinit__(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self, PyObject *__pyx_v_args, PyObject *__pyx_v_kwargs); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_2is_open(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_4_open(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self, PyObject *__pyx_v_filename, PyObject *__pyx_v_persist); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_6close(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self); /* proto */
+static void __pyx_pf_5pysam_9libcfaidx_9FastxFile_8__dealloc__(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_10__enter__(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_12__exit__(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v_exc_type, CYTHON_UNUSED PyObject *__pyx_v_exc_value, CYTHON_UNUSED PyObject *__pyx_v_traceback); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_6closed___get__(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_8filename___get__(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_14__iter__(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_16__next__(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_18__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_20__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastqFile___reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_FastqFile *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastqFile_2__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_FastqFile *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9Fastafile___reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_Fastafile *__pyx_v_self); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9Fastafile_2__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_Fastafile *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state); /* proto */
+static PyObject *__pyx_pf_5pysam_9libcfaidx___pyx_unpickle_FastxRecord(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v___pyx_type, long __pyx_v___pyx_checksum, PyObject *__pyx_v___pyx_state); /* proto */
+static PyObject *__pyx_tp_new_5pysam_9libcfaidx_FastaFile(PyTypeObject *t, PyObject *a, PyObject *k); /*proto*/
+static PyObject *__pyx_tp_new_5pysam_9libcfaidx_FastqProxy(PyTypeObject *t, PyObject *a, PyObject *k); /*proto*/
+static PyObject *__pyx_tp_new_5pysam_9libcfaidx_FastxRecord(PyTypeObject *t, PyObject *a, PyObject *k); /*proto*/
+static PyObject *__pyx_tp_new_5pysam_9libcfaidx_FastxFile(PyTypeObject *t, PyObject *a, PyObject *k); /*proto*/
+static PyObject *__pyx_tp_new_5pysam_9libcfaidx_FastqFile(PyTypeObject *t, PyObject *a, PyObject *k); /*proto*/
+static PyObject *__pyx_tp_new_5pysam_9libcfaidx_Fastafile(PyTypeObject *t, PyObject *a, PyObject *k); /*proto*/
+/* #### Code section: late_includes ### */
+/* #### Code section: module_state ### */
+typedef struct {
+PyObject *__pyx_d;
+PyObject *__pyx_b;
+PyObject *__pyx_cython_runtime;
+PyObject *__pyx_empty_tuple;
+PyObject *__pyx_empty_bytes;
+PyObject *__pyx_empty_unicode;
+#ifdef __Pyx_CyFunction_USED
+PyTypeObject *__pyx_CyFunctionType;
+#endif
+#ifdef __Pyx_FusedFunction_USED
+PyTypeObject *__pyx_FusedFunctionType;
+#endif
+#ifdef __Pyx_Generator_USED
+PyTypeObject *__pyx_GeneratorType;
+#endif
+#ifdef __Pyx_IterableCoroutine_USED
+PyTypeObject *__pyx_IterableCoroutineType;
+#endif
+#ifdef __Pyx_Coroutine_USED
+PyTypeObject *__pyx_CoroutineAwaitType;
+#endif
+#ifdef __Pyx_Coroutine_USED
+PyTypeObject *__pyx_CoroutineType;
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+PyTypeObject *__pyx_ptype_7cpython_4type_type;
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+PyTypeObject *__pyx_ptype_7cpython_4bool_bool;
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+PyTypeObject *__pyx_ptype_7cpython_7complex_complex;
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+PyTypeObject *__pyx_ptype_7cpython_5array_array;
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+PyTypeObject *__pyx_ptype_5pysam_10libchtslib_HTSFile;
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+PyObject *__pyx_type_5pysam_9libcfaidx_FastaFile;
+PyObject *__pyx_type_5pysam_9libcfaidx_FastqProxy;
+PyObject *__pyx_type_5pysam_9libcfaidx_FastxRecord;
+PyObject *__pyx_type_5pysam_9libcfaidx_FastxFile;
+PyObject *__pyx_type_5pysam_9libcfaidx_FastqFile;
+PyObject *__pyx_type_5pysam_9libcfaidx_Fastafile;
+#endif
+PyTypeObject *__pyx_ptype_5pysam_9libcfaidx_FastaFile;
+PyTypeObject *__pyx_ptype_5pysam_9libcfaidx_FastqProxy;
+PyTypeObject *__pyx_ptype_5pysam_9libcfaidx_FastxRecord;
+PyTypeObject *__pyx_ptype_5pysam_9libcfaidx_FastxFile;
+PyTypeObject *__pyx_ptype_5pysam_9libcfaidx_FastqFile;
+PyTypeObject *__pyx_ptype_5pysam_9libcfaidx_Fastafile;
+PyObject *__pyx_n_s_FastaFile;
+PyObject *__pyx_n_u_FastaFile;
+PyObject *__pyx_n_s_FastaFile___enter;
+PyObject *__pyx_n_s_FastaFile___exit;
+PyObject *__pyx_n_s_FastaFile___reduce_cython;
+PyObject *__pyx_n_s_FastaFile___setstate_cython;
+PyObject *__pyx_n_s_FastaFile__open;
+PyObject *__pyx_n_s_FastaFile_close;
+PyObject *__pyx_n_s_FastaFile_fetch;
+PyObject *__pyx_n_s_FastaFile_get_reference_length;
+PyObject *__pyx_n_s_FastaFile_is_open;
+PyObject *__pyx_n_s_Fastafile;
+PyObject *__pyx_n_u_Fastafile;
+PyObject *__pyx_n_s_Fastafile___reduce_cython;
+PyObject *__pyx_n_s_Fastafile___setstate_cython;
+PyObject *__pyx_n_s_FastqFile;
+PyObject *__pyx_n_u_FastqFile;
+PyObject *__pyx_n_s_FastqFile___reduce_cython;
+PyObject *__pyx_n_s_FastqFile___setstate_cython;
+PyObject *__pyx_n_s_FastqProxy;
+PyObject *__pyx_n_u_FastqProxy;
+PyObject *__pyx_n_s_FastqProxy___reduce_cython;
+PyObject *__pyx_n_s_FastqProxy___setstate_cython;
+PyObject *__pyx_n_s_FastqProxy_get_quality_array;
+PyObject *__pyx_n_s_FastxFile;
+PyObject *__pyx_n_u_FastxFile;
+PyObject *__pyx_n_s_FastxFile___enter;
+PyObject *__pyx_n_s_FastxFile___exit;
+PyObject *__pyx_n_s_FastxFile___reduce_cython;
+PyObject *__pyx_n_s_FastxFile___setstate_cython;
+PyObject *__pyx_n_s_FastxFile__open;
+PyObject *__pyx_n_s_FastxFile_close;
+PyObject *__pyx_n_s_FastxFile_is_open;
+PyObject *__pyx_n_s_FastxRecord;
+PyObject *__pyx_n_u_FastxRecord;
+PyObject *__pyx_n_s_FastxRecord___copy;
+PyObject *__pyx_n_s_FastxRecord___deepcopy;
+PyObject *__pyx_n_s_FastxRecord___reduce_cython;
+PyObject *__pyx_n_s_FastxRecord___setstate_cython;
+PyObject *__pyx_n_s_FastxRecord_get_quality_array;
+PyObject *__pyx_kp_u_FastxRecord_must_have_a_name_and;
+PyObject *__pyx_n_s_FastxRecord_set_comment;
+PyObject *__pyx_n_s_FastxRecord_set_name;
+PyObject *__pyx_n_s_FastxRecord_set_sequence;
+PyObject *__pyx_n_s_IOError;
+PyObject *__pyx_kp_u_I_O_operation_on_closed_file;
+PyObject *__pyx_kp_s_Incompatible_checksums_0x_x_vs_0;
+PyObject *__pyx_n_s_KeyError;
+PyObject *__pyx_n_s_MemoryError;
+PyObject *__pyx_kp_u_None;
+PyObject *__pyx_n_s_PickleError;
+PyObject *__pyx_n_s_StopIteration;
+PyObject *__pyx_n_s_TypeError;
+PyObject *__pyx_n_s_ValueError;
+PyObject *__pyx_kp_u__11;
+PyObject *__pyx_kp_u__16;
+PyObject *__pyx_kp_u__17;
+PyObject *__pyx_kp_u__18;
+PyObject *__pyx_kp_u__19;
+PyObject *__pyx_kp_b__4;
+PyObject *__pyx_kp_u__47;
+PyObject *__pyx_n_s__48;
+PyObject *__pyx_n_s__68;
+PyObject *__pyx_n_s_all;
+PyObject *__pyx_n_s_append;
+PyObject *__pyx_n_s_asyncio_coroutines;
+PyObject *__pyx_n_s_bindex_filename;
+PyObject *__pyx_n_s_bindex_filename_compressed;
+PyObject *__pyx_kp_u_calling_len_on_closed_file;
+PyObject *__pyx_kp_u_can_not_write_record_without_a_s;
+PyObject *__pyx_kp_u_can_not_write_record_without_nam;
+PyObject *__pyx_n_s_cfilename;
+PyObject *__pyx_n_s_cindexname;
+PyObject *__pyx_n_s_cindexname_compressed;
+PyObject *__pyx_n_s_class_getitem;
+PyObject *__pyx_n_s_cline_in_traceback;
+PyObject *__pyx_n_s_close;
+PyObject *__pyx_n_s_comment;
+PyObject *__pyx_n_s_contig;
+PyObject *__pyx_n_s_contig_b;
+PyObject *__pyx_n_s_copy;
+PyObject *__pyx_n_s_deepcopy;
+PyObject *__pyx_n_s_dict;
+PyObject *__pyx_n_s_dict_2;
+PyObject *__pyx_kp_u_disable;
+PyObject *__pyx_kp_u_do_not_instantiate_FastqProxy_di;
+PyObject *__pyx_kp_u_enable;
+PyObject *__pyx_n_s_end;
+PyObject *__pyx_n_s_enter;
+PyObject *__pyx_kp_u_error_when_opening_file_s;
+PyObject *__pyx_n_s_exc_type;
+PyObject *__pyx_n_s_exc_value;
+PyObject *__pyx_n_s_exists;
+PyObject *__pyx_n_s_exit;
+PyObject *__pyx_kp_u_failure_when_retrieving_sequence;
+PyObject *__pyx_n_s_fetch;
+PyObject *__pyx_kp_u_file_s_not_found;
+PyObject *__pyx_n_s_filename;
+PyObject *__pyx_kp_u_filename_does_not_exist;
+PyObject *__pyx_n_s_filepath_index;
+PyObject *__pyx_n_s_filepath_index_compressed;
+PyObject *__pyx_n_s_format;
+PyObject *__pyx_kp_u_gc;
+PyObject *__pyx_n_s_get_quality_array;
+PyObject *__pyx_n_s_get_reference_length;
+PyObject *__pyx_n_s_getstate;
+PyObject *__pyx_n_s_import;
+PyObject *__pyx_n_s_initializing;
+PyObject *__pyx_n_s_is_coroutine;
+PyObject *__pyx_n_s_is_open;
+PyObject *__pyx_kp_u_isenabled;
+PyObject *__pyx_n_s_length;
+PyObject *__pyx_n_s_main;
+PyObject *__pyx_n_s_memo;
+PyObject *__pyx_n_s_name;
+PyObject *__pyx_n_s_name_2;
+PyObject *__pyx_n_s_new;
+PyObject *__pyx_kp_s_no_default___reduce___due_to_non;
+PyObject *__pyx_kp_u_no_sequence_region_supplied;
+PyObject *__pyx_n_s_nreferences;
+PyObject *__pyx_n_s_offset;
+PyObject *__pyx_n_s_open;
+PyObject *__pyx_n_s_os;
+PyObject *__pyx_n_s_path;
+PyObject *__pyx_n_s_persist;
+PyObject *__pyx_n_s_pickle;
+PyObject *__pyx_n_s_proxy;
+PyObject *__pyx_n_s_pysam_libcfaidx;
+PyObject *__pyx_kp_s_pysam_libcfaidx_pyx;
+PyObject *__pyx_n_s_pyx_PickleError;
+PyObject *__pyx_n_s_pyx_checksum;
+PyObject *__pyx_n_s_pyx_result;
+PyObject *__pyx_n_s_pyx_state;
+PyObject *__pyx_n_s_pyx_type;
+PyObject *__pyx_n_s_pyx_unpickle_FastxRecord;
+PyObject *__pyx_n_s_pyx_vtable;
+PyObject *__pyx_n_s_quality;
+PyObject *__pyx_n_s_re;
+PyObject *__pyx_n_s_reduce;
+PyObject *__pyx_n_s_reduce_cython;
+PyObject *__pyx_n_s_reduce_ex;
+PyObject *__pyx_n_s_ref;
+PyObject *__pyx_n_s_reference;
+PyObject *__pyx_n_s_references;
+PyObject *__pyx_n_s_region;
+PyObject *__pyx_n_s_rend;
+PyObject *__pyx_n_s_rstart;
+PyObject *__pyx_kp_u_s;
+PyObject *__pyx_n_s_s_2;
+PyObject *__pyx_n_s_self;
+PyObject *__pyx_kp_s_self__delegate_cannot_be_convert;
+PyObject *__pyx_n_s_seq;
+PyObject *__pyx_n_s_sequence;
+PyObject *__pyx_kp_u_sequence_and_quality_length_do_n;
+PyObject *__pyx_kp_u_sequence_s_not_present;
+PyObject *__pyx_n_s_set_comment;
+PyObject *__pyx_n_s_set_name;
+PyObject *__pyx_n_s_set_sequence;
+PyObject *__pyx_n_s_setstate;
+PyObject *__pyx_n_s_setstate_cython;
+PyObject *__pyx_n_s_spec;
+PyObject *__pyx_n_s_ss;
+PyObject *__pyx_n_s_start;
+PyObject *__pyx_n_s_state;
+PyObject *__pyx_kp_s_stringsource;
+PyObject *__pyx_n_s_sys;
+PyObject *__pyx_n_s_test;
+PyObject *__pyx_n_s_traceback;
+PyObject *__pyx_kp_u_truncated_quality_string_in_0;
+PyObject *__pyx_kp_u_unknown_problem_parsing_0;
+PyObject *__pyx_n_s_update;
+PyObject *__pyx_n_s_use_setstate;
+PyObject *__pyx_n_s_x;
+PyObject *__pyx_n_s_zip;
+PyObject *__pyx_int_33;
+PyObject *__pyx_int_29210129;
+PyObject *__pyx_int_71291217;
+PyObject *__pyx_int_191400582;
+PyObject *__pyx_codeobj_;
+PyObject *__pyx_tuple__2;
+PyObject *__pyx_tuple__9;
+PyObject *__pyx_tuple__10;
+PyObject *__pyx_tuple__15;
+PyObject *__pyx_tuple__25;
+PyObject *__pyx_tuple__26;
+PyObject *__pyx_tuple__28;
+PyObject *__pyx_tuple__46;
+PyObject *__pyx_tuple__49;
+PyObject *__pyx_tuple__50;
+PyObject *__pyx_tuple__51;
+PyObject *__pyx_tuple__52;
+PyObject *__pyx_tuple__53;
+PyObject *__pyx_tuple__54;
+PyObject *__pyx_tuple__55;
+PyObject *__pyx_tuple__56;
+PyObject *__pyx_tuple__57;
+PyObject *__pyx_tuple__58;
+PyObject *__pyx_tuple__59;
+PyObject *__pyx_tuple__60;
+PyObject *__pyx_tuple__61;
+PyObject *__pyx_tuple__62;
+PyObject *__pyx_tuple__63;
+PyObject *__pyx_tuple__64;
+PyObject *__pyx_tuple__65;
+PyObject *__pyx_tuple__66;
+PyObject *__pyx_tuple__67;
+PyObject *__pyx_codeobj__3;
+PyObject *__pyx_codeobj__5;
+PyObject *__pyx_codeobj__6;
+PyObject *__pyx_codeobj__7;
+PyObject *__pyx_codeobj__8;
+PyObject *__pyx_codeobj__12;
+PyObject *__pyx_codeobj__13;
+PyObject *__pyx_codeobj__14;
+PyObject *__pyx_codeobj__20;
+PyObject *__pyx_codeobj__21;
+PyObject *__pyx_codeobj__22;
+PyObject *__pyx_codeobj__23;
+PyObject *__pyx_codeobj__24;
+PyObject *__pyx_codeobj__27;
+PyObject *__pyx_codeobj__29;
+PyObject *__pyx_codeobj__30;
+PyObject *__pyx_codeobj__31;
+PyObject *__pyx_codeobj__32;
+PyObject *__pyx_codeobj__33;
+PyObject *__pyx_codeobj__34;
+PyObject *__pyx_codeobj__35;
+PyObject *__pyx_codeobj__36;
+PyObject *__pyx_codeobj__37;
+PyObject *__pyx_codeobj__38;
+PyObject *__pyx_codeobj__39;
+PyObject *__pyx_codeobj__40;
+PyObject *__pyx_codeobj__41;
+PyObject *__pyx_codeobj__42;
+PyObject *__pyx_codeobj__43;
+PyObject *__pyx_codeobj__44;
+PyObject *__pyx_codeobj__45;
+} __pyx_mstate;
+#if CYTHON_USE_MODULE_STATE
+#ifdef __cplusplus
+namespace {
+extern struct PyModuleDef __pyx_moduledef;
+} /* anonymous namespace */
+#else
+static struct PyModuleDef __pyx_moduledef;
+#endif
+#define __pyx_mstate(o) ((__pyx_mstate *)__Pyx_PyModule_GetState(o))
+#define __pyx_mstate_global (__pyx_mstate(PyState_FindModule(&__pyx_moduledef)))
+#define __pyx_m (PyState_FindModule(&__pyx_moduledef))
+#else
+static __pyx_mstate __pyx_mstate_global_static =
+#ifdef __cplusplus
+{};
+#else
+{0};
+#endif
+static __pyx_mstate *__pyx_mstate_global = &__pyx_mstate_global_static;
+#endif
+/* #### Code section: module_state_clear ### */
+#if CYTHON_USE_MODULE_STATE
+static int __pyx_m_clear(PyObject *m) {
+__pyx_mstate *clear_module_state = __pyx_mstate(m);
+if (!clear_module_state) return 0;
+Py_CLEAR(clear_module_state->__pyx_d);
+Py_CLEAR(clear_module_state->__pyx_b);
+Py_CLEAR(clear_module_state->__pyx_cython_runtime);
+Py_CLEAR(clear_module_state->__pyx_empty_tuple);
+Py_CLEAR(clear_module_state->__pyx_empty_bytes);
+Py_CLEAR(clear_module_state->__pyx_empty_unicode);
+#ifdef __Pyx_CyFunction_USED
+Py_CLEAR(clear_module_state->__pyx_CyFunctionType);
+#endif
+#ifdef __Pyx_FusedFunction_USED
+Py_CLEAR(clear_module_state->__pyx_FusedFunctionType);
+#endif
+Py_CLEAR(clear_module_state->__pyx_ptype_7cpython_4type_type);
+Py_CLEAR(clear_module_state->__pyx_ptype_7cpython_4bool_bool);
+Py_CLEAR(clear_module_state->__pyx_ptype_7cpython_7complex_complex);
+Py_CLEAR(clear_module_state->__pyx_ptype_7cpython_5array_array);
+Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_10libchtslib_HTSFile);
+Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_9libcfaidx_FastaFile);
+Py_CLEAR(clear_module_state->__pyx_type_5pysam_9libcfaidx_FastaFile);
+Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_9libcfaidx_FastqProxy);
+Py_CLEAR(clear_module_state->__pyx_type_5pysam_9libcfaidx_FastqProxy);
+Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_9libcfaidx_FastxRecord);
+Py_CLEAR(clear_module_state->__pyx_type_5pysam_9libcfaidx_FastxRecord);
+Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_9libcfaidx_FastxFile);
+Py_CLEAR(clear_module_state->__pyx_type_5pysam_9libcfaidx_FastxFile);
+Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_9libcfaidx_FastqFile);
+Py_CLEAR(clear_module_state->__pyx_type_5pysam_9libcfaidx_FastqFile);
+Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_9libcfaidx_Fastafile);
+Py_CLEAR(clear_module_state->__pyx_type_5pysam_9libcfaidx_Fastafile);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastaFile);
+Py_CLEAR(clear_module_state->__pyx_n_u_FastaFile);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastaFile___enter);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastaFile___exit);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastaFile___reduce_cython);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastaFile___setstate_cython);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastaFile__open);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastaFile_close);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastaFile_fetch);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastaFile_get_reference_length);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastaFile_is_open);
+Py_CLEAR(clear_module_state->__pyx_n_s_Fastafile);
+Py_CLEAR(clear_module_state->__pyx_n_u_Fastafile);
+Py_CLEAR(clear_module_state->__pyx_n_s_Fastafile___reduce_cython);
+Py_CLEAR(clear_module_state->__pyx_n_s_Fastafile___setstate_cython);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastqFile);
+Py_CLEAR(clear_module_state->__pyx_n_u_FastqFile);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastqFile___reduce_cython);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastqFile___setstate_cython);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastqProxy);
+Py_CLEAR(clear_module_state->__pyx_n_u_FastqProxy);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastqProxy___reduce_cython);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastqProxy___setstate_cython);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastqProxy_get_quality_array);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastxFile);
+Py_CLEAR(clear_module_state->__pyx_n_u_FastxFile);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastxFile___enter);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastxFile___exit);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastxFile___reduce_cython);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastxFile___setstate_cython);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastxFile__open);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastxFile_close);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastxFile_is_open);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastxRecord);
+Py_CLEAR(clear_module_state->__pyx_n_u_FastxRecord);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastxRecord___copy);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastxRecord___deepcopy);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastxRecord___reduce_cython);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastxRecord___setstate_cython);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastxRecord_get_quality_array);
+Py_CLEAR(clear_module_state->__pyx_kp_u_FastxRecord_must_have_a_name_and);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastxRecord_set_comment);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastxRecord_set_name);
+Py_CLEAR(clear_module_state->__pyx_n_s_FastxRecord_set_sequence);
+Py_CLEAR(clear_module_state->__pyx_n_s_IOError);
+Py_CLEAR(clear_module_state->__pyx_kp_u_I_O_operation_on_closed_file);
+Py_CLEAR(clear_module_state->__pyx_kp_s_Incompatible_checksums_0x_x_vs_0);
+Py_CLEAR(clear_module_state->__pyx_n_s_KeyError);
+Py_CLEAR(clear_module_state->__pyx_n_s_MemoryError);
+Py_CLEAR(clear_module_state->__pyx_kp_u_None);
+Py_CLEAR(clear_module_state->__pyx_n_s_PickleError);
+Py_CLEAR(clear_module_state->__pyx_n_s_StopIteration);
+Py_CLEAR(clear_module_state->__pyx_n_s_TypeError);
+Py_CLEAR(clear_module_state->__pyx_n_s_ValueError);
+Py_CLEAR(clear_module_state->__pyx_kp_u__11);
+Py_CLEAR(clear_module_state->__pyx_kp_u__16);
+Py_CLEAR(clear_module_state->__pyx_kp_u__17);
+Py_CLEAR(clear_module_state->__pyx_kp_u__18);
+Py_CLEAR(clear_module_state->__pyx_kp_u__19);
+Py_CLEAR(clear_module_state->__pyx_kp_b__4);
+Py_CLEAR(clear_module_state->__pyx_kp_u__47);
+Py_CLEAR(clear_module_state->__pyx_n_s__48);
+Py_CLEAR(clear_module_state->__pyx_n_s__68);
+Py_CLEAR(clear_module_state->__pyx_n_s_all);
+Py_CLEAR(clear_module_state->__pyx_n_s_append);
+Py_CLEAR(clear_module_state->__pyx_n_s_asyncio_coroutines);
+Py_CLEAR(clear_module_state->__pyx_n_s_bindex_filename);
+Py_CLEAR(clear_module_state->__pyx_n_s_bindex_filename_compressed);
+Py_CLEAR(clear_module_state->__pyx_kp_u_calling_len_on_closed_file);
+Py_CLEAR(clear_module_state->__pyx_kp_u_can_not_write_record_without_a_s);
+Py_CLEAR(clear_module_state->__pyx_kp_u_can_not_write_record_without_nam);
+Py_CLEAR(clear_module_state->__pyx_n_s_cfilename);
+Py_CLEAR(clear_module_state->__pyx_n_s_cindexname);
+Py_CLEAR(clear_module_state->__pyx_n_s_cindexname_compressed);
+Py_CLEAR(clear_module_state->__pyx_n_s_class_getitem);
+Py_CLEAR(clear_module_state->__pyx_n_s_cline_in_traceback);
+Py_CLEAR(clear_module_state->__pyx_n_s_close);
+Py_CLEAR(clear_module_state->__pyx_n_s_comment);
+Py_CLEAR(clear_module_state->__pyx_n_s_contig);
+Py_CLEAR(clear_module_state->__pyx_n_s_contig_b);
+Py_CLEAR(clear_module_state->__pyx_n_s_copy);
+Py_CLEAR(clear_module_state->__pyx_n_s_deepcopy);
+Py_CLEAR(clear_module_state->__pyx_n_s_dict);
+Py_CLEAR(clear_module_state->__pyx_n_s_dict_2);
+Py_CLEAR(clear_module_state->__pyx_kp_u_disable);
+Py_CLEAR(clear_module_state->__pyx_kp_u_do_not_instantiate_FastqProxy_di);
+Py_CLEAR(clear_module_state->__pyx_kp_u_enable);
+Py_CLEAR(clear_module_state->__pyx_n_s_end);
+Py_CLEAR(clear_module_state->__pyx_n_s_enter);
+Py_CLEAR(clear_module_state->__pyx_kp_u_error_when_opening_file_s);
+Py_CLEAR(clear_module_state->__pyx_n_s_exc_type);
+Py_CLEAR(clear_module_state->__pyx_n_s_exc_value);
+Py_CLEAR(clear_module_state->__pyx_n_s_exists);
+Py_CLEAR(clear_module_state->__pyx_n_s_exit);
+Py_CLEAR(clear_module_state->__pyx_kp_u_failure_when_retrieving_sequence);
+Py_CLEAR(clear_module_state->__pyx_n_s_fetch);
+Py_CLEAR(clear_module_state->__pyx_kp_u_file_s_not_found);
+Py_CLEAR(clear_module_state->__pyx_n_s_filename);
+Py_CLEAR(clear_module_state->__pyx_kp_u_filename_does_not_exist);
+Py_CLEAR(clear_module_state->__pyx_n_s_filepath_index);
+Py_CLEAR(clear_module_state->__pyx_n_s_filepath_index_compressed);
+Py_CLEAR(clear_module_state->__pyx_n_s_format);
+Py_CLEAR(clear_module_state->__pyx_kp_u_gc);
+Py_CLEAR(clear_module_state->__pyx_n_s_get_quality_array);
+Py_CLEAR(clear_module_state->__pyx_n_s_get_reference_length);
+Py_CLEAR(clear_module_state->__pyx_n_s_getstate);
+Py_CLEAR(clear_module_state->__pyx_n_s_import);
+Py_CLEAR(clear_module_state->__pyx_n_s_initializing);
+Py_CLEAR(clear_module_state->__pyx_n_s_is_coroutine);
+Py_CLEAR(clear_module_state->__pyx_n_s_is_open);
+Py_CLEAR(clear_module_state->__pyx_kp_u_isenabled);
+Py_CLEAR(clear_module_state->__pyx_n_s_length);
+Py_CLEAR(clear_module_state->__pyx_n_s_main);
+Py_CLEAR(clear_module_state->__pyx_n_s_memo);
+Py_CLEAR(clear_module_state->__pyx_n_s_name);
+Py_CLEAR(clear_module_state->__pyx_n_s_name_2);
+Py_CLEAR(clear_module_state->__pyx_n_s_new);
+Py_CLEAR(clear_module_state->__pyx_kp_s_no_default___reduce___due_to_non);
+Py_CLEAR(clear_module_state->__pyx_kp_u_no_sequence_region_supplied);
+Py_CLEAR(clear_module_state->__pyx_n_s_nreferences);
+Py_CLEAR(clear_module_state->__pyx_n_s_offset);
+Py_CLEAR(clear_module_state->__pyx_n_s_open);
+Py_CLEAR(clear_module_state->__pyx_n_s_os);
+Py_CLEAR(clear_module_state->__pyx_n_s_path);
+Py_CLEAR(clear_module_state->__pyx_n_s_persist);
+Py_CLEAR(clear_module_state->__pyx_n_s_pickle);
+Py_CLEAR(clear_module_state->__pyx_n_s_proxy);
+Py_CLEAR(clear_module_state->__pyx_n_s_pysam_libcfaidx);
+Py_CLEAR(clear_module_state->__pyx_kp_s_pysam_libcfaidx_pyx);
+Py_CLEAR(clear_module_state->__pyx_n_s_pyx_PickleError);
+Py_CLEAR(clear_module_state->__pyx_n_s_pyx_checksum);
+Py_CLEAR(clear_module_state->__pyx_n_s_pyx_result);
+Py_CLEAR(clear_module_state->__pyx_n_s_pyx_state);
+Py_CLEAR(clear_module_state->__pyx_n_s_pyx_type);
+Py_CLEAR(clear_module_state->__pyx_n_s_pyx_unpickle_FastxRecord);
+Py_CLEAR(clear_module_state->__pyx_n_s_pyx_vtable);
+Py_CLEAR(clear_module_state->__pyx_n_s_quality);
+Py_CLEAR(clear_module_state->__pyx_n_s_re);
+Py_CLEAR(clear_module_state->__pyx_n_s_reduce);
+Py_CLEAR(clear_module_state->__pyx_n_s_reduce_cython);
+Py_CLEAR(clear_module_state->__pyx_n_s_reduce_ex);
+Py_CLEAR(clear_module_state->__pyx_n_s_ref);
+Py_CLEAR(clear_module_state->__pyx_n_s_reference);
+Py_CLEAR(clear_module_state->__pyx_n_s_references);
+Py_CLEAR(clear_module_state->__pyx_n_s_region);
+Py_CLEAR(clear_module_state->__pyx_n_s_rend);
+Py_CLEAR(clear_module_state->__pyx_n_s_rstart);
+Py_CLEAR(clear_module_state->__pyx_kp_u_s);
+Py_CLEAR(clear_module_state->__pyx_n_s_s_2);
+Py_CLEAR(clear_module_state->__pyx_n_s_self);
+Py_CLEAR(clear_module_state->__pyx_kp_s_self__delegate_cannot_be_convert);
+Py_CLEAR(clear_module_state->__pyx_n_s_seq);
+Py_CLEAR(clear_module_state->__pyx_n_s_sequence);
+Py_CLEAR(clear_module_state->__pyx_kp_u_sequence_and_quality_length_do_n);
+Py_CLEAR(clear_module_state->__pyx_kp_u_sequence_s_not_present);
+Py_CLEAR(clear_module_state->__pyx_n_s_set_comment);
+Py_CLEAR(clear_module_state->__pyx_n_s_set_name);
+Py_CLEAR(clear_module_state->__pyx_n_s_set_sequence);
+Py_CLEAR(clear_module_state->__pyx_n_s_setstate);
+Py_CLEAR(clear_module_state->__pyx_n_s_setstate_cython);
+Py_CLEAR(clear_module_state->__pyx_n_s_spec);
+Py_CLEAR(clear_module_state->__pyx_n_s_ss);
+Py_CLEAR(clear_module_state->__pyx_n_s_start);
+Py_CLEAR(clear_module_state->__pyx_n_s_state);
+Py_CLEAR(clear_module_state->__pyx_kp_s_stringsource);
+Py_CLEAR(clear_module_state->__pyx_n_s_sys);
+Py_CLEAR(clear_module_state->__pyx_n_s_test);
+Py_CLEAR(clear_module_state->__pyx_n_s_traceback);
+Py_CLEAR(clear_module_state->__pyx_kp_u_truncated_quality_string_in_0);
+Py_CLEAR(clear_module_state->__pyx_kp_u_unknown_problem_parsing_0);
+Py_CLEAR(clear_module_state->__pyx_n_s_update);
+Py_CLEAR(clear_module_state->__pyx_n_s_use_setstate);
+Py_CLEAR(clear_module_state->__pyx_n_s_x);
+Py_CLEAR(clear_module_state->__pyx_n_s_zip);
+Py_CLEAR(clear_module_state->__pyx_int_33);
+Py_CLEAR(clear_module_state->__pyx_int_29210129);
+Py_CLEAR(clear_module_state->__pyx_int_71291217);
+Py_CLEAR(clear_module_state->__pyx_int_191400582);
+Py_CLEAR(clear_module_state->__pyx_codeobj_);
+Py_CLEAR(clear_module_state->__pyx_tuple__2);
+Py_CLEAR(clear_module_state->__pyx_tuple__9);
+Py_CLEAR(clear_module_state->__pyx_tuple__10);
+Py_CLEAR(clear_module_state->__pyx_tuple__15);
+Py_CLEAR(clear_module_state->__pyx_tuple__25);
+Py_CLEAR(clear_module_state->__pyx_tuple__26);
+Py_CLEAR(clear_module_state->__pyx_tuple__28);
+Py_CLEAR(clear_module_state->__pyx_tuple__46);
+Py_CLEAR(clear_module_state->__pyx_tuple__49);
+Py_CLEAR(clear_module_state->__pyx_tuple__50);
+Py_CLEAR(clear_module_state->__pyx_tuple__51);
+Py_CLEAR(clear_module_state->__pyx_tuple__52);
+Py_CLEAR(clear_module_state->__pyx_tuple__53);
+Py_CLEAR(clear_module_state->__pyx_tuple__54);
+Py_CLEAR(clear_module_state->__pyx_tuple__55);
+Py_CLEAR(clear_module_state->__pyx_tuple__56);
+Py_CLEAR(clear_module_state->__pyx_tuple__57);
+Py_CLEAR(clear_module_state->__pyx_tuple__58);
+Py_CLEAR(clear_module_state->__pyx_tuple__59);
+Py_CLEAR(clear_module_state->__pyx_tuple__60);
+Py_CLEAR(clear_module_state->__pyx_tuple__61);
+Py_CLEAR(clear_module_state->__pyx_tuple__62);
+Py_CLEAR(clear_module_state->__pyx_tuple__63);
+Py_CLEAR(clear_module_state->__pyx_tuple__64);
+Py_CLEAR(clear_module_state->__pyx_tuple__65);
+Py_CLEAR(clear_module_state->__pyx_tuple__66);
+Py_CLEAR(clear_module_state->__pyx_tuple__67);
+Py_CLEAR(clear_module_state->__pyx_codeobj__3);
+Py_CLEAR(clear_module_state->__pyx_codeobj__5);
+Py_CLEAR(clear_module_state->__pyx_codeobj__6);
+Py_CLEAR(clear_module_state->__pyx_codeobj__7);
+Py_CLEAR(clear_module_state->__pyx_codeobj__8);
+Py_CLEAR(clear_module_state->__pyx_codeobj__12);
+Py_CLEAR(clear_module_state->__pyx_codeobj__13);
+Py_CLEAR(clear_module_state->__pyx_codeobj__14);
+Py_CLEAR(clear_module_state->__pyx_codeobj__20);
+Py_CLEAR(clear_module_state->__pyx_codeobj__21);
+Py_CLEAR(clear_module_state->__pyx_codeobj__22);
+Py_CLEAR(clear_module_state->__pyx_codeobj__23);
+Py_CLEAR(clear_module_state->__pyx_codeobj__24);
+Py_CLEAR(clear_module_state->__pyx_codeobj__27);
+Py_CLEAR(clear_module_state->__pyx_codeobj__29);
+Py_CLEAR(clear_module_state->__pyx_codeobj__30);
+Py_CLEAR(clear_module_state->__pyx_codeobj__31);
+Py_CLEAR(clear_module_state->__pyx_codeobj__32);
+Py_CLEAR(clear_module_state->__pyx_codeobj__33);
+Py_CLEAR(clear_module_state->__pyx_codeobj__34);
+Py_CLEAR(clear_module_state->__pyx_codeobj__35);
+Py_CLEAR(clear_module_state->__pyx_codeobj__36);
+Py_CLEAR(clear_module_state->__pyx_codeobj__37);
+Py_CLEAR(clear_module_state->__pyx_codeobj__38);
+Py_CLEAR(clear_module_state->__pyx_codeobj__39);
+Py_CLEAR(clear_module_state->__pyx_codeobj__40);
+Py_CLEAR(clear_module_state->__pyx_codeobj__41);
+Py_CLEAR(clear_module_state->__pyx_codeobj__42);
+Py_CLEAR(clear_module_state->__pyx_codeobj__43);
+Py_CLEAR(clear_module_state->__pyx_codeobj__44);
+Py_CLEAR(clear_module_state->__pyx_codeobj__45);
+return 0;
+}
+#endif
+/* #### Code section: module_state_traverse ### */
+#if CYTHON_USE_MODULE_STATE
+static int __pyx_m_traverse(PyObject *m, visitproc visit, void *arg) {
+__pyx_mstate *traverse_module_state = __pyx_mstate(m);
+if (!traverse_module_state) return 0;
+Py_VISIT(traverse_module_state->__pyx_d);
+Py_VISIT(traverse_module_state->__pyx_b);
+Py_VISIT(traverse_module_state->__pyx_cython_runtime);
+Py_VISIT(traverse_module_state->__pyx_empty_tuple);
+Py_VISIT(traverse_module_state->__pyx_empty_bytes);
+Py_VISIT(traverse_module_state->__pyx_empty_unicode);
+#ifdef __Pyx_CyFunction_USED
+Py_VISIT(traverse_module_state->__pyx_CyFunctionType);
+#endif
+#ifdef __Pyx_FusedFunction_USED
+Py_VISIT(traverse_module_state->__pyx_FusedFunctionType);
+#endif
+Py_VISIT(traverse_module_state->__pyx_ptype_7cpython_4type_type);
+Py_VISIT(traverse_module_state->__pyx_ptype_7cpython_4bool_bool);
+Py_VISIT(traverse_module_state->__pyx_ptype_7cpython_7complex_complex);
+Py_VISIT(traverse_module_state->__pyx_ptype_7cpython_5array_array);
+Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_10libchtslib_HTSFile);
+Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_9libcfaidx_FastaFile);
+Py_VISIT(traverse_module_state->__pyx_type_5pysam_9libcfaidx_FastaFile);
+Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_9libcfaidx_FastqProxy);
+Py_VISIT(traverse_module_state->__pyx_type_5pysam_9libcfaidx_FastqProxy);
+Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_9libcfaidx_FastxRecord);
+Py_VISIT(traverse_module_state->__pyx_type_5pysam_9libcfaidx_FastxRecord);
+Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_9libcfaidx_FastxFile);
+Py_VISIT(traverse_module_state->__pyx_type_5pysam_9libcfaidx_FastxFile);
+Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_9libcfaidx_FastqFile);
+Py_VISIT(traverse_module_state->__pyx_type_5pysam_9libcfaidx_FastqFile);
+Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_9libcfaidx_Fastafile);
+Py_VISIT(traverse_module_state->__pyx_type_5pysam_9libcfaidx_Fastafile);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastaFile);
+Py_VISIT(traverse_module_state->__pyx_n_u_FastaFile);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastaFile___enter);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastaFile___exit);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastaFile___reduce_cython);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastaFile___setstate_cython);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastaFile__open);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastaFile_close);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastaFile_fetch);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastaFile_get_reference_length);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastaFile_is_open);
+Py_VISIT(traverse_module_state->__pyx_n_s_Fastafile);
+Py_VISIT(traverse_module_state->__pyx_n_u_Fastafile);
+Py_VISIT(traverse_module_state->__pyx_n_s_Fastafile___reduce_cython);
+Py_VISIT(traverse_module_state->__pyx_n_s_Fastafile___setstate_cython);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastqFile);
+Py_VISIT(traverse_module_state->__pyx_n_u_FastqFile);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastqFile___reduce_cython);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastqFile___setstate_cython);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastqProxy);
+Py_VISIT(traverse_module_state->__pyx_n_u_FastqProxy);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastqProxy___reduce_cython);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastqProxy___setstate_cython);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastqProxy_get_quality_array);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastxFile);
+Py_VISIT(traverse_module_state->__pyx_n_u_FastxFile);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastxFile___enter);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastxFile___exit);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastxFile___reduce_cython);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastxFile___setstate_cython);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastxFile__open);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastxFile_close);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastxFile_is_open);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastxRecord);
+Py_VISIT(traverse_module_state->__pyx_n_u_FastxRecord);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastxRecord___copy);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastxRecord___deepcopy);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastxRecord___reduce_cython);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastxRecord___setstate_cython);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastxRecord_get_quality_array);
+Py_VISIT(traverse_module_state->__pyx_kp_u_FastxRecord_must_have_a_name_and);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastxRecord_set_comment);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastxRecord_set_name);
+Py_VISIT(traverse_module_state->__pyx_n_s_FastxRecord_set_sequence);
+Py_VISIT(traverse_module_state->__pyx_n_s_IOError);
+Py_VISIT(traverse_module_state->__pyx_kp_u_I_O_operation_on_closed_file);
+Py_VISIT(traverse_module_state->__pyx_kp_s_Incompatible_checksums_0x_x_vs_0);
+Py_VISIT(traverse_module_state->__pyx_n_s_KeyError);
+Py_VISIT(traverse_module_state->__pyx_n_s_MemoryError);
+Py_VISIT(traverse_module_state->__pyx_kp_u_None);
+Py_VISIT(traverse_module_state->__pyx_n_s_PickleError);
+Py_VISIT(traverse_module_state->__pyx_n_s_StopIteration);
+Py_VISIT(traverse_module_state->__pyx_n_s_TypeError);
+Py_VISIT(traverse_module_state->__pyx_n_s_ValueError);
+Py_VISIT(traverse_module_state->__pyx_kp_u__11);
+Py_VISIT(traverse_module_state->__pyx_kp_u__16);
+Py_VISIT(traverse_module_state->__pyx_kp_u__17);
+Py_VISIT(traverse_module_state->__pyx_kp_u__18);
+Py_VISIT(traverse_module_state->__pyx_kp_u__19);
+Py_VISIT(traverse_module_state->__pyx_kp_b__4);
+Py_VISIT(traverse_module_state->__pyx_kp_u__47);
+Py_VISIT(traverse_module_state->__pyx_n_s__48);
+Py_VISIT(traverse_module_state->__pyx_n_s__68);
+Py_VISIT(traverse_module_state->__pyx_n_s_all);
+Py_VISIT(traverse_module_state->__pyx_n_s_append);
+Py_VISIT(traverse_module_state->__pyx_n_s_asyncio_coroutines);
+Py_VISIT(traverse_module_state->__pyx_n_s_bindex_filename);
+Py_VISIT(traverse_module_state->__pyx_n_s_bindex_filename_compressed);
+Py_VISIT(traverse_module_state->__pyx_kp_u_calling_len_on_closed_file);
+Py_VISIT(traverse_module_state->__pyx_kp_u_can_not_write_record_without_a_s);
+Py_VISIT(traverse_module_state->__pyx_kp_u_can_not_write_record_without_nam);
+Py_VISIT(traverse_module_state->__pyx_n_s_cfilename);
+Py_VISIT(traverse_module_state->__pyx_n_s_cindexname);
+Py_VISIT(traverse_module_state->__pyx_n_s_cindexname_compressed);
+Py_VISIT(traverse_module_state->__pyx_n_s_class_getitem);
+Py_VISIT(traverse_module_state->__pyx_n_s_cline_in_traceback);
+Py_VISIT(traverse_module_state->__pyx_n_s_close);
+Py_VISIT(traverse_module_state->__pyx_n_s_comment);
+Py_VISIT(traverse_module_state->__pyx_n_s_contig);
+Py_VISIT(traverse_module_state->__pyx_n_s_contig_b);
+Py_VISIT(traverse_module_state->__pyx_n_s_copy);
+Py_VISIT(traverse_module_state->__pyx_n_s_deepcopy);
+Py_VISIT(traverse_module_state->__pyx_n_s_dict);
+Py_VISIT(traverse_module_state->__pyx_n_s_dict_2);
+Py_VISIT(traverse_module_state->__pyx_kp_u_disable);
+Py_VISIT(traverse_module_state->__pyx_kp_u_do_not_instantiate_FastqProxy_di);
+Py_VISIT(traverse_module_state->__pyx_kp_u_enable);
+Py_VISIT(traverse_module_state->__pyx_n_s_end);
+Py_VISIT(traverse_module_state->__pyx_n_s_enter);
+Py_VISIT(traverse_module_state->__pyx_kp_u_error_when_opening_file_s);
+Py_VISIT(traverse_module_state->__pyx_n_s_exc_type);
+Py_VISIT(traverse_module_state->__pyx_n_s_exc_value);
+Py_VISIT(traverse_module_state->__pyx_n_s_exists);
+Py_VISIT(traverse_module_state->__pyx_n_s_exit);
+Py_VISIT(traverse_module_state->__pyx_kp_u_failure_when_retrieving_sequence);
+Py_VISIT(traverse_module_state->__pyx_n_s_fetch);
+Py_VISIT(traverse_module_state->__pyx_kp_u_file_s_not_found);
+Py_VISIT(traverse_module_state->__pyx_n_s_filename);
+Py_VISIT(traverse_module_state->__pyx_kp_u_filename_does_not_exist);
+Py_VISIT(traverse_module_state->__pyx_n_s_filepath_index);
+Py_VISIT(traverse_module_state->__pyx_n_s_filepath_index_compressed);
+Py_VISIT(traverse_module_state->__pyx_n_s_format);
+Py_VISIT(traverse_module_state->__pyx_kp_u_gc);
+Py_VISIT(traverse_module_state->__pyx_n_s_get_quality_array);
+Py_VISIT(traverse_module_state->__pyx_n_s_get_reference_length);
+Py_VISIT(traverse_module_state->__pyx_n_s_getstate);
+Py_VISIT(traverse_module_state->__pyx_n_s_import);
+Py_VISIT(traverse_module_state->__pyx_n_s_initializing);
+Py_VISIT(traverse_module_state->__pyx_n_s_is_coroutine);
+Py_VISIT(traverse_module_state->__pyx_n_s_is_open);
+Py_VISIT(traverse_module_state->__pyx_kp_u_isenabled);
+Py_VISIT(traverse_module_state->__pyx_n_s_length);
+Py_VISIT(traverse_module_state->__pyx_n_s_main);
+Py_VISIT(traverse_module_state->__pyx_n_s_memo);
+Py_VISIT(traverse_module_state->__pyx_n_s_name);
+Py_VISIT(traverse_module_state->__pyx_n_s_name_2);
+Py_VISIT(traverse_module_state->__pyx_n_s_new);
+Py_VISIT(traverse_module_state->__pyx_kp_s_no_default___reduce___due_to_non);
+Py_VISIT(traverse_module_state->__pyx_kp_u_no_sequence_region_supplied);
+Py_VISIT(traverse_module_state->__pyx_n_s_nreferences);
+Py_VISIT(traverse_module_state->__pyx_n_s_offset);
+Py_VISIT(traverse_module_state->__pyx_n_s_open);
+Py_VISIT(traverse_module_state->__pyx_n_s_os);
+Py_VISIT(traverse_module_state->__pyx_n_s_path);
+Py_VISIT(traverse_module_state->__pyx_n_s_persist);
+Py_VISIT(traverse_module_state->__pyx_n_s_pickle);
+Py_VISIT(traverse_module_state->__pyx_n_s_proxy);
+Py_VISIT(traverse_module_state->__pyx_n_s_pysam_libcfaidx);
+Py_VISIT(traverse_module_state->__pyx_kp_s_pysam_libcfaidx_pyx);
+Py_VISIT(traverse_module_state->__pyx_n_s_pyx_PickleError);
+Py_VISIT(traverse_module_state->__pyx_n_s_pyx_checksum);
+Py_VISIT(traverse_module_state->__pyx_n_s_pyx_result);
+Py_VISIT(traverse_module_state->__pyx_n_s_pyx_state);
+Py_VISIT(traverse_module_state->__pyx_n_s_pyx_type);
+Py_VISIT(traverse_module_state->__pyx_n_s_pyx_unpickle_FastxRecord);
+Py_VISIT(traverse_module_state->__pyx_n_s_pyx_vtable);
+Py_VISIT(traverse_module_state->__pyx_n_s_quality);
+Py_VISIT(traverse_module_state->__pyx_n_s_re);
+Py_VISIT(traverse_module_state->__pyx_n_s_reduce);
+Py_VISIT(traverse_module_state->__pyx_n_s_reduce_cython);
+Py_VISIT(traverse_module_state->__pyx_n_s_reduce_ex);
+Py_VISIT(traverse_module_state->__pyx_n_s_ref);
+Py_VISIT(traverse_module_state->__pyx_n_s_reference);
+Py_VISIT(traverse_module_state->__pyx_n_s_references);
+Py_VISIT(traverse_module_state->__pyx_n_s_region);
+Py_VISIT(traverse_module_state->__pyx_n_s_rend);
+Py_VISIT(traverse_module_state->__pyx_n_s_rstart);
+Py_VISIT(traverse_module_state->__pyx_kp_u_s);
+Py_VISIT(traverse_module_state->__pyx_n_s_s_2);
+Py_VISIT(traverse_module_state->__pyx_n_s_self);
+Py_VISIT(traverse_module_state->__pyx_kp_s_self__delegate_cannot_be_convert);
+Py_VISIT(traverse_module_state->__pyx_n_s_seq);
+Py_VISIT(traverse_module_state->__pyx_n_s_sequence);
+Py_VISIT(traverse_module_state->__pyx_kp_u_sequence_and_quality_length_do_n);
+Py_VISIT(traverse_module_state->__pyx_kp_u_sequence_s_not_present);
+Py_VISIT(traverse_module_state->__pyx_n_s_set_comment);
+Py_VISIT(traverse_module_state->__pyx_n_s_set_name);
+Py_VISIT(traverse_module_state->__pyx_n_s_set_sequence);
+Py_VISIT(traverse_module_state->__pyx_n_s_setstate);
+Py_VISIT(traverse_module_state->__pyx_n_s_setstate_cython);
+Py_VISIT(traverse_module_state->__pyx_n_s_spec);
+Py_VISIT(traverse_module_state->__pyx_n_s_ss);
+Py_VISIT(traverse_module_state->__pyx_n_s_start);
+Py_VISIT(traverse_module_state->__pyx_n_s_state);
+Py_VISIT(traverse_module_state->__pyx_kp_s_stringsource);
+Py_VISIT(traverse_module_state->__pyx_n_s_sys);
+Py_VISIT(traverse_module_state->__pyx_n_s_test);
+Py_VISIT(traverse_module_state->__pyx_n_s_traceback);
+Py_VISIT(traverse_module_state->__pyx_kp_u_truncated_quality_string_in_0);
+Py_VISIT(traverse_module_state->__pyx_kp_u_unknown_problem_parsing_0);
+Py_VISIT(traverse_module_state->__pyx_n_s_update);
+Py_VISIT(traverse_module_state->__pyx_n_s_use_setstate);
+Py_VISIT(traverse_module_state->__pyx_n_s_x);
+Py_VISIT(traverse_module_state->__pyx_n_s_zip);
+Py_VISIT(traverse_module_state->__pyx_int_33);
+Py_VISIT(traverse_module_state->__pyx_int_29210129);
+Py_VISIT(traverse_module_state->__pyx_int_71291217);
+Py_VISIT(traverse_module_state->__pyx_int_191400582);
+Py_VISIT(traverse_module_state->__pyx_codeobj_);
+Py_VISIT(traverse_module_state->__pyx_tuple__2);
+Py_VISIT(traverse_module_state->__pyx_tuple__9);
+Py_VISIT(traverse_module_state->__pyx_tuple__10);
+Py_VISIT(traverse_module_state->__pyx_tuple__15);
+Py_VISIT(traverse_module_state->__pyx_tuple__25);
+Py_VISIT(traverse_module_state->__pyx_tuple__26);
+Py_VISIT(traverse_module_state->__pyx_tuple__28);
+Py_VISIT(traverse_module_state->__pyx_tuple__46);
+Py_VISIT(traverse_module_state->__pyx_tuple__49);
+Py_VISIT(traverse_module_state->__pyx_tuple__50);
+Py_VISIT(traverse_module_state->__pyx_tuple__51);
+Py_VISIT(traverse_module_state->__pyx_tuple__52);
+Py_VISIT(traverse_module_state->__pyx_tuple__53);
+Py_VISIT(traverse_module_state->__pyx_tuple__54);
+Py_VISIT(traverse_module_state->__pyx_tuple__55);
+Py_VISIT(traverse_module_state->__pyx_tuple__56);
+Py_VISIT(traverse_module_state->__pyx_tuple__57);
+Py_VISIT(traverse_module_state->__pyx_tuple__58);
+Py_VISIT(traverse_module_state->__pyx_tuple__59);
+Py_VISIT(traverse_module_state->__pyx_tuple__60);
+Py_VISIT(traverse_module_state->__pyx_tuple__61);
+Py_VISIT(traverse_module_state->__pyx_tuple__62);
+Py_VISIT(traverse_module_state->__pyx_tuple__63);
+Py_VISIT(traverse_module_state->__pyx_tuple__64);
+Py_VISIT(traverse_module_state->__pyx_tuple__65);
+Py_VISIT(traverse_module_state->__pyx_tuple__66);
+Py_VISIT(traverse_module_state->__pyx_tuple__67);
+Py_VISIT(traverse_module_state->__pyx_codeobj__3);
+Py_VISIT(traverse_module_state->__pyx_codeobj__5);
+Py_VISIT(traverse_module_state->__pyx_codeobj__6);
+Py_VISIT(traverse_module_state->__pyx_codeobj__7);
+Py_VISIT(traverse_module_state->__pyx_codeobj__8);
+Py_VISIT(traverse_module_state->__pyx_codeobj__12);
+Py_VISIT(traverse_module_state->__pyx_codeobj__13);
+Py_VISIT(traverse_module_state->__pyx_codeobj__14);
+Py_VISIT(traverse_module_state->__pyx_codeobj__20);
+Py_VISIT(traverse_module_state->__pyx_codeobj__21);
+Py_VISIT(traverse_module_state->__pyx_codeobj__22);
+Py_VISIT(traverse_module_state->__pyx_codeobj__23);
+Py_VISIT(traverse_module_state->__pyx_codeobj__24);
+Py_VISIT(traverse_module_state->__pyx_codeobj__27);
+Py_VISIT(traverse_module_state->__pyx_codeobj__29);
+Py_VISIT(traverse_module_state->__pyx_codeobj__30);
+Py_VISIT(traverse_module_state->__pyx_codeobj__31);
+Py_VISIT(traverse_module_state->__pyx_codeobj__32);
+Py_VISIT(traverse_module_state->__pyx_codeobj__33);
+Py_VISIT(traverse_module_state->__pyx_codeobj__34);
+Py_VISIT(traverse_module_state->__pyx_codeobj__35);
+Py_VISIT(traverse_module_state->__pyx_codeobj__36);
+Py_VISIT(traverse_module_state->__pyx_codeobj__37);
+Py_VISIT(traverse_module_state->__pyx_codeobj__38);
+Py_VISIT(traverse_module_state->__pyx_codeobj__39);
+Py_VISIT(traverse_module_state->__pyx_codeobj__40);
+Py_VISIT(traverse_module_state->__pyx_codeobj__41);
+Py_VISIT(traverse_module_state->__pyx_codeobj__42);
+Py_VISIT(traverse_module_state->__pyx_codeobj__43);
+Py_VISIT(traverse_module_state->__pyx_codeobj__44);
+Py_VISIT(traverse_module_state->__pyx_codeobj__45);
+return 0;
+}
+#endif
+/* #### Code section: module_state_defines ### */
+#define __pyx_d __pyx_mstate_global->__pyx_d
+#define __pyx_b __pyx_mstate_global->__pyx_b
+#define __pyx_cython_runtime __pyx_mstate_global->__pyx_cython_runtime
+#define __pyx_empty_tuple __pyx_mstate_global->__pyx_empty_tuple
+#define __pyx_empty_bytes __pyx_mstate_global->__pyx_empty_bytes
+#define __pyx_empty_unicode __pyx_mstate_global->__pyx_empty_unicode
+#ifdef __Pyx_CyFunction_USED
+#define __pyx_CyFunctionType __pyx_mstate_global->__pyx_CyFunctionType
+#endif
+#ifdef __Pyx_FusedFunction_USED
+#define __pyx_FusedFunctionType __pyx_mstate_global->__pyx_FusedFunctionType
+#endif
+#ifdef __Pyx_Generator_USED
+#define __pyx_GeneratorType __pyx_mstate_global->__pyx_GeneratorType
+#endif
+#ifdef __Pyx_IterableCoroutine_USED
+#define __pyx_IterableCoroutineType __pyx_mstate_global->__pyx_IterableCoroutineType
+#endif
+#ifdef __Pyx_Coroutine_USED
+#define __pyx_CoroutineAwaitType __pyx_mstate_global->__pyx_CoroutineAwaitType
+#endif
+#ifdef __Pyx_Coroutine_USED
+#define __pyx_CoroutineType __pyx_mstate_global->__pyx_CoroutineType
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#define __pyx_ptype_7cpython_4type_type __pyx_mstate_global->__pyx_ptype_7cpython_4type_type
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#define __pyx_ptype_7cpython_4bool_bool __pyx_mstate_global->__pyx_ptype_7cpython_4bool_bool
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#define __pyx_ptype_7cpython_7complex_complex __pyx_mstate_global->__pyx_ptype_7cpython_7complex_complex
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#define __pyx_ptype_7cpython_5array_array __pyx_mstate_global->__pyx_ptype_7cpython_5array_array
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#define __pyx_ptype_5pysam_10libchtslib_HTSFile __pyx_mstate_global->__pyx_ptype_5pysam_10libchtslib_HTSFile
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#endif
+#if CYTHON_USE_MODULE_STATE
+#define __pyx_type_5pysam_9libcfaidx_FastaFile __pyx_mstate_global->__pyx_type_5pysam_9libcfaidx_FastaFile
+#define __pyx_type_5pysam_9libcfaidx_FastqProxy __pyx_mstate_global->__pyx_type_5pysam_9libcfaidx_FastqProxy
+#define __pyx_type_5pysam_9libcfaidx_FastxRecord __pyx_mstate_global->__pyx_type_5pysam_9libcfaidx_FastxRecord
+#define __pyx_type_5pysam_9libcfaidx_FastxFile __pyx_mstate_global->__pyx_type_5pysam_9libcfaidx_FastxFile
+#define __pyx_type_5pysam_9libcfaidx_FastqFile __pyx_mstate_global->__pyx_type_5pysam_9libcfaidx_FastqFile
+#define __pyx_type_5pysam_9libcfaidx_Fastafile __pyx_mstate_global->__pyx_type_5pysam_9libcfaidx_Fastafile
+#endif
+#define __pyx_ptype_5pysam_9libcfaidx_FastaFile __pyx_mstate_global->__pyx_ptype_5pysam_9libcfaidx_FastaFile
+#define __pyx_ptype_5pysam_9libcfaidx_FastqProxy __pyx_mstate_global->__pyx_ptype_5pysam_9libcfaidx_FastqProxy
+#define __pyx_ptype_5pysam_9libcfaidx_FastxRecord __pyx_mstate_global->__pyx_ptype_5pysam_9libcfaidx_FastxRecord
+#define __pyx_ptype_5pysam_9libcfaidx_FastxFile __pyx_mstate_global->__pyx_ptype_5pysam_9libcfaidx_FastxFile
+#define __pyx_ptype_5pysam_9libcfaidx_FastqFile __pyx_mstate_global->__pyx_ptype_5pysam_9libcfaidx_FastqFile
+#define __pyx_ptype_5pysam_9libcfaidx_Fastafile __pyx_mstate_global->__pyx_ptype_5pysam_9libcfaidx_Fastafile
+#define __pyx_n_s_FastaFile __pyx_mstate_global->__pyx_n_s_FastaFile
+#define __pyx_n_u_FastaFile __pyx_mstate_global->__pyx_n_u_FastaFile
+#define __pyx_n_s_FastaFile___enter __pyx_mstate_global->__pyx_n_s_FastaFile___enter
+#define __pyx_n_s_FastaFile___exit __pyx_mstate_global->__pyx_n_s_FastaFile___exit
+#define __pyx_n_s_FastaFile___reduce_cython __pyx_mstate_global->__pyx_n_s_FastaFile___reduce_cython
+#define __pyx_n_s_FastaFile___setstate_cython __pyx_mstate_global->__pyx_n_s_FastaFile___setstate_cython
+#define __pyx_n_s_FastaFile__open __pyx_mstate_global->__pyx_n_s_FastaFile__open
+#define __pyx_n_s_FastaFile_close __pyx_mstate_global->__pyx_n_s_FastaFile_close
+#define __pyx_n_s_FastaFile_fetch __pyx_mstate_global->__pyx_n_s_FastaFile_fetch
+#define __pyx_n_s_FastaFile_get_reference_length __pyx_mstate_global->__pyx_n_s_FastaFile_get_reference_length
+#define __pyx_n_s_FastaFile_is_open __pyx_mstate_global->__pyx_n_s_FastaFile_is_open
+#define __pyx_n_s_Fastafile __pyx_mstate_global->__pyx_n_s_Fastafile
+#define __pyx_n_u_Fastafile __pyx_mstate_global->__pyx_n_u_Fastafile
+#define __pyx_n_s_Fastafile___reduce_cython __pyx_mstate_global->__pyx_n_s_Fastafile___reduce_cython
+#define __pyx_n_s_Fastafile___setstate_cython __pyx_mstate_global->__pyx_n_s_Fastafile___setstate_cython
+#define __pyx_n_s_FastqFile __pyx_mstate_global->__pyx_n_s_FastqFile
+#define __pyx_n_u_FastqFile __pyx_mstate_global->__pyx_n_u_FastqFile
+#define __pyx_n_s_FastqFile___reduce_cython __pyx_mstate_global->__pyx_n_s_FastqFile___reduce_cython
+#define __pyx_n_s_FastqFile___setstate_cython __pyx_mstate_global->__pyx_n_s_FastqFile___setstate_cython
+#define __pyx_n_s_FastqProxy __pyx_mstate_global->__pyx_n_s_FastqProxy
+#define __pyx_n_u_FastqProxy __pyx_mstate_global->__pyx_n_u_FastqProxy
+#define __pyx_n_s_FastqProxy___reduce_cython __pyx_mstate_global->__pyx_n_s_FastqProxy___reduce_cython
+#define __pyx_n_s_FastqProxy___setstate_cython __pyx_mstate_global->__pyx_n_s_FastqProxy___setstate_cython
+#define __pyx_n_s_FastqProxy_get_quality_array __pyx_mstate_global->__pyx_n_s_FastqProxy_get_quality_array
+#define __pyx_n_s_FastxFile __pyx_mstate_global->__pyx_n_s_FastxFile
+#define __pyx_n_u_FastxFile __pyx_mstate_global->__pyx_n_u_FastxFile
+#define __pyx_n_s_FastxFile___enter __pyx_mstate_global->__pyx_n_s_FastxFile___enter
+#define __pyx_n_s_FastxFile___exit __pyx_mstate_global->__pyx_n_s_FastxFile___exit
+#define __pyx_n_s_FastxFile___reduce_cython __pyx_mstate_global->__pyx_n_s_FastxFile___reduce_cython
+#define __pyx_n_s_FastxFile___setstate_cython __pyx_mstate_global->__pyx_n_s_FastxFile___setstate_cython
+#define __pyx_n_s_FastxFile__open __pyx_mstate_global->__pyx_n_s_FastxFile__open
+#define __pyx_n_s_FastxFile_close __pyx_mstate_global->__pyx_n_s_FastxFile_close
+#define __pyx_n_s_FastxFile_is_open __pyx_mstate_global->__pyx_n_s_FastxFile_is_open
+#define __pyx_n_s_FastxRecord __pyx_mstate_global->__pyx_n_s_FastxRecord
+#define __pyx_n_u_FastxRecord __pyx_mstate_global->__pyx_n_u_FastxRecord
+#define __pyx_n_s_FastxRecord___copy __pyx_mstate_global->__pyx_n_s_FastxRecord___copy
+#define __pyx_n_s_FastxRecord___deepcopy __pyx_mstate_global->__pyx_n_s_FastxRecord___deepcopy
+#define __pyx_n_s_FastxRecord___reduce_cython __pyx_mstate_global->__pyx_n_s_FastxRecord___reduce_cython
+#define __pyx_n_s_FastxRecord___setstate_cython __pyx_mstate_global->__pyx_n_s_FastxRecord___setstate_cython
+#define __pyx_n_s_FastxRecord_get_quality_array __pyx_mstate_global->__pyx_n_s_FastxRecord_get_quality_array
+#define __pyx_kp_u_FastxRecord_must_have_a_name_and __pyx_mstate_global->__pyx_kp_u_FastxRecord_must_have_a_name_and
+#define __pyx_n_s_FastxRecord_set_comment __pyx_mstate_global->__pyx_n_s_FastxRecord_set_comment
+#define __pyx_n_s_FastxRecord_set_name __pyx_mstate_global->__pyx_n_s_FastxRecord_set_name
+#define __pyx_n_s_FastxRecord_set_sequence __pyx_mstate_global->__pyx_n_s_FastxRecord_set_sequence
+#define __pyx_n_s_IOError __pyx_mstate_global->__pyx_n_s_IOError
+#define __pyx_kp_u_I_O_operation_on_closed_file __pyx_mstate_global->__pyx_kp_u_I_O_operation_on_closed_file
+#define __pyx_kp_s_Incompatible_checksums_0x_x_vs_0 __pyx_mstate_global->__pyx_kp_s_Incompatible_checksums_0x_x_vs_0
+#define __pyx_n_s_KeyError __pyx_mstate_global->__pyx_n_s_KeyError
+#define __pyx_n_s_MemoryError __pyx_mstate_global->__pyx_n_s_MemoryError
+#define __pyx_kp_u_None __pyx_mstate_global->__pyx_kp_u_None
+#define __pyx_n_s_PickleError __pyx_mstate_global->__pyx_n_s_PickleError
+#define __pyx_n_s_StopIteration __pyx_mstate_global->__pyx_n_s_StopIteration
+#define __pyx_n_s_TypeError __pyx_mstate_global->__pyx_n_s_TypeError
+#define __pyx_n_s_ValueError __pyx_mstate_global->__pyx_n_s_ValueError
+#define __pyx_kp_u__11 __pyx_mstate_global->__pyx_kp_u__11
+#define __pyx_kp_u__16 __pyx_mstate_global->__pyx_kp_u__16
+#define __pyx_kp_u__17 __pyx_mstate_global->__pyx_kp_u__17
+#define __pyx_kp_u__18 __pyx_mstate_global->__pyx_kp_u__18
+#define __pyx_kp_u__19 __pyx_mstate_global->__pyx_kp_u__19
+#define __pyx_kp_b__4 __pyx_mstate_global->__pyx_kp_b__4
+#define __pyx_kp_u__47 __pyx_mstate_global->__pyx_kp_u__47
+#define __pyx_n_s__48 __pyx_mstate_global->__pyx_n_s__48
+#define __pyx_n_s__68 __pyx_mstate_global->__pyx_n_s__68
+#define __pyx_n_s_all __pyx_mstate_global->__pyx_n_s_all
+#define __pyx_n_s_append __pyx_mstate_global->__pyx_n_s_append
+#define __pyx_n_s_asyncio_coroutines __pyx_mstate_global->__pyx_n_s_asyncio_coroutines
+#define __pyx_n_s_bindex_filename __pyx_mstate_global->__pyx_n_s_bindex_filename
+#define __pyx_n_s_bindex_filename_compressed __pyx_mstate_global->__pyx_n_s_bindex_filename_compressed
+#define __pyx_kp_u_calling_len_on_closed_file __pyx_mstate_global->__pyx_kp_u_calling_len_on_closed_file
+#define __pyx_kp_u_can_not_write_record_without_a_s __pyx_mstate_global->__pyx_kp_u_can_not_write_record_without_a_s
+#define __pyx_kp_u_can_not_write_record_without_nam __pyx_mstate_global->__pyx_kp_u_can_not_write_record_without_nam
+#define __pyx_n_s_cfilename __pyx_mstate_global->__pyx_n_s_cfilename
+#define __pyx_n_s_cindexname __pyx_mstate_global->__pyx_n_s_cindexname
+#define __pyx_n_s_cindexname_compressed __pyx_mstate_global->__pyx_n_s_cindexname_compressed
+#define __pyx_n_s_class_getitem __pyx_mstate_global->__pyx_n_s_class_getitem
+#define __pyx_n_s_cline_in_traceback __pyx_mstate_global->__pyx_n_s_cline_in_traceback
+#define __pyx_n_s_close __pyx_mstate_global->__pyx_n_s_close
+#define __pyx_n_s_comment __pyx_mstate_global->__pyx_n_s_comment
+#define __pyx_n_s_contig __pyx_mstate_global->__pyx_n_s_contig
+#define __pyx_n_s_contig_b __pyx_mstate_global->__pyx_n_s_contig_b
+#define __pyx_n_s_copy __pyx_mstate_global->__pyx_n_s_copy
+#define __pyx_n_s_deepcopy __pyx_mstate_global->__pyx_n_s_deepcopy
+#define __pyx_n_s_dict __pyx_mstate_global->__pyx_n_s_dict
+#define __pyx_n_s_dict_2 __pyx_mstate_global->__pyx_n_s_dict_2
+#define __pyx_kp_u_disable __pyx_mstate_global->__pyx_kp_u_disable
+#define __pyx_kp_u_do_not_instantiate_FastqProxy_di __pyx_mstate_global->__pyx_kp_u_do_not_instantiate_FastqProxy_di
+#define __pyx_kp_u_enable __pyx_mstate_global->__pyx_kp_u_enable
+#define __pyx_n_s_end __pyx_mstate_global->__pyx_n_s_end
+#define __pyx_n_s_enter __pyx_mstate_global->__pyx_n_s_enter
+#define __pyx_kp_u_error_when_opening_file_s __pyx_mstate_global->__pyx_kp_u_error_when_opening_file_s
+#define __pyx_n_s_exc_type __pyx_mstate_global->__pyx_n_s_exc_type
+#define __pyx_n_s_exc_value __pyx_mstate_global->__pyx_n_s_exc_value
+#define __pyx_n_s_exists __pyx_mstate_global->__pyx_n_s_exists
+#define __pyx_n_s_exit __pyx_mstate_global->__pyx_n_s_exit
+#define __pyx_kp_u_failure_when_retrieving_sequence __pyx_mstate_global->__pyx_kp_u_failure_when_retrieving_sequence
+#define __pyx_n_s_fetch __pyx_mstate_global->__pyx_n_s_fetch
+#define __pyx_kp_u_file_s_not_found __pyx_mstate_global->__pyx_kp_u_file_s_not_found
+#define __pyx_n_s_filename __pyx_mstate_global->__pyx_n_s_filename
+#define __pyx_kp_u_filename_does_not_exist __pyx_mstate_global->__pyx_kp_u_filename_does_not_exist
+#define __pyx_n_s_filepath_index __pyx_mstate_global->__pyx_n_s_filepath_index
+#define __pyx_n_s_filepath_index_compressed __pyx_mstate_global->__pyx_n_s_filepath_index_compressed
+#define __pyx_n_s_format __pyx_mstate_global->__pyx_n_s_format
+#define __pyx_kp_u_gc __pyx_mstate_global->__pyx_kp_u_gc
+#define __pyx_n_s_get_quality_array __pyx_mstate_global->__pyx_n_s_get_quality_array
+#define __pyx_n_s_get_reference_length __pyx_mstate_global->__pyx_n_s_get_reference_length
+#define __pyx_n_s_getstate __pyx_mstate_global->__pyx_n_s_getstate
+#define __pyx_n_s_import __pyx_mstate_global->__pyx_n_s_import
+#define __pyx_n_s_initializing __pyx_mstate_global->__pyx_n_s_initializing
+#define __pyx_n_s_is_coroutine __pyx_mstate_global->__pyx_n_s_is_coroutine
+#define __pyx_n_s_is_open __pyx_mstate_global->__pyx_n_s_is_open
+#define __pyx_kp_u_isenabled __pyx_mstate_global->__pyx_kp_u_isenabled
+#define __pyx_n_s_length __pyx_mstate_global->__pyx_n_s_length
+#define __pyx_n_s_main __pyx_mstate_global->__pyx_n_s_main
+#define __pyx_n_s_memo __pyx_mstate_global->__pyx_n_s_memo
+#define __pyx_n_s_name __pyx_mstate_global->__pyx_n_s_name
+#define __pyx_n_s_name_2 __pyx_mstate_global->__pyx_n_s_name_2
+#define __pyx_n_s_new __pyx_mstate_global->__pyx_n_s_new
+#define __pyx_kp_s_no_default___reduce___due_to_non __pyx_mstate_global->__pyx_kp_s_no_default___reduce___due_to_non
+#define __pyx_kp_u_no_sequence_region_supplied __pyx_mstate_global->__pyx_kp_u_no_sequence_region_supplied
+#define __pyx_n_s_nreferences __pyx_mstate_global->__pyx_n_s_nreferences
+#define __pyx_n_s_offset __pyx_mstate_global->__pyx_n_s_offset
+#define __pyx_n_s_open __pyx_mstate_global->__pyx_n_s_open
+#define __pyx_n_s_os __pyx_mstate_global->__pyx_n_s_os
+#define __pyx_n_s_path __pyx_mstate_global->__pyx_n_s_path
+#define __pyx_n_s_persist __pyx_mstate_global->__pyx_n_s_persist
+#define __pyx_n_s_pickle __pyx_mstate_global->__pyx_n_s_pickle
+#define __pyx_n_s_proxy __pyx_mstate_global->__pyx_n_s_proxy
+#define __pyx_n_s_pysam_libcfaidx __pyx_mstate_global->__pyx_n_s_pysam_libcfaidx
+#define __pyx_kp_s_pysam_libcfaidx_pyx __pyx_mstate_global->__pyx_kp_s_pysam_libcfaidx_pyx
+#define __pyx_n_s_pyx_PickleError __pyx_mstate_global->__pyx_n_s_pyx_PickleError
+#define __pyx_n_s_pyx_checksum __pyx_mstate_global->__pyx_n_s_pyx_checksum
+#define __pyx_n_s_pyx_result __pyx_mstate_global->__pyx_n_s_pyx_result
+#define __pyx_n_s_pyx_state __pyx_mstate_global->__pyx_n_s_pyx_state
+#define __pyx_n_s_pyx_type __pyx_mstate_global->__pyx_n_s_pyx_type
+#define __pyx_n_s_pyx_unpickle_FastxRecord __pyx_mstate_global->__pyx_n_s_pyx_unpickle_FastxRecord
+#define __pyx_n_s_pyx_vtable __pyx_mstate_global->__pyx_n_s_pyx_vtable
+#define __pyx_n_s_quality __pyx_mstate_global->__pyx_n_s_quality
+#define __pyx_n_s_re __pyx_mstate_global->__pyx_n_s_re
+#define __pyx_n_s_reduce __pyx_mstate_global->__pyx_n_s_reduce
+#define __pyx_n_s_reduce_cython __pyx_mstate_global->__pyx_n_s_reduce_cython
+#define __pyx_n_s_reduce_ex __pyx_mstate_global->__pyx_n_s_reduce_ex
+#define __pyx_n_s_ref __pyx_mstate_global->__pyx_n_s_ref
+#define __pyx_n_s_reference __pyx_mstate_global->__pyx_n_s_reference
+#define __pyx_n_s_references __pyx_mstate_global->__pyx_n_s_references
+#define __pyx_n_s_region __pyx_mstate_global->__pyx_n_s_region
+#define __pyx_n_s_rend __pyx_mstate_global->__pyx_n_s_rend
+#define __pyx_n_s_rstart __pyx_mstate_global->__pyx_n_s_rstart
+#define __pyx_kp_u_s __pyx_mstate_global->__pyx_kp_u_s
+#define __pyx_n_s_s_2 __pyx_mstate_global->__pyx_n_s_s_2
+#define __pyx_n_s_self __pyx_mstate_global->__pyx_n_s_self
+#define __pyx_kp_s_self__delegate_cannot_be_convert __pyx_mstate_global->__pyx_kp_s_self__delegate_cannot_be_convert
+#define __pyx_n_s_seq __pyx_mstate_global->__pyx_n_s_seq
+#define __pyx_n_s_sequence __pyx_mstate_global->__pyx_n_s_sequence
+#define __pyx_kp_u_sequence_and_quality_length_do_n __pyx_mstate_global->__pyx_kp_u_sequence_and_quality_length_do_n
+#define __pyx_kp_u_sequence_s_not_present __pyx_mstate_global->__pyx_kp_u_sequence_s_not_present
+#define __pyx_n_s_set_comment __pyx_mstate_global->__pyx_n_s_set_comment
+#define __pyx_n_s_set_name __pyx_mstate_global->__pyx_n_s_set_name
+#define __pyx_n_s_set_sequence __pyx_mstate_global->__pyx_n_s_set_sequence
+#define __pyx_n_s_setstate __pyx_mstate_global->__pyx_n_s_setstate
+#define __pyx_n_s_setstate_cython __pyx_mstate_global->__pyx_n_s_setstate_cython
+#define __pyx_n_s_spec __pyx_mstate_global->__pyx_n_s_spec
+#define __pyx_n_s_ss __pyx_mstate_global->__pyx_n_s_ss
+#define __pyx_n_s_start __pyx_mstate_global->__pyx_n_s_start
+#define __pyx_n_s_state __pyx_mstate_global->__pyx_n_s_state
+#define __pyx_kp_s_stringsource __pyx_mstate_global->__pyx_kp_s_stringsource
+#define __pyx_n_s_sys __pyx_mstate_global->__pyx_n_s_sys
+#define __pyx_n_s_test __pyx_mstate_global->__pyx_n_s_test
+#define __pyx_n_s_traceback __pyx_mstate_global->__pyx_n_s_traceback
+#define __pyx_kp_u_truncated_quality_string_in_0 __pyx_mstate_global->__pyx_kp_u_truncated_quality_string_in_0
+#define __pyx_kp_u_unknown_problem_parsing_0 __pyx_mstate_global->__pyx_kp_u_unknown_problem_parsing_0
+#define __pyx_n_s_update __pyx_mstate_global->__pyx_n_s_update
+#define __pyx_n_s_use_setstate __pyx_mstate_global->__pyx_n_s_use_setstate
+#define __pyx_n_s_x __pyx_mstate_global->__pyx_n_s_x
+#define __pyx_n_s_zip __pyx_mstate_global->__pyx_n_s_zip
+#define __pyx_int_33 __pyx_mstate_global->__pyx_int_33
+#define __pyx_int_29210129 __pyx_mstate_global->__pyx_int_29210129
+#define __pyx_int_71291217 __pyx_mstate_global->__pyx_int_71291217
+#define __pyx_int_191400582 __pyx_mstate_global->__pyx_int_191400582
+#define __pyx_codeobj_ __pyx_mstate_global->__pyx_codeobj_
+#define __pyx_tuple__2 __pyx_mstate_global->__pyx_tuple__2
+#define __pyx_tuple__9 __pyx_mstate_global->__pyx_tuple__9
+#define __pyx_tuple__10 __pyx_mstate_global->__pyx_tuple__10
+#define __pyx_tuple__15 __pyx_mstate_global->__pyx_tuple__15
+#define __pyx_tuple__25 __pyx_mstate_global->__pyx_tuple__25
+#define __pyx_tuple__26 __pyx_mstate_global->__pyx_tuple__26
+#define __pyx_tuple__28 __pyx_mstate_global->__pyx_tuple__28
+#define __pyx_tuple__46 __pyx_mstate_global->__pyx_tuple__46
+#define __pyx_tuple__49 __pyx_mstate_global->__pyx_tuple__49
+#define __pyx_tuple__50 __pyx_mstate_global->__pyx_tuple__50
+#define __pyx_tuple__51 __pyx_mstate_global->__pyx_tuple__51
+#define __pyx_tuple__52 __pyx_mstate_global->__pyx_tuple__52
+#define __pyx_tuple__53 __pyx_mstate_global->__pyx_tuple__53
+#define __pyx_tuple__54 __pyx_mstate_global->__pyx_tuple__54
+#define __pyx_tuple__55 __pyx_mstate_global->__pyx_tuple__55
+#define __pyx_tuple__56 __pyx_mstate_global->__pyx_tuple__56
+#define __pyx_tuple__57 __pyx_mstate_global->__pyx_tuple__57
+#define __pyx_tuple__58 __pyx_mstate_global->__pyx_tuple__58
+#define __pyx_tuple__59 __pyx_mstate_global->__pyx_tuple__59
+#define __pyx_tuple__60 __pyx_mstate_global->__pyx_tuple__60
+#define __pyx_tuple__61 __pyx_mstate_global->__pyx_tuple__61
+#define __pyx_tuple__62 __pyx_mstate_global->__pyx_tuple__62
+#define __pyx_tuple__63 __pyx_mstate_global->__pyx_tuple__63
+#define __pyx_tuple__64 __pyx_mstate_global->__pyx_tuple__64
+#define __pyx_tuple__65 __pyx_mstate_global->__pyx_tuple__65
+#define __pyx_tuple__66 __pyx_mstate_global->__pyx_tuple__66
+#define __pyx_tuple__67 __pyx_mstate_global->__pyx_tuple__67
+#define __pyx_codeobj__3 __pyx_mstate_global->__pyx_codeobj__3
+#define __pyx_codeobj__5 __pyx_mstate_global->__pyx_codeobj__5
+#define __pyx_codeobj__6 __pyx_mstate_global->__pyx_codeobj__6
+#define __pyx_codeobj__7 __pyx_mstate_global->__pyx_codeobj__7
+#define __pyx_codeobj__8 __pyx_mstate_global->__pyx_codeobj__8
+#define __pyx_codeobj__12 __pyx_mstate_global->__pyx_codeobj__12
+#define __pyx_codeobj__13 __pyx_mstate_global->__pyx_codeobj__13
+#define __pyx_codeobj__14 __pyx_mstate_global->__pyx_codeobj__14
+#define __pyx_codeobj__20 __pyx_mstate_global->__pyx_codeobj__20
+#define __pyx_codeobj__21 __pyx_mstate_global->__pyx_codeobj__21
+#define __pyx_codeobj__22 __pyx_mstate_global->__pyx_codeobj__22
+#define __pyx_codeobj__23 __pyx_mstate_global->__pyx_codeobj__23
+#define __pyx_codeobj__24 __pyx_mstate_global->__pyx_codeobj__24
+#define __pyx_codeobj__27 __pyx_mstate_global->__pyx_codeobj__27
+#define __pyx_codeobj__29 __pyx_mstate_global->__pyx_codeobj__29
+#define __pyx_codeobj__30 __pyx_mstate_global->__pyx_codeobj__30
+#define __pyx_codeobj__31 __pyx_mstate_global->__pyx_codeobj__31
+#define __pyx_codeobj__32 __pyx_mstate_global->__pyx_codeobj__32
+#define __pyx_codeobj__33 __pyx_mstate_global->__pyx_codeobj__33
+#define __pyx_codeobj__34 __pyx_mstate_global->__pyx_codeobj__34
+#define __pyx_codeobj__35 __pyx_mstate_global->__pyx_codeobj__35
+#define __pyx_codeobj__36 __pyx_mstate_global->__pyx_codeobj__36
+#define __pyx_codeobj__37 __pyx_mstate_global->__pyx_codeobj__37
+#define __pyx_codeobj__38 __pyx_mstate_global->__pyx_codeobj__38
+#define __pyx_codeobj__39 __pyx_mstate_global->__pyx_codeobj__39
+#define __pyx_codeobj__40 __pyx_mstate_global->__pyx_codeobj__40
+#define __pyx_codeobj__41 __pyx_mstate_global->__pyx_codeobj__41
+#define __pyx_codeobj__42 __pyx_mstate_global->__pyx_codeobj__42
+#define __pyx_codeobj__43 __pyx_mstate_global->__pyx_codeobj__43
+#define __pyx_codeobj__44 __pyx_mstate_global->__pyx_codeobj__44
+#define __pyx_codeobj__45 __pyx_mstate_global->__pyx_codeobj__45
+/* #### Code section: module_code ### */
+/* "cpython/complex.pxd":19
+*
+*         @property
+*         cdef inline double real(self) noexcept:             # <<<<<<<<<<<<<<
+*             return self.cval.real
+*
+*/
+static CYTHON_INLINE double __pyx_f_7cpython_7complex_7complex_4real_real(PyComplexObject *__pyx_v_self) {
+double __pyx_r;
+/* "cpython/complex.pxd":20
+*         @property
+*         cdef inline double real(self) noexcept:
+*             return self.cval.real             # <<<<<<<<<<<<<<
+*
+*         @property
+*/
+__pyx_r = __pyx_v_self->cval.real;
+goto __pyx_L0;
+/* "cpython/complex.pxd":19
+*
+*         @property
+*         cdef inline double real(self) noexcept:             # <<<<<<<<<<<<<<
+*             return self.cval.real
+*
+*/
+/* function exit code */
+__pyx_L0:;
+return __pyx_r;
+}
+/* "cpython/complex.pxd":23
+*
+*         @property
+*         cdef inline double imag(self) noexcept:             # <<<<<<<<<<<<<<
+*             return self.cval.imag
+*
+*/
+static CYTHON_INLINE double __pyx_f_7cpython_7complex_7complex_4imag_imag(PyComplexObject *__pyx_v_self) {
+double __pyx_r;
+/* "cpython/complex.pxd":24
+*         @property
+*         cdef inline double imag(self) noexcept:
+*             return self.cval.imag             # <<<<<<<<<<<<<<
+*
+*     # PyTypeObject PyComplex_Type
+*/
+__pyx_r = __pyx_v_self->cval.imag;
+goto __pyx_L0;
+/* "cpython/complex.pxd":23
+*
+*         @property
+*         cdef inline double imag(self) noexcept:             # <<<<<<<<<<<<<<
+*             return self.cval.imag
+*
+*/
+/* function exit code */
+__pyx_L0:;
+return __pyx_r;
+}
+/* "cpython/contextvars.pxd":112
+*
+*
+* cdef inline object get_value(var, default_value=None):             # <<<<<<<<<<<<<<
+*     """Return a new reference to the value of the context variable,
+*     or the default value of the context variable,
+*/
+static CYTHON_INLINE PyObject *__pyx_f_7cpython_11contextvars_get_value(PyObject *__pyx_v_var, struct __pyx_opt_args_7cpython_11contextvars_get_value *__pyx_optional_args) {
+PyObject *__pyx_v_default_value = ((PyObject *)Py_None);
+PyObject *__pyx_v_value;
+PyObject *__pyx_v_pyvalue = NULL;
+PyObject *__pyx_r = NULL;
+__Pyx_RefNannyDeclarations
+int __pyx_t_1;
+int __pyx_t_2;
+PyObject *__pyx_t_3 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("get_value", 1);
+if (__pyx_optional_args) {
+if (__pyx_optional_args->__pyx_n > 0) {
+__pyx_v_default_value = __pyx_optional_args->default_value;
+}
+}
+/* "cpython/contextvars.pxd":117
+*     or None if no such value or default was found.
+*     """
+*     cdef PyObject *value = NULL             # <<<<<<<<<<<<<<
+*     PyContextVar_Get(var, NULL, &value)
+*     if value is NULL:
+*/
+__pyx_v_value = NULL;
+/* "cpython/contextvars.pxd":118
+*     """
+*     cdef PyObject *value = NULL
+*     PyContextVar_Get(var, NULL, &value)             # <<<<<<<<<<<<<<
+*     if value is NULL:
+*         # context variable does not have a default
+*/
+__pyx_t_1 = PyContextVar_Get(__pyx_v_var, NULL, (&__pyx_v_value)); if (unlikely(__pyx_t_1 == ((int)-1))) __PYX_ERR(2, 118, __pyx_L1_error)
+/* "cpython/contextvars.pxd":119
+*     cdef PyObject *value = NULL
+*     PyContextVar_Get(var, NULL, &value)
+*     if value is NULL:             # <<<<<<<<<<<<<<
+*         # context variable does not have a default
+*         pyvalue = default_value
+*/
+__pyx_t_2 = (__pyx_v_value == NULL);
+if (__pyx_t_2) {
+/* "cpython/contextvars.pxd":121
+*     if value is NULL:
+*         # context variable does not have a default
+*         pyvalue = default_value             # <<<<<<<<<<<<<<
+*     else:
+*         # value or default value of context variable
+*/
+__Pyx_INCREF(__pyx_v_default_value);
+__pyx_v_pyvalue = __pyx_v_default_value;
+/* "cpython/contextvars.pxd":119
+*     cdef PyObject *value = NULL
+*     PyContextVar_Get(var, NULL, &value)
+*     if value is NULL:             # <<<<<<<<<<<<<<
+*         # context variable does not have a default
+*         pyvalue = default_value
+*/
+goto __pyx_L3;
+}
+/* "cpython/contextvars.pxd":124
+*     else:
+*         # value or default value of context variable
+*         pyvalue = <object>value             # <<<<<<<<<<<<<<
+*         Py_XDECREF(value)  # PyContextVar_Get() returned an owned reference as 'PyObject*'
+*     return pyvalue
+*/
+/*else*/ {
+__pyx_t_3 = ((PyObject *)__pyx_v_value);
+__Pyx_INCREF(__pyx_t_3);
+__pyx_v_pyvalue = __pyx_t_3;
+__pyx_t_3 = 0;
+/* "cpython/contextvars.pxd":125
+*         # value or default value of context variable
+*         pyvalue = <object>value
+*         Py_XDECREF(value)  # PyContextVar_Get() returned an owned reference as 'PyObject*'             # <<<<<<<<<<<<<<
+*     return pyvalue
+*
+*/
+Py_XDECREF(__pyx_v_value);
+}
+__pyx_L3:;
+/* "cpython/contextvars.pxd":126
+*         pyvalue = <object>value
+*         Py_XDECREF(value)  # PyContextVar_Get() returned an owned reference as 'PyObject*'
+*     return pyvalue             # <<<<<<<<<<<<<<
+*
+*
+*/
+__Pyx_XDECREF(__pyx_r);
+__Pyx_INCREF(__pyx_v_pyvalue);
+__pyx_r = __pyx_v_pyvalue;
+goto __pyx_L0;
+/* "cpython/contextvars.pxd":112
+*
+*
+* cdef inline object get_value(var, default_value=None):             # <<<<<<<<<<<<<<
+*     """Return a new reference to the value of the context variable,
+*     or the default value of the context variable,
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_3);
+__Pyx_AddTraceback("cpython.contextvars.get_value", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = 0;
+__pyx_L0:;
+__Pyx_XDECREF(__pyx_v_pyvalue);
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "cpython/contextvars.pxd":129
+*
+*
+* cdef inline object get_value_no_default(var, default_value=None):             # <<<<<<<<<<<<<<
+*     """Return a new reference to the value of the context variable,
+*     or the provided default value if no such value was found.
+*/
+static CYTHON_INLINE PyObject *__pyx_f_7cpython_11contextvars_get_value_no_default(PyObject *__pyx_v_var, struct __pyx_opt_args_7cpython_11contextvars_get_value_no_default *__pyx_optional_args) {
+PyObject *__pyx_v_default_value = ((PyObject *)Py_None);
+PyObject *__pyx_v_value;
+PyObject *__pyx_v_pyvalue = NULL;
+PyObject *__pyx_r = NULL;
+__Pyx_RefNannyDeclarations
+int __pyx_t_1;
+PyObject *__pyx_t_2 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("get_value_no_default", 1);
+if (__pyx_optional_args) {
+if (__pyx_optional_args->__pyx_n > 0) {
+__pyx_v_default_value = __pyx_optional_args->default_value;
+}
+}
+/* "cpython/contextvars.pxd":135
+*     Ignores the default value of the context variable, if any.
+*     """
+*     cdef PyObject *value = NULL             # <<<<<<<<<<<<<<
+*     PyContextVar_Get(var, <PyObject*>default_value, &value)
+*     # value of context variable or 'default_value'
+*/
+__pyx_v_value = NULL;
+/* "cpython/contextvars.pxd":136
+*     """
+*     cdef PyObject *value = NULL
+*     PyContextVar_Get(var, <PyObject*>default_value, &value)             # <<<<<<<<<<<<<<
+*     # value of context variable or 'default_value'
+*     pyvalue = <object>value
+*/
+__pyx_t_1 = PyContextVar_Get(__pyx_v_var, ((PyObject *)__pyx_v_default_value), (&__pyx_v_value)); if (unlikely(__pyx_t_1 == ((int)-1))) __PYX_ERR(2, 136, __pyx_L1_error)
+/* "cpython/contextvars.pxd":138
+*     PyContextVar_Get(var, <PyObject*>default_value, &value)
+*     # value of context variable or 'default_value'
+*     pyvalue = <object>value             # <<<<<<<<<<<<<<
+*     Py_XDECREF(value)  # PyContextVar_Get() returned an owned reference as 'PyObject*'
+*     return pyvalue
+*/
+__pyx_t_2 = ((PyObject *)__pyx_v_value);
+__Pyx_INCREF(__pyx_t_2);
+__pyx_v_pyvalue = __pyx_t_2;
+__pyx_t_2 = 0;
+/* "cpython/contextvars.pxd":139
+*     # value of context variable or 'default_value'
+*     pyvalue = <object>value
+*     Py_XDECREF(value)  # PyContextVar_Get() returned an owned reference as 'PyObject*'             # <<<<<<<<<<<<<<
+*     return pyvalue
+*/
+Py_XDECREF(__pyx_v_value);
+/* "cpython/contextvars.pxd":140
+*     pyvalue = <object>value
+*     Py_XDECREF(value)  # PyContextVar_Get() returned an owned reference as 'PyObject*'
+*     return pyvalue             # <<<<<<<<<<<<<<
+*/
+__Pyx_XDECREF(__pyx_r);
+__Pyx_INCREF(__pyx_v_pyvalue);
+__pyx_r = __pyx_v_pyvalue;
+goto __pyx_L0;
+/* "cpython/contextvars.pxd":129
+*
+*
+* cdef inline object get_value_no_default(var, default_value=None):             # <<<<<<<<<<<<<<
+*     """Return a new reference to the value of the context variable,
+*     or the provided default value if no such value was found.
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_AddTraceback("cpython.contextvars.get_value_no_default", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = 0;
+__pyx_L0:;
+__Pyx_XDECREF(__pyx_v_pyvalue);
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "array.pxd":104
+*             __data_union data
+*
+*         def __getbuffer__(self, Py_buffer* info, int flags):             # <<<<<<<<<<<<<<
+*             # This implementation of getbuffer is geared towards Cython
+*             # requirements, and does not yet fulfill the PEP.
+*/
+/* Python wrapper */
+CYTHON_UNUSED static int __pyx_pw_7cpython_5array_5array_1__getbuffer__(PyObject *__pyx_v_self, Py_buffer *__pyx_v_info, int __pyx_v_flags); /*proto*/
+CYTHON_UNUSED static int __pyx_pw_7cpython_5array_5array_1__getbuffer__(PyObject *__pyx_v_self, Py_buffer *__pyx_v_info, int __pyx_v_flags) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+int __pyx_r;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__getbuffer__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_7cpython_5array_5array___getbuffer__(((arrayobject *)__pyx_v_self), ((Py_buffer *)__pyx_v_info), ((int)__pyx_v_flags));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static int __pyx_pf_7cpython_5array_5array___getbuffer__(arrayobject *__pyx_v_self, Py_buffer *__pyx_v_info, CYTHON_UNUSED int __pyx_v_flags) {
+PyObject *__pyx_v_item_count = NULL;
+int __pyx_r;
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+char *__pyx_t_2;
+int __pyx_t_3;
+PyObject *__pyx_t_4 = NULL;
+Py_ssize_t __pyx_t_5;
+int __pyx_t_6;
+char __pyx_t_7;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+if (unlikely(__pyx_v_info == NULL)) {
+PyErr_SetString(PyExc_BufferError, "PyObject_GetBuffer: view==NULL argument is obsolete");
+return -1;
+}
+__Pyx_RefNannySetupContext("__getbuffer__", 0);
+__pyx_v_info->obj = Py_None; __Pyx_INCREF(Py_None);
+__Pyx_GIVEREF(__pyx_v_info->obj);
+/* "array.pxd":109
+*             # In particular strided access is always provided regardless
+*             # of flags
+*             item_count = Py_SIZE(self)             # <<<<<<<<<<<<<<
+*
+*             info.suboffsets = NULL
+*/
+__pyx_t_1 = PyInt_FromSsize_t(Py_SIZE(((PyObject *)__pyx_v_self))); if (unlikely(!__pyx_t_1)) __PYX_ERR(3, 109, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_v_item_count = __pyx_t_1;
+__pyx_t_1 = 0;
+/* "array.pxd":111
+*             item_count = Py_SIZE(self)
+*
+*             info.suboffsets = NULL             # <<<<<<<<<<<<<<
+*             info.buf = self.data.as_chars
+*             info.readonly = 0
+*/
+__pyx_v_info->suboffsets = NULL;
+/* "array.pxd":112
+*
+*             info.suboffsets = NULL
+*             info.buf = self.data.as_chars             # <<<<<<<<<<<<<<
+*             info.readonly = 0
+*             info.ndim = 1
+*/
+__pyx_t_2 = __pyx_v_self->data.as_chars;
+__pyx_v_info->buf = __pyx_t_2;
+/* "array.pxd":113
+*             info.suboffsets = NULL
+*             info.buf = self.data.as_chars
+*             info.readonly = 0             # <<<<<<<<<<<<<<
+*             info.ndim = 1
+*             info.itemsize = self.ob_descr.itemsize   # e.g. sizeof(float)
+*/
+__pyx_v_info->readonly = 0;
+/* "array.pxd":114
+*             info.buf = self.data.as_chars
+*             info.readonly = 0
+*             info.ndim = 1             # <<<<<<<<<<<<<<
+*             info.itemsize = self.ob_descr.itemsize   # e.g. sizeof(float)
+*             info.len = info.itemsize * item_count
+*/
+__pyx_v_info->ndim = 1;
+/* "array.pxd":115
+*             info.readonly = 0
+*             info.ndim = 1
+*             info.itemsize = self.ob_descr.itemsize   # e.g. sizeof(float)             # <<<<<<<<<<<<<<
+*             info.len = info.itemsize * item_count
+*
+*/
+__pyx_t_3 = __pyx_v_self->ob_descr->itemsize;
+__pyx_v_info->itemsize = __pyx_t_3;
+/* "array.pxd":116
+*             info.ndim = 1
+*             info.itemsize = self.ob_descr.itemsize   # e.g. sizeof(float)
+*             info.len = info.itemsize * item_count             # <<<<<<<<<<<<<<
+*
+*             info.shape = <Py_ssize_t*> PyObject_Malloc(sizeof(Py_ssize_t) + 2)
+*/
+__pyx_t_1 = PyInt_FromSsize_t(__pyx_v_info->itemsize); if (unlikely(!__pyx_t_1)) __PYX_ERR(3, 116, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_t_4 = PyNumber_Multiply(__pyx_t_1, __pyx_v_item_count); if (unlikely(!__pyx_t_4)) __PYX_ERR(3, 116, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_4);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__pyx_t_5 = __Pyx_PyIndex_AsSsize_t(__pyx_t_4); if (unlikely((__pyx_t_5 == (Py_ssize_t)-1) && PyErr_Occurred())) __PYX_ERR(3, 116, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+__pyx_v_info->len = __pyx_t_5;
+/* "array.pxd":118
+*             info.len = info.itemsize * item_count
+*
+*             info.shape = <Py_ssize_t*> PyObject_Malloc(sizeof(Py_ssize_t) + 2)             # <<<<<<<<<<<<<<
+*             if not info.shape:
+*                 raise MemoryError()
+*/
+__pyx_v_info->shape = ((Py_ssize_t *)PyObject_Malloc(((sizeof(Py_ssize_t)) + 2)));
+/* "array.pxd":119
+*
+*             info.shape = <Py_ssize_t*> PyObject_Malloc(sizeof(Py_ssize_t) + 2)
+*             if not info.shape:             # <<<<<<<<<<<<<<
+*                 raise MemoryError()
+*             info.shape[0] = item_count      # constant regardless of resizing
+*/
+__pyx_t_6 = (!(__pyx_v_info->shape != 0));
+if (unlikely(__pyx_t_6)) {
+/* "array.pxd":120
+*             info.shape = <Py_ssize_t*> PyObject_Malloc(sizeof(Py_ssize_t) + 2)
+*             if not info.shape:
+*                 raise MemoryError()             # <<<<<<<<<<<<<<
+*             info.shape[0] = item_count      # constant regardless of resizing
+*             info.strides = &info.itemsize
+*/
+PyErr_NoMemory(); __PYX_ERR(3, 120, __pyx_L1_error)
+/* "array.pxd":119
+*
+*             info.shape = <Py_ssize_t*> PyObject_Malloc(sizeof(Py_ssize_t) + 2)
+*             if not info.shape:             # <<<<<<<<<<<<<<
+*                 raise MemoryError()
+*             info.shape[0] = item_count      # constant regardless of resizing
+*/
+}
+/* "array.pxd":121
+*             if not info.shape:
+*                 raise MemoryError()
+*             info.shape[0] = item_count      # constant regardless of resizing             # <<<<<<<<<<<<<<
+*             info.strides = &info.itemsize
+*
+*/
+__pyx_t_5 = __Pyx_PyIndex_AsSsize_t(__pyx_v_item_count); if (unlikely((__pyx_t_5 == (Py_ssize_t)-1) && PyErr_Occurred())) __PYX_ERR(3, 121, __pyx_L1_error)
+(__pyx_v_info->shape[0]) = __pyx_t_5;
+/* "array.pxd":122
+*                 raise MemoryError()
+*             info.shape[0] = item_count      # constant regardless of resizing
+*             info.strides = &info.itemsize             # <<<<<<<<<<<<<<
+*
+*             info.format = <char*> (info.shape + 1)
+*/
+__pyx_v_info->strides = (&__pyx_v_info->itemsize);
+/* "array.pxd":124
+*             info.strides = &info.itemsize
+*
+*             info.format = <char*> (info.shape + 1)             # <<<<<<<<<<<<<<
+*             info.format[0] = self.ob_descr.typecode
+*             info.format[1] = 0
+*/
+__pyx_v_info->format = ((char *)(__pyx_v_info->shape + 1));
+/* "array.pxd":125
+*
+*             info.format = <char*> (info.shape + 1)
+*             info.format[0] = self.ob_descr.typecode             # <<<<<<<<<<<<<<
+*             info.format[1] = 0
+*             info.obj = self
+*/
+__pyx_t_7 = __pyx_v_self->ob_descr->typecode;
+(__pyx_v_info->format[0]) = __pyx_t_7;
+/* "array.pxd":126
+*             info.format = <char*> (info.shape + 1)
+*             info.format[0] = self.ob_descr.typecode
+*             info.format[1] = 0             # <<<<<<<<<<<<<<
+*             info.obj = self
+*
+*/
+(__pyx_v_info->format[1]) = 0;
+/* "array.pxd":127
+*             info.format[0] = self.ob_descr.typecode
+*             info.format[1] = 0
+*             info.obj = self             # <<<<<<<<<<<<<<
+*
+*         def __releasebuffer__(self, Py_buffer* info):
+*/
+__Pyx_INCREF((PyObject *)__pyx_v_self);
+__Pyx_GIVEREF((PyObject *)__pyx_v_self);
+__Pyx_GOTREF(__pyx_v_info->obj);
+__Pyx_DECREF(__pyx_v_info->obj);
+__pyx_v_info->obj = ((PyObject *)__pyx_v_self);
+/* "array.pxd":104
+*             __data_union data
+*
+*         def __getbuffer__(self, Py_buffer* info, int flags):             # <<<<<<<<<<<<<<
+*             # This implementation of getbuffer is geared towards Cython
+*             # requirements, and does not yet fulfill the PEP.
+*/
+/* function exit code */
+__pyx_r = 0;
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_XDECREF(__pyx_t_4);
+__Pyx_AddTraceback("cpython.array.array.__getbuffer__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = -1;
+if (__pyx_v_info->obj != NULL) {
+__Pyx_GOTREF(__pyx_v_info->obj);
+__Pyx_DECREF(__pyx_v_info->obj); __pyx_v_info->obj = 0;
+}
+goto __pyx_L2;
+__pyx_L0:;
+if (__pyx_v_info->obj == Py_None) {
+__Pyx_GOTREF(__pyx_v_info->obj);
+__Pyx_DECREF(__pyx_v_info->obj); __pyx_v_info->obj = 0;
+}
+__pyx_L2:;
+__Pyx_XDECREF(__pyx_v_item_count);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "array.pxd":129
+*             info.obj = self
+*
+*         def __releasebuffer__(self, Py_buffer* info):             # <<<<<<<<<<<<<<
+*             PyObject_Free(info.shape)
+*
+*/
+/* Python wrapper */
+CYTHON_UNUSED static void __pyx_pw_7cpython_5array_5array_3__releasebuffer__(PyObject *__pyx_v_self, Py_buffer *__pyx_v_info); /*proto*/
+CYTHON_UNUSED static void __pyx_pw_7cpython_5array_5array_3__releasebuffer__(PyObject *__pyx_v_self, Py_buffer *__pyx_v_info) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__releasebuffer__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_pf_7cpython_5array_5array_2__releasebuffer__(((arrayobject *)__pyx_v_self), ((Py_buffer *)__pyx_v_info));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+}
+static void __pyx_pf_7cpython_5array_5array_2__releasebuffer__(CYTHON_UNUSED arrayobject *__pyx_v_self, Py_buffer *__pyx_v_info) {
+/* "array.pxd":130
+*
+*         def __releasebuffer__(self, Py_buffer* info):
+*             PyObject_Free(info.shape)             # <<<<<<<<<<<<<<
+*
+*     array newarrayobject(PyTypeObject* type, Py_ssize_t size, arraydescr *descr)
+*/
+PyObject_Free(__pyx_v_info->shape);
+/* "array.pxd":129
+*             info.obj = self
+*
+*         def __releasebuffer__(self, Py_buffer* info):             # <<<<<<<<<<<<<<
+*             PyObject_Free(info.shape)
+*
+*/
+/* function exit code */
+}
+/* "array.pxd":141
+*
+*
+* cdef inline array clone(array template, Py_ssize_t length, bint zero):             # <<<<<<<<<<<<<<
+*     """ fast creation of a new array, given a template array.
+*     type will be same as template.
+*/
+static CYTHON_INLINE arrayobject *__pyx_f_7cpython_5array_clone(arrayobject *__pyx_v_template, Py_ssize_t __pyx_v_length, int __pyx_v_zero) {
+arrayobject *__pyx_v_op = 0;
+arrayobject *__pyx_r = NULL;
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_t_2;
+int __pyx_t_3;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("clone", 1);
+/* "array.pxd":145
+*     type will be same as template.
+*     if zero is true, new array will be initialized with zeroes."""
+*     cdef array op = newarrayobject(Py_TYPE(template), length, template.ob_descr)             # <<<<<<<<<<<<<<
+*     if zero and op is not None:
+*         memset(op.data.as_chars, 0, length * op.ob_descr.itemsize)
+*/
+__pyx_t_1 = ((PyObject *)newarrayobject(Py_TYPE(((PyObject *)__pyx_v_template)), __pyx_v_length, __pyx_v_template->ob_descr)); if (unlikely(!__pyx_t_1)) __PYX_ERR(3, 145, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_v_op = ((arrayobject *)__pyx_t_1);
+__pyx_t_1 = 0;
+/* "array.pxd":146
+*     if zero is true, new array will be initialized with zeroes."""
+*     cdef array op = newarrayobject(Py_TYPE(template), length, template.ob_descr)
+*     if zero and op is not None:             # <<<<<<<<<<<<<<
+*         memset(op.data.as_chars, 0, length * op.ob_descr.itemsize)
+*     return op
+*/
+if (__pyx_v_zero) {
+} else {
+__pyx_t_2 = __pyx_v_zero;
+goto __pyx_L4_bool_binop_done;
+}
+__pyx_t_3 = (((PyObject *)__pyx_v_op) != Py_None);
+__pyx_t_2 = __pyx_t_3;
+__pyx_L4_bool_binop_done:;
+if (__pyx_t_2) {
+/* "array.pxd":147
+*     cdef array op = newarrayobject(Py_TYPE(template), length, template.ob_descr)
+*     if zero and op is not None:
+*         memset(op.data.as_chars, 0, length * op.ob_descr.itemsize)             # <<<<<<<<<<<<<<
+*     return op
+*
+*/
+(void)(memset(__pyx_v_op->data.as_chars, 0, (__pyx_v_length * __pyx_v_op->ob_descr->itemsize)));
+/* "array.pxd":146
+*     if zero is true, new array will be initialized with zeroes."""
+*     cdef array op = newarrayobject(Py_TYPE(template), length, template.ob_descr)
+*     if zero and op is not None:             # <<<<<<<<<<<<<<
+*         memset(op.data.as_chars, 0, length * op.ob_descr.itemsize)
+*     return op
+*/
+}
+/* "array.pxd":148
+*     if zero and op is not None:
+*         memset(op.data.as_chars, 0, length * op.ob_descr.itemsize)
+*     return op             # <<<<<<<<<<<<<<
+*
+* cdef inline array copy(array self):
+*/
+__Pyx_XDECREF((PyObject *)__pyx_r);
+__Pyx_INCREF((PyObject *)__pyx_v_op);
+__pyx_r = __pyx_v_op;
+goto __pyx_L0;
+/* "array.pxd":141
+*
+*
+* cdef inline array clone(array template, Py_ssize_t length, bint zero):             # <<<<<<<<<<<<<<
+*     """ fast creation of a new array, given a template array.
+*     type will be same as template.
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_AddTraceback("cpython.array.clone", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = 0;
+__pyx_L0:;
+__Pyx_XDECREF((PyObject *)__pyx_v_op);
+__Pyx_XGIVEREF((PyObject *)__pyx_r);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "array.pxd":150
+*     return op
+*
+* cdef inline array copy(array self):             # <<<<<<<<<<<<<<
+*     """ make a copy of an array. """
+*     cdef array op = newarrayobject(Py_TYPE(self), Py_SIZE(self), self.ob_descr)
+*/
+static CYTHON_INLINE arrayobject *__pyx_f_7cpython_5array_copy(arrayobject *__pyx_v_self) {
+arrayobject *__pyx_v_op = 0;
+arrayobject *__pyx_r = NULL;
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("copy", 1);
+/* "array.pxd":152
+* cdef inline array copy(array self):
+*     """ make a copy of an array. """
+*     cdef array op = newarrayobject(Py_TYPE(self), Py_SIZE(self), self.ob_descr)             # <<<<<<<<<<<<<<
+*     memcpy(op.data.as_chars, self.data.as_chars, Py_SIZE(op) * op.ob_descr.itemsize)
+*     return op
+*/
+__pyx_t_1 = ((PyObject *)newarrayobject(Py_TYPE(((PyObject *)__pyx_v_self)), Py_SIZE(((PyObject *)__pyx_v_self)), __pyx_v_self->ob_descr)); if (unlikely(!__pyx_t_1)) __PYX_ERR(3, 152, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_v_op = ((arrayobject *)__pyx_t_1);
+__pyx_t_1 = 0;
+/* "array.pxd":153
+*     """ make a copy of an array. """
+*     cdef array op = newarrayobject(Py_TYPE(self), Py_SIZE(self), self.ob_descr)
+*     memcpy(op.data.as_chars, self.data.as_chars, Py_SIZE(op) * op.ob_descr.itemsize)             # <<<<<<<<<<<<<<
+*     return op
+*
+*/
+(void)(memcpy(__pyx_v_op->data.as_chars, __pyx_v_self->data.as_chars, (Py_SIZE(((PyObject *)__pyx_v_op)) * __pyx_v_op->ob_descr->itemsize)));
+/* "array.pxd":154
+*     cdef array op = newarrayobject(Py_TYPE(self), Py_SIZE(self), self.ob_descr)
+*     memcpy(op.data.as_chars, self.data.as_chars, Py_SIZE(op) * op.ob_descr.itemsize)
+*     return op             # <<<<<<<<<<<<<<
+*
+* cdef inline int extend_buffer(array self, char* stuff, Py_ssize_t n) except -1:
+*/
+__Pyx_XDECREF((PyObject *)__pyx_r);
+__Pyx_INCREF((PyObject *)__pyx_v_op);
+__pyx_r = __pyx_v_op;
+goto __pyx_L0;
+/* "array.pxd":150
+*     return op
+*
+* cdef inline array copy(array self):             # <<<<<<<<<<<<<<
+*     """ make a copy of an array. """
+*     cdef array op = newarrayobject(Py_TYPE(self), Py_SIZE(self), self.ob_descr)
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_AddTraceback("cpython.array.copy", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = 0;
+__pyx_L0:;
+__Pyx_XDECREF((PyObject *)__pyx_v_op);
+__Pyx_XGIVEREF((PyObject *)__pyx_r);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "array.pxd":156
+*     return op
+*
+* cdef inline int extend_buffer(array self, char* stuff, Py_ssize_t n) except -1:             # <<<<<<<<<<<<<<
+*     """ efficient appending of new stuff of same type
+*     (e.g. of same array type)
+*/
+static CYTHON_INLINE int __pyx_f_7cpython_5array_extend_buffer(arrayobject *__pyx_v_self, char *__pyx_v_stuff, Py_ssize_t __pyx_v_n) {
+Py_ssize_t __pyx_v_itemsize;
+Py_ssize_t __pyx_v_origsize;
+int __pyx_r;
+int __pyx_t_1;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+/* "array.pxd":160
+*     (e.g. of same array type)
+*     n: number of elements (not number of bytes!) """
+*     cdef Py_ssize_t itemsize = self.ob_descr.itemsize             # <<<<<<<<<<<<<<
+*     cdef Py_ssize_t origsize = Py_SIZE(self)
+*     resize_smart(self, origsize + n)
+*/
+__pyx_t_1 = __pyx_v_self->ob_descr->itemsize;
+__pyx_v_itemsize = __pyx_t_1;
+/* "array.pxd":161
+*     n: number of elements (not number of bytes!) """
+*     cdef Py_ssize_t itemsize = self.ob_descr.itemsize
+*     cdef Py_ssize_t origsize = Py_SIZE(self)             # <<<<<<<<<<<<<<
+*     resize_smart(self, origsize + n)
+*     memcpy(self.data.as_chars + origsize * itemsize, stuff, n * itemsize)
+*/
+__pyx_v_origsize = Py_SIZE(((PyObject *)__pyx_v_self));
+/* "array.pxd":162
+*     cdef Py_ssize_t itemsize = self.ob_descr.itemsize
+*     cdef Py_ssize_t origsize = Py_SIZE(self)
+*     resize_smart(self, origsize + n)             # <<<<<<<<<<<<<<
+*     memcpy(self.data.as_chars + origsize * itemsize, stuff, n * itemsize)
+*     return 0
+*/
+__pyx_t_1 = resize_smart(__pyx_v_self, (__pyx_v_origsize + __pyx_v_n)); if (unlikely(__pyx_t_1 == ((int)-1))) __PYX_ERR(3, 162, __pyx_L1_error)
+/* "array.pxd":163
+*     cdef Py_ssize_t origsize = Py_SIZE(self)
+*     resize_smart(self, origsize + n)
+*     memcpy(self.data.as_chars + origsize * itemsize, stuff, n * itemsize)             # <<<<<<<<<<<<<<
+*     return 0
+*
+*/
+(void)(memcpy((__pyx_v_self->data.as_chars + (__pyx_v_origsize * __pyx_v_itemsize)), __pyx_v_stuff, (__pyx_v_n * __pyx_v_itemsize)));
+/* "array.pxd":164
+*     resize_smart(self, origsize + n)
+*     memcpy(self.data.as_chars + origsize * itemsize, stuff, n * itemsize)
+*     return 0             # <<<<<<<<<<<<<<
+*
+* cdef inline int extend(array self, array other) except -1:
+*/
+__pyx_r = 0;
+goto __pyx_L0;
+/* "array.pxd":156
+*     return op
+*
+* cdef inline int extend_buffer(array self, char* stuff, Py_ssize_t n) except -1:             # <<<<<<<<<<<<<<
+*     """ efficient appending of new stuff of same type
+*     (e.g. of same array type)
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("cpython.array.extend_buffer", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = -1;
+__pyx_L0:;
+return __pyx_r;
+}
+/* "array.pxd":166
+*     return 0
+*
+* cdef inline int extend(array self, array other) except -1:             # <<<<<<<<<<<<<<
+*     """ extend array with data from another array; types must match. """
+*     if self.ob_descr.typecode != other.ob_descr.typecode:
+*/
+static CYTHON_INLINE int __pyx_f_7cpython_5array_extend(arrayobject *__pyx_v_self, arrayobject *__pyx_v_other) {
+int __pyx_r;
+int __pyx_t_1;
+int __pyx_t_2;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+/* "array.pxd":168
+* cdef inline int extend(array self, array other) except -1:
+*     """ extend array with data from another array; types must match. """
+*     if self.ob_descr.typecode != other.ob_descr.typecode:             # <<<<<<<<<<<<<<
+*         PyErr_BadArgument()
+*     return extend_buffer(self, other.data.as_chars, Py_SIZE(other))
+*/
+__pyx_t_1 = (__pyx_v_self->ob_descr->typecode != __pyx_v_other->ob_descr->typecode);
+if (__pyx_t_1) {
+/* "array.pxd":169
+*     """ extend array with data from another array; types must match. """
+*     if self.ob_descr.typecode != other.ob_descr.typecode:
+*         PyErr_BadArgument()             # <<<<<<<<<<<<<<
+*     return extend_buffer(self, other.data.as_chars, Py_SIZE(other))
+*
+*/
+__pyx_t_2 = PyErr_BadArgument(); if (unlikely(__pyx_t_2 == ((int)0))) __PYX_ERR(3, 169, __pyx_L1_error)
+/* "array.pxd":168
+* cdef inline int extend(array self, array other) except -1:
+*     """ extend array with data from another array; types must match. """
+*     if self.ob_descr.typecode != other.ob_descr.typecode:             # <<<<<<<<<<<<<<
+*         PyErr_BadArgument()
+*     return extend_buffer(self, other.data.as_chars, Py_SIZE(other))
+*/
+}
+/* "array.pxd":170
+*     if self.ob_descr.typecode != other.ob_descr.typecode:
+*         PyErr_BadArgument()
+*     return extend_buffer(self, other.data.as_chars, Py_SIZE(other))             # <<<<<<<<<<<<<<
+*
+* cdef inline void zero(array self) noexcept:
+*/
+__pyx_t_2 = __pyx_f_7cpython_5array_extend_buffer(__pyx_v_self, __pyx_v_other->data.as_chars, Py_SIZE(((PyObject *)__pyx_v_other))); if (unlikely(__pyx_t_2 == ((int)-1))) __PYX_ERR(3, 170, __pyx_L1_error)
+__pyx_r = __pyx_t_2;
+goto __pyx_L0;
+/* "array.pxd":166
+*     return 0
+*
+* cdef inline int extend(array self, array other) except -1:             # <<<<<<<<<<<<<<
+*     """ extend array with data from another array; types must match. """
+*     if self.ob_descr.typecode != other.ob_descr.typecode:
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("cpython.array.extend", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = -1;
+__pyx_L0:;
+return __pyx_r;
+}
+/* "array.pxd":172
+*     return extend_buffer(self, other.data.as_chars, Py_SIZE(other))
+*
+* cdef inline void zero(array self) noexcept:             # <<<<<<<<<<<<<<
+*     """ set all elements of array to zero. """
+*     memset(self.data.as_chars, 0, Py_SIZE(self) * self.ob_descr.itemsize)
+*/
+static CYTHON_INLINE void __pyx_f_7cpython_5array_zero(arrayobject *__pyx_v_self) {
+/* "array.pxd":174
+* cdef inline void zero(array self) noexcept:
+*     """ set all elements of array to zero. """
+*     memset(self.data.as_chars, 0, Py_SIZE(self) * self.ob_descr.itemsize)             # <<<<<<<<<<<<<<
+*/
+(void)(memset(__pyx_v_self->data.as_chars, 0, (Py_SIZE(((PyObject *)__pyx_v_self)) * __pyx_v_self->ob_descr->itemsize)));
+/* "array.pxd":172
+*     return extend_buffer(self, other.data.as_chars, Py_SIZE(other))
+*
+* cdef inline void zero(array self) noexcept:             # <<<<<<<<<<<<<<
+*     """ set all elements of array to zero. """
+*     memset(self.data.as_chars, 0, Py_SIZE(self) * self.ob_descr.itemsize)
+*/
+/* function exit code */
+}
+/* "pysam/libcfaidx.pyx":74
+*
+* cdef class FastqProxy
+* cdef makeFastqProxy(kseq_t * src):             # <<<<<<<<<<<<<<
+*     '''enter src into AlignedRead.'''
+*     cdef FastqProxy dest = FastqProxy.__new__(FastqProxy)
+*/
+static PyObject *__pyx_f_5pysam_9libcfaidx_makeFastqProxy(kseq_t *__pyx_v_src) {
+struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_dest = 0;
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("makeFastqProxy", 1);
+__Pyx_TraceCall("makeFastqProxy", __pyx_f[0], 74, 0, __PYX_ERR(0, 74, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":76
+* cdef makeFastqProxy(kseq_t * src):
+*     '''enter src into AlignedRead.'''
+*     cdef FastqProxy dest = FastqProxy.__new__(FastqProxy)             # <<<<<<<<<<<<<<
+*     dest._delegate = src
+*     return dest
+*/
+__pyx_t_1 = ((PyObject *)__pyx_tp_new_5pysam_9libcfaidx_FastqProxy(((PyTypeObject *)__pyx_ptype_5pysam_9libcfaidx_FastqProxy), __pyx_empty_tuple, NULL)); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 76, __pyx_L1_error)
+__Pyx_GOTREF((PyObject *)__pyx_t_1);
+__pyx_v_dest = ((struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *)__pyx_t_1);
+__pyx_t_1 = 0;
+/* "pysam/libcfaidx.pyx":77
+*     '''enter src into AlignedRead.'''
+*     cdef FastqProxy dest = FastqProxy.__new__(FastqProxy)
+*     dest._delegate = src             # <<<<<<<<<<<<<<
+*     return dest
+*
+*/
+__pyx_v_dest->_delegate = __pyx_v_src;
+/* "pysam/libcfaidx.pyx":78
+*     cdef FastqProxy dest = FastqProxy.__new__(FastqProxy)
+*     dest._delegate = src
+*     return dest             # <<<<<<<<<<<<<<
+*
+* ## TODO:
+*/
+__Pyx_XDECREF(__pyx_r);
+__Pyx_INCREF((PyObject *)__pyx_v_dest);
+__pyx_r = ((PyObject *)__pyx_v_dest);
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":74
+*
+* cdef class FastqProxy
+* cdef makeFastqProxy(kseq_t * src):             # <<<<<<<<<<<<<<
+*     '''enter src into AlignedRead.'''
+*     cdef FastqProxy dest = FastqProxy.__new__(FastqProxy)
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_AddTraceback("pysam.libcfaidx.makeFastqProxy", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = 0;
+__pyx_L0:;
+__Pyx_XDECREF((PyObject *)__pyx_v_dest);
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":115
+*     """
+*
+*     def __cinit__(self, *args, **kwargs):             # <<<<<<<<<<<<<<
+*         self.fastafile = NULL
+*         self._filename = None
+*/
+/* Python wrapper */
+static int __pyx_pw_5pysam_9libcfaidx_9FastaFile_1__cinit__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
+static int __pyx_pw_5pysam_9libcfaidx_9FastaFile_1__cinit__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds) {
+PyObject *__pyx_v_args = 0;
+PyObject *__pyx_v_kwargs = 0;
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+int __pyx_r;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__cinit__ (wrapper)", 0);
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return -1;
+#endif
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+if (unlikely(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__cinit__", 1))) return -1;
+if (unlikely(__pyx_kwds)) {
+__pyx_v_kwargs = __Pyx_KwargsAsDict_VARARGS(__pyx_kwds, __pyx_kwvalues);
+if (unlikely(!__pyx_v_kwargs)) return -1;
+__Pyx_GOTREF(__pyx_v_kwargs);
+} else {
+__pyx_v_kwargs = PyDict_New();
+if (unlikely(!__pyx_v_kwargs)) return -1;
+__Pyx_GOTREF(__pyx_v_kwargs);
+}
+__Pyx_INCREF(__pyx_args);
+__pyx_v_args = __pyx_args;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastaFile___cinit__(((struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)__pyx_v_self), __pyx_v_args, __pyx_v_kwargs);
+/* function exit code */
+__Pyx_DECREF(__pyx_v_args);
+__Pyx_DECREF(__pyx_v_kwargs);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static int __pyx_pf_5pysam_9libcfaidx_9FastaFile___cinit__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self, PyObject *__pyx_v_args, PyObject *__pyx_v_kwargs) {
+int __pyx_r;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+PyObject *__pyx_t_2 = NULL;
+PyObject *__pyx_t_3 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__cinit__", 1);
+__Pyx_TraceCall("__cinit__", __pyx_f[0], 115, 0, __PYX_ERR(0, 115, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":116
+*
+*     def __cinit__(self, *args, **kwargs):
+*         self.fastafile = NULL             # <<<<<<<<<<<<<<
+*         self._filename = None
+*         self._references = None
+*/
+__pyx_v_self->fastafile = NULL;
+/* "pysam/libcfaidx.pyx":117
+*     def __cinit__(self, *args, **kwargs):
+*         self.fastafile = NULL
+*         self._filename = None             # <<<<<<<<<<<<<<
+*         self._references = None
+*         self._lengths = None
+*/
+__Pyx_INCREF(Py_None);
+__Pyx_GIVEREF(Py_None);
+__Pyx_GOTREF(__pyx_v_self->_filename);
+__Pyx_DECREF(__pyx_v_self->_filename);
+__pyx_v_self->_filename = Py_None;
+/* "pysam/libcfaidx.pyx":118
+*         self.fastafile = NULL
+*         self._filename = None
+*         self._references = None             # <<<<<<<<<<<<<<
+*         self._lengths = None
+*         self.reference2length = None
+*/
+__Pyx_INCREF(Py_None);
+__Pyx_GIVEREF(Py_None);
+__Pyx_GOTREF(__pyx_v_self->_references);
+__Pyx_DECREF(__pyx_v_self->_references);
+__pyx_v_self->_references = Py_None;
+/* "pysam/libcfaidx.pyx":119
+*         self._filename = None
+*         self._references = None
+*         self._lengths = None             # <<<<<<<<<<<<<<
+*         self.reference2length = None
+*         self._open(*args, **kwargs)
+*/
+__Pyx_INCREF(Py_None);
+__Pyx_GIVEREF(Py_None);
+__Pyx_GOTREF(__pyx_v_self->_lengths);
+__Pyx_DECREF(__pyx_v_self->_lengths);
+__pyx_v_self->_lengths = Py_None;
+/* "pysam/libcfaidx.pyx":120
+*         self._references = None
+*         self._lengths = None
+*         self.reference2length = None             # <<<<<<<<<<<<<<
+*         self._open(*args, **kwargs)
+*
+*/
+__Pyx_INCREF(Py_None);
+__Pyx_GIVEREF(Py_None);
+__Pyx_GOTREF(__pyx_v_self->reference2length);
+__Pyx_DECREF(__pyx_v_self->reference2length);
+__pyx_v_self->reference2length = Py_None;
+/* "pysam/libcfaidx.pyx":121
+*         self._lengths = None
+*         self.reference2length = None
+*         self._open(*args, **kwargs)             # <<<<<<<<<<<<<<
+*
+*     def is_open(self):
+*/
+__pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_open); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 121, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_t_2 = PyDict_Copy(__pyx_v_kwargs); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 121, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_3 = __Pyx_PyObject_Call(__pyx_t_1, __pyx_v_args, __pyx_t_2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 121, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+/* "pysam/libcfaidx.pyx":115
+*     """
+*
+*     def __cinit__(self, *args, **kwargs):             # <<<<<<<<<<<<<<
+*         self.fastafile = NULL
+*         self._filename = None
+*/
+/* function exit code */
+__pyx_r = 0;
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_XDECREF(__pyx_t_3);
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile.__cinit__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = -1;
+__pyx_L0:;
+__Pyx_TraceReturn(Py_None, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":123
+*         self._open(*args, **kwargs)
+*
+*     def is_open(self):             # <<<<<<<<<<<<<<
+*         '''return true if samfile has been opened.'''
+*         return self.fastafile != NULL
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_3is_open(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9FastaFile_2is_open, "FastaFile.is_open(self)\nreturn true if samfile has been opened.");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_9FastaFile_3is_open = {"is_open", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastaFile_3is_open, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastaFile_2is_open};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_3is_open(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("is_open (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+if (unlikely(__pyx_nargs > 0)) {
+__Pyx_RaiseArgtupleInvalid("is_open", 1, 0, 0, __pyx_nargs); return NULL;}
+if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "is_open", 0))) return NULL;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastaFile_2is_open(((struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_2is_open(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj_)
+__Pyx_RefNannySetupContext("is_open", 1);
+__Pyx_TraceCall("is_open", __pyx_f[0], 123, 0, __PYX_ERR(0, 123, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":125
+*     def is_open(self):
+*         '''return true if samfile has been opened.'''
+*         return self.fastafile != NULL             # <<<<<<<<<<<<<<
+*
+*     def __len__(self):
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_1 = __Pyx_PyBool_FromLong((__pyx_v_self->fastafile != NULL)); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 125, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_r = __pyx_t_1;
+__pyx_t_1 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":123
+*         self._open(*args, **kwargs)
+*
+*     def is_open(self):             # <<<<<<<<<<<<<<
+*         '''return true if samfile has been opened.'''
+*         return self.fastafile != NULL
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile.is_open", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":127
+*         return self.fastafile != NULL
+*
+*     def __len__(self):             # <<<<<<<<<<<<<<
+*         if self.fastafile == NULL:
+*             raise ValueError("calling len() on closed file")
+*/
+/* Python wrapper */
+static Py_ssize_t __pyx_pw_5pysam_9libcfaidx_9FastaFile_5__len__(PyObject *__pyx_v_self); /*proto*/
+static Py_ssize_t __pyx_pw_5pysam_9libcfaidx_9FastaFile_5__len__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+Py_ssize_t __pyx_r;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__len__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastaFile_4__len__(((struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static Py_ssize_t __pyx_pf_5pysam_9libcfaidx_9FastaFile_4__len__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self) {
+Py_ssize_t __pyx_r;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_t_1;
+PyObject *__pyx_t_2 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__len__", 1);
+__Pyx_TraceCall("__len__", __pyx_f[0], 127, 0, __PYX_ERR(0, 127, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":128
+*
+*     def __len__(self):
+*         if self.fastafile == NULL:             # <<<<<<<<<<<<<<
+*             raise ValueError("calling len() on closed file")
+*
+*/
+__pyx_t_1 = (__pyx_v_self->fastafile == NULL);
+if (unlikely(__pyx_t_1)) {
+/* "pysam/libcfaidx.pyx":129
+*     def __len__(self):
+*         if self.fastafile == NULL:
+*             raise ValueError("calling len() on closed file")             # <<<<<<<<<<<<<<
+*
+*         return faidx_nseq(self.fastafile)
+*/
+__pyx_t_2 = __Pyx_PyObject_Call(__pyx_builtin_ValueError, __pyx_tuple__2, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 129, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_Raise(__pyx_t_2, 0, 0, 0);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__PYX_ERR(0, 129, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":128
+*
+*     def __len__(self):
+*         if self.fastafile == NULL:             # <<<<<<<<<<<<<<
+*             raise ValueError("calling len() on closed file")
+*
+*/
+}
+/* "pysam/libcfaidx.pyx":131
+*             raise ValueError("calling len() on closed file")
+*
+*         return faidx_nseq(self.fastafile)             # <<<<<<<<<<<<<<
+*
+*     def _open(self, filename, filepath_index=None, filepath_index_compressed=None):
+*/
+__pyx_r = faidx_nseq(__pyx_v_self->fastafile);
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":127
+*         return self.fastafile != NULL
+*
+*     def __len__(self):             # <<<<<<<<<<<<<<
+*         if self.fastafile == NULL:
+*             raise ValueError("calling len() on closed file")
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile.__len__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = -1;
+__pyx_L0:;
+__Pyx_TraceReturn(Py_None, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":133
+*         return faidx_nseq(self.fastafile)
+*
+*     def _open(self, filename, filepath_index=None, filepath_index_compressed=None):             # <<<<<<<<<<<<<<
+*         '''open an indexed fasta file.
+*
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_7_open(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9FastaFile_6_open, "FastaFile._open(self, filename, filepath_index=None, filepath_index_compressed=None)\nopen an indexed fasta file.\n\n        This method expects an indexed fasta file.\n        ");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_9FastaFile_7_open = {"_open", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastaFile_7_open, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastaFile_6_open};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_7_open(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+PyObject *__pyx_v_filename = 0;
+PyObject *__pyx_v_filepath_index = 0;
+PyObject *__pyx_v_filepath_index_compressed = 0;
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject* values[3] = {0,0,0};
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("_open (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+{
+PyObject **__pyx_pyargnames[] = {&__pyx_n_s_filename,&__pyx_n_s_filepath_index,&__pyx_n_s_filepath_index_compressed,0};
+values[1] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)Py_None));
+values[2] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)Py_None));
+if (__pyx_kwds) {
+Py_ssize_t kw_args;
+switch (__pyx_nargs) {
+case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
+CYTHON_FALLTHROUGH;
+case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
+CYTHON_FALLTHROUGH;
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
+switch (__pyx_nargs) {
+case  0:
+if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_filename)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 133, __pyx_L3_error)
+else goto __pyx_L5_argtuple_error;
+CYTHON_FALLTHROUGH;
+case  1:
+if (kw_args > 0) {
+PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_filepath_index);
+if (value) { values[1] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 133, __pyx_L3_error)
+}
+CYTHON_FALLTHROUGH;
+case  2:
+if (kw_args > 0) {
+PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_filepath_index_compressed);
+if (value) { values[2] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 133, __pyx_L3_error)
+}
+}
+if (unlikely(kw_args > 0)) {
+const Py_ssize_t kwd_pos_args = __pyx_nargs;
+if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "_open") < 0)) __PYX_ERR(0, 133, __pyx_L3_error)
+}
+} else {
+switch (__pyx_nargs) {
+case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
+CYTHON_FALLTHROUGH;
+case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
+CYTHON_FALLTHROUGH;
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+break;
+default: goto __pyx_L5_argtuple_error;
+}
+}
+__pyx_v_filename = values[0];
+__pyx_v_filepath_index = values[1];
+__pyx_v_filepath_index_compressed = values[2];
+}
+goto __pyx_L6_skip;
+__pyx_L5_argtuple_error:;
+__Pyx_RaiseArgtupleInvalid("_open", 0, 1, 3, __pyx_nargs); __PYX_ERR(0, 133, __pyx_L3_error)
+__pyx_L6_skip:;
+goto __pyx_L4_argument_unpacking_done;
+__pyx_L3_error:;
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile._open", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__Pyx_RefNannyFinishContext();
+return NULL;
+__pyx_L4_argument_unpacking_done:;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastaFile_6_open(((struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)__pyx_v_self), __pyx_v_filename, __pyx_v_filepath_index, __pyx_v_filepath_index_compressed);
+/* function exit code */
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_6_open(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self, PyObject *__pyx_v_filename, PyObject *__pyx_v_filepath_index, PyObject *__pyx_v_filepath_index_compressed) {
+char *__pyx_v_cfilename;
+char *__pyx_v_cindexname;
+char *__pyx_v_cindexname_compressed;
+CYTHON_UNUSED PyObject *__pyx_v_bindex_filename = NULL;
+CYTHON_UNUSED PyObject *__pyx_v_bindex_filename_compressed = NULL;
+int __pyx_v_nreferences;
+int __pyx_v_x;
+char const *__pyx_v_s;
+PyObject *__pyx_v_ss = NULL;
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_t_1;
+PyObject *__pyx_t_2 = NULL;
+PyObject *__pyx_t_3 = NULL;
+PyObject *__pyx_t_4 = NULL;
+unsigned int __pyx_t_5;
+char *__pyx_t_6;
+int __pyx_t_7;
+int __pyx_t_8;
+int __pyx_t_9;
+int __pyx_t_10;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__3)
+__Pyx_RefNannySetupContext("_open", 1);
+__Pyx_TraceCall("_open", __pyx_f[0], 133, 0, __PYX_ERR(0, 133, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":140
+*
+*         # close a previously opened file
+*         if self.fastafile != NULL:             # <<<<<<<<<<<<<<
+*             self.close()
+*
+*/
+__pyx_t_1 = (__pyx_v_self->fastafile != NULL);
+if (__pyx_t_1) {
+/* "pysam/libcfaidx.pyx":141
+*         # close a previously opened file
+*         if self.fastafile != NULL:
+*             self.close()             # <<<<<<<<<<<<<<
+*
+*         self._filename = encode_filename(filename)
+*/
+__pyx_t_3 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_close); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 141, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__pyx_t_4 = NULL;
+__pyx_t_5 = 0;
+#if CYTHON_UNPACK_METHODS
+if (likely(PyMethod_Check(__pyx_t_3))) {
+__pyx_t_4 = PyMethod_GET_SELF(__pyx_t_3);
+if (likely(__pyx_t_4)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
+__Pyx_INCREF(__pyx_t_4);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_3, function);
+__pyx_t_5 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[2] = {__pyx_t_4, NULL};
+__pyx_t_2 = __Pyx_PyObject_FastCall(__pyx_t_3, __pyx_callargs+1-__pyx_t_5, 0+__pyx_t_5);
+__Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
+if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 141, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+}
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":140
+*
+*         # close a previously opened file
+*         if self.fastafile != NULL:             # <<<<<<<<<<<<<<
+*             self.close()
+*
+*/
+}
+/* "pysam/libcfaidx.pyx":143
+*             self.close()
+*
+*         self._filename = encode_filename(filename)             # <<<<<<<<<<<<<<
+*         cdef char *cfilename = self._filename
+*         cdef char *cindexname = NULL
+*/
+__pyx_t_2 = __pyx_f_5pysam_9libcutils_encode_filename(__pyx_v_filename); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 143, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_GIVEREF(__pyx_t_2);
+__Pyx_GOTREF(__pyx_v_self->_filename);
+__Pyx_DECREF(__pyx_v_self->_filename);
+__pyx_v_self->_filename = __pyx_t_2;
+__pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":144
+*
+*         self._filename = encode_filename(filename)
+*         cdef char *cfilename = self._filename             # <<<<<<<<<<<<<<
+*         cdef char *cindexname = NULL
+*         cdef char *cindexname_compressed = NULL
+*/
+__pyx_t_6 = __Pyx_PyObject_AsWritableString(__pyx_v_self->_filename); if (unlikely((!__pyx_t_6) && PyErr_Occurred())) __PYX_ERR(0, 144, __pyx_L1_error)
+__pyx_v_cfilename = __pyx_t_6;
+/* "pysam/libcfaidx.pyx":145
+*         self._filename = encode_filename(filename)
+*         cdef char *cfilename = self._filename
+*         cdef char *cindexname = NULL             # <<<<<<<<<<<<<<
+*         cdef char *cindexname_compressed = NULL
+*         self.is_remote = hisremote(cfilename)
+*/
+__pyx_v_cindexname = NULL;
+/* "pysam/libcfaidx.pyx":146
+*         cdef char *cfilename = self._filename
+*         cdef char *cindexname = NULL
+*         cdef char *cindexname_compressed = NULL             # <<<<<<<<<<<<<<
+*         self.is_remote = hisremote(cfilename)
+*
+*/
+__pyx_v_cindexname_compressed = NULL;
+/* "pysam/libcfaidx.pyx":147
+*         cdef char *cindexname = NULL
+*         cdef char *cindexname_compressed = NULL
+*         self.is_remote = hisremote(cfilename)             # <<<<<<<<<<<<<<
+*
+*         # open file for reading
+*/
+__pyx_v_self->is_remote = hisremote(__pyx_v_cfilename);
+/* "pysam/libcfaidx.pyx":150
+*
+*         # open file for reading
+*         if (self._filename != b"-"             # <<<<<<<<<<<<<<
+*             and not self.is_remote
+*             and not os.path.exists(filename)):
+*/
+__pyx_t_7 = (__Pyx_PyBytes_Equals(__pyx_v_self->_filename, __pyx_kp_b__4, Py_NE)); if (unlikely((__pyx_t_7 < 0))) __PYX_ERR(0, 150, __pyx_L1_error)
+if (__pyx_t_7) {
+} else {
+__pyx_t_1 = __pyx_t_7;
+goto __pyx_L5_bool_binop_done;
+}
+/* "pysam/libcfaidx.pyx":151
+*         # open file for reading
+*         if (self._filename != b"-"
+*             and not self.is_remote             # <<<<<<<<<<<<<<
+*             and not os.path.exists(filename)):
+*             raise IOError("file `%s` not found" % filename)
+*/
+__pyx_t_7 = (!__pyx_v_self->is_remote);
+if (__pyx_t_7) {
+} else {
+__pyx_t_1 = __pyx_t_7;
+goto __pyx_L5_bool_binop_done;
+}
+/* "pysam/libcfaidx.pyx":152
+*         if (self._filename != b"-"
+*             and not self.is_remote
+*             and not os.path.exists(filename)):             # <<<<<<<<<<<<<<
+*             raise IOError("file `%s` not found" % filename)
+*
+*/
+__Pyx_GetModuleGlobalName(__pyx_t_3, __pyx_n_s_os); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 152, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__pyx_t_4 = __Pyx_PyObject_GetAttrStr(__pyx_t_3, __pyx_n_s_path); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 152, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_4);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__pyx_t_3 = __Pyx_PyObject_GetAttrStr(__pyx_t_4, __pyx_n_s_exists); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 152, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+__pyx_t_4 = NULL;
+__pyx_t_5 = 0;
+#if CYTHON_UNPACK_METHODS
+if (likely(PyMethod_Check(__pyx_t_3))) {
+__pyx_t_4 = PyMethod_GET_SELF(__pyx_t_3);
+if (likely(__pyx_t_4)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
+__Pyx_INCREF(__pyx_t_4);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_3, function);
+__pyx_t_5 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[2] = {__pyx_t_4, __pyx_v_filename};
+__pyx_t_2 = __Pyx_PyObject_FastCall(__pyx_t_3, __pyx_callargs+1-__pyx_t_5, 1+__pyx_t_5);
+__Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
+if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 152, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+}
+__pyx_t_7 = __Pyx_PyObject_IsTrue(__pyx_t_2); if (unlikely((__pyx_t_7 < 0))) __PYX_ERR(0, 152, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__pyx_t_8 = (!__pyx_t_7);
+__pyx_t_1 = __pyx_t_8;
+__pyx_L5_bool_binop_done:;
+/* "pysam/libcfaidx.pyx":150
+*
+*         # open file for reading
+*         if (self._filename != b"-"             # <<<<<<<<<<<<<<
+*             and not self.is_remote
+*             and not os.path.exists(filename)):
+*/
+if (unlikely(__pyx_t_1)) {
+/* "pysam/libcfaidx.pyx":153
+*             and not self.is_remote
+*             and not os.path.exists(filename)):
+*             raise IOError("file `%s` not found" % filename)             # <<<<<<<<<<<<<<
+*
+*         # 3 modes to open:
+*/
+__pyx_t_2 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_file_s_not_found, __pyx_v_filename); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 153, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_3 = __Pyx_PyObject_CallOneArg(__pyx_builtin_IOError, __pyx_t_2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 153, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__Pyx_Raise(__pyx_t_3, 0, 0, 0);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__PYX_ERR(0, 153, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":150
+*
+*         # open file for reading
+*         if (self._filename != b"-"             # <<<<<<<<<<<<<<
+*             and not self.is_remote
+*             and not os.path.exists(filename)):
+*/
+}
+/* "pysam/libcfaidx.pyx":159
+*         # uncompressed fa: fai_load3 with filename and index_fai
+*         # uncompressed fa: fai_load with default index name
+*         if filepath_index:             # <<<<<<<<<<<<<<
+*             # when opening, set flags to 0 - do not automatically
+*             # build index if it does not exist.
+*/
+__pyx_t_1 = __Pyx_PyObject_IsTrue(__pyx_v_filepath_index); if (unlikely((__pyx_t_1 < 0))) __PYX_ERR(0, 159, __pyx_L1_error)
+if (__pyx_t_1) {
+/* "pysam/libcfaidx.pyx":163
+*             # build index if it does not exist.
+*
+*             if not os.path.exists(filepath_index):             # <<<<<<<<<<<<<<
+*                 raise IOError("filename {} does not exist".format(filepath_index))
+*             cindexname = bindex_filename = encode_filename(filepath_index)
+*/
+__Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_os); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 163, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_4 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_path); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 163, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_4);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_4, __pyx_n_s_exists); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 163, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+__pyx_t_4 = NULL;
+__pyx_t_5 = 0;
+#if CYTHON_UNPACK_METHODS
+if (likely(PyMethod_Check(__pyx_t_2))) {
+__pyx_t_4 = PyMethod_GET_SELF(__pyx_t_2);
+if (likely(__pyx_t_4)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
+__Pyx_INCREF(__pyx_t_4);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_2, function);
+__pyx_t_5 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[2] = {__pyx_t_4, __pyx_v_filepath_index};
+__pyx_t_3 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_5, 1+__pyx_t_5);
+__Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
+if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 163, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+}
+__pyx_t_1 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely((__pyx_t_1 < 0))) __PYX_ERR(0, 163, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__pyx_t_8 = (!__pyx_t_1);
+if (unlikely(__pyx_t_8)) {
+/* "pysam/libcfaidx.pyx":164
+*
+*             if not os.path.exists(filepath_index):
+*                 raise IOError("filename {} does not exist".format(filepath_index))             # <<<<<<<<<<<<<<
+*             cindexname = bindex_filename = encode_filename(filepath_index)
+*
+*/
+__pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_kp_u_filename_does_not_exist, __pyx_n_s_format); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 164, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_4 = NULL;
+__pyx_t_5 = 0;
+#if CYTHON_UNPACK_METHODS
+if (likely(PyMethod_Check(__pyx_t_2))) {
+__pyx_t_4 = PyMethod_GET_SELF(__pyx_t_2);
+if (likely(__pyx_t_4)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
+__Pyx_INCREF(__pyx_t_4);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_2, function);
+__pyx_t_5 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[2] = {__pyx_t_4, __pyx_v_filepath_index};
+__pyx_t_3 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_5, 1+__pyx_t_5);
+__Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
+if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 164, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+}
+__pyx_t_2 = __Pyx_PyObject_CallOneArg(__pyx_builtin_IOError, __pyx_t_3); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 164, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__Pyx_Raise(__pyx_t_2, 0, 0, 0);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__PYX_ERR(0, 164, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":163
+*             # build index if it does not exist.
+*
+*             if not os.path.exists(filepath_index):             # <<<<<<<<<<<<<<
+*                 raise IOError("filename {} does not exist".format(filepath_index))
+*             cindexname = bindex_filename = encode_filename(filepath_index)
+*/
+}
+/* "pysam/libcfaidx.pyx":165
+*             if not os.path.exists(filepath_index):
+*                 raise IOError("filename {} does not exist".format(filepath_index))
+*             cindexname = bindex_filename = encode_filename(filepath_index)             # <<<<<<<<<<<<<<
+*
+*             if filepath_index_compressed:
+*/
+__pyx_t_2 = __pyx_f_5pysam_9libcutils_encode_filename(__pyx_v_filepath_index); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 165, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (unlikely(__pyx_t_2 == Py_None)) {
+PyErr_SetString(PyExc_TypeError, "expected bytes, NoneType found");
+__PYX_ERR(0, 165, __pyx_L1_error)
+}
+__pyx_t_6 = __Pyx_PyBytes_AsWritableString(__pyx_t_2); if (unlikely((!__pyx_t_6) && PyErr_Occurred())) __PYX_ERR(0, 165, __pyx_L1_error)
+__pyx_v_cindexname = __pyx_t_6;
+__Pyx_INCREF(__pyx_t_2);
+__pyx_v_bindex_filename = ((PyObject*)__pyx_t_2);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":167
+*             cindexname = bindex_filename = encode_filename(filepath_index)
+*
+*             if filepath_index_compressed:             # <<<<<<<<<<<<<<
+*                 if not os.path.exists(filepath_index_compressed):
+*                     raise IOError("filename {} does not exist".format(filepath_index_compressed))
+*/
+__pyx_t_8 = __Pyx_PyObject_IsTrue(__pyx_v_filepath_index_compressed); if (unlikely((__pyx_t_8 < 0))) __PYX_ERR(0, 167, __pyx_L1_error)
+if (__pyx_t_8) {
+/* "pysam/libcfaidx.pyx":168
+*
+*             if filepath_index_compressed:
+*                 if not os.path.exists(filepath_index_compressed):             # <<<<<<<<<<<<<<
+*                     raise IOError("filename {} does not exist".format(filepath_index_compressed))
+*                 cindexname_compressed = bindex_filename_compressed = encode_filename(filepath_index_compressed)
+*/
+__Pyx_GetModuleGlobalName(__pyx_t_3, __pyx_n_s_os); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 168, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__pyx_t_4 = __Pyx_PyObject_GetAttrStr(__pyx_t_3, __pyx_n_s_path); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 168, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_4);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__pyx_t_3 = __Pyx_PyObject_GetAttrStr(__pyx_t_4, __pyx_n_s_exists); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 168, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+__pyx_t_4 = NULL;
+__pyx_t_5 = 0;
+#if CYTHON_UNPACK_METHODS
+if (likely(PyMethod_Check(__pyx_t_3))) {
+__pyx_t_4 = PyMethod_GET_SELF(__pyx_t_3);
+if (likely(__pyx_t_4)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
+__Pyx_INCREF(__pyx_t_4);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_3, function);
+__pyx_t_5 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[2] = {__pyx_t_4, __pyx_v_filepath_index_compressed};
+__pyx_t_2 = __Pyx_PyObject_FastCall(__pyx_t_3, __pyx_callargs+1-__pyx_t_5, 1+__pyx_t_5);
+__Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
+if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 168, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+}
+__pyx_t_8 = __Pyx_PyObject_IsTrue(__pyx_t_2); if (unlikely((__pyx_t_8 < 0))) __PYX_ERR(0, 168, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__pyx_t_1 = (!__pyx_t_8);
+if (unlikely(__pyx_t_1)) {
+/* "pysam/libcfaidx.pyx":169
+*             if filepath_index_compressed:
+*                 if not os.path.exists(filepath_index_compressed):
+*                     raise IOError("filename {} does not exist".format(filepath_index_compressed))             # <<<<<<<<<<<<<<
+*                 cindexname_compressed = bindex_filename_compressed = encode_filename(filepath_index_compressed)
+*                 with nogil:
+*/
+__pyx_t_3 = __Pyx_PyObject_GetAttrStr(__pyx_kp_u_filename_does_not_exist, __pyx_n_s_format); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 169, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__pyx_t_4 = NULL;
+__pyx_t_5 = 0;
+#if CYTHON_UNPACK_METHODS
+if (likely(PyMethod_Check(__pyx_t_3))) {
+__pyx_t_4 = PyMethod_GET_SELF(__pyx_t_3);
+if (likely(__pyx_t_4)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
+__Pyx_INCREF(__pyx_t_4);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_3, function);
+__pyx_t_5 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[2] = {__pyx_t_4, __pyx_v_filepath_index_compressed};
+__pyx_t_2 = __Pyx_PyObject_FastCall(__pyx_t_3, __pyx_callargs+1-__pyx_t_5, 1+__pyx_t_5);
+__Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
+if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 169, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+}
+__pyx_t_3 = __Pyx_PyObject_CallOneArg(__pyx_builtin_IOError, __pyx_t_2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 169, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__Pyx_Raise(__pyx_t_3, 0, 0, 0);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__PYX_ERR(0, 169, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":168
+*
+*             if filepath_index_compressed:
+*                 if not os.path.exists(filepath_index_compressed):             # <<<<<<<<<<<<<<
+*                     raise IOError("filename {} does not exist".format(filepath_index_compressed))
+*                 cindexname_compressed = bindex_filename_compressed = encode_filename(filepath_index_compressed)
+*/
+}
+/* "pysam/libcfaidx.pyx":170
+*                 if not os.path.exists(filepath_index_compressed):
+*                     raise IOError("filename {} does not exist".format(filepath_index_compressed))
+*                 cindexname_compressed = bindex_filename_compressed = encode_filename(filepath_index_compressed)             # <<<<<<<<<<<<<<
+*                 with nogil:
+*                     self.fastafile = fai_load3(cfilename, cindexname, cindexname_compressed, 0)
+*/
+__pyx_t_3 = __pyx_f_5pysam_9libcutils_encode_filename(__pyx_v_filepath_index_compressed); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 170, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+if (unlikely(__pyx_t_3 == Py_None)) {
+PyErr_SetString(PyExc_TypeError, "expected bytes, NoneType found");
+__PYX_ERR(0, 170, __pyx_L1_error)
+}
+__pyx_t_6 = __Pyx_PyBytes_AsWritableString(__pyx_t_3); if (unlikely((!__pyx_t_6) && PyErr_Occurred())) __PYX_ERR(0, 170, __pyx_L1_error)
+__pyx_v_cindexname_compressed = __pyx_t_6;
+__Pyx_INCREF(__pyx_t_3);
+__pyx_v_bindex_filename_compressed = ((PyObject*)__pyx_t_3);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+/* "pysam/libcfaidx.pyx":171
+*                     raise IOError("filename {} does not exist".format(filepath_index_compressed))
+*                 cindexname_compressed = bindex_filename_compressed = encode_filename(filepath_index_compressed)
+*                 with nogil:             # <<<<<<<<<<<<<<
+*                     self.fastafile = fai_load3(cfilename, cindexname, cindexname_compressed, 0)
+*             else:
+*/
+{
+#ifdef WITH_THREAD
+PyThreadState *_save;
+_save = NULL;
+Py_UNBLOCK_THREADS
+__Pyx_FastGIL_Remember();
+#endif
+/*try:*/ {
+/* "pysam/libcfaidx.pyx":172
+*                 cindexname_compressed = bindex_filename_compressed = encode_filename(filepath_index_compressed)
+*                 with nogil:
+*                     self.fastafile = fai_load3(cfilename, cindexname, cindexname_compressed, 0)             # <<<<<<<<<<<<<<
+*             else:
+*                 with nogil:
+*/
+__pyx_v_self->fastafile = fai_load3(__pyx_v_cfilename, __pyx_v_cindexname, __pyx_v_cindexname_compressed, 0);
+}
+/* "pysam/libcfaidx.pyx":171
+*                     raise IOError("filename {} does not exist".format(filepath_index_compressed))
+*                 cindexname_compressed = bindex_filename_compressed = encode_filename(filepath_index_compressed)
+*                 with nogil:             # <<<<<<<<<<<<<<
+*                     self.fastafile = fai_load3(cfilename, cindexname, cindexname_compressed, 0)
+*             else:
+*/
+/*finally:*/ {
+/*normal exit:*/{
+#ifdef WITH_THREAD
+__Pyx_FastGIL_Forget();
+Py_BLOCK_THREADS
+#endif
+goto __pyx_L14;
+}
+__pyx_L14:;
+}
+}
+/* "pysam/libcfaidx.pyx":167
+*             cindexname = bindex_filename = encode_filename(filepath_index)
+*
+*             if filepath_index_compressed:             # <<<<<<<<<<<<<<
+*                 if not os.path.exists(filepath_index_compressed):
+*                     raise IOError("filename {} does not exist".format(filepath_index_compressed))
+*/
+goto __pyx_L10;
+}
+/* "pysam/libcfaidx.pyx":174
+*                     self.fastafile = fai_load3(cfilename, cindexname, cindexname_compressed, 0)
+*             else:
+*                 with nogil:             # <<<<<<<<<<<<<<
+*                     self.fastafile = fai_load3(cfilename, cindexname, NULL, 0)
+*         else:
+*/
+/*else*/ {
+{
+#ifdef WITH_THREAD
+PyThreadState *_save;
+_save = NULL;
+Py_UNBLOCK_THREADS
+__Pyx_FastGIL_Remember();
+#endif
+/*try:*/ {
+/* "pysam/libcfaidx.pyx":175
+*             else:
+*                 with nogil:
+*                     self.fastafile = fai_load3(cfilename, cindexname, NULL, 0)             # <<<<<<<<<<<<<<
+*         else:
+*             with nogil:
+*/
+__pyx_v_self->fastafile = fai_load3(__pyx_v_cfilename, __pyx_v_cindexname, NULL, 0);
+}
+/* "pysam/libcfaidx.pyx":174
+*                     self.fastafile = fai_load3(cfilename, cindexname, cindexname_compressed, 0)
+*             else:
+*                 with nogil:             # <<<<<<<<<<<<<<
+*                     self.fastafile = fai_load3(cfilename, cindexname, NULL, 0)
+*         else:
+*/
+/*finally:*/ {
+/*normal exit:*/{
+#ifdef WITH_THREAD
+__Pyx_FastGIL_Forget();
+Py_BLOCK_THREADS
+#endif
+goto __pyx_L17;
+}
+__pyx_L17:;
+}
+}
+}
+__pyx_L10:;
+/* "pysam/libcfaidx.pyx":159
+*         # uncompressed fa: fai_load3 with filename and index_fai
+*         # uncompressed fa: fai_load with default index name
+*         if filepath_index:             # <<<<<<<<<<<<<<
+*             # when opening, set flags to 0 - do not automatically
+*             # build index if it does not exist.
+*/
+goto __pyx_L8;
+}
+/* "pysam/libcfaidx.pyx":177
+*                     self.fastafile = fai_load3(cfilename, cindexname, NULL, 0)
+*         else:
+*             with nogil:             # <<<<<<<<<<<<<<
+*                 self.fastafile = fai_load(cfilename)
+*
+*/
+/*else*/ {
+{
+#ifdef WITH_THREAD
+PyThreadState *_save;
+_save = NULL;
+Py_UNBLOCK_THREADS
+__Pyx_FastGIL_Remember();
+#endif
+/*try:*/ {
+/* "pysam/libcfaidx.pyx":178
+*         else:
+*             with nogil:
+*                 self.fastafile = fai_load(cfilename)             # <<<<<<<<<<<<<<
+*
+*         if self.fastafile == NULL:
+*/
+__pyx_v_self->fastafile = fai_load(__pyx_v_cfilename);
+}
+/* "pysam/libcfaidx.pyx":177
+*                     self.fastafile = fai_load3(cfilename, cindexname, NULL, 0)
+*         else:
+*             with nogil:             # <<<<<<<<<<<<<<
+*                 self.fastafile = fai_load(cfilename)
+*
+*/
+/*finally:*/ {
+/*normal exit:*/{
+#ifdef WITH_THREAD
+__Pyx_FastGIL_Forget();
+Py_BLOCK_THREADS
+#endif
+goto __pyx_L20;
+}
+__pyx_L20:;
+}
+}
+}
+__pyx_L8:;
+/* "pysam/libcfaidx.pyx":180
+*                 self.fastafile = fai_load(cfilename)
+*
+*         if self.fastafile == NULL:             # <<<<<<<<<<<<<<
+*             raise IOError("error when opening file `%s`" % filename)
+*
+*/
+__pyx_t_1 = (__pyx_v_self->fastafile == NULL);
+if (unlikely(__pyx_t_1)) {
+/* "pysam/libcfaidx.pyx":181
+*
+*         if self.fastafile == NULL:
+*             raise IOError("error when opening file `%s`" % filename)             # <<<<<<<<<<<<<<
+*
+*         cdef int nreferences = faidx_nseq(self.fastafile)
+*/
+__pyx_t_3 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_error_when_opening_file_s, __pyx_v_filename); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 181, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__pyx_t_2 = __Pyx_PyObject_CallOneArg(__pyx_builtin_IOError, __pyx_t_3); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 181, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__Pyx_Raise(__pyx_t_2, 0, 0, 0);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__PYX_ERR(0, 181, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":180
+*                 self.fastafile = fai_load(cfilename)
+*
+*         if self.fastafile == NULL:             # <<<<<<<<<<<<<<
+*             raise IOError("error when opening file `%s`" % filename)
+*
+*/
+}
+/* "pysam/libcfaidx.pyx":183
+*             raise IOError("error when opening file `%s`" % filename)
+*
+*         cdef int nreferences = faidx_nseq(self.fastafile)             # <<<<<<<<<<<<<<
+*         cdef int x
+*         cdef const char * s
+*/
+__pyx_v_nreferences = faidx_nseq(__pyx_v_self->fastafile);
+/* "pysam/libcfaidx.pyx":186
+*         cdef int x
+*         cdef const char * s
+*         self._references = []             # <<<<<<<<<<<<<<
+*         self._lengths = []
+*         for x from 0 <= x < nreferences:
+*/
+__pyx_t_2 = PyList_New(0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 186, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_GIVEREF(__pyx_t_2);
+__Pyx_GOTREF(__pyx_v_self->_references);
+__Pyx_DECREF(__pyx_v_self->_references);
+__pyx_v_self->_references = __pyx_t_2;
+__pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":187
+*         cdef const char * s
+*         self._references = []
+*         self._lengths = []             # <<<<<<<<<<<<<<
+*         for x from 0 <= x < nreferences:
+*             s = faidx_iseq(self.fastafile, x)
+*/
+__pyx_t_2 = PyList_New(0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 187, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_GIVEREF(__pyx_t_2);
+__Pyx_GOTREF(__pyx_v_self->_lengths);
+__Pyx_DECREF(__pyx_v_self->_lengths);
+__pyx_v_self->_lengths = __pyx_t_2;
+__pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":188
+*         self._references = []
+*         self._lengths = []
+*         for x from 0 <= x < nreferences:             # <<<<<<<<<<<<<<
+*             s = faidx_iseq(self.fastafile, x)
+*             ss = force_str(s)
+*/
+__pyx_t_9 = __pyx_v_nreferences;
+for (__pyx_v_x = 0; __pyx_v_x < __pyx_t_9; __pyx_v_x++) {
+/* "pysam/libcfaidx.pyx":189
+*         self._lengths = []
+*         for x from 0 <= x < nreferences:
+*             s = faidx_iseq(self.fastafile, x)             # <<<<<<<<<<<<<<
+*             ss = force_str(s)
+*             self._references.append(ss)
+*/
+__pyx_v_s = faidx_iseq(__pyx_v_self->fastafile, __pyx_v_x);
+/* "pysam/libcfaidx.pyx":190
+*         for x from 0 <= x < nreferences:
+*             s = faidx_iseq(self.fastafile, x)
+*             ss = force_str(s)             # <<<<<<<<<<<<<<
+*             self._references.append(ss)
+*             self._lengths.append(faidx_seq_len(self.fastafile, s))
+*/
+__pyx_t_2 = __Pyx_PyBytes_FromString(__pyx_v_s); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 190, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_3 = __pyx_f_5pysam_9libcutils_force_str(__pyx_t_2, NULL); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 190, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__Pyx_XDECREF_SET(__pyx_v_ss, __pyx_t_3);
+__pyx_t_3 = 0;
+/* "pysam/libcfaidx.pyx":191
+*             s = faidx_iseq(self.fastafile, x)
+*             ss = force_str(s)
+*             self._references.append(ss)             # <<<<<<<<<<<<<<
+*             self._lengths.append(faidx_seq_len(self.fastafile, s))
+*         self.reference2length = dict(zip(self._references, self._lengths))
+*/
+__pyx_t_10 = __Pyx_PyObject_Append(__pyx_v_self->_references, __pyx_v_ss); if (unlikely(__pyx_t_10 == ((int)-1))) __PYX_ERR(0, 191, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":192
+*             ss = force_str(s)
+*             self._references.append(ss)
+*             self._lengths.append(faidx_seq_len(self.fastafile, s))             # <<<<<<<<<<<<<<
+*         self.reference2length = dict(zip(self._references, self._lengths))
+*
+*/
+__pyx_t_3 = __Pyx_PyInt_From_int(faidx_seq_len(__pyx_v_self->fastafile, __pyx_v_s)); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 192, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__pyx_t_10 = __Pyx_PyObject_Append(__pyx_v_self->_lengths, __pyx_t_3); if (unlikely(__pyx_t_10 == ((int)-1))) __PYX_ERR(0, 192, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+}
+/* "pysam/libcfaidx.pyx":193
+*             self._references.append(ss)
+*             self._lengths.append(faidx_seq_len(self.fastafile, s))
+*         self.reference2length = dict(zip(self._references, self._lengths))             # <<<<<<<<<<<<<<
+*
+*     def close(self):
+*/
+__pyx_t_3 = PyTuple_New(2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 193, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_INCREF(__pyx_v_self->_references);
+__Pyx_GIVEREF(__pyx_v_self->_references);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_v_self->_references)) __PYX_ERR(0, 193, __pyx_L1_error);
+__Pyx_INCREF(__pyx_v_self->_lengths);
+__Pyx_GIVEREF(__pyx_v_self->_lengths);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_v_self->_lengths)) __PYX_ERR(0, 193, __pyx_L1_error);
+__pyx_t_2 = __Pyx_PyObject_Call(__pyx_builtin_zip, __pyx_t_3, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 193, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__pyx_t_3 = __Pyx_PyObject_CallOneArg(((PyObject *)(&PyDict_Type)), __pyx_t_2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 193, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__Pyx_GIVEREF(__pyx_t_3);
+__Pyx_GOTREF(__pyx_v_self->reference2length);
+__Pyx_DECREF(__pyx_v_self->reference2length);
+__pyx_v_self->reference2length = __pyx_t_3;
+__pyx_t_3 = 0;
+/* "pysam/libcfaidx.pyx":133
+*         return faidx_nseq(self.fastafile)
+*
+*     def _open(self, filename, filepath_index=None, filepath_index_compressed=None):             # <<<<<<<<<<<<<<
+*         '''open an indexed fasta file.
+*
+*/
+/* function exit code */
+__pyx_r = Py_None; __Pyx_INCREF(Py_None);
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_XDECREF(__pyx_t_3);
+__Pyx_XDECREF(__pyx_t_4);
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile._open", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XDECREF(__pyx_v_bindex_filename);
+__Pyx_XDECREF(__pyx_v_bindex_filename_compressed);
+__Pyx_XDECREF(__pyx_v_ss);
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":195
+*         self.reference2length = dict(zip(self._references, self._lengths))
+*
+*     def close(self):             # <<<<<<<<<<<<<<
+*         """close the file."""
+*         if self.fastafile != NULL:
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_9close(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9FastaFile_8close, "FastaFile.close(self)\nclose the file.");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_9FastaFile_9close = {"close", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastaFile_9close, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastaFile_8close};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_9close(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("close (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+if (unlikely(__pyx_nargs > 0)) {
+__Pyx_RaiseArgtupleInvalid("close", 1, 0, 0, __pyx_nargs); return NULL;}
+if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "close", 0))) return NULL;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastaFile_8close(((struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_8close(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_t_1;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__5)
+__Pyx_RefNannySetupContext("close", 1);
+__Pyx_TraceCall("close", __pyx_f[0], 195, 0, __PYX_ERR(0, 195, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":197
+*     def close(self):
+*         """close the file."""
+*         if self.fastafile != NULL:             # <<<<<<<<<<<<<<
+*             fai_destroy(self.fastafile)
+*             self.fastafile = NULL
+*/
+__pyx_t_1 = (__pyx_v_self->fastafile != NULL);
+if (__pyx_t_1) {
+/* "pysam/libcfaidx.pyx":198
+*         """close the file."""
+*         if self.fastafile != NULL:
+*             fai_destroy(self.fastafile)             # <<<<<<<<<<<<<<
+*             self.fastafile = NULL
+*
+*/
+fai_destroy(__pyx_v_self->fastafile);
+/* "pysam/libcfaidx.pyx":199
+*         if self.fastafile != NULL:
+*             fai_destroy(self.fastafile)
+*             self.fastafile = NULL             # <<<<<<<<<<<<<<
+*
+*     def __dealloc__(self):
+*/
+__pyx_v_self->fastafile = NULL;
+/* "pysam/libcfaidx.pyx":197
+*     def close(self):
+*         """close the file."""
+*         if self.fastafile != NULL:             # <<<<<<<<<<<<<<
+*             fai_destroy(self.fastafile)
+*             self.fastafile = NULL
+*/
+}
+/* "pysam/libcfaidx.pyx":195
+*         self.reference2length = dict(zip(self._references, self._lengths))
+*
+*     def close(self):             # <<<<<<<<<<<<<<
+*         """close the file."""
+*         if self.fastafile != NULL:
+*/
+/* function exit code */
+__pyx_r = Py_None; __Pyx_INCREF(Py_None);
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile.close", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":201
+*             self.fastafile = NULL
+*
+*     def __dealloc__(self):             # <<<<<<<<<<<<<<
+*         if self.fastafile != NULL:
+*             fai_destroy(self.fastafile)
+*/
+/* Python wrapper */
+static void __pyx_pw_5pysam_9libcfaidx_9FastaFile_11__dealloc__(PyObject *__pyx_v_self); /*proto*/
+static void __pyx_pw_5pysam_9libcfaidx_9FastaFile_11__dealloc__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__dealloc__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_pf_5pysam_9libcfaidx_9FastaFile_10__dealloc__(((struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+}
+static void __pyx_pf_5pysam_9libcfaidx_9FastaFile_10__dealloc__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self) {
+__Pyx_TraceDeclarations
+int __pyx_t_1;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceCall("__dealloc__", __pyx_f[0], 201, 0, __PYX_ERR(0, 201, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":202
+*
+*     def __dealloc__(self):
+*         if self.fastafile != NULL:             # <<<<<<<<<<<<<<
+*             fai_destroy(self.fastafile)
+*             self.fastafile = NULL
+*/
+__pyx_t_1 = (__pyx_v_self->fastafile != NULL);
+if (__pyx_t_1) {
+/* "pysam/libcfaidx.pyx":203
+*     def __dealloc__(self):
+*         if self.fastafile != NULL:
+*             fai_destroy(self.fastafile)             # <<<<<<<<<<<<<<
+*             self.fastafile = NULL
+*
+*/
+fai_destroy(__pyx_v_self->fastafile);
+/* "pysam/libcfaidx.pyx":204
+*         if self.fastafile != NULL:
+*             fai_destroy(self.fastafile)
+*             self.fastafile = NULL             # <<<<<<<<<<<<<<
+*
+*     # context manager interface
+*/
+__pyx_v_self->fastafile = NULL;
+/* "pysam/libcfaidx.pyx":202
+*
+*     def __dealloc__(self):
+*         if self.fastafile != NULL:             # <<<<<<<<<<<<<<
+*             fai_destroy(self.fastafile)
+*             self.fastafile = NULL
+*/
+}
+/* "pysam/libcfaidx.pyx":201
+*             self.fastafile = NULL
+*
+*     def __dealloc__(self):             # <<<<<<<<<<<<<<
+*         if self.fastafile != NULL:
+*             fai_destroy(self.fastafile)
+*/
+/* function exit code */
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_WriteUnraisable("pysam.libcfaidx.FastaFile.__dealloc__", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
+__pyx_L0:;
+__Pyx_TraceReturn(Py_None, 0);
+}
+/* "pysam/libcfaidx.pyx":207
+*
+*     # context manager interface
+*     def __enter__(self):             # <<<<<<<<<<<<<<
+*         return self
+*
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_13__enter__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9FastaFile_12__enter__, "FastaFile.__enter__(self)");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_9FastaFile_13__enter__ = {"__enter__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastaFile_13__enter__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastaFile_12__enter__};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_13__enter__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__enter__ (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+if (unlikely(__pyx_nargs > 0)) {
+__Pyx_RaiseArgtupleInvalid("__enter__", 1, 0, 0, __pyx_nargs); return NULL;}
+if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__enter__", 0))) return NULL;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastaFile_12__enter__(((struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_12__enter__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__6)
+__Pyx_RefNannySetupContext("__enter__", 1);
+__Pyx_TraceCall("__enter__", __pyx_f[0], 207, 0, __PYX_ERR(0, 207, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":208
+*     # context manager interface
+*     def __enter__(self):
+*         return self             # <<<<<<<<<<<<<<
+*
+*     def __exit__(self, exc_type, exc_value, traceback):
+*/
+__Pyx_XDECREF(__pyx_r);
+__Pyx_INCREF((PyObject *)__pyx_v_self);
+__pyx_r = ((PyObject *)__pyx_v_self);
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":207
+*
+*     # context manager interface
+*     def __enter__(self):             # <<<<<<<<<<<<<<
+*         return self
+*
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile.__enter__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":210
+*         return self
+*
+*     def __exit__(self, exc_type, exc_value, traceback):             # <<<<<<<<<<<<<<
+*         self.close()
+*         return False
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_15__exit__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9FastaFile_14__exit__, "FastaFile.__exit__(self, exc_type, exc_value, traceback)");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_9FastaFile_15__exit__ = {"__exit__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastaFile_15__exit__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastaFile_14__exit__};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_15__exit__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+CYTHON_UNUSED PyObject *__pyx_v_exc_type = 0;
+CYTHON_UNUSED PyObject *__pyx_v_exc_value = 0;
+CYTHON_UNUSED PyObject *__pyx_v_traceback = 0;
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject* values[3] = {0,0,0};
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__exit__ (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+{
+PyObject **__pyx_pyargnames[] = {&__pyx_n_s_exc_type,&__pyx_n_s_exc_value,&__pyx_n_s_traceback,0};
+if (__pyx_kwds) {
+Py_ssize_t kw_args;
+switch (__pyx_nargs) {
+case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
+CYTHON_FALLTHROUGH;
+case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
+CYTHON_FALLTHROUGH;
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
+switch (__pyx_nargs) {
+case  0:
+if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_exc_type)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 210, __pyx_L3_error)
+else goto __pyx_L5_argtuple_error;
+CYTHON_FALLTHROUGH;
+case  1:
+if (likely((values[1] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_exc_value)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[1]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 210, __pyx_L3_error)
+else {
+__Pyx_RaiseArgtupleInvalid("__exit__", 1, 3, 3, 1); __PYX_ERR(0, 210, __pyx_L3_error)
+}
+CYTHON_FALLTHROUGH;
+case  2:
+if (likely((values[2] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_traceback)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[2]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 210, __pyx_L3_error)
+else {
+__Pyx_RaiseArgtupleInvalid("__exit__", 1, 3, 3, 2); __PYX_ERR(0, 210, __pyx_L3_error)
+}
+}
+if (unlikely(kw_args > 0)) {
+const Py_ssize_t kwd_pos_args = __pyx_nargs;
+if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__exit__") < 0)) __PYX_ERR(0, 210, __pyx_L3_error)
+}
+} else if (unlikely(__pyx_nargs != 3)) {
+goto __pyx_L5_argtuple_error;
+} else {
+values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
+values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
+}
+__pyx_v_exc_type = values[0];
+__pyx_v_exc_value = values[1];
+__pyx_v_traceback = values[2];
+}
+goto __pyx_L6_skip;
+__pyx_L5_argtuple_error:;
+__Pyx_RaiseArgtupleInvalid("__exit__", 1, 3, 3, __pyx_nargs); __PYX_ERR(0, 210, __pyx_L3_error)
+__pyx_L6_skip:;
+goto __pyx_L4_argument_unpacking_done;
+__pyx_L3_error:;
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile.__exit__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__Pyx_RefNannyFinishContext();
+return NULL;
+__pyx_L4_argument_unpacking_done:;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastaFile_14__exit__(((struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)__pyx_v_self), __pyx_v_exc_type, __pyx_v_exc_value, __pyx_v_traceback);
+/* function exit code */
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_14__exit__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v_exc_type, CYTHON_UNUSED PyObject *__pyx_v_exc_value, CYTHON_UNUSED PyObject *__pyx_v_traceback) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+PyObject *__pyx_t_2 = NULL;
+PyObject *__pyx_t_3 = NULL;
+unsigned int __pyx_t_4;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__7)
+__Pyx_RefNannySetupContext("__exit__", 1);
+__Pyx_TraceCall("__exit__", __pyx_f[0], 210, 0, __PYX_ERR(0, 210, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":211
+*
+*     def __exit__(self, exc_type, exc_value, traceback):
+*         self.close()             # <<<<<<<<<<<<<<
+*         return False
+*
+*/
+__pyx_t_2 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_close); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 211, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_3 = NULL;
+__pyx_t_4 = 0;
+#if CYTHON_UNPACK_METHODS
+if (likely(PyMethod_Check(__pyx_t_2))) {
+__pyx_t_3 = PyMethod_GET_SELF(__pyx_t_2);
+if (likely(__pyx_t_3)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
+__Pyx_INCREF(__pyx_t_3);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_2, function);
+__pyx_t_4 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[2] = {__pyx_t_3, NULL};
+__pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_4, 0+__pyx_t_4);
+__Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
+if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 211, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+}
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+/* "pysam/libcfaidx.pyx":212
+*     def __exit__(self, exc_type, exc_value, traceback):
+*         self.close()
+*         return False             # <<<<<<<<<<<<<<
+*
+*     property closed:
+*/
+__Pyx_XDECREF(__pyx_r);
+__Pyx_INCREF(Py_False);
+__pyx_r = Py_False;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":210
+*         return self
+*
+*     def __exit__(self, exc_type, exc_value, traceback):             # <<<<<<<<<<<<<<
+*         self.close()
+*         return False
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_XDECREF(__pyx_t_3);
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile.__exit__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":218
+*         This is a read-only attribute; the close() method changes the value.
+*         """
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             return not self.is_open()
+*
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_6closed_1__get__(PyObject *__pyx_v_self); /*proto*/
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_6closed_1__get__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__get__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastaFile_6closed___get__(((struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_6closed___get__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+PyObject *__pyx_t_2 = NULL;
+PyObject *__pyx_t_3 = NULL;
+unsigned int __pyx_t_4;
+int __pyx_t_5;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__get__", 1);
+__Pyx_TraceCall("__get__", __pyx_f[0], 218, 0, __PYX_ERR(0, 218, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":219
+*         """
+*         def __get__(self):
+*             return not self.is_open()             # <<<<<<<<<<<<<<
+*
+*     property filename:
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_2 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_is_open); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 219, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_3 = NULL;
+__pyx_t_4 = 0;
+#if CYTHON_UNPACK_METHODS
+if (likely(PyMethod_Check(__pyx_t_2))) {
+__pyx_t_3 = PyMethod_GET_SELF(__pyx_t_2);
+if (likely(__pyx_t_3)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
+__Pyx_INCREF(__pyx_t_3);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_2, function);
+__pyx_t_4 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[2] = {__pyx_t_3, NULL};
+__pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_4, 0+__pyx_t_4);
+__Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
+if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 219, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+}
+__pyx_t_5 = __Pyx_PyObject_IsTrue(__pyx_t_1); if (unlikely((__pyx_t_5 < 0))) __PYX_ERR(0, 219, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__pyx_t_1 = __Pyx_PyBool_FromLong((!__pyx_t_5)); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 219, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_r = __pyx_t_1;
+__pyx_t_1 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":218
+*         This is a read-only attribute; the close() method changes the value.
+*         """
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             return not self.is_open()
+*
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_XDECREF(__pyx_t_3);
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile.closed.__get__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":223
+*     property filename:
+*         """filename associated with this object. This is a read-only attribute."""
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             return self._filename
+*
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_8filename_1__get__(PyObject *__pyx_v_self); /*proto*/
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_8filename_1__get__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__get__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastaFile_8filename___get__(((struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_8filename___get__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__get__", 1);
+__Pyx_TraceCall("__get__", __pyx_f[0], 223, 0, __PYX_ERR(0, 223, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":224
+*         """filename associated with this object. This is a read-only attribute."""
+*         def __get__(self):
+*             return self._filename             # <<<<<<<<<<<<<<
+*
+*     property references:
+*/
+__Pyx_XDECREF(__pyx_r);
+__Pyx_INCREF(__pyx_v_self->_filename);
+__pyx_r = __pyx_v_self->_filename;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":223
+*     property filename:
+*         """filename associated with this object. This is a read-only attribute."""
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             return self._filename
+*
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile.filename.__get__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":228
+*     property references:
+*         '''tuple with the names of :term:`reference` sequences.'''
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             return self._references
+*
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_10references_1__get__(PyObject *__pyx_v_self); /*proto*/
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_10references_1__get__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__get__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastaFile_10references___get__(((struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_10references___get__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__get__", 1);
+__Pyx_TraceCall("__get__", __pyx_f[0], 228, 0, __PYX_ERR(0, 228, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":229
+*         '''tuple with the names of :term:`reference` sequences.'''
+*         def __get__(self):
+*             return self._references             # <<<<<<<<<<<<<<
+*
+*     property nreferences:
+*/
+__Pyx_XDECREF(__pyx_r);
+__Pyx_INCREF(__pyx_v_self->_references);
+__pyx_r = __pyx_v_self->_references;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":228
+*     property references:
+*         '''tuple with the names of :term:`reference` sequences.'''
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             return self._references
+*
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile.references.__get__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":234
+*         """int with the number of :term:`reference` sequences in the file.
+*         This is a read-only attribute."""
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             return len(self._references) if self.references else None
+*
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_11nreferences_1__get__(PyObject *__pyx_v_self); /*proto*/
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_11nreferences_1__get__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__get__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastaFile_11nreferences___get__(((struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_11nreferences___get__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+PyObject *__pyx_t_2 = NULL;
+int __pyx_t_3;
+Py_ssize_t __pyx_t_4;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__get__", 1);
+__Pyx_TraceCall("__get__", __pyx_f[0], 234, 0, __PYX_ERR(0, 234, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":235
+*         This is a read-only attribute."""
+*         def __get__(self):
+*             return len(self._references) if self.references else None             # <<<<<<<<<<<<<<
+*
+*     property lengths:
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_2 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_references); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 235, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_3 = __Pyx_PyObject_IsTrue(__pyx_t_2); if (unlikely((__pyx_t_3 < 0))) __PYX_ERR(0, 235, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+if (__pyx_t_3) {
+__pyx_t_2 = __pyx_v_self->_references;
+__Pyx_INCREF(__pyx_t_2);
+__pyx_t_4 = PyObject_Length(__pyx_t_2); if (unlikely(__pyx_t_4 == ((Py_ssize_t)-1))) __PYX_ERR(0, 235, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__pyx_t_2 = PyInt_FromSsize_t(__pyx_t_4); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 235, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_1 = __pyx_t_2;
+__pyx_t_2 = 0;
+} else {
+__Pyx_INCREF(Py_None);
+__pyx_t_1 = Py_None;
+}
+__pyx_r = __pyx_t_1;
+__pyx_t_1 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":234
+*         """int with the number of :term:`reference` sequences in the file.
+*         This is a read-only attribute."""
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             return len(self._references) if self.references else None
+*
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile.nreferences.__get__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":239
+*     property lengths:
+*         """tuple with the lengths of :term:`reference` sequences."""
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             return self._lengths
+*
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_7lengths_1__get__(PyObject *__pyx_v_self); /*proto*/
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_7lengths_1__get__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__get__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastaFile_7lengths___get__(((struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_7lengths___get__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__get__", 1);
+__Pyx_TraceCall("__get__", __pyx_f[0], 239, 0, __PYX_ERR(0, 239, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":240
+*         """tuple with the lengths of :term:`reference` sequences."""
+*         def __get__(self):
+*             return self._lengths             # <<<<<<<<<<<<<<
+*
+*     def fetch(self,
+*/
+__Pyx_XDECREF(__pyx_r);
+__Pyx_INCREF(__pyx_v_self->_lengths);
+__pyx_r = __pyx_v_self->_lengths;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":239
+*     property lengths:
+*         """tuple with the lengths of :term:`reference` sequences."""
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             return self._lengths
+*
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile.lengths.__get__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":242
+*             return self._lengths
+*
+*     def fetch(self,             # <<<<<<<<<<<<<<
+*               reference=None,
+*               start=None,
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_17fetch(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9FastaFile_16fetch, "FastaFile.fetch(self, reference=None, start=None, end=None, region=None)\nfetch sequences in a :term:`region`.\n\n        A region can\n        either be specified by :term:`reference`, `start` and\n        `end`. `start` and `end` denote 0-based, half-open\n        intervals.\n\n        Alternatively, a samtools :term:`region` string can be\n        supplied.\n\n        If any of the coordinates are missing they will be replaced by the\n        minimum (`start`) or maximum (`end`) coordinate.\n\n        Note that region strings are 1-based, while `start` and `end` denote\n        an interval in python coordinates.\n        The region is specified by :term:`reference`, `start` and `end`.\n\n        Returns\n        -------\n\n        string : a string with the sequence specified by the region.\n\n        Raises\n        ------\n\n        IndexError\n            if the coordinates are out of range\n\n        ValueError\n            if the region is invalid\n\n        ");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_9FastaFile_17fetch = {"fetch", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastaFile_17fetch, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastaFile_16fetch};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_17fetch(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+PyObject *__pyx_v_reference = 0;
+PyObject *__pyx_v_start = 0;
+PyObject *__pyx_v_end = 0;
+PyObject *__pyx_v_region = 0;
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject* values[4] = {0,0,0,0};
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("fetch (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+{
+PyObject **__pyx_pyargnames[] = {&__pyx_n_s_reference,&__pyx_n_s_start,&__pyx_n_s_end,&__pyx_n_s_region,0};
+/* "pysam/libcfaidx.pyx":243
+*
+*     def fetch(self,
+*               reference=None,             # <<<<<<<<<<<<<<
+*               start=None,
+*               end=None,
+*/
+values[0] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)Py_None));
+/* "pysam/libcfaidx.pyx":244
+*     def fetch(self,
+*               reference=None,
+*               start=None,             # <<<<<<<<<<<<<<
+*               end=None,
+*               region=None):
+*/
+values[1] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)Py_None));
+/* "pysam/libcfaidx.pyx":245
+*               reference=None,
+*               start=None,
+*               end=None,             # <<<<<<<<<<<<<<
+*               region=None):
+*         """fetch sequences in a :term:`region`.
+*/
+values[2] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)Py_None));
+/* "pysam/libcfaidx.pyx":246
+*               start=None,
+*               end=None,
+*               region=None):             # <<<<<<<<<<<<<<
+*         """fetch sequences in a :term:`region`.
+*
+*/
+values[3] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)Py_None));
+if (__pyx_kwds) {
+Py_ssize_t kw_args;
+switch (__pyx_nargs) {
+case  4: values[3] = __Pyx_Arg_FASTCALL(__pyx_args, 3);
+CYTHON_FALLTHROUGH;
+case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
+CYTHON_FALLTHROUGH;
+case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
+CYTHON_FALLTHROUGH;
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
+switch (__pyx_nargs) {
+case  0:
+if (kw_args > 0) {
+PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_reference);
+if (value) { values[0] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 242, __pyx_L3_error)
+}
+CYTHON_FALLTHROUGH;
+case  1:
+if (kw_args > 0) {
+PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_start);
+if (value) { values[1] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 242, __pyx_L3_error)
+}
+CYTHON_FALLTHROUGH;
+case  2:
+if (kw_args > 0) {
+PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_end);
+if (value) { values[2] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 242, __pyx_L3_error)
+}
+CYTHON_FALLTHROUGH;
+case  3:
+if (kw_args > 0) {
+PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_region);
+if (value) { values[3] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 242, __pyx_L3_error)
+}
+}
+if (unlikely(kw_args > 0)) {
+const Py_ssize_t kwd_pos_args = __pyx_nargs;
+if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "fetch") < 0)) __PYX_ERR(0, 242, __pyx_L3_error)
+}
+} else {
+switch (__pyx_nargs) {
+case  4: values[3] = __Pyx_Arg_FASTCALL(__pyx_args, 3);
+CYTHON_FALLTHROUGH;
+case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
+CYTHON_FALLTHROUGH;
+case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
+CYTHON_FALLTHROUGH;
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+}
+__pyx_v_reference = values[0];
+__pyx_v_start = values[1];
+__pyx_v_end = values[2];
+__pyx_v_region = values[3];
+}
+goto __pyx_L6_skip;
+__pyx_L5_argtuple_error:;
+__Pyx_RaiseArgtupleInvalid("fetch", 0, 0, 4, __pyx_nargs); __PYX_ERR(0, 242, __pyx_L3_error)
+__pyx_L6_skip:;
+goto __pyx_L4_argument_unpacking_done;
+__pyx_L3_error:;
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile.fetch", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__Pyx_RefNannyFinishContext();
+return NULL;
+__pyx_L4_argument_unpacking_done:;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastaFile_16fetch(((struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)__pyx_v_self), __pyx_v_reference, __pyx_v_start, __pyx_v_end, __pyx_v_region);
+/* "pysam/libcfaidx.pyx":242
+*             return self._lengths
+*
+*     def fetch(self,             # <<<<<<<<<<<<<<
+*               reference=None,
+*               start=None,
+*/
+/* function exit code */
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_16fetch(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self, PyObject *__pyx_v_reference, PyObject *__pyx_v_start, PyObject *__pyx_v_end, PyObject *__pyx_v_region) {
+int __pyx_v_length;
+char *__pyx_v_seq;
+char *__pyx_v_ref;
+int __pyx_v_rstart;
+int __pyx_v_rend;
+PyObject *__pyx_v_contig = NULL;
+PyObject *__pyx_v_contig_b = NULL;
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+PyObject *__pyx_t_2 = NULL;
+PyObject *__pyx_t_3 = NULL;
+unsigned int __pyx_t_4;
+int __pyx_t_5;
+int __pyx_t_6;
+struct __pyx_opt_args_5pysam_9libcutils_parse_region __pyx_t_7;
+PyObject *__pyx_t_8 = NULL;
+PyObject *__pyx_t_9 = NULL;
+PyObject *(*__pyx_t_10)(PyObject *);
+int __pyx_t_11;
+int __pyx_t_12;
+char *__pyx_t_13;
+char const *__pyx_t_14;
+PyObject *__pyx_t_15 = NULL;
+PyObject *__pyx_t_16 = NULL;
+PyObject *__pyx_t_17 = NULL;
+PyObject *__pyx_t_18 = NULL;
+PyObject *__pyx_t_19 = NULL;
+PyObject *__pyx_t_20 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__8)
+__Pyx_RefNannySetupContext("fetch", 1);
+__Pyx_TraceCall("fetch", __pyx_f[0], 242, 0, __PYX_ERR(0, 242, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":280
+*         """
+*
+*         if not self.is_open():             # <<<<<<<<<<<<<<
+*             raise ValueError("I/O operation on closed file" )
+*
+*/
+__pyx_t_2 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_is_open); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 280, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_3 = NULL;
+__pyx_t_4 = 0;
+#if CYTHON_UNPACK_METHODS
+if (likely(PyMethod_Check(__pyx_t_2))) {
+__pyx_t_3 = PyMethod_GET_SELF(__pyx_t_2);
+if (likely(__pyx_t_3)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
+__Pyx_INCREF(__pyx_t_3);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_2, function);
+__pyx_t_4 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[2] = {__pyx_t_3, NULL};
+__pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_4, 0+__pyx_t_4);
+__Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
+if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 280, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+}
+__pyx_t_5 = __Pyx_PyObject_IsTrue(__pyx_t_1); if (unlikely((__pyx_t_5 < 0))) __PYX_ERR(0, 280, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__pyx_t_6 = (!__pyx_t_5);
+if (unlikely(__pyx_t_6)) {
+/* "pysam/libcfaidx.pyx":281
+*
+*         if not self.is_open():
+*             raise ValueError("I/O operation on closed file" )             # <<<<<<<<<<<<<<
+*
+*         cdef int length
+*/
+__pyx_t_1 = __Pyx_PyObject_Call(__pyx_builtin_ValueError, __pyx_tuple__9, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 281, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_Raise(__pyx_t_1, 0, 0, 0);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__PYX_ERR(0, 281, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":280
+*         """
+*
+*         if not self.is_open():             # <<<<<<<<<<<<<<
+*             raise ValueError("I/O operation on closed file" )
+*
+*/
+}
+/* "pysam/libcfaidx.pyx":288
+*         cdef int rstart, rend
+*
+*         contig, rstart, rend = parse_region(reference, start, end, region)             # <<<<<<<<<<<<<<
+*
+*         if contig is None:
+*/
+__pyx_t_7.__pyx_n = 4;
+__pyx_t_7.contig = __pyx_v_reference;
+__pyx_t_7.start = __pyx_v_start;
+__pyx_t_7.stop = __pyx_v_end;
+__pyx_t_7.region = __pyx_v_region;
+__pyx_t_1 = __pyx_f_5pysam_9libcutils_parse_region(0, &__pyx_t_7); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 288, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+if ((likely(PyTuple_CheckExact(__pyx_t_1))) || (PyList_CheckExact(__pyx_t_1))) {
+PyObject* sequence = __pyx_t_1;
+Py_ssize_t size = __Pyx_PySequence_SIZE(sequence);
+if (unlikely(size != 3)) {
+if (size > 3) __Pyx_RaiseTooManyValuesError(3);
+else if (size >= 0) __Pyx_RaiseNeedMoreValuesError(size);
+__PYX_ERR(0, 288, __pyx_L1_error)
+}
+#if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
+if (likely(PyTuple_CheckExact(sequence))) {
+__pyx_t_2 = PyTuple_GET_ITEM(sequence, 0);
+__pyx_t_3 = PyTuple_GET_ITEM(sequence, 1);
+__pyx_t_8 = PyTuple_GET_ITEM(sequence, 2);
+} else {
+__pyx_t_2 = PyList_GET_ITEM(sequence, 0);
+__pyx_t_3 = PyList_GET_ITEM(sequence, 1);
+__pyx_t_8 = PyList_GET_ITEM(sequence, 2);
+}
+__Pyx_INCREF(__pyx_t_2);
+__Pyx_INCREF(__pyx_t_3);
+__Pyx_INCREF(__pyx_t_8);
+#else
+__pyx_t_2 = PySequence_ITEM(sequence, 0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 288, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_3 = PySequence_ITEM(sequence, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 288, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__pyx_t_8 = PySequence_ITEM(sequence, 2); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 288, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_8);
+#endif
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+} else {
+Py_ssize_t index = -1;
+__pyx_t_9 = PyObject_GetIter(__pyx_t_1); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 288, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_9);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__pyx_t_10 = __Pyx_PyObject_GetIterNextFunc(__pyx_t_9);
+index = 0; __pyx_t_2 = __pyx_t_10(__pyx_t_9); if (unlikely(!__pyx_t_2)) goto __pyx_L4_unpacking_failed;
+__Pyx_GOTREF(__pyx_t_2);
+index = 1; __pyx_t_3 = __pyx_t_10(__pyx_t_9); if (unlikely(!__pyx_t_3)) goto __pyx_L4_unpacking_failed;
+__Pyx_GOTREF(__pyx_t_3);
+index = 2; __pyx_t_8 = __pyx_t_10(__pyx_t_9); if (unlikely(!__pyx_t_8)) goto __pyx_L4_unpacking_failed;
+__Pyx_GOTREF(__pyx_t_8);
+if (__Pyx_IternextUnpackEndCheck(__pyx_t_10(__pyx_t_9), 3) < 0) __PYX_ERR(0, 288, __pyx_L1_error)
+__pyx_t_10 = NULL;
+__Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
+goto __pyx_L5_unpacking_done;
+__pyx_L4_unpacking_failed:;
+__Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
+__pyx_t_10 = NULL;
+if (__Pyx_IterFinish() == 0) __Pyx_RaiseNeedMoreValuesError(index);
+__PYX_ERR(0, 288, __pyx_L1_error)
+__pyx_L5_unpacking_done:;
+}
+__pyx_t_11 = __Pyx_PyInt_As_int(__pyx_t_3); if (unlikely((__pyx_t_11 == (int)-1) && PyErr_Occurred())) __PYX_ERR(0, 288, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__pyx_t_12 = __Pyx_PyInt_As_int(__pyx_t_8); if (unlikely((__pyx_t_12 == (int)-1) && PyErr_Occurred())) __PYX_ERR(0, 288, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
+__pyx_v_contig = __pyx_t_2;
+__pyx_t_2 = 0;
+__pyx_v_rstart = __pyx_t_11;
+__pyx_v_rend = __pyx_t_12;
+/* "pysam/libcfaidx.pyx":290
+*         contig, rstart, rend = parse_region(reference, start, end, region)
+*
+*         if contig is None:             # <<<<<<<<<<<<<<
+*             raise ValueError("no sequence/region supplied.")
+*
+*/
+__pyx_t_6 = (__pyx_v_contig == Py_None);
+if (unlikely(__pyx_t_6)) {
+/* "pysam/libcfaidx.pyx":291
+*
+*         if contig is None:
+*             raise ValueError("no sequence/region supplied.")             # <<<<<<<<<<<<<<
+*
+*         if rstart == rend:
+*/
+__pyx_t_1 = __Pyx_PyObject_Call(__pyx_builtin_ValueError, __pyx_tuple__10, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 291, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_Raise(__pyx_t_1, 0, 0, 0);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__PYX_ERR(0, 291, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":290
+*         contig, rstart, rend = parse_region(reference, start, end, region)
+*
+*         if contig is None:             # <<<<<<<<<<<<<<
+*             raise ValueError("no sequence/region supplied.")
+*
+*/
+}
+/* "pysam/libcfaidx.pyx":293
+*             raise ValueError("no sequence/region supplied.")
+*
+*         if rstart == rend:             # <<<<<<<<<<<<<<
+*             return ""
+*
+*/
+__pyx_t_6 = (__pyx_v_rstart == __pyx_v_rend);
+if (__pyx_t_6) {
+/* "pysam/libcfaidx.pyx":294
+*
+*         if rstart == rend:
+*             return ""             # <<<<<<<<<<<<<<
+*
+*         contig_b = force_bytes(contig)
+*/
+__Pyx_XDECREF(__pyx_r);
+__Pyx_INCREF(__pyx_kp_u__11);
+__pyx_r = __pyx_kp_u__11;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":293
+*             raise ValueError("no sequence/region supplied.")
+*
+*         if rstart == rend:             # <<<<<<<<<<<<<<
+*             return ""
+*
+*/
+}
+/* "pysam/libcfaidx.pyx":296
+*             return ""
+*
+*         contig_b = force_bytes(contig)             # <<<<<<<<<<<<<<
+*         ref = contig_b
+*         with nogil:
+*/
+__pyx_t_1 = __pyx_f_5pysam_9libcutils_force_bytes(__pyx_v_contig, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 296, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_v_contig_b = ((PyObject*)__pyx_t_1);
+__pyx_t_1 = 0;
+/* "pysam/libcfaidx.pyx":297
+*
+*         contig_b = force_bytes(contig)
+*         ref = contig_b             # <<<<<<<<<<<<<<
+*         with nogil:
+*             length = faidx_seq_len(self.fastafile, ref)
+*/
+if (unlikely(__pyx_v_contig_b == Py_None)) {
+PyErr_SetString(PyExc_TypeError, "expected bytes, NoneType found");
+__PYX_ERR(0, 297, __pyx_L1_error)
+}
+__pyx_t_13 = __Pyx_PyBytes_AsWritableString(__pyx_v_contig_b); if (unlikely((!__pyx_t_13) && PyErr_Occurred())) __PYX_ERR(0, 297, __pyx_L1_error)
+__pyx_v_ref = __pyx_t_13;
+/* "pysam/libcfaidx.pyx":298
+*         contig_b = force_bytes(contig)
+*         ref = contig_b
+*         with nogil:             # <<<<<<<<<<<<<<
+*             length = faidx_seq_len(self.fastafile, ref)
+*         if length == -1:
+*/
+{
+#ifdef WITH_THREAD
+PyThreadState *_save;
+_save = NULL;
+Py_UNBLOCK_THREADS
+__Pyx_FastGIL_Remember();
+#endif
+/*try:*/ {
+/* "pysam/libcfaidx.pyx":299
+*         ref = contig_b
+*         with nogil:
+*             length = faidx_seq_len(self.fastafile, ref)             # <<<<<<<<<<<<<<
+*         if length == -1:
+*             raise KeyError("sequence '%s' not present" % contig)
+*/
+__pyx_v_length = faidx_seq_len(__pyx_v_self->fastafile, __pyx_v_ref);
+}
+/* "pysam/libcfaidx.pyx":298
+*         contig_b = force_bytes(contig)
+*         ref = contig_b
+*         with nogil:             # <<<<<<<<<<<<<<
+*             length = faidx_seq_len(self.fastafile, ref)
+*         if length == -1:
+*/
+/*finally:*/ {
+/*normal exit:*/{
+#ifdef WITH_THREAD
+__Pyx_FastGIL_Forget();
+Py_BLOCK_THREADS
+#endif
+goto __pyx_L10;
+}
+__pyx_L10:;
+}
+}
+/* "pysam/libcfaidx.pyx":300
+*         with nogil:
+*             length = faidx_seq_len(self.fastafile, ref)
+*         if length == -1:             # <<<<<<<<<<<<<<
+*             raise KeyError("sequence '%s' not present" % contig)
+*         if rstart >= length:
+*/
+__pyx_t_6 = (__pyx_v_length == -1L);
+if (unlikely(__pyx_t_6)) {
+/* "pysam/libcfaidx.pyx":301
+*             length = faidx_seq_len(self.fastafile, ref)
+*         if length == -1:
+*             raise KeyError("sequence '%s' not present" % contig)             # <<<<<<<<<<<<<<
+*         if rstart >= length:
+*             return ""
+*/
+__pyx_t_1 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_sequence_s_not_present, __pyx_v_contig); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 301, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_t_8 = __Pyx_PyObject_CallOneArg(__pyx_builtin_KeyError, __pyx_t_1); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 301, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_8);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__Pyx_Raise(__pyx_t_8, 0, 0, 0);
+__Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
+__PYX_ERR(0, 301, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":300
+*         with nogil:
+*             length = faidx_seq_len(self.fastafile, ref)
+*         if length == -1:             # <<<<<<<<<<<<<<
+*             raise KeyError("sequence '%s' not present" % contig)
+*         if rstart >= length:
+*/
+}
+/* "pysam/libcfaidx.pyx":302
+*         if length == -1:
+*             raise KeyError("sequence '%s' not present" % contig)
+*         if rstart >= length:             # <<<<<<<<<<<<<<
+*             return ""
+*
+*/
+__pyx_t_6 = (__pyx_v_rstart >= __pyx_v_length);
+if (__pyx_t_6) {
+/* "pysam/libcfaidx.pyx":303
+*             raise KeyError("sequence '%s' not present" % contig)
+*         if rstart >= length:
+*             return ""             # <<<<<<<<<<<<<<
+*
+*         # fai_fetch adds a '\0' at the end
+*/
+__Pyx_XDECREF(__pyx_r);
+__Pyx_INCREF(__pyx_kp_u__11);
+__pyx_r = __pyx_kp_u__11;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":302
+*         if length == -1:
+*             raise KeyError("sequence '%s' not present" % contig)
+*         if rstart >= length:             # <<<<<<<<<<<<<<
+*             return ""
+*
+*/
+}
+/* "pysam/libcfaidx.pyx":306
+*
+*         # fai_fetch adds a '\0' at the end
+*         with nogil:             # <<<<<<<<<<<<<<
+*             seq = faidx_fetch_seq(self.fastafile,
+*                                   ref,
+*/
+{
+#ifdef WITH_THREAD
+PyThreadState *_save;
+_save = NULL;
+Py_UNBLOCK_THREADS
+__Pyx_FastGIL_Remember();
+#endif
+/*try:*/ {
+/* "pysam/libcfaidx.pyx":307
+*         # fai_fetch adds a '\0' at the end
+*         with nogil:
+*             seq = faidx_fetch_seq(self.fastafile,             # <<<<<<<<<<<<<<
+*                                   ref,
+*                                   rstart,
+*/
+__pyx_v_seq = faidx_fetch_seq(__pyx_v_self->fastafile, __pyx_v_ref, __pyx_v_rstart, (__pyx_v_rend - 1), (&__pyx_v_length));
+}
+/* "pysam/libcfaidx.pyx":306
+*
+*         # fai_fetch adds a '\0' at the end
+*         with nogil:             # <<<<<<<<<<<<<<
+*             seq = faidx_fetch_seq(self.fastafile,
+*                                   ref,
+*/
+/*finally:*/ {
+/*normal exit:*/{
+#ifdef WITH_THREAD
+__Pyx_FastGIL_Forget();
+Py_BLOCK_THREADS
+#endif
+goto __pyx_L15;
+}
+__pyx_L15:;
+}
+}
+/* "pysam/libcfaidx.pyx":313
+*                                   &length)
+*
+*         if not seq:             # <<<<<<<<<<<<<<
+*             if errno:
+*                 raise IOError(errno, strerror(errno))
+*/
+__pyx_t_6 = (!(__pyx_v_seq != 0));
+if (__pyx_t_6) {
+/* "pysam/libcfaidx.pyx":314
+*
+*         if not seq:
+*             if errno:             # <<<<<<<<<<<<<<
+*                 raise IOError(errno, strerror(errno))
+*             else:
+*/
+__pyx_t_6 = (errno != 0);
+if (unlikely(__pyx_t_6)) {
+/* "pysam/libcfaidx.pyx":315
+*         if not seq:
+*             if errno:
+*                 raise IOError(errno, strerror(errno))             # <<<<<<<<<<<<<<
+*             else:
+*                 raise ValueError("failure when retrieving sequence on '%s'" % contig)
+*/
+__pyx_t_8 = __Pyx_PyInt_From_int(errno); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 315, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_8);
+__pyx_t_1 = __Pyx_PyBytes_FromString(strerror(errno)); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 315, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_t_3 = PyTuple_New(2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 315, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_GIVEREF(__pyx_t_8);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_8)) __PYX_ERR(0, 315, __pyx_L1_error);
+__Pyx_GIVEREF(__pyx_t_1);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_1)) __PYX_ERR(0, 315, __pyx_L1_error);
+__pyx_t_8 = 0;
+__pyx_t_1 = 0;
+__pyx_t_1 = __Pyx_PyObject_Call(__pyx_builtin_IOError, __pyx_t_3, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 315, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__Pyx_Raise(__pyx_t_1, 0, 0, 0);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__PYX_ERR(0, 315, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":314
+*
+*         if not seq:
+*             if errno:             # <<<<<<<<<<<<<<
+*                 raise IOError(errno, strerror(errno))
+*             else:
+*/
+}
+/* "pysam/libcfaidx.pyx":317
+*                 raise IOError(errno, strerror(errno))
+*             else:
+*                 raise ValueError("failure when retrieving sequence on '%s'" % contig)             # <<<<<<<<<<<<<<
+*
+*         try:
+*/
+/*else*/ {
+__pyx_t_1 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_failure_when_retrieving_sequence, __pyx_v_contig); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 317, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_t_3 = __Pyx_PyObject_CallOneArg(__pyx_builtin_ValueError, __pyx_t_1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 317, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__Pyx_Raise(__pyx_t_3, 0, 0, 0);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__PYX_ERR(0, 317, __pyx_L1_error)
+}
+/* "pysam/libcfaidx.pyx":313
+*                                   &length)
+*
+*         if not seq:             # <<<<<<<<<<<<<<
+*             if errno:
+*                 raise IOError(errno, strerror(errno))
+*/
+}
+/* "pysam/libcfaidx.pyx":319
+*                 raise ValueError("failure when retrieving sequence on '%s'" % contig)
+*
+*         try:             # <<<<<<<<<<<<<<
+*             return charptr_to_str(seq)
+*         finally:
+*/
+/*try:*/ {
+/* "pysam/libcfaidx.pyx":320
+*
+*         try:
+*             return charptr_to_str(seq)             # <<<<<<<<<<<<<<
+*         finally:
+*             free(seq)
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_3 = __pyx_f_5pysam_9libcutils_charptr_to_str(__pyx_v_seq, NULL); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 320, __pyx_L19_error)
+__Pyx_GOTREF(__pyx_t_3);
+__pyx_r = __pyx_t_3;
+__pyx_t_3 = 0;
+goto __pyx_L18_return;
+}
+/* "pysam/libcfaidx.pyx":322
+*             return charptr_to_str(seq)
+*         finally:
+*             free(seq)             # <<<<<<<<<<<<<<
+*
+*     cdef char *_fetch(self, char *reference, int start, int end, int *length) except? NULL:
+*/
+/*finally:*/ {
+__pyx_L19_error:;
+/*exception exit:*/{
+__Pyx_PyThreadState_declare
+__Pyx_PyThreadState_assign
+__pyx_t_15 = 0; __pyx_t_16 = 0; __pyx_t_17 = 0; __pyx_t_18 = 0; __pyx_t_19 = 0; __pyx_t_20 = 0;
+__Pyx_XDECREF(__pyx_t_1); __pyx_t_1 = 0;
+__Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
+__Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
+__Pyx_XDECREF(__pyx_t_8); __pyx_t_8 = 0;
+__Pyx_XDECREF(__pyx_t_9); __pyx_t_9 = 0;
+if (PY_MAJOR_VERSION >= 3) __Pyx_ExceptionSwap(&__pyx_t_18, &__pyx_t_19, &__pyx_t_20);
+if ((PY_MAJOR_VERSION < 3) || unlikely(__Pyx_GetException(&__pyx_t_15, &__pyx_t_16, &__pyx_t_17) < 0)) __Pyx_ErrFetch(&__pyx_t_15, &__pyx_t_16, &__pyx_t_17);
+__Pyx_XGOTREF(__pyx_t_15);
+__Pyx_XGOTREF(__pyx_t_16);
+__Pyx_XGOTREF(__pyx_t_17);
+__Pyx_XGOTREF(__pyx_t_18);
+__Pyx_XGOTREF(__pyx_t_19);
+__Pyx_XGOTREF(__pyx_t_20);
+__pyx_t_12 = __pyx_lineno; __pyx_t_11 = __pyx_clineno; __pyx_t_14 = __pyx_filename;
+{
+free(__pyx_v_seq);
+}
+if (PY_MAJOR_VERSION >= 3) {
+__Pyx_XGIVEREF(__pyx_t_18);
+__Pyx_XGIVEREF(__pyx_t_19);
+__Pyx_XGIVEREF(__pyx_t_20);
+__Pyx_ExceptionReset(__pyx_t_18, __pyx_t_19, __pyx_t_20);
+}
+__Pyx_XGIVEREF(__pyx_t_15);
+__Pyx_XGIVEREF(__pyx_t_16);
+__Pyx_XGIVEREF(__pyx_t_17);
+__Pyx_ErrRestore(__pyx_t_15, __pyx_t_16, __pyx_t_17);
+__pyx_t_15 = 0; __pyx_t_16 = 0; __pyx_t_17 = 0; __pyx_t_18 = 0; __pyx_t_19 = 0; __pyx_t_20 = 0;
+__pyx_lineno = __pyx_t_12; __pyx_clineno = __pyx_t_11; __pyx_filename = __pyx_t_14;
+goto __pyx_L1_error;
+}
+__pyx_L18_return: {
+__pyx_t_20 = __pyx_r;
+__pyx_r = 0;
+free(__pyx_v_seq);
+__pyx_r = __pyx_t_20;
+__pyx_t_20 = 0;
+goto __pyx_L0;
+}
+}
+/* "pysam/libcfaidx.pyx":242
+*             return self._lengths
+*
+*     def fetch(self,             # <<<<<<<<<<<<<<
+*               reference=None,
+*               start=None,
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_XDECREF(__pyx_t_3);
+__Pyx_XDECREF(__pyx_t_8);
+__Pyx_XDECREF(__pyx_t_9);
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile.fetch", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XDECREF(__pyx_v_contig);
+__Pyx_XDECREF(__pyx_v_contig_b);
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":324
+*             free(seq)
+*
+*     cdef char *_fetch(self, char *reference, int start, int end, int *length) except? NULL:             # <<<<<<<<<<<<<<
+*         '''fetch sequence for reference, start and end'''
+*
+*/
+static char *__pyx_f_5pysam_9libcfaidx_9FastaFile__fetch(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self, char *__pyx_v_reference, int __pyx_v_start, int __pyx_v_end, int *__pyx_v_length) {
+char *__pyx_v_seq;
+char *__pyx_r;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_t_1;
+PyObject *__pyx_t_2 = NULL;
+PyObject *__pyx_t_3 = NULL;
+PyObject *__pyx_t_4 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("_fetch", 1);
+__Pyx_TraceCall("_fetch", __pyx_f[0], 324, 0, __PYX_ERR(0, 324, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":328
+*
+*         cdef char *seq
+*         with nogil:             # <<<<<<<<<<<<<<
+*             seq = faidx_fetch_seq(self.fastafile,
+*                                   reference,
+*/
+{
+#ifdef WITH_THREAD
+PyThreadState *_save;
+_save = NULL;
+Py_UNBLOCK_THREADS
+__Pyx_FastGIL_Remember();
+#endif
+/*try:*/ {
+/* "pysam/libcfaidx.pyx":329
+*         cdef char *seq
+*         with nogil:
+*             seq = faidx_fetch_seq(self.fastafile,             # <<<<<<<<<<<<<<
+*                                   reference,
+*                                   start,
+*/
+__pyx_v_seq = faidx_fetch_seq(__pyx_v_self->fastafile, __pyx_v_reference, __pyx_v_start, (__pyx_v_end - 1), __pyx_v_length);
+}
+/* "pysam/libcfaidx.pyx":328
+*
+*         cdef char *seq
+*         with nogil:             # <<<<<<<<<<<<<<
+*             seq = faidx_fetch_seq(self.fastafile,
+*                                   reference,
+*/
+/*finally:*/ {
+/*normal exit:*/{
+#ifdef WITH_THREAD
+__Pyx_FastGIL_Forget();
+Py_BLOCK_THREADS
+#endif
+goto __pyx_L5;
+}
+__pyx_L5:;
+}
+}
+/* "pysam/libcfaidx.pyx":335
+*                                   length)
+*
+*         if not seq:             # <<<<<<<<<<<<<<
+*             if errno:
+*                 raise IOError(errno, strerror(errno))
+*/
+__pyx_t_1 = (!(__pyx_v_seq != 0));
+if (__pyx_t_1) {
+/* "pysam/libcfaidx.pyx":336
+*
+*         if not seq:
+*             if errno:             # <<<<<<<<<<<<<<
+*                 raise IOError(errno, strerror(errno))
+*             else:
+*/
+__pyx_t_1 = (errno != 0);
+if (unlikely(__pyx_t_1)) {
+/* "pysam/libcfaidx.pyx":337
+*         if not seq:
+*             if errno:
+*                 raise IOError(errno, strerror(errno))             # <<<<<<<<<<<<<<
+*             else:
+*                 raise ValueError("failure when retrieving sequence on '%s'" % reference)
+*/
+__pyx_t_2 = __Pyx_PyInt_From_int(errno); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 337, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_3 = __Pyx_PyBytes_FromString(strerror(errno)); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 337, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__pyx_t_4 = PyTuple_New(2); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 337, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_4);
+__Pyx_GIVEREF(__pyx_t_2);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 0, __pyx_t_2)) __PYX_ERR(0, 337, __pyx_L1_error);
+__Pyx_GIVEREF(__pyx_t_3);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 1, __pyx_t_3)) __PYX_ERR(0, 337, __pyx_L1_error);
+__pyx_t_2 = 0;
+__pyx_t_3 = 0;
+__pyx_t_3 = __Pyx_PyObject_Call(__pyx_builtin_IOError, __pyx_t_4, NULL); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 337, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+__Pyx_Raise(__pyx_t_3, 0, 0, 0);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__PYX_ERR(0, 337, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":336
+*
+*         if not seq:
+*             if errno:             # <<<<<<<<<<<<<<
+*                 raise IOError(errno, strerror(errno))
+*             else:
+*/
+}
+/* "pysam/libcfaidx.pyx":339
+*                 raise IOError(errno, strerror(errno))
+*             else:
+*                 raise ValueError("failure when retrieving sequence on '%s'" % reference)             # <<<<<<<<<<<<<<
+*
+*         return seq
+*/
+/*else*/ {
+__pyx_t_3 = __Pyx_PyBytes_FromString(__pyx_v_reference); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 339, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__pyx_t_4 = PyUnicode_Format(__pyx_kp_u_failure_when_retrieving_sequence, __pyx_t_3); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 339, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_4);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__pyx_t_3 = __Pyx_PyObject_CallOneArg(__pyx_builtin_ValueError, __pyx_t_4); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 339, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+__Pyx_Raise(__pyx_t_3, 0, 0, 0);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__PYX_ERR(0, 339, __pyx_L1_error)
+}
+/* "pysam/libcfaidx.pyx":335
+*                                   length)
+*
+*         if not seq:             # <<<<<<<<<<<<<<
+*             if errno:
+*                 raise IOError(errno, strerror(errno))
+*/
+}
+/* "pysam/libcfaidx.pyx":341
+*                 raise ValueError("failure when retrieving sequence on '%s'" % reference)
+*
+*         return seq             # <<<<<<<<<<<<<<
+*
+*     def get_reference_length(self, reference):
+*/
+__pyx_r = __pyx_v_seq;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":324
+*             free(seq)
+*
+*     cdef char *_fetch(self, char *reference, int start, int end, int *length) except? NULL:             # <<<<<<<<<<<<<<
+*         '''fetch sequence for reference, start and end'''
+*
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_XDECREF(__pyx_t_3);
+__Pyx_XDECREF(__pyx_t_4);
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile._fetch", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_TraceReturn(Py_None, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":343
+*         return seq
+*
+*     def get_reference_length(self, reference):             # <<<<<<<<<<<<<<
+*         '''return the length of reference.'''
+*         return self.reference2length[reference]
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_19get_reference_length(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9FastaFile_18get_reference_length, "FastaFile.get_reference_length(self, reference)\nreturn the length of reference.");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_9FastaFile_19get_reference_length = {"get_reference_length", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastaFile_19get_reference_length, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastaFile_18get_reference_length};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_19get_reference_length(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+PyObject *__pyx_v_reference = 0;
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject* values[1] = {0};
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("get_reference_length (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+{
+PyObject **__pyx_pyargnames[] = {&__pyx_n_s_reference,0};
+if (__pyx_kwds) {
+Py_ssize_t kw_args;
+switch (__pyx_nargs) {
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
+switch (__pyx_nargs) {
+case  0:
+if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_reference)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 343, __pyx_L3_error)
+else goto __pyx_L5_argtuple_error;
+}
+if (unlikely(kw_args > 0)) {
+const Py_ssize_t kwd_pos_args = __pyx_nargs;
+if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "get_reference_length") < 0)) __PYX_ERR(0, 343, __pyx_L3_error)
+}
+} else if (unlikely(__pyx_nargs != 1)) {
+goto __pyx_L5_argtuple_error;
+} else {
+values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+}
+__pyx_v_reference = values[0];
+}
+goto __pyx_L6_skip;
+__pyx_L5_argtuple_error:;
+__Pyx_RaiseArgtupleInvalid("get_reference_length", 1, 1, 1, __pyx_nargs); __PYX_ERR(0, 343, __pyx_L3_error)
+__pyx_L6_skip:;
+goto __pyx_L4_argument_unpacking_done;
+__pyx_L3_error:;
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile.get_reference_length", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__Pyx_RefNannyFinishContext();
+return NULL;
+__pyx_L4_argument_unpacking_done:;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastaFile_18get_reference_length(((struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)__pyx_v_self), __pyx_v_reference);
+/* function exit code */
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_18get_reference_length(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self, PyObject *__pyx_v_reference) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__12)
+__Pyx_RefNannySetupContext("get_reference_length", 1);
+__Pyx_TraceCall("get_reference_length", __pyx_f[0], 343, 0, __PYX_ERR(0, 343, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":345
+*     def get_reference_length(self, reference):
+*         '''return the length of reference.'''
+*         return self.reference2length[reference]             # <<<<<<<<<<<<<<
+*
+*     def __getitem__(self, reference):
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_1 = __Pyx_PyObject_GetItem(__pyx_v_self->reference2length, __pyx_v_reference); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 345, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_r = __pyx_t_1;
+__pyx_t_1 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":343
+*         return seq
+*
+*     def get_reference_length(self, reference):             # <<<<<<<<<<<<<<
+*         '''return the length of reference.'''
+*         return self.reference2length[reference]
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile.get_reference_length", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":347
+*         return self.reference2length[reference]
+*
+*     def __getitem__(self, reference):             # <<<<<<<<<<<<<<
+*         return self.fetch(reference)
+*
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_21__getitem__(PyObject *__pyx_v_self, PyObject *__pyx_v_reference); /*proto*/
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_21__getitem__(PyObject *__pyx_v_self, PyObject *__pyx_v_reference) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__getitem__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastaFile_20__getitem__(((struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)__pyx_v_self), ((PyObject *)__pyx_v_reference));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_20__getitem__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self, PyObject *__pyx_v_reference) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+PyObject *__pyx_t_2 = NULL;
+PyObject *__pyx_t_3 = NULL;
+unsigned int __pyx_t_4;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__getitem__", 1);
+__Pyx_TraceCall("__getitem__", __pyx_f[0], 347, 0, __PYX_ERR(0, 347, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":348
+*
+*     def __getitem__(self, reference):
+*         return self.fetch(reference)             # <<<<<<<<<<<<<<
+*
+*     def __contains__(self, reference):
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_2 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_fetch); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 348, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_3 = NULL;
+__pyx_t_4 = 0;
+#if CYTHON_UNPACK_METHODS
+if (likely(PyMethod_Check(__pyx_t_2))) {
+__pyx_t_3 = PyMethod_GET_SELF(__pyx_t_2);
+if (likely(__pyx_t_3)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
+__Pyx_INCREF(__pyx_t_3);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_2, function);
+__pyx_t_4 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[2] = {__pyx_t_3, __pyx_v_reference};
+__pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_4, 1+__pyx_t_4);
+__Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
+if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 348, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+}
+__pyx_r = __pyx_t_1;
+__pyx_t_1 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":347
+*         return self.reference2length[reference]
+*
+*     def __getitem__(self, reference):             # <<<<<<<<<<<<<<
+*         return self.fetch(reference)
+*
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_XDECREF(__pyx_t_3);
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile.__getitem__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":350
+*         return self.fetch(reference)
+*
+*     def __contains__(self, reference):             # <<<<<<<<<<<<<<
+*         '''return true if reference in fasta file.'''
+*         return reference in self.reference2length
+*/
+/* Python wrapper */
+static int __pyx_pw_5pysam_9libcfaidx_9FastaFile_23__contains__(PyObject *__pyx_v_self, PyObject *__pyx_v_reference); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9FastaFile_22__contains__, "return true if reference in fasta file.");
+#if CYTHON_UPDATE_DESCRIPTOR_DOC
+struct wrapperbase __pyx_wrapperbase_5pysam_9libcfaidx_9FastaFile_22__contains__;
+#endif
+static int __pyx_pw_5pysam_9libcfaidx_9FastaFile_23__contains__(PyObject *__pyx_v_self, PyObject *__pyx_v_reference) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+int __pyx_r;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__contains__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastaFile_22__contains__(((struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)__pyx_v_self), ((PyObject *)__pyx_v_reference));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static int __pyx_pf_5pysam_9libcfaidx_9FastaFile_22__contains__(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self, PyObject *__pyx_v_reference) {
+int __pyx_r;
+__Pyx_TraceDeclarations
+int __pyx_t_1;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceCall("__contains__", __pyx_f[0], 350, 0, __PYX_ERR(0, 350, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":352
+*     def __contains__(self, reference):
+*         '''return true if reference in fasta file.'''
+*         return reference in self.reference2length             # <<<<<<<<<<<<<<
+*
+*
+*/
+__pyx_t_1 = (__Pyx_PySequence_ContainsTF(__pyx_v_reference, __pyx_v_self->reference2length, Py_EQ)); if (unlikely((__pyx_t_1 < 0))) __PYX_ERR(0, 352, __pyx_L1_error)
+__pyx_r = __pyx_t_1;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":350
+*         return self.fetch(reference)
+*
+*     def __contains__(self, reference):             # <<<<<<<<<<<<<<
+*         '''return true if reference in fasta file.'''
+*         return reference in self.reference2length
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile.__contains__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = -1;
+__pyx_L0:;
+__Pyx_TraceReturn(Py_None, 0);
+return __pyx_r;
+}
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_25__reduce_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9FastaFile_24__reduce_cython__, "FastaFile.__reduce_cython__(self)");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_9FastaFile_25__reduce_cython__ = {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastaFile_25__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastaFile_24__reduce_cython__};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_25__reduce_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__reduce_cython__ (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+if (unlikely(__pyx_nargs > 0)) {
+__Pyx_RaiseArgtupleInvalid("__reduce_cython__", 1, 0, 0, __pyx_nargs); return NULL;}
+if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__reduce_cython__", 0))) return NULL;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastaFile_24__reduce_cython__(((struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_24__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__13)
+__Pyx_RefNannySetupContext("__reduce_cython__", 1);
+__Pyx_TraceCall("__reduce_cython__", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));
+/* "(tree fragment)":2
+* def __reduce_cython__(self):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"             # <<<<<<<<<<<<<<
+* def __setstate_cython__(self, __pyx_state):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+*/
+__Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_no_default___reduce___due_to_non, 0, 0);
+__PYX_ERR(1, 2, __pyx_L1_error)
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "(tree fragment)":3
+* def __reduce_cython__(self):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_27__setstate_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9FastaFile_26__setstate_cython__, "FastaFile.__setstate_cython__(self, __pyx_state)");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_9FastaFile_27__setstate_cython__ = {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastaFile_27__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastaFile_26__setstate_cython__};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastaFile_27__setstate_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+CYTHON_UNUSED PyObject *__pyx_v___pyx_state = 0;
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject* values[1] = {0};
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__setstate_cython__ (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+{
+PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_state,0};
+if (__pyx_kwds) {
+Py_ssize_t kw_args;
+switch (__pyx_nargs) {
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
+switch (__pyx_nargs) {
+case  0:
+if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 3, __pyx_L3_error)
+else goto __pyx_L5_argtuple_error;
+}
+if (unlikely(kw_args > 0)) {
+const Py_ssize_t kwd_pos_args = __pyx_nargs;
+if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__setstate_cython__") < 0)) __PYX_ERR(1, 3, __pyx_L3_error)
+}
+} else if (unlikely(__pyx_nargs != 1)) {
+goto __pyx_L5_argtuple_error;
+} else {
+values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+}
+__pyx_v___pyx_state = values[0];
+}
+goto __pyx_L6_skip;
+__pyx_L5_argtuple_error:;
+__Pyx_RaiseArgtupleInvalid("__setstate_cython__", 1, 1, 1, __pyx_nargs); __PYX_ERR(1, 3, __pyx_L3_error)
+__pyx_L6_skip:;
+goto __pyx_L4_argument_unpacking_done;
+__pyx_L3_error:;
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__Pyx_RefNannyFinishContext();
+return NULL;
+__pyx_L4_argument_unpacking_done:;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastaFile_26__setstate_cython__(((struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)__pyx_v_self), __pyx_v___pyx_state);
+/* function exit code */
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastaFile_26__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_FastaFile *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__14)
+__Pyx_RefNannySetupContext("__setstate_cython__", 1);
+__Pyx_TraceCall("__setstate_cython__", __pyx_f[1], 3, 0, __PYX_ERR(1, 3, __pyx_L1_error));
+/* "(tree fragment)":4
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"             # <<<<<<<<<<<<<<
+*/
+__Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_no_default___reduce___due_to_non, 0, 0);
+__PYX_ERR(1, 4, __pyx_L1_error)
+/* "(tree fragment)":3
+* def __reduce_cython__(self):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastaFile.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":357
+* cdef class FastqProxy:
+*     """A single entry in a fastq file."""
+*     def __init__(self):             # <<<<<<<<<<<<<<
+*         raise ValueError("do not instantiate FastqProxy directly")
+*
+*/
+/* Python wrapper */
+static int __pyx_pw_5pysam_9libcfaidx_10FastqProxy_1__init__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
+static int __pyx_pw_5pysam_9libcfaidx_10FastqProxy_1__init__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds) {
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+int __pyx_r;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__init__ (wrapper)", 0);
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return -1;
+#endif
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+if (unlikely(__pyx_nargs > 0)) {
+__Pyx_RaiseArgtupleInvalid("__init__", 1, 0, 0, __pyx_nargs); return -1;}
+if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_VARARGS(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__init__", 0))) return -1;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_10FastqProxy___init__(((struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static int __pyx_pf_5pysam_9libcfaidx_10FastqProxy___init__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self) {
+int __pyx_r;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__init__", 1);
+__Pyx_TraceCall("__init__", __pyx_f[0], 357, 0, __PYX_ERR(0, 357, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":358
+*     """A single entry in a fastq file."""
+*     def __init__(self):
+*         raise ValueError("do not instantiate FastqProxy directly")             # <<<<<<<<<<<<<<
+*
+*     property name:
+*/
+__pyx_t_1 = __Pyx_PyObject_Call(__pyx_builtin_ValueError, __pyx_tuple__15, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 358, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_Raise(__pyx_t_1, 0, 0, 0);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__PYX_ERR(0, 358, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":357
+* cdef class FastqProxy:
+*     """A single entry in a fastq file."""
+*     def __init__(self):             # <<<<<<<<<<<<<<
+*         raise ValueError("do not instantiate FastqProxy directly")
+*
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_AddTraceback("pysam.libcfaidx.FastqProxy.__init__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = -1;
+__Pyx_TraceReturn(Py_None, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":362
+*     property name:
+*         """The name of each entry in the fastq file."""
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             return charptr_to_str(self._delegate.name.s)
+*
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_10FastqProxy_4name_1__get__(PyObject *__pyx_v_self); /*proto*/
+static PyObject *__pyx_pw_5pysam_9libcfaidx_10FastqProxy_4name_1__get__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__get__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_10FastqProxy_4name___get__(((struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_10FastqProxy_4name___get__(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__get__", 1);
+__Pyx_TraceCall("__get__", __pyx_f[0], 362, 0, __PYX_ERR(0, 362, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":363
+*         """The name of each entry in the fastq file."""
+*         def __get__(self):
+*             return charptr_to_str(self._delegate.name.s)             # <<<<<<<<<<<<<<
+*
+*     property sequence:
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_1 = __pyx_f_5pysam_9libcutils_charptr_to_str(__pyx_v_self->_delegate->name.s, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 363, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_r = __pyx_t_1;
+__pyx_t_1 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":362
+*     property name:
+*         """The name of each entry in the fastq file."""
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             return charptr_to_str(self._delegate.name.s)
+*
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_AddTraceback("pysam.libcfaidx.FastqProxy.name.__get__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":367
+*     property sequence:
+*         """The sequence of each entry in the fastq file."""
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             return charptr_to_str(self._delegate.seq.s)
+*
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_10FastqProxy_8sequence_1__get__(PyObject *__pyx_v_self); /*proto*/
+static PyObject *__pyx_pw_5pysam_9libcfaidx_10FastqProxy_8sequence_1__get__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__get__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_10FastqProxy_8sequence___get__(((struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_10FastqProxy_8sequence___get__(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__get__", 1);
+__Pyx_TraceCall("__get__", __pyx_f[0], 367, 0, __PYX_ERR(0, 367, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":368
+*         """The sequence of each entry in the fastq file."""
+*         def __get__(self):
+*             return charptr_to_str(self._delegate.seq.s)             # <<<<<<<<<<<<<<
+*
+*     property comment:
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_1 = __pyx_f_5pysam_9libcutils_charptr_to_str(__pyx_v_self->_delegate->seq.s, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 368, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_r = __pyx_t_1;
+__pyx_t_1 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":367
+*     property sequence:
+*         """The sequence of each entry in the fastq file."""
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             return charptr_to_str(self._delegate.seq.s)
+*
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_AddTraceback("pysam.libcfaidx.FastqProxy.sequence.__get__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":371
+*
+*     property comment:
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             if self._delegate.comment.l:
+*                 return charptr_to_str(self._delegate.comment.s)
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_10FastqProxy_7comment_1__get__(PyObject *__pyx_v_self); /*proto*/
+static PyObject *__pyx_pw_5pysam_9libcfaidx_10FastqProxy_7comment_1__get__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__get__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_10FastqProxy_7comment___get__(((struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_10FastqProxy_7comment___get__(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_t_1;
+PyObject *__pyx_t_2 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__get__", 1);
+__Pyx_TraceCall("__get__", __pyx_f[0], 371, 0, __PYX_ERR(0, 371, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":372
+*     property comment:
+*         def __get__(self):
+*             if self._delegate.comment.l:             # <<<<<<<<<<<<<<
+*                 return charptr_to_str(self._delegate.comment.s)
+*             else:
+*/
+__pyx_t_1 = (__pyx_v_self->_delegate->comment.l != 0);
+if (__pyx_t_1) {
+/* "pysam/libcfaidx.pyx":373
+*         def __get__(self):
+*             if self._delegate.comment.l:
+*                 return charptr_to_str(self._delegate.comment.s)             # <<<<<<<<<<<<<<
+*             else:
+*                 return None
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_2 = __pyx_f_5pysam_9libcutils_charptr_to_str(__pyx_v_self->_delegate->comment.s, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 373, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_r = __pyx_t_2;
+__pyx_t_2 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":372
+*     property comment:
+*         def __get__(self):
+*             if self._delegate.comment.l:             # <<<<<<<<<<<<<<
+*                 return charptr_to_str(self._delegate.comment.s)
+*             else:
+*/
+}
+/* "pysam/libcfaidx.pyx":375
+*                 return charptr_to_str(self._delegate.comment.s)
+*             else:
+*                 return None             # <<<<<<<<<<<<<<
+*
+*     property quality:
+*/
+/*else*/ {
+__Pyx_XDECREF(__pyx_r);
+__pyx_r = Py_None; __Pyx_INCREF(Py_None);
+goto __pyx_L0;
+}
+/* "pysam/libcfaidx.pyx":371
+*
+*     property comment:
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             if self._delegate.comment.l:
+*                 return charptr_to_str(self._delegate.comment.s)
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_AddTraceback("pysam.libcfaidx.FastqProxy.comment.__get__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":379
+*     property quality:
+*         """The quality score of each entry in the fastq file, represented as a string."""
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             if self._delegate.qual.l:
+*                 return charptr_to_str(self._delegate.qual.s)
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_10FastqProxy_7quality_1__get__(PyObject *__pyx_v_self); /*proto*/
+static PyObject *__pyx_pw_5pysam_9libcfaidx_10FastqProxy_7quality_1__get__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__get__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_10FastqProxy_7quality___get__(((struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_10FastqProxy_7quality___get__(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_t_1;
+PyObject *__pyx_t_2 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__get__", 1);
+__Pyx_TraceCall("__get__", __pyx_f[0], 379, 0, __PYX_ERR(0, 379, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":380
+*         """The quality score of each entry in the fastq file, represented as a string."""
+*         def __get__(self):
+*             if self._delegate.qual.l:             # <<<<<<<<<<<<<<
+*                 return charptr_to_str(self._delegate.qual.s)
+*             else:
+*/
+__pyx_t_1 = (__pyx_v_self->_delegate->qual.l != 0);
+if (__pyx_t_1) {
+/* "pysam/libcfaidx.pyx":381
+*         def __get__(self):
+*             if self._delegate.qual.l:
+*                 return charptr_to_str(self._delegate.qual.s)             # <<<<<<<<<<<<<<
+*             else:
+*                 return None
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_2 = __pyx_f_5pysam_9libcutils_charptr_to_str(__pyx_v_self->_delegate->qual.s, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 381, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_r = __pyx_t_2;
+__pyx_t_2 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":380
+*         """The quality score of each entry in the fastq file, represented as a string."""
+*         def __get__(self):
+*             if self._delegate.qual.l:             # <<<<<<<<<<<<<<
+*                 return charptr_to_str(self._delegate.qual.s)
+*             else:
+*/
+}
+/* "pysam/libcfaidx.pyx":383
+*                 return charptr_to_str(self._delegate.qual.s)
+*             else:
+*                 return None             # <<<<<<<<<<<<<<
+*
+*     cdef cython.str to_string(self):
+*/
+/*else*/ {
+__Pyx_XDECREF(__pyx_r);
+__pyx_r = Py_None; __Pyx_INCREF(Py_None);
+goto __pyx_L0;
+}
+/* "pysam/libcfaidx.pyx":379
+*     property quality:
+*         """The quality score of each entry in the fastq file, represented as a string."""
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             if self._delegate.qual.l:
+*                 return charptr_to_str(self._delegate.qual.s)
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_AddTraceback("pysam.libcfaidx.FastqProxy.quality.__get__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":385
+*                 return None
+*
+*     cdef cython.str to_string(self):             # <<<<<<<<<<<<<<
+*         if self.comment is None:
+*             comment = ""
+*/
+static PyObject *__pyx_f_5pysam_9libcfaidx_10FastqProxy_to_string(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self) {
+PyObject *__pyx_v_comment = NULL;
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_t_2;
+PyObject *__pyx_t_3 = NULL;
+Py_ssize_t __pyx_t_4;
+Py_UCS4 __pyx_t_5;
+PyObject *__pyx_t_6 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("to_string", 1);
+__Pyx_TraceCall("to_string", __pyx_f[0], 385, 0, __PYX_ERR(0, 385, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":386
+*
+*     cdef cython.str to_string(self):
+*         if self.comment is None:             # <<<<<<<<<<<<<<
+*             comment = ""
+*         else:
+*/
+__pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_comment); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 386, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_t_2 = (__pyx_t_1 == Py_None);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+if (__pyx_t_2) {
+/* "pysam/libcfaidx.pyx":387
+*     cdef cython.str to_string(self):
+*         if self.comment is None:
+*             comment = ""             # <<<<<<<<<<<<<<
+*         else:
+*             comment = " %s" % self.comment
+*/
+__Pyx_INCREF(__pyx_kp_u__11);
+__pyx_v_comment = __pyx_kp_u__11;
+/* "pysam/libcfaidx.pyx":386
+*
+*     cdef cython.str to_string(self):
+*         if self.comment is None:             # <<<<<<<<<<<<<<
+*             comment = ""
+*         else:
+*/
+goto __pyx_L3;
+}
+/* "pysam/libcfaidx.pyx":389
+*             comment = ""
+*         else:
+*             comment = " %s" % self.comment             # <<<<<<<<<<<<<<
+*
+*         if self.quality is None:
+*/
+/*else*/ {
+__pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_comment); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 389, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_t_3 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_s, __pyx_t_1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 389, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__pyx_v_comment = ((PyObject*)__pyx_t_3);
+__pyx_t_3 = 0;
+}
+__pyx_L3:;
+/* "pysam/libcfaidx.pyx":391
+*             comment = " %s" % self.comment
+*
+*         if self.quality is None:             # <<<<<<<<<<<<<<
+*             return ">%s%s\n%s" % (self.name, comment, self.sequence)
+*         else:
+*/
+__pyx_t_3 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_quality); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 391, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__pyx_t_2 = (__pyx_t_3 == Py_None);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+if (__pyx_t_2) {
+/* "pysam/libcfaidx.pyx":392
+*
+*         if self.quality is None:
+*             return ">%s%s\n%s" % (self.name, comment, self.sequence)             # <<<<<<<<<<<<<<
+*         else:
+*             return "@%s%s\n%s\n+\n%s" % (self.name, comment,
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_3 = PyTuple_New(5); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 392, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__pyx_t_4 = 0;
+__pyx_t_5 = 127;
+__Pyx_INCREF(__pyx_kp_u__16);
+__pyx_t_4 += 1;
+__Pyx_GIVEREF(__pyx_kp_u__16);
+PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_kp_u__16);
+__pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_name); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 392, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_t_6 = __Pyx_PyObject_FormatSimpleAndDecref(PyObject_Unicode(__pyx_t_1), __pyx_empty_unicode); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 392, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_6);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__pyx_t_5 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_6) > __pyx_t_5) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_6) : __pyx_t_5;
+__pyx_t_4 += __Pyx_PyUnicode_GET_LENGTH(__pyx_t_6);
+__Pyx_GIVEREF(__pyx_t_6);
+PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_6);
+__pyx_t_6 = 0;
+__Pyx_INCREF(__pyx_v_comment);
+__pyx_t_5 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_v_comment) > __pyx_t_5) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_v_comment) : __pyx_t_5;
+__pyx_t_4 += __Pyx_PyUnicode_GET_LENGTH(__pyx_v_comment);
+__Pyx_GIVEREF(__pyx_v_comment);
+PyTuple_SET_ITEM(__pyx_t_3, 2, __pyx_v_comment);
+__Pyx_INCREF(__pyx_kp_u__17);
+__pyx_t_4 += 1;
+__Pyx_GIVEREF(__pyx_kp_u__17);
+PyTuple_SET_ITEM(__pyx_t_3, 3, __pyx_kp_u__17);
+__pyx_t_6 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_sequence); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 392, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_6);
+__pyx_t_1 = __Pyx_PyObject_FormatSimpleAndDecref(PyObject_Unicode(__pyx_t_6), __pyx_empty_unicode); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 392, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
+__pyx_t_5 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_1) > __pyx_t_5) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_1) : __pyx_t_5;
+__pyx_t_4 += __Pyx_PyUnicode_GET_LENGTH(__pyx_t_1);
+__Pyx_GIVEREF(__pyx_t_1);
+PyTuple_SET_ITEM(__pyx_t_3, 4, __pyx_t_1);
+__pyx_t_1 = 0;
+__pyx_t_1 = __Pyx_PyUnicode_Join(__pyx_t_3, 5, __pyx_t_4, __pyx_t_5); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 392, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__pyx_r = ((PyObject*)__pyx_t_1);
+__pyx_t_1 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":391
+*             comment = " %s" % self.comment
+*
+*         if self.quality is None:             # <<<<<<<<<<<<<<
+*             return ">%s%s\n%s" % (self.name, comment, self.sequence)
+*         else:
+*/
+}
+/* "pysam/libcfaidx.pyx":394
+*             return ">%s%s\n%s" % (self.name, comment, self.sequence)
+*         else:
+*             return "@%s%s\n%s\n+\n%s" % (self.name, comment,             # <<<<<<<<<<<<<<
+*                                          self.sequence, self.quality)
+*
+*/
+/*else*/ {
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_1 = PyTuple_New(7); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 394, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_t_4 = 0;
+__pyx_t_5 = 127;
+__Pyx_INCREF(__pyx_kp_u__18);
+__pyx_t_4 += 1;
+__Pyx_GIVEREF(__pyx_kp_u__18);
+PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_kp_u__18);
+__pyx_t_3 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_name); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 394, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__pyx_t_6 = __Pyx_PyObject_FormatSimpleAndDecref(PyObject_Unicode(__pyx_t_3), __pyx_empty_unicode); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 394, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_6);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__pyx_t_5 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_6) > __pyx_t_5) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_6) : __pyx_t_5;
+__pyx_t_4 += __Pyx_PyUnicode_GET_LENGTH(__pyx_t_6);
+__Pyx_GIVEREF(__pyx_t_6);
+PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_t_6);
+__pyx_t_6 = 0;
+__Pyx_INCREF(__pyx_v_comment);
+__pyx_t_5 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_v_comment) > __pyx_t_5) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_v_comment) : __pyx_t_5;
+__pyx_t_4 += __Pyx_PyUnicode_GET_LENGTH(__pyx_v_comment);
+__Pyx_GIVEREF(__pyx_v_comment);
+PyTuple_SET_ITEM(__pyx_t_1, 2, __pyx_v_comment);
+__Pyx_INCREF(__pyx_kp_u__17);
+__pyx_t_4 += 1;
+__Pyx_GIVEREF(__pyx_kp_u__17);
+PyTuple_SET_ITEM(__pyx_t_1, 3, __pyx_kp_u__17);
+/* "pysam/libcfaidx.pyx":395
+*         else:
+*             return "@%s%s\n%s\n+\n%s" % (self.name, comment,
+*                                          self.sequence, self.quality)             # <<<<<<<<<<<<<<
+*
+*     cdef cython.str tostring(self):
+*/
+__pyx_t_6 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_sequence); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 395, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_6);
+__pyx_t_3 = __Pyx_PyObject_FormatSimpleAndDecref(PyObject_Unicode(__pyx_t_6), __pyx_empty_unicode); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 395, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
+__pyx_t_5 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_3) > __pyx_t_5) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_3) : __pyx_t_5;
+__pyx_t_4 += __Pyx_PyUnicode_GET_LENGTH(__pyx_t_3);
+__Pyx_GIVEREF(__pyx_t_3);
+PyTuple_SET_ITEM(__pyx_t_1, 4, __pyx_t_3);
+__pyx_t_3 = 0;
+__Pyx_INCREF(__pyx_kp_u__19);
+__pyx_t_4 += 3;
+__Pyx_GIVEREF(__pyx_kp_u__19);
+PyTuple_SET_ITEM(__pyx_t_1, 5, __pyx_kp_u__19);
+__pyx_t_3 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_quality); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 395, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__pyx_t_6 = __Pyx_PyObject_FormatSimpleAndDecref(PyObject_Unicode(__pyx_t_3), __pyx_empty_unicode); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 395, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_6);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__pyx_t_5 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_6) > __pyx_t_5) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_6) : __pyx_t_5;
+__pyx_t_4 += __Pyx_PyUnicode_GET_LENGTH(__pyx_t_6);
+__Pyx_GIVEREF(__pyx_t_6);
+PyTuple_SET_ITEM(__pyx_t_1, 6, __pyx_t_6);
+__pyx_t_6 = 0;
+/* "pysam/libcfaidx.pyx":394
+*             return ">%s%s\n%s" % (self.name, comment, self.sequence)
+*         else:
+*             return "@%s%s\n%s\n+\n%s" % (self.name, comment,             # <<<<<<<<<<<<<<
+*                                          self.sequence, self.quality)
+*
+*/
+__pyx_t_6 = __Pyx_PyUnicode_Join(__pyx_t_1, 7, __pyx_t_4, __pyx_t_5); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 394, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_6);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__pyx_r = ((PyObject*)__pyx_t_6);
+__pyx_t_6 = 0;
+goto __pyx_L0;
+}
+/* "pysam/libcfaidx.pyx":385
+*                 return None
+*
+*     cdef cython.str to_string(self):             # <<<<<<<<<<<<<<
+*         if self.comment is None:
+*             comment = ""
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_XDECREF(__pyx_t_3);
+__Pyx_XDECREF(__pyx_t_6);
+__Pyx_AddTraceback("pysam.libcfaidx.FastqProxy.to_string", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = 0;
+__pyx_L0:;
+__Pyx_XDECREF(__pyx_v_comment);
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":397
+*                                          self.sequence, self.quality)
+*
+*     cdef cython.str tostring(self):             # <<<<<<<<<<<<<<
+*         """deprecated : use :meth:`to_string`"""
+*         return self.to_string()
+*/
+static PyObject *__pyx_f_5pysam_9libcfaidx_10FastqProxy_tostring(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("tostring", 1);
+__Pyx_TraceCall("tostring", __pyx_f[0], 397, 0, __PYX_ERR(0, 397, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":399
+*     cdef cython.str tostring(self):
+*         """deprecated : use :meth:`to_string`"""
+*         return self.to_string()             # <<<<<<<<<<<<<<
+*
+*     def __str__(self):
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_1 = ((struct __pyx_vtabstruct_5pysam_9libcfaidx_FastqProxy *)__pyx_v_self->__pyx_vtab)->to_string(__pyx_v_self); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 399, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_r = ((PyObject*)__pyx_t_1);
+__pyx_t_1 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":397
+*                                          self.sequence, self.quality)
+*
+*     cdef cython.str tostring(self):             # <<<<<<<<<<<<<<
+*         """deprecated : use :meth:`to_string`"""
+*         return self.to_string()
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_AddTraceback("pysam.libcfaidx.FastqProxy.tostring", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = 0;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":401
+*         return self.to_string()
+*
+*     def __str__(self):             # <<<<<<<<<<<<<<
+*         return self.to_string()
+*
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_10FastqProxy_3__str__(PyObject *__pyx_v_self); /*proto*/
+static PyObject *__pyx_pw_5pysam_9libcfaidx_10FastqProxy_3__str__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__str__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_10FastqProxy_2__str__(((struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_10FastqProxy_2__str__(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__str__", 1);
+__Pyx_TraceCall("__str__", __pyx_f[0], 401, 0, __PYX_ERR(0, 401, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":402
+*
+*     def __str__(self):
+*         return self.to_string()             # <<<<<<<<<<<<<<
+*
+*     cpdef array.array get_quality_array(self, int offset=33):
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_1 = ((struct __pyx_vtabstruct_5pysam_9libcfaidx_FastqProxy *)__pyx_v_self->__pyx_vtab)->to_string(__pyx_v_self); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 402, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_r = __pyx_t_1;
+__pyx_t_1 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":401
+*         return self.to_string()
+*
+*     def __str__(self):             # <<<<<<<<<<<<<<
+*         return self.to_string()
+*
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_AddTraceback("pysam.libcfaidx.FastqProxy.__str__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":404
+*         return self.to_string()
+*
+*     cpdef array.array get_quality_array(self, int offset=33):             # <<<<<<<<<<<<<<
+*         '''return quality values as integer array after subtracting offset.'''
+*         if self.quality is None:
+*/
+static PyObject *__pyx_pw_5pysam_9libcfaidx_10FastqProxy_5get_quality_array(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+static arrayobject *__pyx_f_5pysam_9libcfaidx_10FastqProxy_get_quality_array(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self, int __pyx_skip_dispatch, struct __pyx_opt_args_5pysam_9libcfaidx_10FastqProxy_get_quality_array *__pyx_optional_args) {
+int __pyx_v_offset = ((int)33);
+arrayobject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+PyObject *__pyx_t_2 = NULL;
+PyObject *__pyx_t_3 = NULL;
+PyObject *__pyx_t_4 = NULL;
+PyObject *__pyx_t_5 = NULL;
+unsigned int __pyx_t_6;
+int __pyx_t_7;
+struct __pyx_opt_args_5pysam_9libcutils_qualitystring_to_array __pyx_t_8;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__20)
+__Pyx_RefNannySetupContext("get_quality_array", 1);
+__Pyx_TraceCall("get_quality_array", __pyx_f[0], 404, 0, __PYX_ERR(0, 404, __pyx_L1_error));
+if (__pyx_optional_args) {
+if (__pyx_optional_args->__pyx_n > 0) {
+__pyx_v_offset = __pyx_optional_args->offset;
+}
+}
+/* Check if called by wrapper */
+if (unlikely(__pyx_skip_dispatch)) ;
+/* Check if overridden in Python */
+else if (unlikely((Py_TYPE(((PyObject *)__pyx_v_self))->tp_dictoffset != 0) || __Pyx_PyType_HasFeature(Py_TYPE(((PyObject *)__pyx_v_self)), (Py_TPFLAGS_IS_ABSTRACT | Py_TPFLAGS_HEAPTYPE)))) {
+#if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
+static PY_UINT64_T __pyx_tp_dict_version = __PYX_DICT_VERSION_INIT, __pyx_obj_dict_version = __PYX_DICT_VERSION_INIT;
+if (unlikely(!__Pyx_object_dict_version_matches(((PyObject *)__pyx_v_self), __pyx_tp_dict_version, __pyx_obj_dict_version))) {
+PY_UINT64_T __pyx_typedict_guard = __Pyx_get_tp_dict_version(((PyObject *)__pyx_v_self));
+#endif
+__pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_get_quality_array); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 404, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+if (!__Pyx_IsSameCFunction(__pyx_t_1, (void*) __pyx_pw_5pysam_9libcfaidx_10FastqProxy_5get_quality_array)) {
+__Pyx_XDECREF((PyObject *)__pyx_r);
+__pyx_t_3 = __Pyx_PyInt_From_int(__pyx_v_offset); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 404, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_INCREF(__pyx_t_1);
+__pyx_t_4 = __pyx_t_1; __pyx_t_5 = NULL;
+__pyx_t_6 = 0;
+#if CYTHON_UNPACK_METHODS
+if (unlikely(PyMethod_Check(__pyx_t_4))) {
+__pyx_t_5 = PyMethod_GET_SELF(__pyx_t_4);
+if (likely(__pyx_t_5)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_4);
+__Pyx_INCREF(__pyx_t_5);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_4, function);
+__pyx_t_6 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[2] = {__pyx_t_5, __pyx_t_3};
+__pyx_t_2 = __Pyx_PyObject_FastCall(__pyx_t_4, __pyx_callargs+1-__pyx_t_6, 1+__pyx_t_6);
+__Pyx_XDECREF(__pyx_t_5); __pyx_t_5 = 0;
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 404, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+}
+if (!(likely(((__pyx_t_2) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_2, __pyx_ptype_7cpython_5array_array))))) __PYX_ERR(0, 404, __pyx_L1_error)
+__pyx_r = ((arrayobject *)__pyx_t_2);
+__pyx_t_2 = 0;
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+goto __pyx_L0;
+}
+#if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
+__pyx_tp_dict_version = __Pyx_get_tp_dict_version(((PyObject *)__pyx_v_self));
+__pyx_obj_dict_version = __Pyx_get_object_dict_version(((PyObject *)__pyx_v_self));
+if (unlikely(__pyx_typedict_guard != __pyx_tp_dict_version)) {
+__pyx_tp_dict_version = __pyx_obj_dict_version = __PYX_DICT_VERSION_INIT;
+}
+#endif
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+#if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
+}
+#endif
+}
+/* "pysam/libcfaidx.pyx":406
+*     cpdef array.array get_quality_array(self, int offset=33):
+*         '''return quality values as integer array after subtracting offset.'''
+*         if self.quality is None:             # <<<<<<<<<<<<<<
+*             return None
+*         return qualitystring_to_array(force_bytes(self.quality),
+*/
+__pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_quality); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 406, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_t_7 = (__pyx_t_1 == Py_None);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+if (__pyx_t_7) {
+/* "pysam/libcfaidx.pyx":407
+*         '''return quality values as integer array after subtracting offset.'''
+*         if self.quality is None:
+*             return None             # <<<<<<<<<<<<<<
+*         return qualitystring_to_array(force_bytes(self.quality),
+*                                       offset=offset)
+*/
+__Pyx_XDECREF((PyObject *)__pyx_r);
+__pyx_r = ((arrayobject *)Py_None); __Pyx_INCREF(Py_None);
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":406
+*     cpdef array.array get_quality_array(self, int offset=33):
+*         '''return quality values as integer array after subtracting offset.'''
+*         if self.quality is None:             # <<<<<<<<<<<<<<
+*             return None
+*         return qualitystring_to_array(force_bytes(self.quality),
+*/
+}
+/* "pysam/libcfaidx.pyx":408
+*         if self.quality is None:
+*             return None
+*         return qualitystring_to_array(force_bytes(self.quality),             # <<<<<<<<<<<<<<
+*                                       offset=offset)
+*
+*/
+__Pyx_XDECREF((PyObject *)__pyx_r);
+__pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_quality); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 408, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_t_2 = __pyx_f_5pysam_9libcutils_force_bytes(__pyx_t_1, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 408, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+/* "pysam/libcfaidx.pyx":409
+*             return None
+*         return qualitystring_to_array(force_bytes(self.quality),
+*                                       offset=offset)             # <<<<<<<<<<<<<<
+*
+* cdef class FastxRecord:
+*/
+__pyx_t_8.__pyx_n = 1;
+__pyx_t_8.offset = __pyx_v_offset;
+__pyx_t_1 = ((PyObject *)__pyx_f_5pysam_9libcutils_qualitystring_to_array(__pyx_t_2, 0, &__pyx_t_8)); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 408, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__pyx_r = ((arrayobject *)__pyx_t_1);
+__pyx_t_1 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":404
+*         return self.to_string()
+*
+*     cpdef array.array get_quality_array(self, int offset=33):             # <<<<<<<<<<<<<<
+*         '''return quality values as integer array after subtracting offset.'''
+*         if self.quality is None:
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_XDECREF(__pyx_t_3);
+__Pyx_XDECREF(__pyx_t_4);
+__Pyx_XDECREF(__pyx_t_5);
+__Pyx_AddTraceback("pysam.libcfaidx.FastqProxy.get_quality_array", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = 0;
+__pyx_L0:;
+__Pyx_XGIVEREF((PyObject *)__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_10FastqProxy_5get_quality_array(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_10FastqProxy_4get_quality_array, "FastqProxy.get_quality_array(self, int offset=33) -> array\nreturn quality values as integer array after subtracting offset.");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_10FastqProxy_5get_quality_array = {"get_quality_array", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_10FastqProxy_5get_quality_array, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_10FastqProxy_4get_quality_array};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_10FastqProxy_5get_quality_array(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+int __pyx_v_offset;
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject* values[1] = {0};
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("get_quality_array (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+{
+PyObject **__pyx_pyargnames[] = {&__pyx_n_s_offset,0};
+if (__pyx_kwds) {
+Py_ssize_t kw_args;
+switch (__pyx_nargs) {
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
+switch (__pyx_nargs) {
+case  0:
+if (kw_args > 0) {
+PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_offset);
+if (value) { values[0] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 404, __pyx_L3_error)
+}
+}
+if (unlikely(kw_args > 0)) {
+const Py_ssize_t kwd_pos_args = __pyx_nargs;
+if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "get_quality_array") < 0)) __PYX_ERR(0, 404, __pyx_L3_error)
+}
+} else {
+switch (__pyx_nargs) {
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+}
+if (values[0]) {
+__pyx_v_offset = __Pyx_PyInt_As_int(values[0]); if (unlikely((__pyx_v_offset == (int)-1) && PyErr_Occurred())) __PYX_ERR(0, 404, __pyx_L3_error)
+} else {
+__pyx_v_offset = ((int)33);
+}
+}
+goto __pyx_L6_skip;
+__pyx_L5_argtuple_error:;
+__Pyx_RaiseArgtupleInvalid("get_quality_array", 0, 0, 1, __pyx_nargs); __PYX_ERR(0, 404, __pyx_L3_error)
+__pyx_L6_skip:;
+goto __pyx_L4_argument_unpacking_done;
+__pyx_L3_error:;
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_AddTraceback("pysam.libcfaidx.FastqProxy.get_quality_array", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__Pyx_RefNannyFinishContext();
+return NULL;
+__pyx_L4_argument_unpacking_done:;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_10FastqProxy_4get_quality_array(((struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *)__pyx_v_self), __pyx_v_offset);
+/* function exit code */
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_10FastqProxy_4get_quality_array(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self, int __pyx_v_offset) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+struct __pyx_opt_args_5pysam_9libcfaidx_10FastqProxy_get_quality_array __pyx_t_2;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__20)
+__Pyx_RefNannySetupContext("get_quality_array", 1);
+__Pyx_TraceCall("get_quality_array (wrapper)", __pyx_f[0], 404, 0, __PYX_ERR(0, 404, __pyx_L1_error));
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_2.__pyx_n = 1;
+__pyx_t_2.offset = __pyx_v_offset;
+__pyx_t_1 = ((PyObject *)__pyx_vtabptr_5pysam_9libcfaidx_FastqProxy->get_quality_array(__pyx_v_self, 1, &__pyx_t_2)); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 404, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_r = __pyx_t_1;
+__pyx_t_1 = 0;
+goto __pyx_L0;
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_AddTraceback("pysam.libcfaidx.FastqProxy.get_quality_array", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     raise TypeError, "self._delegate cannot be converted to a Python object for pickling"
+* def __setstate_cython__(self, __pyx_state):
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_10FastqProxy_7__reduce_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_10FastqProxy_6__reduce_cython__, "FastqProxy.__reduce_cython__(self)");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_10FastqProxy_7__reduce_cython__ = {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_10FastqProxy_7__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_10FastqProxy_6__reduce_cython__};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_10FastqProxy_7__reduce_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__reduce_cython__ (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+if (unlikely(__pyx_nargs > 0)) {
+__Pyx_RaiseArgtupleInvalid("__reduce_cython__", 1, 0, 0, __pyx_nargs); return NULL;}
+if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__reduce_cython__", 0))) return NULL;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_10FastqProxy_6__reduce_cython__(((struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_10FastqProxy_6__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__21)
+__Pyx_RefNannySetupContext("__reduce_cython__", 1);
+__Pyx_TraceCall("__reduce_cython__", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));
+/* "(tree fragment)":2
+* def __reduce_cython__(self):
+*     raise TypeError, "self._delegate cannot be converted to a Python object for pickling"             # <<<<<<<<<<<<<<
+* def __setstate_cython__(self, __pyx_state):
+*     raise TypeError, "self._delegate cannot be converted to a Python object for pickling"
+*/
+__Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_self__delegate_cannot_be_convert, 0, 0);
+__PYX_ERR(1, 2, __pyx_L1_error)
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     raise TypeError, "self._delegate cannot be converted to a Python object for pickling"
+* def __setstate_cython__(self, __pyx_state):
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastqProxy.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "(tree fragment)":3
+* def __reduce_cython__(self):
+*     raise TypeError, "self._delegate cannot be converted to a Python object for pickling"
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     raise TypeError, "self._delegate cannot be converted to a Python object for pickling"
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_10FastqProxy_9__setstate_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_10FastqProxy_8__setstate_cython__, "FastqProxy.__setstate_cython__(self, __pyx_state)");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_10FastqProxy_9__setstate_cython__ = {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_10FastqProxy_9__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_10FastqProxy_8__setstate_cython__};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_10FastqProxy_9__setstate_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+CYTHON_UNUSED PyObject *__pyx_v___pyx_state = 0;
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject* values[1] = {0};
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__setstate_cython__ (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+{
+PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_state,0};
+if (__pyx_kwds) {
+Py_ssize_t kw_args;
+switch (__pyx_nargs) {
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
+switch (__pyx_nargs) {
+case  0:
+if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 3, __pyx_L3_error)
+else goto __pyx_L5_argtuple_error;
+}
+if (unlikely(kw_args > 0)) {
+const Py_ssize_t kwd_pos_args = __pyx_nargs;
+if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__setstate_cython__") < 0)) __PYX_ERR(1, 3, __pyx_L3_error)
+}
+} else if (unlikely(__pyx_nargs != 1)) {
+goto __pyx_L5_argtuple_error;
+} else {
+values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+}
+__pyx_v___pyx_state = values[0];
+}
+goto __pyx_L6_skip;
+__pyx_L5_argtuple_error:;
+__Pyx_RaiseArgtupleInvalid("__setstate_cython__", 1, 1, 1, __pyx_nargs); __PYX_ERR(1, 3, __pyx_L3_error)
+__pyx_L6_skip:;
+goto __pyx_L4_argument_unpacking_done;
+__pyx_L3_error:;
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_AddTraceback("pysam.libcfaidx.FastqProxy.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__Pyx_RefNannyFinishContext();
+return NULL;
+__pyx_L4_argument_unpacking_done:;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_10FastqProxy_8__setstate_cython__(((struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *)__pyx_v_self), __pyx_v___pyx_state);
+/* function exit code */
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_10FastqProxy_8__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__22)
+__Pyx_RefNannySetupContext("__setstate_cython__", 1);
+__Pyx_TraceCall("__setstate_cython__", __pyx_f[1], 3, 0, __PYX_ERR(1, 3, __pyx_L1_error));
+/* "(tree fragment)":4
+*     raise TypeError, "self._delegate cannot be converted to a Python object for pickling"
+* def __setstate_cython__(self, __pyx_state):
+*     raise TypeError, "self._delegate cannot be converted to a Python object for pickling"             # <<<<<<<<<<<<<<
+*/
+__Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_self__delegate_cannot_be_convert, 0, 0);
+__PYX_ERR(1, 4, __pyx_L1_error)
+/* "(tree fragment)":3
+* def __reduce_cython__(self):
+*     raise TypeError, "self._delegate cannot be converted to a Python object for pickling"
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     raise TypeError, "self._delegate cannot be converted to a Python object for pickling"
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastqProxy.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":418
+*
+*     """
+*     def __init__(self,             # <<<<<<<<<<<<<<
+*                  name=None,
+*                  comment=None,
+*/
+/* Python wrapper */
+static int __pyx_pw_5pysam_9libcfaidx_11FastxRecord_1__init__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
+static int __pyx_pw_5pysam_9libcfaidx_11FastxRecord_1__init__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds) {
+PyObject *__pyx_v_name = 0;
+PyObject *__pyx_v_comment = 0;
+PyObject *__pyx_v_sequence = 0;
+PyObject *__pyx_v_quality = 0;
+struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_proxy = 0;
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject* values[5] = {0,0,0,0,0};
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+int __pyx_r;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__init__ (wrapper)", 0);
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return -1;
+#endif
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+{
+PyObject **__pyx_pyargnames[] = {&__pyx_n_s_name,&__pyx_n_s_comment,&__pyx_n_s_sequence,&__pyx_n_s_quality,&__pyx_n_s_proxy,0};
+/* "pysam/libcfaidx.pyx":419
+*     """
+*     def __init__(self,
+*                  name=None,             # <<<<<<<<<<<<<<
+*                  comment=None,
+*                  sequence=None,
+*/
+values[0] = __Pyx_Arg_NewRef_VARARGS(((PyObject *)Py_None));
+/* "pysam/libcfaidx.pyx":420
+*     def __init__(self,
+*                  name=None,
+*                  comment=None,             # <<<<<<<<<<<<<<
+*                  sequence=None,
+*                  quality=None,
+*/
+values[1] = __Pyx_Arg_NewRef_VARARGS(((PyObject *)Py_None));
+/* "pysam/libcfaidx.pyx":421
+*                  name=None,
+*                  comment=None,
+*                  sequence=None,             # <<<<<<<<<<<<<<
+*                  quality=None,
+*                  FastqProxy proxy=None):
+*/
+values[2] = __Pyx_Arg_NewRef_VARARGS(((PyObject *)Py_None));
+/* "pysam/libcfaidx.pyx":422
+*                  comment=None,
+*                  sequence=None,
+*                  quality=None,             # <<<<<<<<<<<<<<
+*                  FastqProxy proxy=None):
+*         if proxy is not None:
+*/
+values[3] = __Pyx_Arg_NewRef_VARARGS(((PyObject *)Py_None));
+/* "pysam/libcfaidx.pyx":423
+*                  sequence=None,
+*                  quality=None,
+*                  FastqProxy proxy=None):             # <<<<<<<<<<<<<<
+*         if proxy is not None:
+*             self.comment = proxy.comment
+*/
+values[4] = __Pyx_Arg_NewRef_VARARGS((PyObject *)((struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *)Py_None));
+if (__pyx_kwds) {
+Py_ssize_t kw_args;
+switch (__pyx_nargs) {
+case  5: values[4] = __Pyx_Arg_VARARGS(__pyx_args, 4);
+CYTHON_FALLTHROUGH;
+case  4: values[3] = __Pyx_Arg_VARARGS(__pyx_args, 3);
+CYTHON_FALLTHROUGH;
+case  3: values[2] = __Pyx_Arg_VARARGS(__pyx_args, 2);
+CYTHON_FALLTHROUGH;
+case  2: values[1] = __Pyx_Arg_VARARGS(__pyx_args, 1);
+CYTHON_FALLTHROUGH;
+case  1: values[0] = __Pyx_Arg_VARARGS(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+kw_args = __Pyx_NumKwargs_VARARGS(__pyx_kwds);
+switch (__pyx_nargs) {
+case  0:
+if (kw_args > 0) {
+PyObject* value = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_name);
+if (value) { values[0] = __Pyx_Arg_NewRef_VARARGS(value); kw_args--; }
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 418, __pyx_L3_error)
+}
+CYTHON_FALLTHROUGH;
+case  1:
+if (kw_args > 0) {
+PyObject* value = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_comment);
+if (value) { values[1] = __Pyx_Arg_NewRef_VARARGS(value); kw_args--; }
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 418, __pyx_L3_error)
+}
+CYTHON_FALLTHROUGH;
+case  2:
+if (kw_args > 0) {
+PyObject* value = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_sequence);
+if (value) { values[2] = __Pyx_Arg_NewRef_VARARGS(value); kw_args--; }
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 418, __pyx_L3_error)
+}
+CYTHON_FALLTHROUGH;
+case  3:
+if (kw_args > 0) {
+PyObject* value = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_quality);
+if (value) { values[3] = __Pyx_Arg_NewRef_VARARGS(value); kw_args--; }
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 418, __pyx_L3_error)
+}
+CYTHON_FALLTHROUGH;
+case  4:
+if (kw_args > 0) {
+PyObject* value = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_proxy);
+if (value) { values[4] = __Pyx_Arg_NewRef_VARARGS(value); kw_args--; }
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 418, __pyx_L3_error)
+}
+}
+if (unlikely(kw_args > 0)) {
+const Py_ssize_t kwd_pos_args = __pyx_nargs;
+if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__init__") < 0)) __PYX_ERR(0, 418, __pyx_L3_error)
+}
+} else {
+switch (__pyx_nargs) {
+case  5: values[4] = __Pyx_Arg_VARARGS(__pyx_args, 4);
+CYTHON_FALLTHROUGH;
+case  4: values[3] = __Pyx_Arg_VARARGS(__pyx_args, 3);
+CYTHON_FALLTHROUGH;
+case  3: values[2] = __Pyx_Arg_VARARGS(__pyx_args, 2);
+CYTHON_FALLTHROUGH;
+case  2: values[1] = __Pyx_Arg_VARARGS(__pyx_args, 1);
+CYTHON_FALLTHROUGH;
+case  1: values[0] = __Pyx_Arg_VARARGS(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+}
+__pyx_v_name = values[0];
+__pyx_v_comment = values[1];
+__pyx_v_sequence = values[2];
+__pyx_v_quality = values[3];
+__pyx_v_proxy = ((struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *)values[4]);
+}
+goto __pyx_L6_skip;
+__pyx_L5_argtuple_error:;
+__Pyx_RaiseArgtupleInvalid("__init__", 0, 0, 5, __pyx_nargs); __PYX_ERR(0, 418, __pyx_L3_error)
+__pyx_L6_skip:;
+goto __pyx_L4_argument_unpacking_done;
+__pyx_L3_error:;
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_VARARGS(values[__pyx_temp]);
+}
+}
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.__init__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__Pyx_RefNannyFinishContext();
+return -1;
+__pyx_L4_argument_unpacking_done:;
+if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_proxy), __pyx_ptype_5pysam_9libcfaidx_FastqProxy, 1, "proxy", 0))) __PYX_ERR(0, 423, __pyx_L1_error)
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord___init__(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self), __pyx_v_name, __pyx_v_comment, __pyx_v_sequence, __pyx_v_quality, __pyx_v_proxy);
+/* "pysam/libcfaidx.pyx":418
+*
+*     """
+*     def __init__(self,             # <<<<<<<<<<<<<<
+*                  name=None,
+*                  comment=None,
+*/
+/* function exit code */
+goto __pyx_L0;
+__pyx_L1_error:;
+__pyx_r = -1;
+__pyx_L0:;
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_VARARGS(values[__pyx_temp]);
+}
+}
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static int __pyx_pf_5pysam_9libcfaidx_11FastxRecord___init__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, PyObject *__pyx_v_name, PyObject *__pyx_v_comment, PyObject *__pyx_v_sequence, PyObject *__pyx_v_quality, struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *__pyx_v_proxy) {
+int __pyx_r;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_t_1;
+PyObject *__pyx_t_2 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__init__", 1);
+__Pyx_TraceCall("__init__", __pyx_f[0], 418, 0, __PYX_ERR(0, 418, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":424
+*                  quality=None,
+*                  FastqProxy proxy=None):
+*         if proxy is not None:             # <<<<<<<<<<<<<<
+*             self.comment = proxy.comment
+*             self.quality = proxy.quality
+*/
+__pyx_t_1 = (((PyObject *)__pyx_v_proxy) != Py_None);
+if (__pyx_t_1) {
+/* "pysam/libcfaidx.pyx":425
+*                  FastqProxy proxy=None):
+*         if proxy is not None:
+*             self.comment = proxy.comment             # <<<<<<<<<<<<<<
+*             self.quality = proxy.quality
+*             self.sequence = proxy.sequence
+*/
+__pyx_t_2 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_proxy), __pyx_n_s_comment); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 425, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (!(likely(PyUnicode_CheckExact(__pyx_t_2))||((__pyx_t_2) == Py_None) || __Pyx_RaiseUnexpectedTypeError("unicode", __pyx_t_2))) __PYX_ERR(0, 425, __pyx_L1_error)
+__Pyx_GIVEREF(__pyx_t_2);
+__Pyx_GOTREF(__pyx_v_self->comment);
+__Pyx_DECREF(__pyx_v_self->comment);
+__pyx_v_self->comment = ((PyObject*)__pyx_t_2);
+__pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":426
+*         if proxy is not None:
+*             self.comment = proxy.comment
+*             self.quality = proxy.quality             # <<<<<<<<<<<<<<
+*             self.sequence = proxy.sequence
+*             self.name = proxy.name
+*/
+__pyx_t_2 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_proxy), __pyx_n_s_quality); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 426, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (!(likely(PyUnicode_CheckExact(__pyx_t_2))||((__pyx_t_2) == Py_None) || __Pyx_RaiseUnexpectedTypeError("unicode", __pyx_t_2))) __PYX_ERR(0, 426, __pyx_L1_error)
+__Pyx_GIVEREF(__pyx_t_2);
+__Pyx_GOTREF(__pyx_v_self->quality);
+__Pyx_DECREF(__pyx_v_self->quality);
+__pyx_v_self->quality = ((PyObject*)__pyx_t_2);
+__pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":427
+*             self.comment = proxy.comment
+*             self.quality = proxy.quality
+*             self.sequence = proxy.sequence             # <<<<<<<<<<<<<<
+*             self.name = proxy.name
+*         else:
+*/
+__pyx_t_2 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_proxy), __pyx_n_s_sequence); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 427, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (!(likely(PyUnicode_CheckExact(__pyx_t_2))||((__pyx_t_2) == Py_None) || __Pyx_RaiseUnexpectedTypeError("unicode", __pyx_t_2))) __PYX_ERR(0, 427, __pyx_L1_error)
+__Pyx_GIVEREF(__pyx_t_2);
+__Pyx_GOTREF(__pyx_v_self->sequence);
+__Pyx_DECREF(__pyx_v_self->sequence);
+__pyx_v_self->sequence = ((PyObject*)__pyx_t_2);
+__pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":428
+*             self.quality = proxy.quality
+*             self.sequence = proxy.sequence
+*             self.name = proxy.name             # <<<<<<<<<<<<<<
+*         else:
+*             self.comment = comment
+*/
+__pyx_t_2 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_proxy), __pyx_n_s_name); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 428, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (!(likely(PyUnicode_CheckExact(__pyx_t_2))||((__pyx_t_2) == Py_None) || __Pyx_RaiseUnexpectedTypeError("unicode", __pyx_t_2))) __PYX_ERR(0, 428, __pyx_L1_error)
+__Pyx_GIVEREF(__pyx_t_2);
+__Pyx_GOTREF(__pyx_v_self->name);
+__Pyx_DECREF(__pyx_v_self->name);
+__pyx_v_self->name = ((PyObject*)__pyx_t_2);
+__pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":424
+*                  quality=None,
+*                  FastqProxy proxy=None):
+*         if proxy is not None:             # <<<<<<<<<<<<<<
+*             self.comment = proxy.comment
+*             self.quality = proxy.quality
+*/
+goto __pyx_L3;
+}
+/* "pysam/libcfaidx.pyx":430
+*             self.name = proxy.name
+*         else:
+*             self.comment = comment             # <<<<<<<<<<<<<<
+*             self.quality = quality
+*             self.sequence = sequence
+*/
+/*else*/ {
+if (!(likely(PyUnicode_CheckExact(__pyx_v_comment))||((__pyx_v_comment) == Py_None) || __Pyx_RaiseUnexpectedTypeError("unicode", __pyx_v_comment))) __PYX_ERR(0, 430, __pyx_L1_error)
+__pyx_t_2 = __pyx_v_comment;
+__Pyx_INCREF(__pyx_t_2);
+__Pyx_GIVEREF(__pyx_t_2);
+__Pyx_GOTREF(__pyx_v_self->comment);
+__Pyx_DECREF(__pyx_v_self->comment);
+__pyx_v_self->comment = ((PyObject*)__pyx_t_2);
+__pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":431
+*         else:
+*             self.comment = comment
+*             self.quality = quality             # <<<<<<<<<<<<<<
+*             self.sequence = sequence
+*             self.name = name
+*/
+if (!(likely(PyUnicode_CheckExact(__pyx_v_quality))||((__pyx_v_quality) == Py_None) || __Pyx_RaiseUnexpectedTypeError("unicode", __pyx_v_quality))) __PYX_ERR(0, 431, __pyx_L1_error)
+__pyx_t_2 = __pyx_v_quality;
+__Pyx_INCREF(__pyx_t_2);
+__Pyx_GIVEREF(__pyx_t_2);
+__Pyx_GOTREF(__pyx_v_self->quality);
+__Pyx_DECREF(__pyx_v_self->quality);
+__pyx_v_self->quality = ((PyObject*)__pyx_t_2);
+__pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":432
+*             self.comment = comment
+*             self.quality = quality
+*             self.sequence = sequence             # <<<<<<<<<<<<<<
+*             self.name = name
+*
+*/
+if (!(likely(PyUnicode_CheckExact(__pyx_v_sequence))||((__pyx_v_sequence) == Py_None) || __Pyx_RaiseUnexpectedTypeError("unicode", __pyx_v_sequence))) __PYX_ERR(0, 432, __pyx_L1_error)
+__pyx_t_2 = __pyx_v_sequence;
+__Pyx_INCREF(__pyx_t_2);
+__Pyx_GIVEREF(__pyx_t_2);
+__Pyx_GOTREF(__pyx_v_self->sequence);
+__Pyx_DECREF(__pyx_v_self->sequence);
+__pyx_v_self->sequence = ((PyObject*)__pyx_t_2);
+__pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":433
+*             self.quality = quality
+*             self.sequence = sequence
+*             self.name = name             # <<<<<<<<<<<<<<
+*
+*     def __copy__(self):
+*/
+if (!(likely(PyUnicode_CheckExact(__pyx_v_name))||((__pyx_v_name) == Py_None) || __Pyx_RaiseUnexpectedTypeError("unicode", __pyx_v_name))) __PYX_ERR(0, 433, __pyx_L1_error)
+__pyx_t_2 = __pyx_v_name;
+__Pyx_INCREF(__pyx_t_2);
+__Pyx_GIVEREF(__pyx_t_2);
+__Pyx_GOTREF(__pyx_v_self->name);
+__Pyx_DECREF(__pyx_v_self->name);
+__pyx_v_self->name = ((PyObject*)__pyx_t_2);
+__pyx_t_2 = 0;
+}
+__pyx_L3:;
+/* "pysam/libcfaidx.pyx":418
+*
+*     """
+*     def __init__(self,             # <<<<<<<<<<<<<<
+*                  name=None,
+*                  comment=None,
+*/
+/* function exit code */
+__pyx_r = 0;
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.__init__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = -1;
+__pyx_L0:;
+__Pyx_TraceReturn(Py_None, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":435
+*             self.name = name
+*
+*     def __copy__(self):             # <<<<<<<<<<<<<<
+*         return FastxRecord(self.name, self.comment, self.sequence, self.quality)
+*
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_3__copy__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_11FastxRecord_2__copy__, "FastxRecord.__copy__(self)");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_11FastxRecord_3__copy__ = {"__copy__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_11FastxRecord_3__copy__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_11FastxRecord_2__copy__};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_3__copy__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__copy__ (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+if (unlikely(__pyx_nargs > 0)) {
+__Pyx_RaiseArgtupleInvalid("__copy__", 1, 0, 0, __pyx_nargs); return NULL;}
+if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__copy__", 0))) return NULL;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord_2__copy__(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_2__copy__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+PyObject *__pyx_t_2 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__23)
+__Pyx_RefNannySetupContext("__copy__", 1);
+__Pyx_TraceCall("__copy__", __pyx_f[0], 435, 0, __PYX_ERR(0, 435, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":436
+*
+*     def __copy__(self):
+*         return FastxRecord(self.name, self.comment, self.sequence, self.quality)             # <<<<<<<<<<<<<<
+*
+*     def __deepcopy__(self, memo):
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_1 = PyTuple_New(4); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 436, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_INCREF(__pyx_v_self->name);
+__Pyx_GIVEREF(__pyx_v_self->name);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_v_self->name)) __PYX_ERR(0, 436, __pyx_L1_error);
+__Pyx_INCREF(__pyx_v_self->comment);
+__Pyx_GIVEREF(__pyx_v_self->comment);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_v_self->comment)) __PYX_ERR(0, 436, __pyx_L1_error);
+__Pyx_INCREF(__pyx_v_self->sequence);
+__Pyx_GIVEREF(__pyx_v_self->sequence);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 2, __pyx_v_self->sequence)) __PYX_ERR(0, 436, __pyx_L1_error);
+__Pyx_INCREF(__pyx_v_self->quality);
+__Pyx_GIVEREF(__pyx_v_self->quality);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 3, __pyx_v_self->quality)) __PYX_ERR(0, 436, __pyx_L1_error);
+__pyx_t_2 = __Pyx_PyObject_Call(((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastxRecord), __pyx_t_1, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 436, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__pyx_r = __pyx_t_2;
+__pyx_t_2 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":435
+*             self.name = name
+*
+*     def __copy__(self):             # <<<<<<<<<<<<<<
+*         return FastxRecord(self.name, self.comment, self.sequence, self.quality)
+*
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.__copy__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":438
+*         return FastxRecord(self.name, self.comment, self.sequence, self.quality)
+*
+*     def __deepcopy__(self, memo):             # <<<<<<<<<<<<<<
+*         return FastxRecord(self.name, self.comment, self.sequence, self.quality)
+*
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_5__deepcopy__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_11FastxRecord_4__deepcopy__, "FastxRecord.__deepcopy__(self, memo)");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_11FastxRecord_5__deepcopy__ = {"__deepcopy__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_11FastxRecord_5__deepcopy__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_11FastxRecord_4__deepcopy__};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_5__deepcopy__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+CYTHON_UNUSED PyObject *__pyx_v_memo = 0;
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject* values[1] = {0};
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__deepcopy__ (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+{
+PyObject **__pyx_pyargnames[] = {&__pyx_n_s_memo,0};
+if (__pyx_kwds) {
+Py_ssize_t kw_args;
+switch (__pyx_nargs) {
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
+switch (__pyx_nargs) {
+case  0:
+if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_memo)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 438, __pyx_L3_error)
+else goto __pyx_L5_argtuple_error;
+}
+if (unlikely(kw_args > 0)) {
+const Py_ssize_t kwd_pos_args = __pyx_nargs;
+if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__deepcopy__") < 0)) __PYX_ERR(0, 438, __pyx_L3_error)
+}
+} else if (unlikely(__pyx_nargs != 1)) {
+goto __pyx_L5_argtuple_error;
+} else {
+values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+}
+__pyx_v_memo = values[0];
+}
+goto __pyx_L6_skip;
+__pyx_L5_argtuple_error:;
+__Pyx_RaiseArgtupleInvalid("__deepcopy__", 1, 1, 1, __pyx_nargs); __PYX_ERR(0, 438, __pyx_L3_error)
+__pyx_L6_skip:;
+goto __pyx_L4_argument_unpacking_done;
+__pyx_L3_error:;
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.__deepcopy__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__Pyx_RefNannyFinishContext();
+return NULL;
+__pyx_L4_argument_unpacking_done:;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord_4__deepcopy__(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self), __pyx_v_memo);
+/* function exit code */
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_4__deepcopy__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v_memo) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+PyObject *__pyx_t_2 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__24)
+__Pyx_RefNannySetupContext("__deepcopy__", 1);
+__Pyx_TraceCall("__deepcopy__", __pyx_f[0], 438, 0, __PYX_ERR(0, 438, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":439
+*
+*     def __deepcopy__(self, memo):
+*         return FastxRecord(self.name, self.comment, self.sequence, self.quality)             # <<<<<<<<<<<<<<
+*
+*     cdef cython.str to_string(self):
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_1 = PyTuple_New(4); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 439, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_INCREF(__pyx_v_self->name);
+__Pyx_GIVEREF(__pyx_v_self->name);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_v_self->name)) __PYX_ERR(0, 439, __pyx_L1_error);
+__Pyx_INCREF(__pyx_v_self->comment);
+__Pyx_GIVEREF(__pyx_v_self->comment);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_v_self->comment)) __PYX_ERR(0, 439, __pyx_L1_error);
+__Pyx_INCREF(__pyx_v_self->sequence);
+__Pyx_GIVEREF(__pyx_v_self->sequence);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 2, __pyx_v_self->sequence)) __PYX_ERR(0, 439, __pyx_L1_error);
+__Pyx_INCREF(__pyx_v_self->quality);
+__Pyx_GIVEREF(__pyx_v_self->quality);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 3, __pyx_v_self->quality)) __PYX_ERR(0, 439, __pyx_L1_error);
+__pyx_t_2 = __Pyx_PyObject_Call(((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastxRecord), __pyx_t_1, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 439, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__pyx_r = __pyx_t_2;
+__pyx_t_2 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":438
+*         return FastxRecord(self.name, self.comment, self.sequence, self.quality)
+*
+*     def __deepcopy__(self, memo):             # <<<<<<<<<<<<<<
+*         return FastxRecord(self.name, self.comment, self.sequence, self.quality)
+*
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.__deepcopy__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":441
+*         return FastxRecord(self.name, self.comment, self.sequence, self.quality)
+*
+*     cdef cython.str to_string(self):             # <<<<<<<<<<<<<<
+*         if self.name is None:
+*             raise ValueError("can not write record without name")
+*/
+static PyObject *__pyx_f_5pysam_9libcfaidx_11FastxRecord_to_string(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self) {
+PyObject *__pyx_v_comment = NULL;
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_t_1;
+PyObject *__pyx_t_2 = NULL;
+Py_ssize_t __pyx_t_3;
+Py_UCS4 __pyx_t_4;
+PyObject *__pyx_t_5 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("to_string", 1);
+__Pyx_TraceCall("to_string", __pyx_f[0], 441, 0, __PYX_ERR(0, 441, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":442
+*
+*     cdef cython.str to_string(self):
+*         if self.name is None:             # <<<<<<<<<<<<<<
+*             raise ValueError("can not write record without name")
+*
+*/
+__pyx_t_1 = (__pyx_v_self->name == ((PyObject*)Py_None));
+if (unlikely(__pyx_t_1)) {
+/* "pysam/libcfaidx.pyx":443
+*     cdef cython.str to_string(self):
+*         if self.name is None:
+*             raise ValueError("can not write record without name")             # <<<<<<<<<<<<<<
+*
+*         if self.sequence is None:
+*/
+__pyx_t_2 = __Pyx_PyObject_Call(__pyx_builtin_ValueError, __pyx_tuple__25, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 443, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_Raise(__pyx_t_2, 0, 0, 0);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__PYX_ERR(0, 443, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":442
+*
+*     cdef cython.str to_string(self):
+*         if self.name is None:             # <<<<<<<<<<<<<<
+*             raise ValueError("can not write record without name")
+*
+*/
+}
+/* "pysam/libcfaidx.pyx":445
+*             raise ValueError("can not write record without name")
+*
+*         if self.sequence is None:             # <<<<<<<<<<<<<<
+*             raise ValueError("can not write record without a sequence")
+*
+*/
+__pyx_t_1 = (__pyx_v_self->sequence == ((PyObject*)Py_None));
+if (unlikely(__pyx_t_1)) {
+/* "pysam/libcfaidx.pyx":446
+*
+*         if self.sequence is None:
+*             raise ValueError("can not write record without a sequence")             # <<<<<<<<<<<<<<
+*
+*         if self.comment is None:
+*/
+__pyx_t_2 = __Pyx_PyObject_Call(__pyx_builtin_ValueError, __pyx_tuple__26, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 446, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_Raise(__pyx_t_2, 0, 0, 0);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__PYX_ERR(0, 446, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":445
+*             raise ValueError("can not write record without name")
+*
+*         if self.sequence is None:             # <<<<<<<<<<<<<<
+*             raise ValueError("can not write record without a sequence")
+*
+*/
+}
+/* "pysam/libcfaidx.pyx":448
+*             raise ValueError("can not write record without a sequence")
+*
+*         if self.comment is None:             # <<<<<<<<<<<<<<
+*             comment = ""
+*         else:
+*/
+__pyx_t_1 = (__pyx_v_self->comment == ((PyObject*)Py_None));
+if (__pyx_t_1) {
+/* "pysam/libcfaidx.pyx":449
+*
+*         if self.comment is None:
+*             comment = ""             # <<<<<<<<<<<<<<
+*         else:
+*             comment = " %s" % self.comment
+*/
+__Pyx_INCREF(__pyx_kp_u__11);
+__pyx_v_comment = __pyx_kp_u__11;
+/* "pysam/libcfaidx.pyx":448
+*             raise ValueError("can not write record without a sequence")
+*
+*         if self.comment is None:             # <<<<<<<<<<<<<<
+*             comment = ""
+*         else:
+*/
+goto __pyx_L5;
+}
+/* "pysam/libcfaidx.pyx":451
+*             comment = ""
+*         else:
+*             comment = " %s" % self.comment             # <<<<<<<<<<<<<<
+*
+*         if self.quality is None:
+*/
+/*else*/ {
+__pyx_t_2 = PyUnicode_Format(__pyx_kp_u_s, __pyx_v_self->comment); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 451, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_v_comment = ((PyObject*)__pyx_t_2);
+__pyx_t_2 = 0;
+}
+__pyx_L5:;
+/* "pysam/libcfaidx.pyx":453
+*             comment = " %s" % self.comment
+*
+*         if self.quality is None:             # <<<<<<<<<<<<<<
+*             return ">%s%s\n%s" % (self.name, comment, self.sequence)
+*         else:
+*/
+__pyx_t_1 = (__pyx_v_self->quality == ((PyObject*)Py_None));
+if (__pyx_t_1) {
+/* "pysam/libcfaidx.pyx":454
+*
+*         if self.quality is None:
+*             return ">%s%s\n%s" % (self.name, comment, self.sequence)             # <<<<<<<<<<<<<<
+*         else:
+*             return "@%s%s\n%s\n+\n%s" % (self.name, comment,
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_2 = PyTuple_New(5); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 454, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_3 = 0;
+__pyx_t_4 = 127;
+__Pyx_INCREF(__pyx_kp_u__16);
+__pyx_t_3 += 1;
+__Pyx_GIVEREF(__pyx_kp_u__16);
+PyTuple_SET_ITEM(__pyx_t_2, 0, __pyx_kp_u__16);
+__pyx_t_5 = __Pyx_PyUnicode_Unicode(__pyx_v_self->name); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 454, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_5);
+__pyx_t_4 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_5) > __pyx_t_4) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_5) : __pyx_t_4;
+__pyx_t_3 += __Pyx_PyUnicode_GET_LENGTH(__pyx_t_5);
+__Pyx_GIVEREF(__pyx_t_5);
+PyTuple_SET_ITEM(__pyx_t_2, 1, __pyx_t_5);
+__pyx_t_5 = 0;
+__Pyx_INCREF(__pyx_v_comment);
+__pyx_t_4 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_v_comment) > __pyx_t_4) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_v_comment) : __pyx_t_4;
+__pyx_t_3 += __Pyx_PyUnicode_GET_LENGTH(__pyx_v_comment);
+__Pyx_GIVEREF(__pyx_v_comment);
+PyTuple_SET_ITEM(__pyx_t_2, 2, __pyx_v_comment);
+__Pyx_INCREF(__pyx_kp_u__17);
+__pyx_t_3 += 1;
+__Pyx_GIVEREF(__pyx_kp_u__17);
+PyTuple_SET_ITEM(__pyx_t_2, 3, __pyx_kp_u__17);
+__pyx_t_5 = __Pyx_PyUnicode_Unicode(__pyx_v_self->sequence); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 454, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_5);
+__pyx_t_4 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_5) > __pyx_t_4) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_5) : __pyx_t_4;
+__pyx_t_3 += __Pyx_PyUnicode_GET_LENGTH(__pyx_t_5);
+__Pyx_GIVEREF(__pyx_t_5);
+PyTuple_SET_ITEM(__pyx_t_2, 4, __pyx_t_5);
+__pyx_t_5 = 0;
+__pyx_t_5 = __Pyx_PyUnicode_Join(__pyx_t_2, 5, __pyx_t_3, __pyx_t_4); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 454, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_5);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__pyx_r = ((PyObject*)__pyx_t_5);
+__pyx_t_5 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":453
+*             comment = " %s" % self.comment
+*
+*         if self.quality is None:             # <<<<<<<<<<<<<<
+*             return ">%s%s\n%s" % (self.name, comment, self.sequence)
+*         else:
+*/
+}
+/* "pysam/libcfaidx.pyx":456
+*             return ">%s%s\n%s" % (self.name, comment, self.sequence)
+*         else:
+*             return "@%s%s\n%s\n+\n%s" % (self.name, comment,             # <<<<<<<<<<<<<<
+*                                          self.sequence, self.quality)
+*
+*/
+/*else*/ {
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_5 = PyTuple_New(7); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 456, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_5);
+__pyx_t_3 = 0;
+__pyx_t_4 = 127;
+__Pyx_INCREF(__pyx_kp_u__18);
+__pyx_t_3 += 1;
+__Pyx_GIVEREF(__pyx_kp_u__18);
+PyTuple_SET_ITEM(__pyx_t_5, 0, __pyx_kp_u__18);
+__pyx_t_2 = __Pyx_PyUnicode_Unicode(__pyx_v_self->name); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 456, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_4 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_2) > __pyx_t_4) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_2) : __pyx_t_4;
+__pyx_t_3 += __Pyx_PyUnicode_GET_LENGTH(__pyx_t_2);
+__Pyx_GIVEREF(__pyx_t_2);
+PyTuple_SET_ITEM(__pyx_t_5, 1, __pyx_t_2);
+__pyx_t_2 = 0;
+__Pyx_INCREF(__pyx_v_comment);
+__pyx_t_4 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_v_comment) > __pyx_t_4) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_v_comment) : __pyx_t_4;
+__pyx_t_3 += __Pyx_PyUnicode_GET_LENGTH(__pyx_v_comment);
+__Pyx_GIVEREF(__pyx_v_comment);
+PyTuple_SET_ITEM(__pyx_t_5, 2, __pyx_v_comment);
+__Pyx_INCREF(__pyx_kp_u__17);
+__pyx_t_3 += 1;
+__Pyx_GIVEREF(__pyx_kp_u__17);
+PyTuple_SET_ITEM(__pyx_t_5, 3, __pyx_kp_u__17);
+/* "pysam/libcfaidx.pyx":457
+*         else:
+*             return "@%s%s\n%s\n+\n%s" % (self.name, comment,
+*                                          self.sequence, self.quality)             # <<<<<<<<<<<<<<
+*
+*     cdef cython.str tostring(self):
+*/
+__pyx_t_2 = __Pyx_PyUnicode_Unicode(__pyx_v_self->sequence); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 457, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_4 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_2) > __pyx_t_4) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_2) : __pyx_t_4;
+__pyx_t_3 += __Pyx_PyUnicode_GET_LENGTH(__pyx_t_2);
+__Pyx_GIVEREF(__pyx_t_2);
+PyTuple_SET_ITEM(__pyx_t_5, 4, __pyx_t_2);
+__pyx_t_2 = 0;
+__Pyx_INCREF(__pyx_kp_u__19);
+__pyx_t_3 += 3;
+__Pyx_GIVEREF(__pyx_kp_u__19);
+PyTuple_SET_ITEM(__pyx_t_5, 5, __pyx_kp_u__19);
+__pyx_t_2 = __Pyx_PyUnicode_Unicode(__pyx_v_self->quality); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 457, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_4 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_2) > __pyx_t_4) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_2) : __pyx_t_4;
+__pyx_t_3 += __Pyx_PyUnicode_GET_LENGTH(__pyx_t_2);
+__Pyx_GIVEREF(__pyx_t_2);
+PyTuple_SET_ITEM(__pyx_t_5, 6, __pyx_t_2);
+__pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":456
+*             return ">%s%s\n%s" % (self.name, comment, self.sequence)
+*         else:
+*             return "@%s%s\n%s\n+\n%s" % (self.name, comment,             # <<<<<<<<<<<<<<
+*                                          self.sequence, self.quality)
+*
+*/
+__pyx_t_2 = __Pyx_PyUnicode_Join(__pyx_t_5, 7, __pyx_t_3, __pyx_t_4); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 456, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
+__pyx_r = ((PyObject*)__pyx_t_2);
+__pyx_t_2 = 0;
+goto __pyx_L0;
+}
+/* "pysam/libcfaidx.pyx":441
+*         return FastxRecord(self.name, self.comment, self.sequence, self.quality)
+*
+*     cdef cython.str to_string(self):             # <<<<<<<<<<<<<<
+*         if self.name is None:
+*             raise ValueError("can not write record without name")
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_XDECREF(__pyx_t_5);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.to_string", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = 0;
+__pyx_L0:;
+__Pyx_XDECREF(__pyx_v_comment);
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":459
+*                                          self.sequence, self.quality)
+*
+*     cdef cython.str tostring(self):             # <<<<<<<<<<<<<<
+*         """deprecated : use :meth:`to_string`"""
+*         return self.to_string()
+*/
+static PyObject *__pyx_f_5pysam_9libcfaidx_11FastxRecord_tostring(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("tostring", 1);
+__Pyx_TraceCall("tostring", __pyx_f[0], 459, 0, __PYX_ERR(0, 459, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":461
+*     cdef cython.str tostring(self):
+*         """deprecated : use :meth:`to_string`"""
+*         return self.to_string()             # <<<<<<<<<<<<<<
+*
+*     def set_name(self, name):
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_1 = ((struct __pyx_vtabstruct_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self->__pyx_vtab)->to_string(__pyx_v_self); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 461, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_r = ((PyObject*)__pyx_t_1);
+__pyx_t_1 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":459
+*                                          self.sequence, self.quality)
+*
+*     cdef cython.str tostring(self):             # <<<<<<<<<<<<<<
+*         """deprecated : use :meth:`to_string`"""
+*         return self.to_string()
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.tostring", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = 0;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":463
+*         return self.to_string()
+*
+*     def set_name(self, name):             # <<<<<<<<<<<<<<
+*         if name is None:
+*             raise ValueError("FastxRecord must have a name and not None")
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_7set_name(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_11FastxRecord_6set_name, "FastxRecord.set_name(self, name)");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_11FastxRecord_7set_name = {"set_name", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_11FastxRecord_7set_name, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_11FastxRecord_6set_name};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_7set_name(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+PyObject *__pyx_v_name = 0;
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject* values[1] = {0};
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("set_name (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+{
+PyObject **__pyx_pyargnames[] = {&__pyx_n_s_name,0};
+if (__pyx_kwds) {
+Py_ssize_t kw_args;
+switch (__pyx_nargs) {
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
+switch (__pyx_nargs) {
+case  0:
+if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_name)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 463, __pyx_L3_error)
+else goto __pyx_L5_argtuple_error;
+}
+if (unlikely(kw_args > 0)) {
+const Py_ssize_t kwd_pos_args = __pyx_nargs;
+if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "set_name") < 0)) __PYX_ERR(0, 463, __pyx_L3_error)
+}
+} else if (unlikely(__pyx_nargs != 1)) {
+goto __pyx_L5_argtuple_error;
+} else {
+values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+}
+__pyx_v_name = values[0];
+}
+goto __pyx_L6_skip;
+__pyx_L5_argtuple_error:;
+__Pyx_RaiseArgtupleInvalid("set_name", 1, 1, 1, __pyx_nargs); __PYX_ERR(0, 463, __pyx_L3_error)
+__pyx_L6_skip:;
+goto __pyx_L4_argument_unpacking_done;
+__pyx_L3_error:;
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.set_name", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__Pyx_RefNannyFinishContext();
+return NULL;
+__pyx_L4_argument_unpacking_done:;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord_6set_name(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self), __pyx_v_name);
+/* function exit code */
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_6set_name(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, PyObject *__pyx_v_name) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_t_1;
+PyObject *__pyx_t_2 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__27)
+__Pyx_RefNannySetupContext("set_name", 1);
+__Pyx_TraceCall("set_name", __pyx_f[0], 463, 0, __PYX_ERR(0, 463, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":464
+*
+*     def set_name(self, name):
+*         if name is None:             # <<<<<<<<<<<<<<
+*             raise ValueError("FastxRecord must have a name and not None")
+*         self.name = name
+*/
+__pyx_t_1 = (__pyx_v_name == Py_None);
+if (unlikely(__pyx_t_1)) {
+/* "pysam/libcfaidx.pyx":465
+*     def set_name(self, name):
+*         if name is None:
+*             raise ValueError("FastxRecord must have a name and not None")             # <<<<<<<<<<<<<<
+*         self.name = name
+*
+*/
+__pyx_t_2 = __Pyx_PyObject_Call(__pyx_builtin_ValueError, __pyx_tuple__28, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 465, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_Raise(__pyx_t_2, 0, 0, 0);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__PYX_ERR(0, 465, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":464
+*
+*     def set_name(self, name):
+*         if name is None:             # <<<<<<<<<<<<<<
+*             raise ValueError("FastxRecord must have a name and not None")
+*         self.name = name
+*/
+}
+/* "pysam/libcfaidx.pyx":466
+*         if name is None:
+*             raise ValueError("FastxRecord must have a name and not None")
+*         self.name = name             # <<<<<<<<<<<<<<
+*
+*     def set_comment(self, comment):
+*/
+if (!(likely(PyUnicode_CheckExact(__pyx_v_name))||((__pyx_v_name) == Py_None) || __Pyx_RaiseUnexpectedTypeError("unicode", __pyx_v_name))) __PYX_ERR(0, 466, __pyx_L1_error)
+__pyx_t_2 = __pyx_v_name;
+__Pyx_INCREF(__pyx_t_2);
+__Pyx_GIVEREF(__pyx_t_2);
+__Pyx_GOTREF(__pyx_v_self->name);
+__Pyx_DECREF(__pyx_v_self->name);
+__pyx_v_self->name = ((PyObject*)__pyx_t_2);
+__pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":463
+*         return self.to_string()
+*
+*     def set_name(self, name):             # <<<<<<<<<<<<<<
+*         if name is None:
+*             raise ValueError("FastxRecord must have a name and not None")
+*/
+/* function exit code */
+__pyx_r = Py_None; __Pyx_INCREF(Py_None);
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.set_name", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":468
+*         self.name = name
+*
+*     def set_comment(self, comment):             # <<<<<<<<<<<<<<
+*         self.comment = comment
+*
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_9set_comment(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_11FastxRecord_8set_comment, "FastxRecord.set_comment(self, comment)");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_11FastxRecord_9set_comment = {"set_comment", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_11FastxRecord_9set_comment, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_11FastxRecord_8set_comment};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_9set_comment(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+PyObject *__pyx_v_comment = 0;
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject* values[1] = {0};
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("set_comment (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+{
+PyObject **__pyx_pyargnames[] = {&__pyx_n_s_comment,0};
+if (__pyx_kwds) {
+Py_ssize_t kw_args;
+switch (__pyx_nargs) {
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
+switch (__pyx_nargs) {
+case  0:
+if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_comment)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 468, __pyx_L3_error)
+else goto __pyx_L5_argtuple_error;
+}
+if (unlikely(kw_args > 0)) {
+const Py_ssize_t kwd_pos_args = __pyx_nargs;
+if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "set_comment") < 0)) __PYX_ERR(0, 468, __pyx_L3_error)
+}
+} else if (unlikely(__pyx_nargs != 1)) {
+goto __pyx_L5_argtuple_error;
+} else {
+values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+}
+__pyx_v_comment = values[0];
+}
+goto __pyx_L6_skip;
+__pyx_L5_argtuple_error:;
+__Pyx_RaiseArgtupleInvalid("set_comment", 1, 1, 1, __pyx_nargs); __PYX_ERR(0, 468, __pyx_L3_error)
+__pyx_L6_skip:;
+goto __pyx_L4_argument_unpacking_done;
+__pyx_L3_error:;
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.set_comment", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__Pyx_RefNannyFinishContext();
+return NULL;
+__pyx_L4_argument_unpacking_done:;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord_8set_comment(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self), __pyx_v_comment);
+/* function exit code */
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_8set_comment(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, PyObject *__pyx_v_comment) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__29)
+__Pyx_RefNannySetupContext("set_comment", 1);
+__Pyx_TraceCall("set_comment", __pyx_f[0], 468, 0, __PYX_ERR(0, 468, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":469
+*
+*     def set_comment(self, comment):
+*         self.comment = comment             # <<<<<<<<<<<<<<
+*
+*     def set_sequence(self, sequence, quality=None):
+*/
+if (!(likely(PyUnicode_CheckExact(__pyx_v_comment))||((__pyx_v_comment) == Py_None) || __Pyx_RaiseUnexpectedTypeError("unicode", __pyx_v_comment))) __PYX_ERR(0, 469, __pyx_L1_error)
+__pyx_t_1 = __pyx_v_comment;
+__Pyx_INCREF(__pyx_t_1);
+__Pyx_GIVEREF(__pyx_t_1);
+__Pyx_GOTREF(__pyx_v_self->comment);
+__Pyx_DECREF(__pyx_v_self->comment);
+__pyx_v_self->comment = ((PyObject*)__pyx_t_1);
+__pyx_t_1 = 0;
+/* "pysam/libcfaidx.pyx":468
+*         self.name = name
+*
+*     def set_comment(self, comment):             # <<<<<<<<<<<<<<
+*         self.comment = comment
+*
+*/
+/* function exit code */
+__pyx_r = Py_None; __Pyx_INCREF(Py_None);
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.set_comment", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":471
+*         self.comment = comment
+*
+*     def set_sequence(self, sequence, quality=None):             # <<<<<<<<<<<<<<
+*         """set sequence of this record.
+*
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_11set_sequence(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_11FastxRecord_10set_sequence, "FastxRecord.set_sequence(self, sequence, quality=None)\nset sequence of this record.\n\n        ");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_11FastxRecord_11set_sequence = {"set_sequence", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_11FastxRecord_11set_sequence, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_11FastxRecord_10set_sequence};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_11set_sequence(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+PyObject *__pyx_v_sequence = 0;
+PyObject *__pyx_v_quality = 0;
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject* values[2] = {0,0};
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("set_sequence (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+{
+PyObject **__pyx_pyargnames[] = {&__pyx_n_s_sequence,&__pyx_n_s_quality,0};
+values[1] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)Py_None));
+if (__pyx_kwds) {
+Py_ssize_t kw_args;
+switch (__pyx_nargs) {
+case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
+CYTHON_FALLTHROUGH;
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
+switch (__pyx_nargs) {
+case  0:
+if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_sequence)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 471, __pyx_L3_error)
+else goto __pyx_L5_argtuple_error;
+CYTHON_FALLTHROUGH;
+case  1:
+if (kw_args > 0) {
+PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_quality);
+if (value) { values[1] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 471, __pyx_L3_error)
+}
+}
+if (unlikely(kw_args > 0)) {
+const Py_ssize_t kwd_pos_args = __pyx_nargs;
+if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "set_sequence") < 0)) __PYX_ERR(0, 471, __pyx_L3_error)
+}
+} else {
+switch (__pyx_nargs) {
+case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
+CYTHON_FALLTHROUGH;
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+break;
+default: goto __pyx_L5_argtuple_error;
+}
+}
+__pyx_v_sequence = values[0];
+__pyx_v_quality = values[1];
+}
+goto __pyx_L6_skip;
+__pyx_L5_argtuple_error:;
+__Pyx_RaiseArgtupleInvalid("set_sequence", 0, 1, 2, __pyx_nargs); __PYX_ERR(0, 471, __pyx_L3_error)
+__pyx_L6_skip:;
+goto __pyx_L4_argument_unpacking_done;
+__pyx_L3_error:;
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.set_sequence", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__Pyx_RefNannyFinishContext();
+return NULL;
+__pyx_L4_argument_unpacking_done:;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord_10set_sequence(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self), __pyx_v_sequence, __pyx_v_quality);
+/* function exit code */
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_10set_sequence(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, PyObject *__pyx_v_sequence, PyObject *__pyx_v_quality) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_t_2;
+Py_ssize_t __pyx_t_3;
+Py_ssize_t __pyx_t_4;
+PyObject *__pyx_t_5 = NULL;
+PyObject *__pyx_t_6 = NULL;
+PyObject *__pyx_t_7 = NULL;
+PyObject *__pyx_t_8 = NULL;
+unsigned int __pyx_t_9;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__30)
+__Pyx_RefNannySetupContext("set_sequence", 1);
+__Pyx_TraceCall("set_sequence", __pyx_f[0], 471, 0, __PYX_ERR(0, 471, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":475
+*
+*         """
+*         self.sequence = sequence             # <<<<<<<<<<<<<<
+*         if quality is not None:
+*             if len(sequence) != len(quality):
+*/
+if (!(likely(PyUnicode_CheckExact(__pyx_v_sequence))||((__pyx_v_sequence) == Py_None) || __Pyx_RaiseUnexpectedTypeError("unicode", __pyx_v_sequence))) __PYX_ERR(0, 475, __pyx_L1_error)
+__pyx_t_1 = __pyx_v_sequence;
+__Pyx_INCREF(__pyx_t_1);
+__Pyx_GIVEREF(__pyx_t_1);
+__Pyx_GOTREF(__pyx_v_self->sequence);
+__Pyx_DECREF(__pyx_v_self->sequence);
+__pyx_v_self->sequence = ((PyObject*)__pyx_t_1);
+__pyx_t_1 = 0;
+/* "pysam/libcfaidx.pyx":476
+*         """
+*         self.sequence = sequence
+*         if quality is not None:             # <<<<<<<<<<<<<<
+*             if len(sequence) != len(quality):
+*                 raise ValueError("sequence and quality length do not match: {} vs {}".format(
+*/
+__pyx_t_2 = (__pyx_v_quality != Py_None);
+if (__pyx_t_2) {
+/* "pysam/libcfaidx.pyx":477
+*         self.sequence = sequence
+*         if quality is not None:
+*             if len(sequence) != len(quality):             # <<<<<<<<<<<<<<
+*                 raise ValueError("sequence and quality length do not match: {} vs {}".format(
+*                     len(sequence), len(quality)))
+*/
+__pyx_t_3 = PyObject_Length(__pyx_v_sequence); if (unlikely(__pyx_t_3 == ((Py_ssize_t)-1))) __PYX_ERR(0, 477, __pyx_L1_error)
+__pyx_t_4 = PyObject_Length(__pyx_v_quality); if (unlikely(__pyx_t_4 == ((Py_ssize_t)-1))) __PYX_ERR(0, 477, __pyx_L1_error)
+__pyx_t_2 = (__pyx_t_3 != __pyx_t_4);
+if (unlikely(__pyx_t_2)) {
+/* "pysam/libcfaidx.pyx":478
+*         if quality is not None:
+*             if len(sequence) != len(quality):
+*                 raise ValueError("sequence and quality length do not match: {} vs {}".format(             # <<<<<<<<<<<<<<
+*                     len(sequence), len(quality)))
+*
+*/
+__pyx_t_5 = __Pyx_PyObject_GetAttrStr(__pyx_kp_u_sequence_and_quality_length_do_n, __pyx_n_s_format); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 478, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_5);
+/* "pysam/libcfaidx.pyx":479
+*             if len(sequence) != len(quality):
+*                 raise ValueError("sequence and quality length do not match: {} vs {}".format(
+*                     len(sequence), len(quality)))             # <<<<<<<<<<<<<<
+*
+*             self.quality = quality
+*/
+__pyx_t_4 = PyObject_Length(__pyx_v_sequence); if (unlikely(__pyx_t_4 == ((Py_ssize_t)-1))) __PYX_ERR(0, 479, __pyx_L1_error)
+__pyx_t_6 = PyInt_FromSsize_t(__pyx_t_4); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 479, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_6);
+__pyx_t_4 = PyObject_Length(__pyx_v_quality); if (unlikely(__pyx_t_4 == ((Py_ssize_t)-1))) __PYX_ERR(0, 479, __pyx_L1_error)
+__pyx_t_7 = PyInt_FromSsize_t(__pyx_t_4); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 479, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_7);
+__pyx_t_8 = NULL;
+__pyx_t_9 = 0;
+#if CYTHON_UNPACK_METHODS
+if (likely(PyMethod_Check(__pyx_t_5))) {
+__pyx_t_8 = PyMethod_GET_SELF(__pyx_t_5);
+if (likely(__pyx_t_8)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_5);
+__Pyx_INCREF(__pyx_t_8);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_5, function);
+__pyx_t_9 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[3] = {__pyx_t_8, __pyx_t_6, __pyx_t_7};
+__pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_5, __pyx_callargs+1-__pyx_t_9, 2+__pyx_t_9);
+__Pyx_XDECREF(__pyx_t_8); __pyx_t_8 = 0;
+__Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
+__Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
+if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 478, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
+}
+/* "pysam/libcfaidx.pyx":478
+*         if quality is not None:
+*             if len(sequence) != len(quality):
+*                 raise ValueError("sequence and quality length do not match: {} vs {}".format(             # <<<<<<<<<<<<<<
+*                     len(sequence), len(quality)))
+*
+*/
+__pyx_t_5 = __Pyx_PyObject_CallOneArg(__pyx_builtin_ValueError, __pyx_t_1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 478, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_5);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__Pyx_Raise(__pyx_t_5, 0, 0, 0);
+__Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
+__PYX_ERR(0, 478, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":477
+*         self.sequence = sequence
+*         if quality is not None:
+*             if len(sequence) != len(quality):             # <<<<<<<<<<<<<<
+*                 raise ValueError("sequence and quality length do not match: {} vs {}".format(
+*                     len(sequence), len(quality)))
+*/
+}
+/* "pysam/libcfaidx.pyx":481
+*                     len(sequence), len(quality)))
+*
+*             self.quality = quality             # <<<<<<<<<<<<<<
+*         else:
+*             self.quality = None
+*/
+if (!(likely(PyUnicode_CheckExact(__pyx_v_quality))||((__pyx_v_quality) == Py_None) || __Pyx_RaiseUnexpectedTypeError("unicode", __pyx_v_quality))) __PYX_ERR(0, 481, __pyx_L1_error)
+__pyx_t_5 = __pyx_v_quality;
+__Pyx_INCREF(__pyx_t_5);
+__Pyx_GIVEREF(__pyx_t_5);
+__Pyx_GOTREF(__pyx_v_self->quality);
+__Pyx_DECREF(__pyx_v_self->quality);
+__pyx_v_self->quality = ((PyObject*)__pyx_t_5);
+__pyx_t_5 = 0;
+/* "pysam/libcfaidx.pyx":476
+*         """
+*         self.sequence = sequence
+*         if quality is not None:             # <<<<<<<<<<<<<<
+*             if len(sequence) != len(quality):
+*                 raise ValueError("sequence and quality length do not match: {} vs {}".format(
+*/
+goto __pyx_L3;
+}
+/* "pysam/libcfaidx.pyx":483
+*             self.quality = quality
+*         else:
+*             self.quality = None             # <<<<<<<<<<<<<<
+*
+*     def __str__(self):
+*/
+/*else*/ {
+__Pyx_INCREF(Py_None);
+__Pyx_GIVEREF(Py_None);
+__Pyx_GOTREF(__pyx_v_self->quality);
+__Pyx_DECREF(__pyx_v_self->quality);
+__pyx_v_self->quality = ((PyObject*)Py_None);
+}
+__pyx_L3:;
+/* "pysam/libcfaidx.pyx":471
+*         self.comment = comment
+*
+*     def set_sequence(self, sequence, quality=None):             # <<<<<<<<<<<<<<
+*         """set sequence of this record.
+*
+*/
+/* function exit code */
+__pyx_r = Py_None; __Pyx_INCREF(Py_None);
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_XDECREF(__pyx_t_5);
+__Pyx_XDECREF(__pyx_t_6);
+__Pyx_XDECREF(__pyx_t_7);
+__Pyx_XDECREF(__pyx_t_8);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.set_sequence", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":485
+*             self.quality = None
+*
+*     def __str__(self):             # <<<<<<<<<<<<<<
+*         return self.to_string()
+*
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_13__str__(PyObject *__pyx_v_self); /*proto*/
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_13__str__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__str__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord_12__str__(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_12__str__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__str__", 1);
+__Pyx_TraceCall("__str__", __pyx_f[0], 485, 0, __PYX_ERR(0, 485, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":486
+*
+*     def __str__(self):
+*         return self.to_string()             # <<<<<<<<<<<<<<
+*
+*     cpdef array.array get_quality_array(self, int offset=33):
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_1 = ((struct __pyx_vtabstruct_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self->__pyx_vtab)->to_string(__pyx_v_self); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 486, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_r = __pyx_t_1;
+__pyx_t_1 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":485
+*             self.quality = None
+*
+*     def __str__(self):             # <<<<<<<<<<<<<<
+*         return self.to_string()
+*
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.__str__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":488
+*         return self.to_string()
+*
+*     cpdef array.array get_quality_array(self, int offset=33):             # <<<<<<<<<<<<<<
+*         '''return quality values as array after subtracting offset.'''
+*         if self.quality is None:
+*/
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_15get_quality_array(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+static arrayobject *__pyx_f_5pysam_9libcfaidx_11FastxRecord_get_quality_array(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, int __pyx_skip_dispatch, struct __pyx_opt_args_5pysam_9libcfaidx_11FastxRecord_get_quality_array *__pyx_optional_args) {
+int __pyx_v_offset = ((int)33);
+arrayobject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+PyObject *__pyx_t_2 = NULL;
+PyObject *__pyx_t_3 = NULL;
+PyObject *__pyx_t_4 = NULL;
+PyObject *__pyx_t_5 = NULL;
+unsigned int __pyx_t_6;
+int __pyx_t_7;
+struct __pyx_opt_args_5pysam_9libcutils_qualitystring_to_array __pyx_t_8;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__31)
+__Pyx_RefNannySetupContext("get_quality_array", 1);
+__Pyx_TraceCall("get_quality_array", __pyx_f[0], 488, 0, __PYX_ERR(0, 488, __pyx_L1_error));
+if (__pyx_optional_args) {
+if (__pyx_optional_args->__pyx_n > 0) {
+__pyx_v_offset = __pyx_optional_args->offset;
+}
+}
+/* Check if called by wrapper */
+if (unlikely(__pyx_skip_dispatch)) ;
+/* Check if overridden in Python */
+else if (unlikely((Py_TYPE(((PyObject *)__pyx_v_self))->tp_dictoffset != 0) || __Pyx_PyType_HasFeature(Py_TYPE(((PyObject *)__pyx_v_self)), (Py_TPFLAGS_IS_ABSTRACT | Py_TPFLAGS_HEAPTYPE)))) {
+#if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
+static PY_UINT64_T __pyx_tp_dict_version = __PYX_DICT_VERSION_INIT, __pyx_obj_dict_version = __PYX_DICT_VERSION_INIT;
+if (unlikely(!__Pyx_object_dict_version_matches(((PyObject *)__pyx_v_self), __pyx_tp_dict_version, __pyx_obj_dict_version))) {
+PY_UINT64_T __pyx_typedict_guard = __Pyx_get_tp_dict_version(((PyObject *)__pyx_v_self));
+#endif
+__pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_get_quality_array); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 488, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+if (!__Pyx_IsSameCFunction(__pyx_t_1, (void*) __pyx_pw_5pysam_9libcfaidx_11FastxRecord_15get_quality_array)) {
+__Pyx_XDECREF((PyObject *)__pyx_r);
+__pyx_t_3 = __Pyx_PyInt_From_int(__pyx_v_offset); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 488, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_INCREF(__pyx_t_1);
+__pyx_t_4 = __pyx_t_1; __pyx_t_5 = NULL;
+__pyx_t_6 = 0;
+#if CYTHON_UNPACK_METHODS
+if (unlikely(PyMethod_Check(__pyx_t_4))) {
+__pyx_t_5 = PyMethod_GET_SELF(__pyx_t_4);
+if (likely(__pyx_t_5)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_4);
+__Pyx_INCREF(__pyx_t_5);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_4, function);
+__pyx_t_6 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[2] = {__pyx_t_5, __pyx_t_3};
+__pyx_t_2 = __Pyx_PyObject_FastCall(__pyx_t_4, __pyx_callargs+1-__pyx_t_6, 1+__pyx_t_6);
+__Pyx_XDECREF(__pyx_t_5); __pyx_t_5 = 0;
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 488, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+}
+if (!(likely(((__pyx_t_2) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_2, __pyx_ptype_7cpython_5array_array))))) __PYX_ERR(0, 488, __pyx_L1_error)
+__pyx_r = ((arrayobject *)__pyx_t_2);
+__pyx_t_2 = 0;
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+goto __pyx_L0;
+}
+#if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
+__pyx_tp_dict_version = __Pyx_get_tp_dict_version(((PyObject *)__pyx_v_self));
+__pyx_obj_dict_version = __Pyx_get_object_dict_version(((PyObject *)__pyx_v_self));
+if (unlikely(__pyx_typedict_guard != __pyx_tp_dict_version)) {
+__pyx_tp_dict_version = __pyx_obj_dict_version = __PYX_DICT_VERSION_INIT;
+}
+#endif
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+#if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
+}
+#endif
+}
+/* "pysam/libcfaidx.pyx":490
+*     cpdef array.array get_quality_array(self, int offset=33):
+*         '''return quality values as array after subtracting offset.'''
+*         if self.quality is None:             # <<<<<<<<<<<<<<
+*             return None
+*         return qualitystring_to_array(force_bytes(self.quality),
+*/
+__pyx_t_7 = (__pyx_v_self->quality == ((PyObject*)Py_None));
+if (__pyx_t_7) {
+/* "pysam/libcfaidx.pyx":491
+*         '''return quality values as array after subtracting offset.'''
+*         if self.quality is None:
+*             return None             # <<<<<<<<<<<<<<
+*         return qualitystring_to_array(force_bytes(self.quality),
+*                                       offset=offset)
+*/
+__Pyx_XDECREF((PyObject *)__pyx_r);
+__pyx_r = ((arrayobject *)Py_None); __Pyx_INCREF(Py_None);
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":490
+*     cpdef array.array get_quality_array(self, int offset=33):
+*         '''return quality values as array after subtracting offset.'''
+*         if self.quality is None:             # <<<<<<<<<<<<<<
+*             return None
+*         return qualitystring_to_array(force_bytes(self.quality),
+*/
+}
+/* "pysam/libcfaidx.pyx":492
+*         if self.quality is None:
+*             return None
+*         return qualitystring_to_array(force_bytes(self.quality),             # <<<<<<<<<<<<<<
+*                                       offset=offset)
+*
+*/
+__Pyx_XDECREF((PyObject *)__pyx_r);
+__pyx_t_1 = __pyx_v_self->quality;
+__Pyx_INCREF(__pyx_t_1);
+__pyx_t_2 = __pyx_f_5pysam_9libcutils_force_bytes(__pyx_t_1, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 492, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+/* "pysam/libcfaidx.pyx":493
+*             return None
+*         return qualitystring_to_array(force_bytes(self.quality),
+*                                       offset=offset)             # <<<<<<<<<<<<<<
+*
+*
+*/
+__pyx_t_8.__pyx_n = 1;
+__pyx_t_8.offset = __pyx_v_offset;
+__pyx_t_1 = ((PyObject *)__pyx_f_5pysam_9libcutils_qualitystring_to_array(__pyx_t_2, 0, &__pyx_t_8)); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 492, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__pyx_r = ((arrayobject *)__pyx_t_1);
+__pyx_t_1 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":488
+*         return self.to_string()
+*
+*     cpdef array.array get_quality_array(self, int offset=33):             # <<<<<<<<<<<<<<
+*         '''return quality values as array after subtracting offset.'''
+*         if self.quality is None:
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_XDECREF(__pyx_t_3);
+__Pyx_XDECREF(__pyx_t_4);
+__Pyx_XDECREF(__pyx_t_5);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.get_quality_array", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = 0;
+__pyx_L0:;
+__Pyx_XGIVEREF((PyObject *)__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_15get_quality_array(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_11FastxRecord_14get_quality_array, "FastxRecord.get_quality_array(self, int offset=33) -> array\nreturn quality values as array after subtracting offset.");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_11FastxRecord_15get_quality_array = {"get_quality_array", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_11FastxRecord_15get_quality_array, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_11FastxRecord_14get_quality_array};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_15get_quality_array(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+int __pyx_v_offset;
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject* values[1] = {0};
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("get_quality_array (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+{
+PyObject **__pyx_pyargnames[] = {&__pyx_n_s_offset,0};
+if (__pyx_kwds) {
+Py_ssize_t kw_args;
+switch (__pyx_nargs) {
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
+switch (__pyx_nargs) {
+case  0:
+if (kw_args > 0) {
+PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_offset);
+if (value) { values[0] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 488, __pyx_L3_error)
+}
+}
+if (unlikely(kw_args > 0)) {
+const Py_ssize_t kwd_pos_args = __pyx_nargs;
+if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "get_quality_array") < 0)) __PYX_ERR(0, 488, __pyx_L3_error)
+}
+} else {
+switch (__pyx_nargs) {
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+}
+if (values[0]) {
+__pyx_v_offset = __Pyx_PyInt_As_int(values[0]); if (unlikely((__pyx_v_offset == (int)-1) && PyErr_Occurred())) __PYX_ERR(0, 488, __pyx_L3_error)
+} else {
+__pyx_v_offset = ((int)33);
+}
+}
+goto __pyx_L6_skip;
+__pyx_L5_argtuple_error:;
+__Pyx_RaiseArgtupleInvalid("get_quality_array", 0, 0, 1, __pyx_nargs); __PYX_ERR(0, 488, __pyx_L3_error)
+__pyx_L6_skip:;
+goto __pyx_L4_argument_unpacking_done;
+__pyx_L3_error:;
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.get_quality_array", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__Pyx_RefNannyFinishContext();
+return NULL;
+__pyx_L4_argument_unpacking_done:;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord_14get_quality_array(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self), __pyx_v_offset);
+/* function exit code */
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_14get_quality_array(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, int __pyx_v_offset) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+struct __pyx_opt_args_5pysam_9libcfaidx_11FastxRecord_get_quality_array __pyx_t_2;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__31)
+__Pyx_RefNannySetupContext("get_quality_array", 1);
+__Pyx_TraceCall("get_quality_array (wrapper)", __pyx_f[0], 488, 0, __PYX_ERR(0, 488, __pyx_L1_error));
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_2.__pyx_n = 1;
+__pyx_t_2.offset = __pyx_v_offset;
+__pyx_t_1 = ((PyObject *)__pyx_vtabptr_5pysam_9libcfaidx_FastxRecord->get_quality_array(__pyx_v_self, 1, &__pyx_t_2)); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 488, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_r = __pyx_t_1;
+__pyx_t_1 = 0;
+goto __pyx_L0;
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.get_quality_array", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pxd":57
+*     Python container for pysam.libcfaidx.FastqProxy with persistence.
+*     """
+*     cdef public str comment, quality, sequence, name             # <<<<<<<<<<<<<<
+*     cdef cython.str to_string(self)
+*     cdef cython.str tostring(self)
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_7comment_1__get__(PyObject *__pyx_v_self); /*proto*/
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_7comment_1__get__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__get__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord_7comment___get__(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_7comment___get__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__get__", 1);
+__Pyx_TraceCall("__get__", __pyx_f[4], 57, 0, __PYX_ERR(4, 57, __pyx_L1_error));
+__Pyx_XDECREF(__pyx_r);
+__Pyx_INCREF(__pyx_v_self->comment);
+__pyx_r = __pyx_v_self->comment;
+goto __pyx_L0;
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.comment.__get__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* Python wrapper */
+static int __pyx_pw_5pysam_9libcfaidx_11FastxRecord_7comment_3__set__(PyObject *__pyx_v_self, PyObject *__pyx_v_value); /*proto*/
+static int __pyx_pw_5pysam_9libcfaidx_11FastxRecord_7comment_3__set__(PyObject *__pyx_v_self, PyObject *__pyx_v_value) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+int __pyx_r;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__set__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord_7comment_2__set__(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self), ((PyObject *)__pyx_v_value));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static int __pyx_pf_5pysam_9libcfaidx_11FastxRecord_7comment_2__set__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, PyObject *__pyx_v_value) {
+int __pyx_r;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__set__", 1);
+__Pyx_TraceCall("__set__", __pyx_f[4], 57, 0, __PYX_ERR(4, 57, __pyx_L1_error));
+if (!(likely(PyUnicode_CheckExact(__pyx_v_value))||((__pyx_v_value) == Py_None) || __Pyx_RaiseUnexpectedTypeError("unicode", __pyx_v_value))) __PYX_ERR(4, 57, __pyx_L1_error)
+__pyx_t_1 = __pyx_v_value;
+__Pyx_INCREF(__pyx_t_1);
+__Pyx_GIVEREF(__pyx_t_1);
+__Pyx_GOTREF(__pyx_v_self->comment);
+__Pyx_DECREF(__pyx_v_self->comment);
+__pyx_v_self->comment = ((PyObject*)__pyx_t_1);
+__pyx_t_1 = 0;
+/* function exit code */
+__pyx_r = 0;
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.comment.__set__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = -1;
+__pyx_L0:;
+__Pyx_TraceReturn(Py_None, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* Python wrapper */
+static int __pyx_pw_5pysam_9libcfaidx_11FastxRecord_7comment_5__del__(PyObject *__pyx_v_self); /*proto*/
+static int __pyx_pw_5pysam_9libcfaidx_11FastxRecord_7comment_5__del__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+int __pyx_r;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__del__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord_7comment_4__del__(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static int __pyx_pf_5pysam_9libcfaidx_11FastxRecord_7comment_4__del__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self) {
+int __pyx_r;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__del__", 1);
+__Pyx_TraceCall("__del__", __pyx_f[4], 57, 0, __PYX_ERR(4, 57, __pyx_L1_error));
+__Pyx_INCREF(Py_None);
+__Pyx_GIVEREF(Py_None);
+__Pyx_GOTREF(__pyx_v_self->comment);
+__Pyx_DECREF(__pyx_v_self->comment);
+__pyx_v_self->comment = ((PyObject*)Py_None);
+/* function exit code */
+__pyx_r = 0;
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.comment.__del__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = -1;
+__pyx_L0:;
+__Pyx_TraceReturn(Py_None, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_7quality_1__get__(PyObject *__pyx_v_self); /*proto*/
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_7quality_1__get__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__get__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord_7quality___get__(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_7quality___get__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__get__", 1);
+__Pyx_TraceCall("__get__", __pyx_f[4], 57, 0, __PYX_ERR(4, 57, __pyx_L1_error));
+__Pyx_XDECREF(__pyx_r);
+__Pyx_INCREF(__pyx_v_self->quality);
+__pyx_r = __pyx_v_self->quality;
+goto __pyx_L0;
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.quality.__get__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* Python wrapper */
+static int __pyx_pw_5pysam_9libcfaidx_11FastxRecord_7quality_3__set__(PyObject *__pyx_v_self, PyObject *__pyx_v_value); /*proto*/
+static int __pyx_pw_5pysam_9libcfaidx_11FastxRecord_7quality_3__set__(PyObject *__pyx_v_self, PyObject *__pyx_v_value) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+int __pyx_r;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__set__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord_7quality_2__set__(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self), ((PyObject *)__pyx_v_value));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static int __pyx_pf_5pysam_9libcfaidx_11FastxRecord_7quality_2__set__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, PyObject *__pyx_v_value) {
+int __pyx_r;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__set__", 1);
+__Pyx_TraceCall("__set__", __pyx_f[4], 57, 0, __PYX_ERR(4, 57, __pyx_L1_error));
+if (!(likely(PyUnicode_CheckExact(__pyx_v_value))||((__pyx_v_value) == Py_None) || __Pyx_RaiseUnexpectedTypeError("unicode", __pyx_v_value))) __PYX_ERR(4, 57, __pyx_L1_error)
+__pyx_t_1 = __pyx_v_value;
+__Pyx_INCREF(__pyx_t_1);
+__Pyx_GIVEREF(__pyx_t_1);
+__Pyx_GOTREF(__pyx_v_self->quality);
+__Pyx_DECREF(__pyx_v_self->quality);
+__pyx_v_self->quality = ((PyObject*)__pyx_t_1);
+__pyx_t_1 = 0;
+/* function exit code */
+__pyx_r = 0;
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.quality.__set__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = -1;
+__pyx_L0:;
+__Pyx_TraceReturn(Py_None, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* Python wrapper */
+static int __pyx_pw_5pysam_9libcfaidx_11FastxRecord_7quality_5__del__(PyObject *__pyx_v_self); /*proto*/
+static int __pyx_pw_5pysam_9libcfaidx_11FastxRecord_7quality_5__del__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+int __pyx_r;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__del__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord_7quality_4__del__(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static int __pyx_pf_5pysam_9libcfaidx_11FastxRecord_7quality_4__del__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self) {
+int __pyx_r;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__del__", 1);
+__Pyx_TraceCall("__del__", __pyx_f[4], 57, 0, __PYX_ERR(4, 57, __pyx_L1_error));
+__Pyx_INCREF(Py_None);
+__Pyx_GIVEREF(Py_None);
+__Pyx_GOTREF(__pyx_v_self->quality);
+__Pyx_DECREF(__pyx_v_self->quality);
+__pyx_v_self->quality = ((PyObject*)Py_None);
+/* function exit code */
+__pyx_r = 0;
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.quality.__del__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = -1;
+__pyx_L0:;
+__Pyx_TraceReturn(Py_None, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_8sequence_1__get__(PyObject *__pyx_v_self); /*proto*/
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_8sequence_1__get__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__get__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord_8sequence___get__(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_8sequence___get__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__get__", 1);
+__Pyx_TraceCall("__get__", __pyx_f[4], 57, 0, __PYX_ERR(4, 57, __pyx_L1_error));
+__Pyx_XDECREF(__pyx_r);
+__Pyx_INCREF(__pyx_v_self->sequence);
+__pyx_r = __pyx_v_self->sequence;
+goto __pyx_L0;
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.sequence.__get__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* Python wrapper */
+static int __pyx_pw_5pysam_9libcfaidx_11FastxRecord_8sequence_3__set__(PyObject *__pyx_v_self, PyObject *__pyx_v_value); /*proto*/
+static int __pyx_pw_5pysam_9libcfaidx_11FastxRecord_8sequence_3__set__(PyObject *__pyx_v_self, PyObject *__pyx_v_value) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+int __pyx_r;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__set__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord_8sequence_2__set__(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self), ((PyObject *)__pyx_v_value));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static int __pyx_pf_5pysam_9libcfaidx_11FastxRecord_8sequence_2__set__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, PyObject *__pyx_v_value) {
+int __pyx_r;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__set__", 1);
+__Pyx_TraceCall("__set__", __pyx_f[4], 57, 0, __PYX_ERR(4, 57, __pyx_L1_error));
+if (!(likely(PyUnicode_CheckExact(__pyx_v_value))||((__pyx_v_value) == Py_None) || __Pyx_RaiseUnexpectedTypeError("unicode", __pyx_v_value))) __PYX_ERR(4, 57, __pyx_L1_error)
+__pyx_t_1 = __pyx_v_value;
+__Pyx_INCREF(__pyx_t_1);
+__Pyx_GIVEREF(__pyx_t_1);
+__Pyx_GOTREF(__pyx_v_self->sequence);
+__Pyx_DECREF(__pyx_v_self->sequence);
+__pyx_v_self->sequence = ((PyObject*)__pyx_t_1);
+__pyx_t_1 = 0;
+/* function exit code */
+__pyx_r = 0;
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.sequence.__set__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = -1;
+__pyx_L0:;
+__Pyx_TraceReturn(Py_None, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* Python wrapper */
+static int __pyx_pw_5pysam_9libcfaidx_11FastxRecord_8sequence_5__del__(PyObject *__pyx_v_self); /*proto*/
+static int __pyx_pw_5pysam_9libcfaidx_11FastxRecord_8sequence_5__del__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+int __pyx_r;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__del__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord_8sequence_4__del__(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static int __pyx_pf_5pysam_9libcfaidx_11FastxRecord_8sequence_4__del__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self) {
+int __pyx_r;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__del__", 1);
+__Pyx_TraceCall("__del__", __pyx_f[4], 57, 0, __PYX_ERR(4, 57, __pyx_L1_error));
+__Pyx_INCREF(Py_None);
+__Pyx_GIVEREF(Py_None);
+__Pyx_GOTREF(__pyx_v_self->sequence);
+__Pyx_DECREF(__pyx_v_self->sequence);
+__pyx_v_self->sequence = ((PyObject*)Py_None);
+/* function exit code */
+__pyx_r = 0;
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.sequence.__del__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = -1;
+__pyx_L0:;
+__Pyx_TraceReturn(Py_None, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_4name_1__get__(PyObject *__pyx_v_self); /*proto*/
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_4name_1__get__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__get__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord_4name___get__(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_4name___get__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__get__", 1);
+__Pyx_TraceCall("__get__", __pyx_f[4], 57, 0, __PYX_ERR(4, 57, __pyx_L1_error));
+__Pyx_XDECREF(__pyx_r);
+__Pyx_INCREF(__pyx_v_self->name);
+__pyx_r = __pyx_v_self->name;
+goto __pyx_L0;
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.name.__get__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* Python wrapper */
+static int __pyx_pw_5pysam_9libcfaidx_11FastxRecord_4name_3__set__(PyObject *__pyx_v_self, PyObject *__pyx_v_value); /*proto*/
+static int __pyx_pw_5pysam_9libcfaidx_11FastxRecord_4name_3__set__(PyObject *__pyx_v_self, PyObject *__pyx_v_value) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+int __pyx_r;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__set__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord_4name_2__set__(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self), ((PyObject *)__pyx_v_value));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static int __pyx_pf_5pysam_9libcfaidx_11FastxRecord_4name_2__set__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, PyObject *__pyx_v_value) {
+int __pyx_r;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__set__", 1);
+__Pyx_TraceCall("__set__", __pyx_f[4], 57, 0, __PYX_ERR(4, 57, __pyx_L1_error));
+if (!(likely(PyUnicode_CheckExact(__pyx_v_value))||((__pyx_v_value) == Py_None) || __Pyx_RaiseUnexpectedTypeError("unicode", __pyx_v_value))) __PYX_ERR(4, 57, __pyx_L1_error)
+__pyx_t_1 = __pyx_v_value;
+__Pyx_INCREF(__pyx_t_1);
+__Pyx_GIVEREF(__pyx_t_1);
+__Pyx_GOTREF(__pyx_v_self->name);
+__Pyx_DECREF(__pyx_v_self->name);
+__pyx_v_self->name = ((PyObject*)__pyx_t_1);
+__pyx_t_1 = 0;
+/* function exit code */
+__pyx_r = 0;
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.name.__set__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = -1;
+__pyx_L0:;
+__Pyx_TraceReturn(Py_None, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* Python wrapper */
+static int __pyx_pw_5pysam_9libcfaidx_11FastxRecord_4name_5__del__(PyObject *__pyx_v_self); /*proto*/
+static int __pyx_pw_5pysam_9libcfaidx_11FastxRecord_4name_5__del__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+int __pyx_r;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__del__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord_4name_4__del__(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static int __pyx_pf_5pysam_9libcfaidx_11FastxRecord_4name_4__del__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self) {
+int __pyx_r;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__del__", 1);
+__Pyx_TraceCall("__del__", __pyx_f[4], 57, 0, __PYX_ERR(4, 57, __pyx_L1_error));
+__Pyx_INCREF(Py_None);
+__Pyx_GIVEREF(Py_None);
+__Pyx_GOTREF(__pyx_v_self->name);
+__Pyx_DECREF(__pyx_v_self->name);
+__pyx_v_self->name = ((PyObject*)Py_None);
+/* function exit code */
+__pyx_r = 0;
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.name.__del__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = -1;
+__pyx_L0:;
+__Pyx_TraceReturn(Py_None, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     cdef tuple state
+*     cdef object _dict
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_17__reduce_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_11FastxRecord_16__reduce_cython__, "FastxRecord.__reduce_cython__(self)");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_11FastxRecord_17__reduce_cython__ = {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_11FastxRecord_17__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_11FastxRecord_16__reduce_cython__};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_17__reduce_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__reduce_cython__ (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+if (unlikely(__pyx_nargs > 0)) {
+__Pyx_RaiseArgtupleInvalid("__reduce_cython__", 1, 0, 0, __pyx_nargs); return NULL;}
+if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__reduce_cython__", 0))) return NULL;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord_16__reduce_cython__(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_16__reduce_cython__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self) {
+PyObject *__pyx_v_state = 0;
+PyObject *__pyx_v__dict = 0;
+int __pyx_v_use_setstate;
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_t_2;
+PyObject *__pyx_t_3 = NULL;
+int __pyx_t_4;
+PyObject *__pyx_t_5 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__32)
+__Pyx_RefNannySetupContext("__reduce_cython__", 1);
+__Pyx_TraceCall("__reduce_cython__", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));
+/* "(tree fragment)":5
+*     cdef object _dict
+*     cdef bint use_setstate
+*     state = (self.comment, self.name, self.quality, self.sequence)             # <<<<<<<<<<<<<<
+*     _dict = getattr(self, '__dict__', None)
+*     if _dict is not None:
+*/
+__pyx_t_1 = PyTuple_New(4); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 5, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_INCREF(__pyx_v_self->comment);
+__Pyx_GIVEREF(__pyx_v_self->comment);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_v_self->comment)) __PYX_ERR(1, 5, __pyx_L1_error);
+__Pyx_INCREF(__pyx_v_self->name);
+__Pyx_GIVEREF(__pyx_v_self->name);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_v_self->name)) __PYX_ERR(1, 5, __pyx_L1_error);
+__Pyx_INCREF(__pyx_v_self->quality);
+__Pyx_GIVEREF(__pyx_v_self->quality);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 2, __pyx_v_self->quality)) __PYX_ERR(1, 5, __pyx_L1_error);
+__Pyx_INCREF(__pyx_v_self->sequence);
+__Pyx_GIVEREF(__pyx_v_self->sequence);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 3, __pyx_v_self->sequence)) __PYX_ERR(1, 5, __pyx_L1_error);
+__pyx_v_state = ((PyObject*)__pyx_t_1);
+__pyx_t_1 = 0;
+/* "(tree fragment)":6
+*     cdef bint use_setstate
+*     state = (self.comment, self.name, self.quality, self.sequence)
+*     _dict = getattr(self, '__dict__', None)             # <<<<<<<<<<<<<<
+*     if _dict is not None:
+*         state += (_dict,)
+*/
+__pyx_t_1 = __Pyx_GetAttr3(((PyObject *)__pyx_v_self), __pyx_n_s_dict, Py_None); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 6, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_v__dict = __pyx_t_1;
+__pyx_t_1 = 0;
+/* "(tree fragment)":7
+*     state = (self.comment, self.name, self.quality, self.sequence)
+*     _dict = getattr(self, '__dict__', None)
+*     if _dict is not None:             # <<<<<<<<<<<<<<
+*         state += (_dict,)
+*         use_setstate = True
+*/
+__pyx_t_2 = (__pyx_v__dict != Py_None);
+if (__pyx_t_2) {
+/* "(tree fragment)":8
+*     _dict = getattr(self, '__dict__', None)
+*     if _dict is not None:
+*         state += (_dict,)             # <<<<<<<<<<<<<<
+*         use_setstate = True
+*     else:
+*/
+__pyx_t_1 = PyTuple_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 8, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_INCREF(__pyx_v__dict);
+__Pyx_GIVEREF(__pyx_v__dict);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_v__dict)) __PYX_ERR(1, 8, __pyx_L1_error);
+__pyx_t_3 = PyNumber_InPlaceAdd(__pyx_v_state, __pyx_t_1); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 8, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__Pyx_DECREF_SET(__pyx_v_state, ((PyObject*)__pyx_t_3));
+__pyx_t_3 = 0;
+/* "(tree fragment)":9
+*     if _dict is not None:
+*         state += (_dict,)
+*         use_setstate = True             # <<<<<<<<<<<<<<
+*     else:
+*         use_setstate = self.comment is not None or self.name is not None or self.quality is not None or self.sequence is not None
+*/
+__pyx_v_use_setstate = 1;
+/* "(tree fragment)":7
+*     state = (self.comment, self.name, self.quality, self.sequence)
+*     _dict = getattr(self, '__dict__', None)
+*     if _dict is not None:             # <<<<<<<<<<<<<<
+*         state += (_dict,)
+*         use_setstate = True
+*/
+goto __pyx_L3;
+}
+/* "(tree fragment)":11
+*         use_setstate = True
+*     else:
+*         use_setstate = self.comment is not None or self.name is not None or self.quality is not None or self.sequence is not None             # <<<<<<<<<<<<<<
+*     if use_setstate:
+*         return __pyx_unpickle_FastxRecord, (type(self), 0x1bdb611, None), state
+*/
+/*else*/ {
+__pyx_t_4 = (__pyx_v_self->comment != ((PyObject*)Py_None));
+if (!__pyx_t_4) {
+} else {
+__pyx_t_2 = __pyx_t_4;
+goto __pyx_L4_bool_binop_done;
+}
+__pyx_t_4 = (__pyx_v_self->name != ((PyObject*)Py_None));
+if (!__pyx_t_4) {
+} else {
+__pyx_t_2 = __pyx_t_4;
+goto __pyx_L4_bool_binop_done;
+}
+__pyx_t_4 = (__pyx_v_self->quality != ((PyObject*)Py_None));
+if (!__pyx_t_4) {
+} else {
+__pyx_t_2 = __pyx_t_4;
+goto __pyx_L4_bool_binop_done;
+}
+__pyx_t_4 = (__pyx_v_self->sequence != ((PyObject*)Py_None));
+__pyx_t_2 = __pyx_t_4;
+__pyx_L4_bool_binop_done:;
+__pyx_v_use_setstate = __pyx_t_2;
+}
+__pyx_L3:;
+/* "(tree fragment)":12
+*     else:
+*         use_setstate = self.comment is not None or self.name is not None or self.quality is not None or self.sequence is not None
+*     if use_setstate:             # <<<<<<<<<<<<<<
+*         return __pyx_unpickle_FastxRecord, (type(self), 0x1bdb611, None), state
+*     else:
+*/
+if (__pyx_v_use_setstate) {
+/* "(tree fragment)":13
+*         use_setstate = self.comment is not None or self.name is not None or self.quality is not None or self.sequence is not None
+*     if use_setstate:
+*         return __pyx_unpickle_FastxRecord, (type(self), 0x1bdb611, None), state             # <<<<<<<<<<<<<<
+*     else:
+*         return __pyx_unpickle_FastxRecord, (type(self), 0x1bdb611, state)
+*/
+__Pyx_XDECREF(__pyx_r);
+__Pyx_GetModuleGlobalName(__pyx_t_3, __pyx_n_s_pyx_unpickle_FastxRecord); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 13, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__pyx_t_1 = PyTuple_New(3); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 13, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_INCREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
+__Pyx_GIVEREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, ((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))))) __PYX_ERR(1, 13, __pyx_L1_error);
+__Pyx_INCREF(__pyx_int_29210129);
+__Pyx_GIVEREF(__pyx_int_29210129);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_int_29210129)) __PYX_ERR(1, 13, __pyx_L1_error);
+__Pyx_INCREF(Py_None);
+__Pyx_GIVEREF(Py_None);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 2, Py_None)) __PYX_ERR(1, 13, __pyx_L1_error);
+__pyx_t_5 = PyTuple_New(3); if (unlikely(!__pyx_t_5)) __PYX_ERR(1, 13, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_5);
+__Pyx_GIVEREF(__pyx_t_3);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_5, 0, __pyx_t_3)) __PYX_ERR(1, 13, __pyx_L1_error);
+__Pyx_GIVEREF(__pyx_t_1);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_5, 1, __pyx_t_1)) __PYX_ERR(1, 13, __pyx_L1_error);
+__Pyx_INCREF(__pyx_v_state);
+__Pyx_GIVEREF(__pyx_v_state);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_5, 2, __pyx_v_state)) __PYX_ERR(1, 13, __pyx_L1_error);
+__pyx_t_3 = 0;
+__pyx_t_1 = 0;
+__pyx_r = __pyx_t_5;
+__pyx_t_5 = 0;
+goto __pyx_L0;
+/* "(tree fragment)":12
+*     else:
+*         use_setstate = self.comment is not None or self.name is not None or self.quality is not None or self.sequence is not None
+*     if use_setstate:             # <<<<<<<<<<<<<<
+*         return __pyx_unpickle_FastxRecord, (type(self), 0x1bdb611, None), state
+*     else:
+*/
+}
+/* "(tree fragment)":15
+*         return __pyx_unpickle_FastxRecord, (type(self), 0x1bdb611, None), state
+*     else:
+*         return __pyx_unpickle_FastxRecord, (type(self), 0x1bdb611, state)             # <<<<<<<<<<<<<<
+* def __setstate_cython__(self, __pyx_state):
+*     __pyx_unpickle_FastxRecord__set_state(self, __pyx_state)
+*/
+/*else*/ {
+__Pyx_XDECREF(__pyx_r);
+__Pyx_GetModuleGlobalName(__pyx_t_5, __pyx_n_s_pyx_unpickle_FastxRecord); if (unlikely(!__pyx_t_5)) __PYX_ERR(1, 15, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_5);
+__pyx_t_1 = PyTuple_New(3); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 15, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_INCREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
+__Pyx_GIVEREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, ((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))))) __PYX_ERR(1, 15, __pyx_L1_error);
+__Pyx_INCREF(__pyx_int_29210129);
+__Pyx_GIVEREF(__pyx_int_29210129);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_int_29210129)) __PYX_ERR(1, 15, __pyx_L1_error);
+__Pyx_INCREF(__pyx_v_state);
+__Pyx_GIVEREF(__pyx_v_state);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 2, __pyx_v_state)) __PYX_ERR(1, 15, __pyx_L1_error);
+__pyx_t_3 = PyTuple_New(2); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 15, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_GIVEREF(__pyx_t_5);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_5)) __PYX_ERR(1, 15, __pyx_L1_error);
+__Pyx_GIVEREF(__pyx_t_1);
+if (__Pyx_PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_1)) __PYX_ERR(1, 15, __pyx_L1_error);
+__pyx_t_5 = 0;
+__pyx_t_1 = 0;
+__pyx_r = __pyx_t_3;
+__pyx_t_3 = 0;
+goto __pyx_L0;
+}
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     cdef tuple state
+*     cdef object _dict
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_XDECREF(__pyx_t_3);
+__Pyx_XDECREF(__pyx_t_5);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XDECREF(__pyx_v_state);
+__Pyx_XDECREF(__pyx_v__dict);
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "(tree fragment)":16
+*     else:
+*         return __pyx_unpickle_FastxRecord, (type(self), 0x1bdb611, state)
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     __pyx_unpickle_FastxRecord__set_state(self, __pyx_state)
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_19__setstate_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_11FastxRecord_18__setstate_cython__, "FastxRecord.__setstate_cython__(self, __pyx_state)");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_11FastxRecord_19__setstate_cython__ = {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_11FastxRecord_19__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_11FastxRecord_18__setstate_cython__};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_11FastxRecord_19__setstate_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+PyObject *__pyx_v___pyx_state = 0;
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject* values[1] = {0};
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__setstate_cython__ (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+{
+PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_state,0};
+if (__pyx_kwds) {
+Py_ssize_t kw_args;
+switch (__pyx_nargs) {
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
+switch (__pyx_nargs) {
+case  0:
+if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 16, __pyx_L3_error)
+else goto __pyx_L5_argtuple_error;
+}
+if (unlikely(kw_args > 0)) {
+const Py_ssize_t kwd_pos_args = __pyx_nargs;
+if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__setstate_cython__") < 0)) __PYX_ERR(1, 16, __pyx_L3_error)
+}
+} else if (unlikely(__pyx_nargs != 1)) {
+goto __pyx_L5_argtuple_error;
+} else {
+values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+}
+__pyx_v___pyx_state = values[0];
+}
+goto __pyx_L6_skip;
+__pyx_L5_argtuple_error:;
+__Pyx_RaiseArgtupleInvalid("__setstate_cython__", 1, 1, 1, __pyx_nargs); __PYX_ERR(1, 16, __pyx_L3_error)
+__pyx_L6_skip:;
+goto __pyx_L4_argument_unpacking_done;
+__pyx_L3_error:;
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__Pyx_RefNannyFinishContext();
+return NULL;
+__pyx_L4_argument_unpacking_done:;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_11FastxRecord_18__setstate_cython__(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v_self), __pyx_v___pyx_state);
+/* function exit code */
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_11FastxRecord_18__setstate_cython__(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v_self, PyObject *__pyx_v___pyx_state) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__33)
+__Pyx_RefNannySetupContext("__setstate_cython__", 1);
+__Pyx_TraceCall("__setstate_cython__", __pyx_f[1], 16, 0, __PYX_ERR(1, 16, __pyx_L1_error));
+/* "(tree fragment)":17
+*         return __pyx_unpickle_FastxRecord, (type(self), 0x1bdb611, state)
+* def __setstate_cython__(self, __pyx_state):
+*     __pyx_unpickle_FastxRecord__set_state(self, __pyx_state)             # <<<<<<<<<<<<<<
+*/
+if (!(likely(PyTuple_CheckExact(__pyx_v___pyx_state))||((__pyx_v___pyx_state) == Py_None) || __Pyx_RaiseUnexpectedTypeError("tuple", __pyx_v___pyx_state))) __PYX_ERR(1, 17, __pyx_L1_error)
+__pyx_t_1 = __pyx_f_5pysam_9libcfaidx___pyx_unpickle_FastxRecord__set_state(__pyx_v_self, ((PyObject*)__pyx_v___pyx_state)); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 17, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+/* "(tree fragment)":16
+*     else:
+*         return __pyx_unpickle_FastxRecord, (type(self), 0x1bdb611, state)
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     __pyx_unpickle_FastxRecord__set_state(self, __pyx_state)
+*/
+/* function exit code */
+__pyx_r = Py_None; __Pyx_INCREF(Py_None);
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxRecord.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":545
+*
+*     """
+*     def __cinit__(self, *args, **kwargs):             # <<<<<<<<<<<<<<
+*         # self.fastqfile = <gzFile*>NULL
+*         self._filename = None
+*/
+/* Python wrapper */
+static int __pyx_pw_5pysam_9libcfaidx_9FastxFile_1__cinit__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
+static int __pyx_pw_5pysam_9libcfaidx_9FastxFile_1__cinit__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds) {
+PyObject *__pyx_v_args = 0;
+PyObject *__pyx_v_kwargs = 0;
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+int __pyx_r;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__cinit__ (wrapper)", 0);
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return -1;
+#endif
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+if (unlikely(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__cinit__", 1))) return -1;
+if (unlikely(__pyx_kwds)) {
+__pyx_v_kwargs = __Pyx_KwargsAsDict_VARARGS(__pyx_kwds, __pyx_kwvalues);
+if (unlikely(!__pyx_v_kwargs)) return -1;
+__Pyx_GOTREF(__pyx_v_kwargs);
+} else {
+__pyx_v_kwargs = PyDict_New();
+if (unlikely(!__pyx_v_kwargs)) return -1;
+__Pyx_GOTREF(__pyx_v_kwargs);
+}
+__Pyx_INCREF(__pyx_args);
+__pyx_v_args = __pyx_args;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastxFile___cinit__(((struct __pyx_obj_5pysam_9libcfaidx_FastxFile *)__pyx_v_self), __pyx_v_args, __pyx_v_kwargs);
+/* function exit code */
+__Pyx_DECREF(__pyx_v_args);
+__Pyx_DECREF(__pyx_v_kwargs);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static int __pyx_pf_5pysam_9libcfaidx_9FastxFile___cinit__(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self, PyObject *__pyx_v_args, PyObject *__pyx_v_kwargs) {
+int __pyx_r;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+PyObject *__pyx_t_2 = NULL;
+PyObject *__pyx_t_3 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__cinit__", 1);
+__Pyx_TraceCall("__cinit__", __pyx_f[0], 545, 0, __PYX_ERR(0, 545, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":547
+*     def __cinit__(self, *args, **kwargs):
+*         # self.fastqfile = <gzFile*>NULL
+*         self._filename = None             # <<<<<<<<<<<<<<
+*         self.entry = NULL
+*         self._open(*args, **kwargs)
+*/
+__Pyx_INCREF(Py_None);
+__Pyx_GIVEREF(Py_None);
+__Pyx_GOTREF(__pyx_v_self->_filename);
+__Pyx_DECREF(__pyx_v_self->_filename);
+__pyx_v_self->_filename = Py_None;
+/* "pysam/libcfaidx.pyx":548
+*         # self.fastqfile = <gzFile*>NULL
+*         self._filename = None
+*         self.entry = NULL             # <<<<<<<<<<<<<<
+*         self._open(*args, **kwargs)
+*
+*/
+__pyx_v_self->entry = NULL;
+/* "pysam/libcfaidx.pyx":549
+*         self._filename = None
+*         self.entry = NULL
+*         self._open(*args, **kwargs)             # <<<<<<<<<<<<<<
+*
+*     def is_open(self):
+*/
+__pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_open); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 549, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_t_2 = PyDict_Copy(__pyx_v_kwargs); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 549, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_3 = __Pyx_PyObject_Call(__pyx_t_1, __pyx_v_args, __pyx_t_2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 549, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+/* "pysam/libcfaidx.pyx":545
+*
+*     """
+*     def __cinit__(self, *args, **kwargs):             # <<<<<<<<<<<<<<
+*         # self.fastqfile = <gzFile*>NULL
+*         self._filename = None
+*/
+/* function exit code */
+__pyx_r = 0;
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_XDECREF(__pyx_t_3);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxFile.__cinit__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = -1;
+__pyx_L0:;
+__Pyx_TraceReturn(Py_None, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":551
+*         self._open(*args, **kwargs)
+*
+*     def is_open(self):             # <<<<<<<<<<<<<<
+*         '''return true if samfile has been opened.'''
+*         return self.entry != NULL
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_3is_open(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9FastxFile_2is_open, "FastxFile.is_open(self)\nreturn true if samfile has been opened.");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_9FastxFile_3is_open = {"is_open", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastxFile_3is_open, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastxFile_2is_open};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_3is_open(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("is_open (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+if (unlikely(__pyx_nargs > 0)) {
+__Pyx_RaiseArgtupleInvalid("is_open", 1, 0, 0, __pyx_nargs); return NULL;}
+if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "is_open", 0))) return NULL;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastxFile_2is_open(((struct __pyx_obj_5pysam_9libcfaidx_FastxFile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_2is_open(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__34)
+__Pyx_RefNannySetupContext("is_open", 1);
+__Pyx_TraceCall("is_open", __pyx_f[0], 551, 0, __PYX_ERR(0, 551, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":553
+*     def is_open(self):
+*         '''return true if samfile has been opened.'''
+*         return self.entry != NULL             # <<<<<<<<<<<<<<
+*
+*     def _open(self, filename, persist=True):
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_1 = __Pyx_PyBool_FromLong((__pyx_v_self->entry != NULL)); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 553, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_r = __pyx_t_1;
+__pyx_t_1 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":551
+*         self._open(*args, **kwargs)
+*
+*     def is_open(self):             # <<<<<<<<<<<<<<
+*         '''return true if samfile has been opened.'''
+*         return self.entry != NULL
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxFile.is_open", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":555
+*         return self.entry != NULL
+*
+*     def _open(self, filename, persist=True):             # <<<<<<<<<<<<<<
+*         '''open a fastq/fasta file in *filename*
+*
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_5_open(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9FastxFile_4_open, "FastxFile._open(self, filename, persist=True)\nopen a fastq/fasta file in *filename*\n\n        Paramentes\n        ----------\n\n        persist : bool\n\n            if True return a copy of the underlying data (default\n            True).  The copy will persist even if the iteration\n            on the file continues.\n\n        ");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_9FastxFile_5_open = {"_open", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastxFile_5_open, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastxFile_4_open};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_5_open(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+PyObject *__pyx_v_filename = 0;
+PyObject *__pyx_v_persist = 0;
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject* values[2] = {0,0};
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("_open (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+{
+PyObject **__pyx_pyargnames[] = {&__pyx_n_s_filename,&__pyx_n_s_persist,0};
+values[1] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)Py_True));
+if (__pyx_kwds) {
+Py_ssize_t kw_args;
+switch (__pyx_nargs) {
+case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
+CYTHON_FALLTHROUGH;
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
+switch (__pyx_nargs) {
+case  0:
+if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_filename)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 555, __pyx_L3_error)
+else goto __pyx_L5_argtuple_error;
+CYTHON_FALLTHROUGH;
+case  1:
+if (kw_args > 0) {
+PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_persist);
+if (value) { values[1] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 555, __pyx_L3_error)
+}
+}
+if (unlikely(kw_args > 0)) {
+const Py_ssize_t kwd_pos_args = __pyx_nargs;
+if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "_open") < 0)) __PYX_ERR(0, 555, __pyx_L3_error)
+}
+} else {
+switch (__pyx_nargs) {
+case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
+CYTHON_FALLTHROUGH;
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+break;
+default: goto __pyx_L5_argtuple_error;
+}
+}
+__pyx_v_filename = values[0];
+__pyx_v_persist = values[1];
+}
+goto __pyx_L6_skip;
+__pyx_L5_argtuple_error:;
+__Pyx_RaiseArgtupleInvalid("_open", 0, 1, 2, __pyx_nargs); __PYX_ERR(0, 555, __pyx_L3_error)
+__pyx_L6_skip:;
+goto __pyx_L4_argument_unpacking_done;
+__pyx_L3_error:;
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_AddTraceback("pysam.libcfaidx.FastxFile._open", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__Pyx_RefNannyFinishContext();
+return NULL;
+__pyx_L4_argument_unpacking_done:;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastxFile_4_open(((struct __pyx_obj_5pysam_9libcfaidx_FastxFile *)__pyx_v_self), __pyx_v_filename, __pyx_v_persist);
+/* function exit code */
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_4_open(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self, PyObject *__pyx_v_filename, PyObject *__pyx_v_persist) {
+char *__pyx_v_cfilename;
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_t_1;
+PyObject *__pyx_t_2 = NULL;
+PyObject *__pyx_t_3 = NULL;
+PyObject *__pyx_t_4 = NULL;
+unsigned int __pyx_t_5;
+char *__pyx_t_6;
+int __pyx_t_7;
+int __pyx_t_8;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__35)
+__Pyx_RefNannySetupContext("_open", 1);
+__Pyx_TraceCall("_open", __pyx_f[0], 555, 0, __PYX_ERR(0, 555, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":568
+*
+*         '''
+*         if self.fastqfile != NULL:             # <<<<<<<<<<<<<<
+*             self.close()
+*
+*/
+__pyx_t_1 = (__pyx_v_self->fastqfile != NULL);
+if (__pyx_t_1) {
+/* "pysam/libcfaidx.pyx":569
+*         '''
+*         if self.fastqfile != NULL:
+*             self.close()             # <<<<<<<<<<<<<<
+*
+*         self._filename = encode_filename(filename)
+*/
+__pyx_t_3 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_close); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 569, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__pyx_t_4 = NULL;
+__pyx_t_5 = 0;
+#if CYTHON_UNPACK_METHODS
+if (likely(PyMethod_Check(__pyx_t_3))) {
+__pyx_t_4 = PyMethod_GET_SELF(__pyx_t_3);
+if (likely(__pyx_t_4)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
+__Pyx_INCREF(__pyx_t_4);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_3, function);
+__pyx_t_5 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[2] = {__pyx_t_4, NULL};
+__pyx_t_2 = __Pyx_PyObject_FastCall(__pyx_t_3, __pyx_callargs+1-__pyx_t_5, 0+__pyx_t_5);
+__Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
+if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 569, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+}
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":568
+*
+*         '''
+*         if self.fastqfile != NULL:             # <<<<<<<<<<<<<<
+*             self.close()
+*
+*/
+}
+/* "pysam/libcfaidx.pyx":571
+*             self.close()
+*
+*         self._filename = encode_filename(filename)             # <<<<<<<<<<<<<<
+*         cdef char *cfilename = self._filename
+*         self.is_remote = hisremote(cfilename)
+*/
+__pyx_t_2 = __pyx_f_5pysam_9libcutils_encode_filename(__pyx_v_filename); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 571, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_GIVEREF(__pyx_t_2);
+__Pyx_GOTREF(__pyx_v_self->_filename);
+__Pyx_DECREF(__pyx_v_self->_filename);
+__pyx_v_self->_filename = __pyx_t_2;
+__pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":572
+*
+*         self._filename = encode_filename(filename)
+*         cdef char *cfilename = self._filename             # <<<<<<<<<<<<<<
+*         self.is_remote = hisremote(cfilename)
+*
+*/
+__pyx_t_6 = __Pyx_PyObject_AsWritableString(__pyx_v_self->_filename); if (unlikely((!__pyx_t_6) && PyErr_Occurred())) __PYX_ERR(0, 572, __pyx_L1_error)
+__pyx_v_cfilename = __pyx_t_6;
+/* "pysam/libcfaidx.pyx":573
+*         self._filename = encode_filename(filename)
+*         cdef char *cfilename = self._filename
+*         self.is_remote = hisremote(cfilename)             # <<<<<<<<<<<<<<
+*
+*         # open file for reading
+*/
+__pyx_v_self->is_remote = hisremote(__pyx_v_cfilename);
+/* "pysam/libcfaidx.pyx":576
+*
+*         # open file for reading
+*         if (self._filename != b"-"             # <<<<<<<<<<<<<<
+*             and not self.is_remote
+*             and not os.path.exists(filename)):
+*/
+__pyx_t_7 = (__Pyx_PyBytes_Equals(__pyx_v_self->_filename, __pyx_kp_b__4, Py_NE)); if (unlikely((__pyx_t_7 < 0))) __PYX_ERR(0, 576, __pyx_L1_error)
+if (__pyx_t_7) {
+} else {
+__pyx_t_1 = __pyx_t_7;
+goto __pyx_L5_bool_binop_done;
+}
+/* "pysam/libcfaidx.pyx":577
+*         # open file for reading
+*         if (self._filename != b"-"
+*             and not self.is_remote             # <<<<<<<<<<<<<<
+*             and not os.path.exists(filename)):
+*             raise IOError("file `%s` not found" % filename)
+*/
+__pyx_t_7 = (!__pyx_v_self->is_remote);
+if (__pyx_t_7) {
+} else {
+__pyx_t_1 = __pyx_t_7;
+goto __pyx_L5_bool_binop_done;
+}
+/* "pysam/libcfaidx.pyx":578
+*         if (self._filename != b"-"
+*             and not self.is_remote
+*             and not os.path.exists(filename)):             # <<<<<<<<<<<<<<
+*             raise IOError("file `%s` not found" % filename)
+*
+*/
+__Pyx_GetModuleGlobalName(__pyx_t_3, __pyx_n_s_os); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 578, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__pyx_t_4 = __Pyx_PyObject_GetAttrStr(__pyx_t_3, __pyx_n_s_path); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 578, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_4);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__pyx_t_3 = __Pyx_PyObject_GetAttrStr(__pyx_t_4, __pyx_n_s_exists); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 578, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+__pyx_t_4 = NULL;
+__pyx_t_5 = 0;
+#if CYTHON_UNPACK_METHODS
+if (likely(PyMethod_Check(__pyx_t_3))) {
+__pyx_t_4 = PyMethod_GET_SELF(__pyx_t_3);
+if (likely(__pyx_t_4)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
+__Pyx_INCREF(__pyx_t_4);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_3, function);
+__pyx_t_5 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[2] = {__pyx_t_4, __pyx_v_filename};
+__pyx_t_2 = __Pyx_PyObject_FastCall(__pyx_t_3, __pyx_callargs+1-__pyx_t_5, 1+__pyx_t_5);
+__Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
+if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 578, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+}
+__pyx_t_7 = __Pyx_PyObject_IsTrue(__pyx_t_2); if (unlikely((__pyx_t_7 < 0))) __PYX_ERR(0, 578, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__pyx_t_8 = (!__pyx_t_7);
+__pyx_t_1 = __pyx_t_8;
+__pyx_L5_bool_binop_done:;
+/* "pysam/libcfaidx.pyx":576
+*
+*         # open file for reading
+*         if (self._filename != b"-"             # <<<<<<<<<<<<<<
+*             and not self.is_remote
+*             and not os.path.exists(filename)):
+*/
+if (unlikely(__pyx_t_1)) {
+/* "pysam/libcfaidx.pyx":579
+*             and not self.is_remote
+*             and not os.path.exists(filename)):
+*             raise IOError("file `%s` not found" % filename)             # <<<<<<<<<<<<<<
+*
+*         self.persist = persist
+*/
+__pyx_t_2 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_file_s_not_found, __pyx_v_filename); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 579, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_3 = __Pyx_PyObject_CallOneArg(__pyx_builtin_IOError, __pyx_t_2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 579, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__Pyx_Raise(__pyx_t_3, 0, 0, 0);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__PYX_ERR(0, 579, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":576
+*
+*         # open file for reading
+*         if (self._filename != b"-"             # <<<<<<<<<<<<<<
+*             and not self.is_remote
+*             and not os.path.exists(filename)):
+*/
+}
+/* "pysam/libcfaidx.pyx":581
+*             raise IOError("file `%s` not found" % filename)
+*
+*         self.persist = persist             # <<<<<<<<<<<<<<
+*
+*         with nogil:
+*/
+__pyx_t_1 = __Pyx_PyObject_IsTrue(__pyx_v_persist); if (unlikely((__pyx_t_1 == (int)-1) && PyErr_Occurred())) __PYX_ERR(0, 581, __pyx_L1_error)
+__pyx_v_self->persist = __pyx_t_1;
+/* "pysam/libcfaidx.pyx":583
+*         self.persist = persist
+*
+*         with nogil:             # <<<<<<<<<<<<<<
+*             self.fastqfile = bgzf_open(cfilename, "r")
+*             self.entry = kseq_init(self.fastqfile)
+*/
+{
+#ifdef WITH_THREAD
+PyThreadState *_save;
+_save = NULL;
+Py_UNBLOCK_THREADS
+__Pyx_FastGIL_Remember();
+#endif
+/*try:*/ {
+/* "pysam/libcfaidx.pyx":584
+*
+*         with nogil:
+*             self.fastqfile = bgzf_open(cfilename, "r")             # <<<<<<<<<<<<<<
+*             self.entry = kseq_init(self.fastqfile)
+*         self._filename = filename
+*/
+__pyx_v_self->fastqfile = bgzf_open(__pyx_v_cfilename, ((char const *)"r"));
+/* "pysam/libcfaidx.pyx":585
+*         with nogil:
+*             self.fastqfile = bgzf_open(cfilename, "r")
+*             self.entry = kseq_init(self.fastqfile)             # <<<<<<<<<<<<<<
+*         self._filename = filename
+*
+*/
+__pyx_v_self->entry = kseq_init(__pyx_v_self->fastqfile);
+}
+/* "pysam/libcfaidx.pyx":583
+*         self.persist = persist
+*
+*         with nogil:             # <<<<<<<<<<<<<<
+*             self.fastqfile = bgzf_open(cfilename, "r")
+*             self.entry = kseq_init(self.fastqfile)
+*/
+/*finally:*/ {
+/*normal exit:*/{
+#ifdef WITH_THREAD
+__Pyx_FastGIL_Forget();
+Py_BLOCK_THREADS
+#endif
+goto __pyx_L10;
+}
+__pyx_L10:;
+}
+}
+/* "pysam/libcfaidx.pyx":586
+*             self.fastqfile = bgzf_open(cfilename, "r")
+*             self.entry = kseq_init(self.fastqfile)
+*         self._filename = filename             # <<<<<<<<<<<<<<
+*
+*     def close(self):
+*/
+__Pyx_INCREF(__pyx_v_filename);
+__Pyx_GIVEREF(__pyx_v_filename);
+__Pyx_GOTREF(__pyx_v_self->_filename);
+__Pyx_DECREF(__pyx_v_self->_filename);
+__pyx_v_self->_filename = __pyx_v_filename;
+/* "pysam/libcfaidx.pyx":555
+*         return self.entry != NULL
+*
+*     def _open(self, filename, persist=True):             # <<<<<<<<<<<<<<
+*         '''open a fastq/fasta file in *filename*
+*
+*/
+/* function exit code */
+__pyx_r = Py_None; __Pyx_INCREF(Py_None);
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_XDECREF(__pyx_t_3);
+__Pyx_XDECREF(__pyx_t_4);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxFile._open", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":588
+*         self._filename = filename
+*
+*     def close(self):             # <<<<<<<<<<<<<<
+*         '''close the file.'''
+*         if self.fastqfile != NULL:
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_7close(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9FastxFile_6close, "FastxFile.close(self)\nclose the file.");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_9FastxFile_7close = {"close", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastxFile_7close, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastxFile_6close};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_7close(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("close (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+if (unlikely(__pyx_nargs > 0)) {
+__Pyx_RaiseArgtupleInvalid("close", 1, 0, 0, __pyx_nargs); return NULL;}
+if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "close", 0))) return NULL;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastxFile_6close(((struct __pyx_obj_5pysam_9libcfaidx_FastxFile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_6close(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_t_1;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__36)
+__Pyx_RefNannySetupContext("close", 1);
+__Pyx_TraceCall("close", __pyx_f[0], 588, 0, __PYX_ERR(0, 588, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":590
+*     def close(self):
+*         '''close the file.'''
+*         if self.fastqfile != NULL:             # <<<<<<<<<<<<<<
+*             bgzf_close(self.fastqfile)
+*             self.fastqfile = NULL
+*/
+__pyx_t_1 = (__pyx_v_self->fastqfile != NULL);
+if (__pyx_t_1) {
+/* "pysam/libcfaidx.pyx":591
+*         '''close the file.'''
+*         if self.fastqfile != NULL:
+*             bgzf_close(self.fastqfile)             # <<<<<<<<<<<<<<
+*             self.fastqfile = NULL
+*         if self.entry != NULL:
+*/
+(void)(bgzf_close(__pyx_v_self->fastqfile));
+/* "pysam/libcfaidx.pyx":592
+*         if self.fastqfile != NULL:
+*             bgzf_close(self.fastqfile)
+*             self.fastqfile = NULL             # <<<<<<<<<<<<<<
+*         if self.entry != NULL:
+*             kseq_destroy(self.entry)
+*/
+__pyx_v_self->fastqfile = NULL;
+/* "pysam/libcfaidx.pyx":590
+*     def close(self):
+*         '''close the file.'''
+*         if self.fastqfile != NULL:             # <<<<<<<<<<<<<<
+*             bgzf_close(self.fastqfile)
+*             self.fastqfile = NULL
+*/
+}
+/* "pysam/libcfaidx.pyx":593
+*             bgzf_close(self.fastqfile)
+*             self.fastqfile = NULL
+*         if self.entry != NULL:             # <<<<<<<<<<<<<<
+*             kseq_destroy(self.entry)
+*             self.entry = NULL
+*/
+__pyx_t_1 = (__pyx_v_self->entry != NULL);
+if (__pyx_t_1) {
+/* "pysam/libcfaidx.pyx":594
+*             self.fastqfile = NULL
+*         if self.entry != NULL:
+*             kseq_destroy(self.entry)             # <<<<<<<<<<<<<<
+*             self.entry = NULL
+*
+*/
+kseq_destroy(__pyx_v_self->entry);
+/* "pysam/libcfaidx.pyx":595
+*         if self.entry != NULL:
+*             kseq_destroy(self.entry)
+*             self.entry = NULL             # <<<<<<<<<<<<<<
+*
+*     def __dealloc__(self):
+*/
+__pyx_v_self->entry = NULL;
+/* "pysam/libcfaidx.pyx":593
+*             bgzf_close(self.fastqfile)
+*             self.fastqfile = NULL
+*         if self.entry != NULL:             # <<<<<<<<<<<<<<
+*             kseq_destroy(self.entry)
+*             self.entry = NULL
+*/
+}
+/* "pysam/libcfaidx.pyx":588
+*         self._filename = filename
+*
+*     def close(self):             # <<<<<<<<<<<<<<
+*         '''close the file.'''
+*         if self.fastqfile != NULL:
+*/
+/* function exit code */
+__pyx_r = Py_None; __Pyx_INCREF(Py_None);
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastxFile.close", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":597
+*             self.entry = NULL
+*
+*     def __dealloc__(self):             # <<<<<<<<<<<<<<
+*         if self.fastqfile != NULL:
+*             bgzf_close(self.fastqfile)
+*/
+/* Python wrapper */
+static void __pyx_pw_5pysam_9libcfaidx_9FastxFile_9__dealloc__(PyObject *__pyx_v_self); /*proto*/
+static void __pyx_pw_5pysam_9libcfaidx_9FastxFile_9__dealloc__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__dealloc__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_pf_5pysam_9libcfaidx_9FastxFile_8__dealloc__(((struct __pyx_obj_5pysam_9libcfaidx_FastxFile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+}
+static void __pyx_pf_5pysam_9libcfaidx_9FastxFile_8__dealloc__(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self) {
+__Pyx_TraceDeclarations
+int __pyx_t_1;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceCall("__dealloc__", __pyx_f[0], 597, 0, __PYX_ERR(0, 597, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":598
+*
+*     def __dealloc__(self):
+*         if self.fastqfile != NULL:             # <<<<<<<<<<<<<<
+*             bgzf_close(self.fastqfile)
+*         if self.entry:
+*/
+__pyx_t_1 = (__pyx_v_self->fastqfile != NULL);
+if (__pyx_t_1) {
+/* "pysam/libcfaidx.pyx":599
+*     def __dealloc__(self):
+*         if self.fastqfile != NULL:
+*             bgzf_close(self.fastqfile)             # <<<<<<<<<<<<<<
+*         if self.entry:
+*             kseq_destroy(self.entry)
+*/
+(void)(bgzf_close(__pyx_v_self->fastqfile));
+/* "pysam/libcfaidx.pyx":598
+*
+*     def __dealloc__(self):
+*         if self.fastqfile != NULL:             # <<<<<<<<<<<<<<
+*             bgzf_close(self.fastqfile)
+*         if self.entry:
+*/
+}
+/* "pysam/libcfaidx.pyx":600
+*         if self.fastqfile != NULL:
+*             bgzf_close(self.fastqfile)
+*         if self.entry:             # <<<<<<<<<<<<<<
+*             kseq_destroy(self.entry)
+*
+*/
+__pyx_t_1 = (__pyx_v_self->entry != 0);
+if (__pyx_t_1) {
+/* "pysam/libcfaidx.pyx":601
+*             bgzf_close(self.fastqfile)
+*         if self.entry:
+*             kseq_destroy(self.entry)             # <<<<<<<<<<<<<<
+*
+*     # context manager interface
+*/
+kseq_destroy(__pyx_v_self->entry);
+/* "pysam/libcfaidx.pyx":600
+*         if self.fastqfile != NULL:
+*             bgzf_close(self.fastqfile)
+*         if self.entry:             # <<<<<<<<<<<<<<
+*             kseq_destroy(self.entry)
+*
+*/
+}
+/* "pysam/libcfaidx.pyx":597
+*             self.entry = NULL
+*
+*     def __dealloc__(self):             # <<<<<<<<<<<<<<
+*         if self.fastqfile != NULL:
+*             bgzf_close(self.fastqfile)
+*/
+/* function exit code */
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_WriteUnraisable("pysam.libcfaidx.FastxFile.__dealloc__", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
+__pyx_L0:;
+__Pyx_TraceReturn(Py_None, 0);
+}
+/* "pysam/libcfaidx.pyx":604
+*
+*     # context manager interface
+*     def __enter__(self):             # <<<<<<<<<<<<<<
+*         return self
+*
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_11__enter__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9FastxFile_10__enter__, "FastxFile.__enter__(self)");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_9FastxFile_11__enter__ = {"__enter__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastxFile_11__enter__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastxFile_10__enter__};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_11__enter__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__enter__ (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+if (unlikely(__pyx_nargs > 0)) {
+__Pyx_RaiseArgtupleInvalid("__enter__", 1, 0, 0, __pyx_nargs); return NULL;}
+if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__enter__", 0))) return NULL;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastxFile_10__enter__(((struct __pyx_obj_5pysam_9libcfaidx_FastxFile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_10__enter__(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__37)
+__Pyx_RefNannySetupContext("__enter__", 1);
+__Pyx_TraceCall("__enter__", __pyx_f[0], 604, 0, __PYX_ERR(0, 604, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":605
+*     # context manager interface
+*     def __enter__(self):
+*         return self             # <<<<<<<<<<<<<<
+*
+*     def __exit__(self, exc_type, exc_value, traceback):
+*/
+__Pyx_XDECREF(__pyx_r);
+__Pyx_INCREF((PyObject *)__pyx_v_self);
+__pyx_r = ((PyObject *)__pyx_v_self);
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":604
+*
+*     # context manager interface
+*     def __enter__(self):             # <<<<<<<<<<<<<<
+*         return self
+*
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastxFile.__enter__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":607
+*         return self
+*
+*     def __exit__(self, exc_type, exc_value, traceback):             # <<<<<<<<<<<<<<
+*         self.close()
+*         return False
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_13__exit__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9FastxFile_12__exit__, "FastxFile.__exit__(self, exc_type, exc_value, traceback)");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_9FastxFile_13__exit__ = {"__exit__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastxFile_13__exit__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastxFile_12__exit__};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_13__exit__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+CYTHON_UNUSED PyObject *__pyx_v_exc_type = 0;
+CYTHON_UNUSED PyObject *__pyx_v_exc_value = 0;
+CYTHON_UNUSED PyObject *__pyx_v_traceback = 0;
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject* values[3] = {0,0,0};
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__exit__ (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+{
+PyObject **__pyx_pyargnames[] = {&__pyx_n_s_exc_type,&__pyx_n_s_exc_value,&__pyx_n_s_traceback,0};
+if (__pyx_kwds) {
+Py_ssize_t kw_args;
+switch (__pyx_nargs) {
+case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
+CYTHON_FALLTHROUGH;
+case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
+CYTHON_FALLTHROUGH;
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
+switch (__pyx_nargs) {
+case  0:
+if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_exc_type)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 607, __pyx_L3_error)
+else goto __pyx_L5_argtuple_error;
+CYTHON_FALLTHROUGH;
+case  1:
+if (likely((values[1] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_exc_value)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[1]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 607, __pyx_L3_error)
+else {
+__Pyx_RaiseArgtupleInvalid("__exit__", 1, 3, 3, 1); __PYX_ERR(0, 607, __pyx_L3_error)
+}
+CYTHON_FALLTHROUGH;
+case  2:
+if (likely((values[2] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_traceback)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[2]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 607, __pyx_L3_error)
+else {
+__Pyx_RaiseArgtupleInvalid("__exit__", 1, 3, 3, 2); __PYX_ERR(0, 607, __pyx_L3_error)
+}
+}
+if (unlikely(kw_args > 0)) {
+const Py_ssize_t kwd_pos_args = __pyx_nargs;
+if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__exit__") < 0)) __PYX_ERR(0, 607, __pyx_L3_error)
+}
+} else if (unlikely(__pyx_nargs != 3)) {
+goto __pyx_L5_argtuple_error;
+} else {
+values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
+values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
+}
+__pyx_v_exc_type = values[0];
+__pyx_v_exc_value = values[1];
+__pyx_v_traceback = values[2];
+}
+goto __pyx_L6_skip;
+__pyx_L5_argtuple_error:;
+__Pyx_RaiseArgtupleInvalid("__exit__", 1, 3, 3, __pyx_nargs); __PYX_ERR(0, 607, __pyx_L3_error)
+__pyx_L6_skip:;
+goto __pyx_L4_argument_unpacking_done;
+__pyx_L3_error:;
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_AddTraceback("pysam.libcfaidx.FastxFile.__exit__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__Pyx_RefNannyFinishContext();
+return NULL;
+__pyx_L4_argument_unpacking_done:;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastxFile_12__exit__(((struct __pyx_obj_5pysam_9libcfaidx_FastxFile *)__pyx_v_self), __pyx_v_exc_type, __pyx_v_exc_value, __pyx_v_traceback);
+/* function exit code */
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_12__exit__(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v_exc_type, CYTHON_UNUSED PyObject *__pyx_v_exc_value, CYTHON_UNUSED PyObject *__pyx_v_traceback) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+PyObject *__pyx_t_2 = NULL;
+PyObject *__pyx_t_3 = NULL;
+unsigned int __pyx_t_4;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__38)
+__Pyx_RefNannySetupContext("__exit__", 1);
+__Pyx_TraceCall("__exit__", __pyx_f[0], 607, 0, __PYX_ERR(0, 607, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":608
+*
+*     def __exit__(self, exc_type, exc_value, traceback):
+*         self.close()             # <<<<<<<<<<<<<<
+*         return False
+*
+*/
+__pyx_t_2 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_close); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 608, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_3 = NULL;
+__pyx_t_4 = 0;
+#if CYTHON_UNPACK_METHODS
+if (likely(PyMethod_Check(__pyx_t_2))) {
+__pyx_t_3 = PyMethod_GET_SELF(__pyx_t_2);
+if (likely(__pyx_t_3)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
+__Pyx_INCREF(__pyx_t_3);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_2, function);
+__pyx_t_4 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[2] = {__pyx_t_3, NULL};
+__pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_4, 0+__pyx_t_4);
+__Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
+if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 608, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+}
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+/* "pysam/libcfaidx.pyx":609
+*     def __exit__(self, exc_type, exc_value, traceback):
+*         self.close()
+*         return False             # <<<<<<<<<<<<<<
+*
+*     property closed:
+*/
+__Pyx_XDECREF(__pyx_r);
+__Pyx_INCREF(Py_False);
+__pyx_r = Py_False;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":607
+*         return self
+*
+*     def __exit__(self, exc_type, exc_value, traceback):             # <<<<<<<<<<<<<<
+*         self.close()
+*         return False
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_XDECREF(__pyx_t_3);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxFile.__exit__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":615
+*         This is a read-only attribute; the close() method changes the value.
+*         """
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             return not self.is_open()
+*
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_6closed_1__get__(PyObject *__pyx_v_self); /*proto*/
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_6closed_1__get__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__get__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastxFile_6closed___get__(((struct __pyx_obj_5pysam_9libcfaidx_FastxFile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_6closed___get__(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+PyObject *__pyx_t_2 = NULL;
+PyObject *__pyx_t_3 = NULL;
+unsigned int __pyx_t_4;
+int __pyx_t_5;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__get__", 1);
+__Pyx_TraceCall("__get__", __pyx_f[0], 615, 0, __PYX_ERR(0, 615, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":616
+*         """
+*         def __get__(self):
+*             return not self.is_open()             # <<<<<<<<<<<<<<
+*
+*     property filename:
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_2 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_is_open); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 616, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_3 = NULL;
+__pyx_t_4 = 0;
+#if CYTHON_UNPACK_METHODS
+if (likely(PyMethod_Check(__pyx_t_2))) {
+__pyx_t_3 = PyMethod_GET_SELF(__pyx_t_2);
+if (likely(__pyx_t_3)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
+__Pyx_INCREF(__pyx_t_3);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_2, function);
+__pyx_t_4 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[2] = {__pyx_t_3, NULL};
+__pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_4, 0+__pyx_t_4);
+__Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
+if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 616, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+}
+__pyx_t_5 = __Pyx_PyObject_IsTrue(__pyx_t_1); if (unlikely((__pyx_t_5 < 0))) __PYX_ERR(0, 616, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__pyx_t_1 = __Pyx_PyBool_FromLong((!__pyx_t_5)); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 616, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_r = __pyx_t_1;
+__pyx_t_1 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":615
+*         This is a read-only attribute; the close() method changes the value.
+*         """
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             return not self.is_open()
+*
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_XDECREF(__pyx_t_3);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxFile.closed.__get__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":620
+*     property filename:
+*         """string with the filename associated with this object."""
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             return self._filename
+*
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_8filename_1__get__(PyObject *__pyx_v_self); /*proto*/
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_8filename_1__get__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__get__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastxFile_8filename___get__(((struct __pyx_obj_5pysam_9libcfaidx_FastxFile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_8filename___get__(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__get__", 1);
+__Pyx_TraceCall("__get__", __pyx_f[0], 620, 0, __PYX_ERR(0, 620, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":621
+*         """string with the filename associated with this object."""
+*         def __get__(self):
+*             return self._filename             # <<<<<<<<<<<<<<
+*
+*     def __iter__(self):
+*/
+__Pyx_XDECREF(__pyx_r);
+__Pyx_INCREF(__pyx_v_self->_filename);
+__pyx_r = __pyx_v_self->_filename;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":620
+*     property filename:
+*         """string with the filename associated with this object."""
+*         def __get__(self):             # <<<<<<<<<<<<<<
+*             return self._filename
+*
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastxFile.filename.__get__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":623
+*             return self._filename
+*
+*     def __iter__(self):             # <<<<<<<<<<<<<<
+*         if not self.is_open():
+*             raise ValueError("I/O operation on closed file")
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_15__iter__(PyObject *__pyx_v_self); /*proto*/
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_15__iter__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__iter__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastxFile_14__iter__(((struct __pyx_obj_5pysam_9libcfaidx_FastxFile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_14__iter__(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+PyObject *__pyx_t_2 = NULL;
+PyObject *__pyx_t_3 = NULL;
+unsigned int __pyx_t_4;
+int __pyx_t_5;
+int __pyx_t_6;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__iter__", 1);
+__Pyx_TraceCall("__iter__", __pyx_f[0], 623, 0, __PYX_ERR(0, 623, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":624
+*
+*     def __iter__(self):
+*         if not self.is_open():             # <<<<<<<<<<<<<<
+*             raise ValueError("I/O operation on closed file")
+*         return self
+*/
+__pyx_t_2 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_is_open); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 624, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_3 = NULL;
+__pyx_t_4 = 0;
+#if CYTHON_UNPACK_METHODS
+if (likely(PyMethod_Check(__pyx_t_2))) {
+__pyx_t_3 = PyMethod_GET_SELF(__pyx_t_2);
+if (likely(__pyx_t_3)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
+__Pyx_INCREF(__pyx_t_3);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_2, function);
+__pyx_t_4 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[2] = {__pyx_t_3, NULL};
+__pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_4, 0+__pyx_t_4);
+__Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
+if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 624, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+}
+__pyx_t_5 = __Pyx_PyObject_IsTrue(__pyx_t_1); if (unlikely((__pyx_t_5 < 0))) __PYX_ERR(0, 624, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__pyx_t_6 = (!__pyx_t_5);
+if (unlikely(__pyx_t_6)) {
+/* "pysam/libcfaidx.pyx":625
+*     def __iter__(self):
+*         if not self.is_open():
+*             raise ValueError("I/O operation on closed file")             # <<<<<<<<<<<<<<
+*         return self
+*
+*/
+__pyx_t_1 = __Pyx_PyObject_Call(__pyx_builtin_ValueError, __pyx_tuple__9, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 625, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_Raise(__pyx_t_1, 0, 0, 0);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__PYX_ERR(0, 625, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":624
+*
+*     def __iter__(self):
+*         if not self.is_open():             # <<<<<<<<<<<<<<
+*             raise ValueError("I/O operation on closed file")
+*         return self
+*/
+}
+/* "pysam/libcfaidx.pyx":626
+*         if not self.is_open():
+*             raise ValueError("I/O operation on closed file")
+*         return self             # <<<<<<<<<<<<<<
+*
+*     cdef kseq_t * getCurrent(self):
+*/
+__Pyx_XDECREF(__pyx_r);
+__Pyx_INCREF((PyObject *)__pyx_v_self);
+__pyx_r = ((PyObject *)__pyx_v_self);
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":623
+*             return self._filename
+*
+*     def __iter__(self):             # <<<<<<<<<<<<<<
+*         if not self.is_open():
+*             raise ValueError("I/O operation on closed file")
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_XDECREF(__pyx_t_3);
+__Pyx_AddTraceback("pysam.libcfaidx.FastxFile.__iter__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":628
+*         return self
+*
+*     cdef kseq_t * getCurrent(self):             # <<<<<<<<<<<<<<
+*         return self.entry
+*
+*/
+static kseq_t *__pyx_f_5pysam_9libcfaidx_9FastxFile_getCurrent(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self) {
+kseq_t *__pyx_r;
+__Pyx_TraceDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceCall("getCurrent", __pyx_f[0], 628, 0, __PYX_ERR(0, 628, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":629
+*
+*     cdef kseq_t * getCurrent(self):
+*         return self.entry             # <<<<<<<<<<<<<<
+*
+*     cdef int cnext(self):
+*/
+__pyx_r = __pyx_v_self->entry;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":628
+*         return self
+*
+*     cdef kseq_t * getCurrent(self):             # <<<<<<<<<<<<<<
+*         return self.entry
+*
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastxFile.getCurrent", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = 0;
+__pyx_L0:;
+__Pyx_TraceReturn(Py_None, 0);
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":631
+*         return self.entry
+*
+*     cdef int cnext(self):             # <<<<<<<<<<<<<<
+*         '''C version of iterator
+*         '''
+*/
+static int __pyx_f_5pysam_9libcfaidx_9FastxFile_cnext(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self) {
+int __pyx_r;
+__Pyx_TraceDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceCall("cnext", __pyx_f[0], 631, 0, __PYX_ERR(0, 631, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":634
+*         '''C version of iterator
+*         '''
+*         with nogil:             # <<<<<<<<<<<<<<
+*             return kseq_read(self.entry)
+*
+*/
+{
+#ifdef WITH_THREAD
+PyThreadState *_save;
+_save = NULL;
+Py_UNBLOCK_THREADS
+__Pyx_FastGIL_Remember();
+#endif
+/*try:*/ {
+/* "pysam/libcfaidx.pyx":635
+*         '''
+*         with nogil:
+*             return kseq_read(self.entry)             # <<<<<<<<<<<<<<
+*
+*     def __next__(self):
+*/
+__pyx_r = kseq_read(__pyx_v_self->entry);
+goto __pyx_L3_return;
+}
+/* "pysam/libcfaidx.pyx":634
+*         '''C version of iterator
+*         '''
+*         with nogil:             # <<<<<<<<<<<<<<
+*             return kseq_read(self.entry)
+*
+*/
+/*finally:*/ {
+__pyx_L3_return: {
+#ifdef WITH_THREAD
+__Pyx_FastGIL_Forget();
+Py_BLOCK_THREADS
+#endif
+goto __pyx_L0;
+}
+}
+}
+/* "pysam/libcfaidx.pyx":631
+*         return self.entry
+*
+*     cdef int cnext(self):             # <<<<<<<<<<<<<<
+*         '''C version of iterator
+*         '''
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastxFile.cnext", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = 0;
+__pyx_L0:;
+__Pyx_TraceReturn(Py_None, 0);
+return __pyx_r;
+}
+/* "pysam/libcfaidx.pyx":637
+*             return kseq_read(self.entry)
+*
+*     def __next__(self):             # <<<<<<<<<<<<<<
+*         """
+*         python version of next().
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_17__next__(PyObject *__pyx_v_self); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9FastxFile_16__next__, "\n        python version of next().\n        ");
+#if CYTHON_UPDATE_DESCRIPTOR_DOC
+struct wrapperbase __pyx_wrapperbase_5pysam_9libcfaidx_9FastxFile_16__next__;
+#endif
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_17__next__(PyObject *__pyx_v_self) {
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__next__ (wrapper)", 0);
+__pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastxFile_16__next__(((struct __pyx_obj_5pysam_9libcfaidx_FastxFile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_16__next__(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self) {
+int __pyx_v_l;
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_error_without_exception = 0; /* StopIteration */
+int __pyx_t_1;
+PyObject *__pyx_t_2 = NULL;
+PyObject *__pyx_t_3 = NULL;
+PyObject *__pyx_t_4 = NULL;
+unsigned int __pyx_t_5;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__next__", 1);
+__Pyx_TraceCall("__next__", __pyx_f[0], 637, 0, __PYX_ERR(0, 637, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":642
+*         """
+*         cdef int l
+*         with nogil:             # <<<<<<<<<<<<<<
+*             l = kseq_read(self.entry)
+*         if (l >= 0):
+*/
+{
+#ifdef WITH_THREAD
+PyThreadState *_save;
+_save = NULL;
+Py_UNBLOCK_THREADS
+__Pyx_FastGIL_Remember();
+#endif
+/*try:*/ {
+/* "pysam/libcfaidx.pyx":643
+*         cdef int l
+*         with nogil:
+*             l = kseq_read(self.entry)             # <<<<<<<<<<<<<<
+*         if (l >= 0):
+*             if self.persist:
+*/
+__pyx_v_l = kseq_read(__pyx_v_self->entry);
+}
+/* "pysam/libcfaidx.pyx":642
+*         """
+*         cdef int l
+*         with nogil:             # <<<<<<<<<<<<<<
+*             l = kseq_read(self.entry)
+*         if (l >= 0):
+*/
+/*finally:*/ {
+/*normal exit:*/{
+#ifdef WITH_THREAD
+__Pyx_FastGIL_Forget();
+Py_BLOCK_THREADS
+#endif
+goto __pyx_L5;
+}
+__pyx_L5:;
+}
+}
+/* "pysam/libcfaidx.pyx":644
+*         with nogil:
+*             l = kseq_read(self.entry)
+*         if (l >= 0):             # <<<<<<<<<<<<<<
+*             if self.persist:
+*                 return FastxRecord(proxy=makeFastqProxy(self.entry))
+*/
+__pyx_t_1 = (__pyx_v_l >= 0);
+if (likely(__pyx_t_1)) {
+/* "pysam/libcfaidx.pyx":645
+*             l = kseq_read(self.entry)
+*         if (l >= 0):
+*             if self.persist:             # <<<<<<<<<<<<<<
+*                 return FastxRecord(proxy=makeFastqProxy(self.entry))
+*             return makeFastqProxy(self.entry)
+*/
+if (__pyx_v_self->persist) {
+/* "pysam/libcfaidx.pyx":646
+*         if (l >= 0):
+*             if self.persist:
+*                 return FastxRecord(proxy=makeFastqProxy(self.entry))             # <<<<<<<<<<<<<<
+*             return makeFastqProxy(self.entry)
+*         elif (l == -1):
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_2 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 646, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_3 = __pyx_f_5pysam_9libcfaidx_makeFastqProxy(__pyx_v_self->entry); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 646, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+if (PyDict_SetItem(__pyx_t_2, __pyx_n_s_proxy, __pyx_t_3) < 0) __PYX_ERR(0, 646, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__pyx_t_3 = __Pyx_PyObject_Call(((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastxRecord), __pyx_empty_tuple, __pyx_t_2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 646, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__pyx_r = __pyx_t_3;
+__pyx_t_3 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":645
+*             l = kseq_read(self.entry)
+*         if (l >= 0):
+*             if self.persist:             # <<<<<<<<<<<<<<
+*                 return FastxRecord(proxy=makeFastqProxy(self.entry))
+*             return makeFastqProxy(self.entry)
+*/
+}
+/* "pysam/libcfaidx.pyx":647
+*             if self.persist:
+*                 return FastxRecord(proxy=makeFastqProxy(self.entry))
+*             return makeFastqProxy(self.entry)             # <<<<<<<<<<<<<<
+*         elif (l == -1):
+*             raise StopIteration
+*/
+__Pyx_XDECREF(__pyx_r);
+__pyx_t_3 = __pyx_f_5pysam_9libcfaidx_makeFastqProxy(__pyx_v_self->entry); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 647, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__pyx_r = __pyx_t_3;
+__pyx_t_3 = 0;
+goto __pyx_L0;
+/* "pysam/libcfaidx.pyx":644
+*         with nogil:
+*             l = kseq_read(self.entry)
+*         if (l >= 0):             # <<<<<<<<<<<<<<
+*             if self.persist:
+*                 return FastxRecord(proxy=makeFastqProxy(self.entry))
+*/
+}
+/* "pysam/libcfaidx.pyx":648
+*                 return FastxRecord(proxy=makeFastqProxy(self.entry))
+*             return makeFastqProxy(self.entry)
+*         elif (l == -1):             # <<<<<<<<<<<<<<
+*             raise StopIteration
+*         elif (l == -2):
+*/
+__pyx_t_1 = (__pyx_v_l == -1L);
+if (unlikely(__pyx_t_1)) {
+/* "pysam/libcfaidx.pyx":649
+*             return makeFastqProxy(self.entry)
+*         elif (l == -1):
+*             raise StopIteration             # <<<<<<<<<<<<<<
+*         elif (l == -2):
+*             raise ValueError('truncated quality string in {0}'
+*/
+__pyx_error_without_exception = 1;
+goto __pyx_L1_error;;
+/* "pysam/libcfaidx.pyx":648
+*                 return FastxRecord(proxy=makeFastqProxy(self.entry))
+*             return makeFastqProxy(self.entry)
+*         elif (l == -1):             # <<<<<<<<<<<<<<
+*             raise StopIteration
+*         elif (l == -2):
+*/
+}
+/* "pysam/libcfaidx.pyx":650
+*         elif (l == -1):
+*             raise StopIteration
+*         elif (l == -2):             # <<<<<<<<<<<<<<
+*             raise ValueError('truncated quality string in {0}'
+*                              .format(self._filename))
+*/
+__pyx_t_1 = (__pyx_v_l == -2L);
+if (unlikely(__pyx_t_1)) {
+/* "pysam/libcfaidx.pyx":652
+*         elif (l == -2):
+*             raise ValueError('truncated quality string in {0}'
+*                              .format(self._filename))             # <<<<<<<<<<<<<<
+*         else:
+*             raise ValueError('unknown problem parsing {0}'
+*/
+__pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_kp_u_truncated_quality_string_in_0, __pyx_n_s_format); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 652, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__pyx_t_4 = NULL;
+__pyx_t_5 = 0;
+#if CYTHON_UNPACK_METHODS
+if (likely(PyMethod_Check(__pyx_t_2))) {
+__pyx_t_4 = PyMethod_GET_SELF(__pyx_t_2);
+if (likely(__pyx_t_4)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
+__Pyx_INCREF(__pyx_t_4);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_2, function);
+__pyx_t_5 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[2] = {__pyx_t_4, __pyx_v_self->_filename};
+__pyx_t_3 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_5, 1+__pyx_t_5);
+__Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
+if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 652, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+}
+/* "pysam/libcfaidx.pyx":651
+*             raise StopIteration
+*         elif (l == -2):
+*             raise ValueError('truncated quality string in {0}'             # <<<<<<<<<<<<<<
+*                              .format(self._filename))
+*         else:
+*/
+__pyx_t_2 = __Pyx_PyObject_CallOneArg(__pyx_builtin_ValueError, __pyx_t_3); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 651, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__Pyx_Raise(__pyx_t_2, 0, 0, 0);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__PYX_ERR(0, 651, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":650
+*         elif (l == -1):
+*             raise StopIteration
+*         elif (l == -2):             # <<<<<<<<<<<<<<
+*             raise ValueError('truncated quality string in {0}'
+*                              .format(self._filename))
+*/
+}
+/* "pysam/libcfaidx.pyx":654
+*                              .format(self._filename))
+*         else:
+*             raise ValueError('unknown problem parsing {0}'             # <<<<<<<<<<<<<<
+*                              .format(self._filename))
+*
+*/
+/*else*/ {
+/* "pysam/libcfaidx.pyx":655
+*         else:
+*             raise ValueError('unknown problem parsing {0}'
+*                              .format(self._filename))             # <<<<<<<<<<<<<<
+*
+* # Compatibility Layer for pysam 0.8.1
+*/
+__pyx_t_3 = __Pyx_PyObject_GetAttrStr(__pyx_kp_u_unknown_problem_parsing_0, __pyx_n_s_format); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 655, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__pyx_t_4 = NULL;
+__pyx_t_5 = 0;
+#if CYTHON_UNPACK_METHODS
+if (likely(PyMethod_Check(__pyx_t_3))) {
+__pyx_t_4 = PyMethod_GET_SELF(__pyx_t_3);
+if (likely(__pyx_t_4)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
+__Pyx_INCREF(__pyx_t_4);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_3, function);
+__pyx_t_5 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[2] = {__pyx_t_4, __pyx_v_self->_filename};
+__pyx_t_2 = __Pyx_PyObject_FastCall(__pyx_t_3, __pyx_callargs+1-__pyx_t_5, 1+__pyx_t_5);
+__Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
+if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 655, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+}
+/* "pysam/libcfaidx.pyx":654
+*                              .format(self._filename))
+*         else:
+*             raise ValueError('unknown problem parsing {0}'             # <<<<<<<<<<<<<<
+*                              .format(self._filename))
+*
+*/
+__pyx_t_3 = __Pyx_PyObject_CallOneArg(__pyx_builtin_ValueError, __pyx_t_2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 654, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__Pyx_Raise(__pyx_t_3, 0, 0, 0);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__PYX_ERR(0, 654, __pyx_L1_error)
+}
+/* "pysam/libcfaidx.pyx":637
+*             return kseq_read(self.entry)
+*
+*     def __next__(self):             # <<<<<<<<<<<<<<
+*         """
+*         python version of next().
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_2);
+__Pyx_XDECREF(__pyx_t_3);
+__Pyx_XDECREF(__pyx_t_4);
+if (!__pyx_error_without_exception) {
+__Pyx_AddTraceback("pysam.libcfaidx.FastxFile.__next__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+}
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_19__reduce_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9FastxFile_18__reduce_cython__, "FastxFile.__reduce_cython__(self)");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_9FastxFile_19__reduce_cython__ = {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastxFile_19__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastxFile_18__reduce_cython__};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_19__reduce_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__reduce_cython__ (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+if (unlikely(__pyx_nargs > 0)) {
+__Pyx_RaiseArgtupleInvalid("__reduce_cython__", 1, 0, 0, __pyx_nargs); return NULL;}
+if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__reduce_cython__", 0))) return NULL;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastxFile_18__reduce_cython__(((struct __pyx_obj_5pysam_9libcfaidx_FastxFile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_18__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__39)
+__Pyx_RefNannySetupContext("__reduce_cython__", 1);
+__Pyx_TraceCall("__reduce_cython__", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));
+/* "(tree fragment)":2
+* def __reduce_cython__(self):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"             # <<<<<<<<<<<<<<
+* def __setstate_cython__(self, __pyx_state):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+*/
+__Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_no_default___reduce___due_to_non, 0, 0);
+__PYX_ERR(1, 2, __pyx_L1_error)
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastxFile.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "(tree fragment)":3
+* def __reduce_cython__(self):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_21__setstate_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9FastxFile_20__setstate_cython__, "FastxFile.__setstate_cython__(self, __pyx_state)");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_9FastxFile_21__setstate_cython__ = {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastxFile_21__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastxFile_20__setstate_cython__};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastxFile_21__setstate_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+CYTHON_UNUSED PyObject *__pyx_v___pyx_state = 0;
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject* values[1] = {0};
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__setstate_cython__ (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+{
+PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_state,0};
+if (__pyx_kwds) {
+Py_ssize_t kw_args;
+switch (__pyx_nargs) {
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
+switch (__pyx_nargs) {
+case  0:
+if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 3, __pyx_L3_error)
+else goto __pyx_L5_argtuple_error;
+}
+if (unlikely(kw_args > 0)) {
+const Py_ssize_t kwd_pos_args = __pyx_nargs;
+if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__setstate_cython__") < 0)) __PYX_ERR(1, 3, __pyx_L3_error)
+}
+} else if (unlikely(__pyx_nargs != 1)) {
+goto __pyx_L5_argtuple_error;
+} else {
+values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+}
+__pyx_v___pyx_state = values[0];
+}
+goto __pyx_L6_skip;
+__pyx_L5_argtuple_error:;
+__Pyx_RaiseArgtupleInvalid("__setstate_cython__", 1, 1, 1, __pyx_nargs); __PYX_ERR(1, 3, __pyx_L3_error)
+__pyx_L6_skip:;
+goto __pyx_L4_argument_unpacking_done;
+__pyx_L3_error:;
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_AddTraceback("pysam.libcfaidx.FastxFile.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__Pyx_RefNannyFinishContext();
+return NULL;
+__pyx_L4_argument_unpacking_done:;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastxFile_20__setstate_cython__(((struct __pyx_obj_5pysam_9libcfaidx_FastxFile *)__pyx_v_self), __pyx_v___pyx_state);
+/* function exit code */
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastxFile_20__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_FastxFile *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__40)
+__Pyx_RefNannySetupContext("__setstate_cython__", 1);
+__Pyx_TraceCall("__setstate_cython__", __pyx_f[1], 3, 0, __PYX_ERR(1, 3, __pyx_L1_error));
+/* "(tree fragment)":4
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"             # <<<<<<<<<<<<<<
+*/
+__Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_no_default___reduce___due_to_non, 0, 0);
+__PYX_ERR(1, 4, __pyx_L1_error)
+/* "(tree fragment)":3
+* def __reduce_cython__(self):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastxFile.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastqFile_1__reduce_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9FastqFile___reduce_cython__, "FastqFile.__reduce_cython__(self)");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_9FastqFile_1__reduce_cython__ = {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastqFile_1__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastqFile___reduce_cython__};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastqFile_1__reduce_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__reduce_cython__ (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+if (unlikely(__pyx_nargs > 0)) {
+__Pyx_RaiseArgtupleInvalid("__reduce_cython__", 1, 0, 0, __pyx_nargs); return NULL;}
+if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__reduce_cython__", 0))) return NULL;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastqFile___reduce_cython__(((struct __pyx_obj_5pysam_9libcfaidx_FastqFile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastqFile___reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_FastqFile *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__41)
+__Pyx_RefNannySetupContext("__reduce_cython__", 1);
+__Pyx_TraceCall("__reduce_cython__", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));
+/* "(tree fragment)":2
+* def __reduce_cython__(self):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"             # <<<<<<<<<<<<<<
+* def __setstate_cython__(self, __pyx_state):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+*/
+__Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_no_default___reduce___due_to_non, 0, 0);
+__PYX_ERR(1, 2, __pyx_L1_error)
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastqFile.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "(tree fragment)":3
+* def __reduce_cython__(self):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastqFile_3__setstate_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9FastqFile_2__setstate_cython__, "FastqFile.__setstate_cython__(self, __pyx_state)");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_9FastqFile_3__setstate_cython__ = {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastqFile_3__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastqFile_2__setstate_cython__};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9FastqFile_3__setstate_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+CYTHON_UNUSED PyObject *__pyx_v___pyx_state = 0;
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject* values[1] = {0};
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__setstate_cython__ (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+{
+PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_state,0};
+if (__pyx_kwds) {
+Py_ssize_t kw_args;
+switch (__pyx_nargs) {
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
+switch (__pyx_nargs) {
+case  0:
+if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 3, __pyx_L3_error)
+else goto __pyx_L5_argtuple_error;
+}
+if (unlikely(kw_args > 0)) {
+const Py_ssize_t kwd_pos_args = __pyx_nargs;
+if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__setstate_cython__") < 0)) __PYX_ERR(1, 3, __pyx_L3_error)
+}
+} else if (unlikely(__pyx_nargs != 1)) {
+goto __pyx_L5_argtuple_error;
+} else {
+values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+}
+__pyx_v___pyx_state = values[0];
+}
+goto __pyx_L6_skip;
+__pyx_L5_argtuple_error:;
+__Pyx_RaiseArgtupleInvalid("__setstate_cython__", 1, 1, 1, __pyx_nargs); __PYX_ERR(1, 3, __pyx_L3_error)
+__pyx_L6_skip:;
+goto __pyx_L4_argument_unpacking_done;
+__pyx_L3_error:;
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_AddTraceback("pysam.libcfaidx.FastqFile.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__Pyx_RefNannyFinishContext();
+return NULL;
+__pyx_L4_argument_unpacking_done:;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9FastqFile_2__setstate_cython__(((struct __pyx_obj_5pysam_9libcfaidx_FastqFile *)__pyx_v_self), __pyx_v___pyx_state);
+/* function exit code */
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9FastqFile_2__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_FastqFile *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__42)
+__Pyx_RefNannySetupContext("__setstate_cython__", 1);
+__Pyx_TraceCall("__setstate_cython__", __pyx_f[1], 3, 0, __PYX_ERR(1, 3, __pyx_L1_error));
+/* "(tree fragment)":4
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"             # <<<<<<<<<<<<<<
+*/
+__Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_no_default___reduce___due_to_non, 0, 0);
+__PYX_ERR(1, 4, __pyx_L1_error)
+/* "(tree fragment)":3
+* def __reduce_cython__(self):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.FastqFile.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9Fastafile_1__reduce_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9Fastafile___reduce_cython__, "Fastafile.__reduce_cython__(self)");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_9Fastafile_1__reduce_cython__ = {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9Fastafile_1__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9Fastafile___reduce_cython__};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9Fastafile_1__reduce_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__reduce_cython__ (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+if (unlikely(__pyx_nargs > 0)) {
+__Pyx_RaiseArgtupleInvalid("__reduce_cython__", 1, 0, 0, __pyx_nargs); return NULL;}
+if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__reduce_cython__", 0))) return NULL;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9Fastafile___reduce_cython__(((struct __pyx_obj_5pysam_9libcfaidx_Fastafile *)__pyx_v_self));
+/* function exit code */
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9Fastafile___reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_Fastafile *__pyx_v_self) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__43)
+__Pyx_RefNannySetupContext("__reduce_cython__", 1);
+__Pyx_TraceCall("__reduce_cython__", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));
+/* "(tree fragment)":2
+* def __reduce_cython__(self):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"             # <<<<<<<<<<<<<<
+* def __setstate_cython__(self, __pyx_state):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+*/
+__Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_no_default___reduce___due_to_non, 0, 0);
+__PYX_ERR(1, 2, __pyx_L1_error)
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.Fastafile.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "(tree fragment)":3
+* def __reduce_cython__(self):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9Fastafile_3__setstate_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx_9Fastafile_2__setstate_cython__, "Fastafile.__setstate_cython__(self, __pyx_state)");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_9Fastafile_3__setstate_cython__ = {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9Fastafile_3__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9Fastafile_2__setstate_cython__};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_9Fastafile_3__setstate_cython__(PyObject *__pyx_v_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+CYTHON_UNUSED PyObject *__pyx_v___pyx_state = 0;
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject* values[1] = {0};
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__setstate_cython__ (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+{
+PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_state,0};
+if (__pyx_kwds) {
+Py_ssize_t kw_args;
+switch (__pyx_nargs) {
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
+switch (__pyx_nargs) {
+case  0:
+if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 3, __pyx_L3_error)
+else goto __pyx_L5_argtuple_error;
+}
+if (unlikely(kw_args > 0)) {
+const Py_ssize_t kwd_pos_args = __pyx_nargs;
+if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__setstate_cython__") < 0)) __PYX_ERR(1, 3, __pyx_L3_error)
+}
+} else if (unlikely(__pyx_nargs != 1)) {
+goto __pyx_L5_argtuple_error;
+} else {
+values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+}
+__pyx_v___pyx_state = values[0];
+}
+goto __pyx_L6_skip;
+__pyx_L5_argtuple_error:;
+__Pyx_RaiseArgtupleInvalid("__setstate_cython__", 1, 1, 1, __pyx_nargs); __PYX_ERR(1, 3, __pyx_L3_error)
+__pyx_L6_skip:;
+goto __pyx_L4_argument_unpacking_done;
+__pyx_L3_error:;
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_AddTraceback("pysam.libcfaidx.Fastafile.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__Pyx_RefNannyFinishContext();
+return NULL;
+__pyx_L4_argument_unpacking_done:;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx_9Fastafile_2__setstate_cython__(((struct __pyx_obj_5pysam_9libcfaidx_Fastafile *)__pyx_v_self), __pyx_v___pyx_state);
+/* function exit code */
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx_9Fastafile_2__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libcfaidx_Fastafile *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__44)
+__Pyx_RefNannySetupContext("__setstate_cython__", 1);
+__Pyx_TraceCall("__setstate_cython__", __pyx_f[1], 3, 0, __PYX_ERR(1, 3, __pyx_L1_error));
+/* "(tree fragment)":4
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"             # <<<<<<<<<<<<<<
+*/
+__Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_no_default___reduce___due_to_non, 0, 0);
+__PYX_ERR(1, 4, __pyx_L1_error)
+/* "(tree fragment)":3
+* def __reduce_cython__(self):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_AddTraceback("pysam.libcfaidx.Fastafile.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "(tree fragment)":1
+* def __pyx_unpickle_FastxRecord(__pyx_type, long __pyx_checksum, __pyx_state):             # <<<<<<<<<<<<<<
+*     cdef object __pyx_PickleError
+*     cdef object __pyx_result
+*/
+/* Python wrapper */
+static PyObject *__pyx_pw_5pysam_9libcfaidx_1__pyx_unpickle_FastxRecord(PyObject *__pyx_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+); /*proto*/
+PyDoc_STRVAR(__pyx_doc_5pysam_9libcfaidx___pyx_unpickle_FastxRecord, "__pyx_unpickle_FastxRecord(__pyx_type, long __pyx_checksum, __pyx_state)");
+static PyMethodDef __pyx_mdef_5pysam_9libcfaidx_1__pyx_unpickle_FastxRecord = {"__pyx_unpickle_FastxRecord", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_1__pyx_unpickle_FastxRecord, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx___pyx_unpickle_FastxRecord};
+static PyObject *__pyx_pw_5pysam_9libcfaidx_1__pyx_unpickle_FastxRecord(PyObject *__pyx_self,
+#if CYTHON_METH_FASTCALL
+PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
+#else
+PyObject *__pyx_args, PyObject *__pyx_kwds
+#endif
+) {
+PyObject *__pyx_v___pyx_type = 0;
+long __pyx_v___pyx_checksum;
+PyObject *__pyx_v___pyx_state = 0;
+#if !CYTHON_METH_FASTCALL
+CYTHON_UNUSED Py_ssize_t __pyx_nargs;
+#endif
+CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
+PyObject* values[3] = {0,0,0};
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+PyObject *__pyx_r = 0;
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__pyx_unpickle_FastxRecord (wrapper)", 0);
+#if !CYTHON_METH_FASTCALL
+#if CYTHON_ASSUME_SAFE_MACROS
+__pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
+#else
+__pyx_nargs = PyTuple_Size(__pyx_args); if (unlikely(__pyx_nargs < 0)) return NULL;
+#endif
+#endif
+__pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
+{
+PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_type,&__pyx_n_s_pyx_checksum,&__pyx_n_s_pyx_state,0};
+if (__pyx_kwds) {
+Py_ssize_t kw_args;
+switch (__pyx_nargs) {
+case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
+CYTHON_FALLTHROUGH;
+case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
+CYTHON_FALLTHROUGH;
+case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+CYTHON_FALLTHROUGH;
+case  0: break;
+default: goto __pyx_L5_argtuple_error;
+}
+kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
+switch (__pyx_nargs) {
+case  0:
+if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_type)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
+else goto __pyx_L5_argtuple_error;
+CYTHON_FALLTHROUGH;
+case  1:
+if (likely((values[1] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_checksum)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[1]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
+else {
+__Pyx_RaiseArgtupleInvalid("__pyx_unpickle_FastxRecord", 1, 3, 3, 1); __PYX_ERR(1, 1, __pyx_L3_error)
+}
+CYTHON_FALLTHROUGH;
+case  2:
+if (likely((values[2] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
+(void)__Pyx_Arg_NewRef_FASTCALL(values[2]);
+kw_args--;
+}
+else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
+else {
+__Pyx_RaiseArgtupleInvalid("__pyx_unpickle_FastxRecord", 1, 3, 3, 2); __PYX_ERR(1, 1, __pyx_L3_error)
+}
+}
+if (unlikely(kw_args > 0)) {
+const Py_ssize_t kwd_pos_args = __pyx_nargs;
+if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__pyx_unpickle_FastxRecord") < 0)) __PYX_ERR(1, 1, __pyx_L3_error)
+}
+} else if (unlikely(__pyx_nargs != 3)) {
+goto __pyx_L5_argtuple_error;
+} else {
+values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
+values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
+values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
+}
+__pyx_v___pyx_type = values[0];
+__pyx_v___pyx_checksum = __Pyx_PyInt_As_long(values[1]); if (unlikely((__pyx_v___pyx_checksum == (long)-1) && PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
+__pyx_v___pyx_state = values[2];
+}
+goto __pyx_L6_skip;
+__pyx_L5_argtuple_error:;
+__Pyx_RaiseArgtupleInvalid("__pyx_unpickle_FastxRecord", 1, 3, 3, __pyx_nargs); __PYX_ERR(1, 1, __pyx_L3_error)
+__pyx_L6_skip:;
+goto __pyx_L4_argument_unpacking_done;
+__pyx_L3_error:;
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_AddTraceback("pysam.libcfaidx.__pyx_unpickle_FastxRecord", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__Pyx_RefNannyFinishContext();
+return NULL;
+__pyx_L4_argument_unpacking_done:;
+__pyx_r = __pyx_pf_5pysam_9libcfaidx___pyx_unpickle_FastxRecord(__pyx_self, __pyx_v___pyx_type, __pyx_v___pyx_checksum, __pyx_v___pyx_state);
+/* function exit code */
+{
+Py_ssize_t __pyx_temp;
+for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
+__Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
+}
+}
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static PyObject *__pyx_pf_5pysam_9libcfaidx___pyx_unpickle_FastxRecord(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v___pyx_type, long __pyx_v___pyx_checksum, PyObject *__pyx_v___pyx_state) {
+PyObject *__pyx_v___pyx_PickleError = 0;
+PyObject *__pyx_v___pyx_result = 0;
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_t_2;
+PyObject *__pyx_t_3 = NULL;
+PyObject *__pyx_t_4 = NULL;
+unsigned int __pyx_t_5;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_TraceFrameInit(__pyx_codeobj__45)
+__Pyx_RefNannySetupContext("__pyx_unpickle_FastxRecord", 1);
+__Pyx_TraceCall("__pyx_unpickle_FastxRecord", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));
+/* "(tree fragment)":4
+*     cdef object __pyx_PickleError
+*     cdef object __pyx_result
+*     if __pyx_checksum not in (0x1bdb611, 0xb688a86, 0x43fd151):             # <<<<<<<<<<<<<<
+*         from pickle import PickleError as __pyx_PickleError
+*         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0x1bdb611, 0xb688a86, 0x43fd151) = (comment, name, quality, sequence))" % __pyx_checksum
+*/
+__pyx_t_1 = __Pyx_PyInt_From_long(__pyx_v___pyx_checksum); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 4, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_t_2 = (__Pyx_PySequence_ContainsTF(__pyx_t_1, __pyx_tuple__46, Py_NE)); if (unlikely((__pyx_t_2 < 0))) __PYX_ERR(1, 4, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+if (__pyx_t_2) {
+/* "(tree fragment)":5
+*     cdef object __pyx_result
+*     if __pyx_checksum not in (0x1bdb611, 0xb688a86, 0x43fd151):
+*         from pickle import PickleError as __pyx_PickleError             # <<<<<<<<<<<<<<
+*         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0x1bdb611, 0xb688a86, 0x43fd151) = (comment, name, quality, sequence))" % __pyx_checksum
+*     __pyx_result = FastxRecord.__new__(__pyx_type)
+*/
+__pyx_t_1 = PyList_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 5, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_INCREF(__pyx_n_s_PickleError);
+__Pyx_GIVEREF(__pyx_n_s_PickleError);
+if (__Pyx_PyList_SET_ITEM(__pyx_t_1, 0, __pyx_n_s_PickleError)) __PYX_ERR(1, 5, __pyx_L1_error);
+__pyx_t_3 = __Pyx_Import(__pyx_n_s_pickle, __pyx_t_1, 0); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 5, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__pyx_t_1 = __Pyx_ImportFrom(__pyx_t_3, __pyx_n_s_PickleError); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 5, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_INCREF(__pyx_t_1);
+__pyx_v___pyx_PickleError = __pyx_t_1;
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+/* "(tree fragment)":6
+*     if __pyx_checksum not in (0x1bdb611, 0xb688a86, 0x43fd151):
+*         from pickle import PickleError as __pyx_PickleError
+*         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0x1bdb611, 0xb688a86, 0x43fd151) = (comment, name, quality, sequence))" % __pyx_checksum             # <<<<<<<<<<<<<<
+*     __pyx_result = FastxRecord.__new__(__pyx_type)
+*     if __pyx_state is not None:
+*/
+__pyx_t_3 = __Pyx_PyInt_From_long(__pyx_v___pyx_checksum); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 6, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__pyx_t_1 = __Pyx_PyString_Format(__pyx_kp_s_Incompatible_checksums_0x_x_vs_0, __pyx_t_3); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 6, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+__Pyx_Raise(__pyx_v___pyx_PickleError, __pyx_t_1, 0, 0);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__PYX_ERR(1, 6, __pyx_L1_error)
+/* "(tree fragment)":4
+*     cdef object __pyx_PickleError
+*     cdef object __pyx_result
+*     if __pyx_checksum not in (0x1bdb611, 0xb688a86, 0x43fd151):             # <<<<<<<<<<<<<<
+*         from pickle import PickleError as __pyx_PickleError
+*         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0x1bdb611, 0xb688a86, 0x43fd151) = (comment, name, quality, sequence))" % __pyx_checksum
+*/
+}
+/* "(tree fragment)":7
+*         from pickle import PickleError as __pyx_PickleError
+*         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0x1bdb611, 0xb688a86, 0x43fd151) = (comment, name, quality, sequence))" % __pyx_checksum
+*     __pyx_result = FastxRecord.__new__(__pyx_type)             # <<<<<<<<<<<<<<
+*     if __pyx_state is not None:
+*         __pyx_unpickle_FastxRecord__set_state(<FastxRecord> __pyx_result, __pyx_state)
+*/
+__pyx_t_3 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastxRecord), __pyx_n_s_new); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 7, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_3);
+__pyx_t_4 = NULL;
+__pyx_t_5 = 0;
+#if CYTHON_UNPACK_METHODS
+if (likely(PyMethod_Check(__pyx_t_3))) {
+__pyx_t_4 = PyMethod_GET_SELF(__pyx_t_3);
+if (likely(__pyx_t_4)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
+__Pyx_INCREF(__pyx_t_4);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_3, function);
+__pyx_t_5 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[2] = {__pyx_t_4, __pyx_v___pyx_type};
+__pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_3, __pyx_callargs+1-__pyx_t_5, 1+__pyx_t_5);
+__Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
+if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 7, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+}
+__pyx_v___pyx_result = __pyx_t_1;
+__pyx_t_1 = 0;
+/* "(tree fragment)":8
+*         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0x1bdb611, 0xb688a86, 0x43fd151) = (comment, name, quality, sequence))" % __pyx_checksum
+*     __pyx_result = FastxRecord.__new__(__pyx_type)
+*     if __pyx_state is not None:             # <<<<<<<<<<<<<<
+*         __pyx_unpickle_FastxRecord__set_state(<FastxRecord> __pyx_result, __pyx_state)
+*     return __pyx_result
+*/
+__pyx_t_2 = (__pyx_v___pyx_state != Py_None);
+if (__pyx_t_2) {
+/* "(tree fragment)":9
+*     __pyx_result = FastxRecord.__new__(__pyx_type)
+*     if __pyx_state is not None:
+*         __pyx_unpickle_FastxRecord__set_state(<FastxRecord> __pyx_result, __pyx_state)             # <<<<<<<<<<<<<<
+*     return __pyx_result
+* cdef __pyx_unpickle_FastxRecord__set_state(FastxRecord __pyx_result, tuple __pyx_state):
+*/
+if (!(likely(PyTuple_CheckExact(__pyx_v___pyx_state))||((__pyx_v___pyx_state) == Py_None) || __Pyx_RaiseUnexpectedTypeError("tuple", __pyx_v___pyx_state))) __PYX_ERR(1, 9, __pyx_L1_error)
+__pyx_t_1 = __pyx_f_5pysam_9libcfaidx___pyx_unpickle_FastxRecord__set_state(((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)__pyx_v___pyx_result), ((PyObject*)__pyx_v___pyx_state)); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 9, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+/* "(tree fragment)":8
+*         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0x1bdb611, 0xb688a86, 0x43fd151) = (comment, name, quality, sequence))" % __pyx_checksum
+*     __pyx_result = FastxRecord.__new__(__pyx_type)
+*     if __pyx_state is not None:             # <<<<<<<<<<<<<<
+*         __pyx_unpickle_FastxRecord__set_state(<FastxRecord> __pyx_result, __pyx_state)
+*     return __pyx_result
+*/
+}
+/* "(tree fragment)":10
+*     if __pyx_state is not None:
+*         __pyx_unpickle_FastxRecord__set_state(<FastxRecord> __pyx_result, __pyx_state)
+*     return __pyx_result             # <<<<<<<<<<<<<<
+* cdef __pyx_unpickle_FastxRecord__set_state(FastxRecord __pyx_result, tuple __pyx_state):
+*     __pyx_result.comment = __pyx_state[0]; __pyx_result.name = __pyx_state[1]; __pyx_result.quality = __pyx_state[2]; __pyx_result.sequence = __pyx_state[3]
+*/
+__Pyx_XDECREF(__pyx_r);
+__Pyx_INCREF(__pyx_v___pyx_result);
+__pyx_r = __pyx_v___pyx_result;
+goto __pyx_L0;
+/* "(tree fragment)":1
+* def __pyx_unpickle_FastxRecord(__pyx_type, long __pyx_checksum, __pyx_state):             # <<<<<<<<<<<<<<
+*     cdef object __pyx_PickleError
+*     cdef object __pyx_result
+*/
+/* function exit code */
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_XDECREF(__pyx_t_3);
+__Pyx_XDECREF(__pyx_t_4);
+__Pyx_AddTraceback("pysam.libcfaidx.__pyx_unpickle_FastxRecord", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = NULL;
+__pyx_L0:;
+__Pyx_XDECREF(__pyx_v___pyx_PickleError);
+__Pyx_XDECREF(__pyx_v___pyx_result);
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+/* "(tree fragment)":11
+*         __pyx_unpickle_FastxRecord__set_state(<FastxRecord> __pyx_result, __pyx_state)
+*     return __pyx_result
+* cdef __pyx_unpickle_FastxRecord__set_state(FastxRecord __pyx_result, tuple __pyx_state):             # <<<<<<<<<<<<<<
+*     __pyx_result.comment = __pyx_state[0]; __pyx_result.name = __pyx_state[1]; __pyx_result.quality = __pyx_state[2]; __pyx_result.sequence = __pyx_state[3]
+*     if len(__pyx_state) > 4 and hasattr(__pyx_result, '__dict__'):
+*/
+static PyObject *__pyx_f_5pysam_9libcfaidx___pyx_unpickle_FastxRecord__set_state(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *__pyx_v___pyx_result, PyObject *__pyx_v___pyx_state) {
+PyObject *__pyx_r = NULL;
+__Pyx_TraceDeclarations
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_t_2;
+Py_ssize_t __pyx_t_3;
+int __pyx_t_4;
+PyObject *__pyx_t_5 = NULL;
+PyObject *__pyx_t_6 = NULL;
+PyObject *__pyx_t_7 = NULL;
+unsigned int __pyx_t_8;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__pyx_unpickle_FastxRecord__set_state", 1);
+__Pyx_TraceCall("__pyx_unpickle_FastxRecord__set_state", __pyx_f[1], 11, 0, __PYX_ERR(1, 11, __pyx_L1_error));
+/* "(tree fragment)":12
+*     return __pyx_result
+* cdef __pyx_unpickle_FastxRecord__set_state(FastxRecord __pyx_result, tuple __pyx_state):
+*     __pyx_result.comment = __pyx_state[0]; __pyx_result.name = __pyx_state[1]; __pyx_result.quality = __pyx_state[2]; __pyx_result.sequence = __pyx_state[3]             # <<<<<<<<<<<<<<
+*     if len(__pyx_state) > 4 and hasattr(__pyx_result, '__dict__'):
+*         __pyx_result.__dict__.update(__pyx_state[4])
+*/
+if (unlikely(__pyx_v___pyx_state == Py_None)) {
+PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
+__PYX_ERR(1, 12, __pyx_L1_error)
+}
+__pyx_t_1 = __Pyx_GetItemInt_Tuple(__pyx_v___pyx_state, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 12, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+if (!(likely(PyUnicode_CheckExact(__pyx_t_1))||((__pyx_t_1) == Py_None) || __Pyx_RaiseUnexpectedTypeError("unicode", __pyx_t_1))) __PYX_ERR(1, 12, __pyx_L1_error)
+__Pyx_GIVEREF(__pyx_t_1);
+__Pyx_GOTREF(__pyx_v___pyx_result->comment);
+__Pyx_DECREF(__pyx_v___pyx_result->comment);
+__pyx_v___pyx_result->comment = ((PyObject*)__pyx_t_1);
+__pyx_t_1 = 0;
+if (unlikely(__pyx_v___pyx_state == Py_None)) {
+PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
+__PYX_ERR(1, 12, __pyx_L1_error)
+}
+__pyx_t_1 = __Pyx_GetItemInt_Tuple(__pyx_v___pyx_state, 1, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 12, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+if (!(likely(PyUnicode_CheckExact(__pyx_t_1))||((__pyx_t_1) == Py_None) || __Pyx_RaiseUnexpectedTypeError("unicode", __pyx_t_1))) __PYX_ERR(1, 12, __pyx_L1_error)
+__Pyx_GIVEREF(__pyx_t_1);
+__Pyx_GOTREF(__pyx_v___pyx_result->name);
+__Pyx_DECREF(__pyx_v___pyx_result->name);
+__pyx_v___pyx_result->name = ((PyObject*)__pyx_t_1);
+__pyx_t_1 = 0;
+if (unlikely(__pyx_v___pyx_state == Py_None)) {
+PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
+__PYX_ERR(1, 12, __pyx_L1_error)
+}
+__pyx_t_1 = __Pyx_GetItemInt_Tuple(__pyx_v___pyx_state, 2, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 12, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+if (!(likely(PyUnicode_CheckExact(__pyx_t_1))||((__pyx_t_1) == Py_None) || __Pyx_RaiseUnexpectedTypeError("unicode", __pyx_t_1))) __PYX_ERR(1, 12, __pyx_L1_error)
+__Pyx_GIVEREF(__pyx_t_1);
+__Pyx_GOTREF(__pyx_v___pyx_result->quality);
+__Pyx_DECREF(__pyx_v___pyx_result->quality);
+__pyx_v___pyx_result->quality = ((PyObject*)__pyx_t_1);
+__pyx_t_1 = 0;
+if (unlikely(__pyx_v___pyx_state == Py_None)) {
+PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
+__PYX_ERR(1, 12, __pyx_L1_error)
+}
+__pyx_t_1 = __Pyx_GetItemInt_Tuple(__pyx_v___pyx_state, 3, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 12, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+if (!(likely(PyUnicode_CheckExact(__pyx_t_1))||((__pyx_t_1) == Py_None) || __Pyx_RaiseUnexpectedTypeError("unicode", __pyx_t_1))) __PYX_ERR(1, 12, __pyx_L1_error)
+__Pyx_GIVEREF(__pyx_t_1);
+__Pyx_GOTREF(__pyx_v___pyx_result->sequence);
+__Pyx_DECREF(__pyx_v___pyx_result->sequence);
+__pyx_v___pyx_result->sequence = ((PyObject*)__pyx_t_1);
+__pyx_t_1 = 0;
+/* "(tree fragment)":13
+* cdef __pyx_unpickle_FastxRecord__set_state(FastxRecord __pyx_result, tuple __pyx_state):
+*     __pyx_result.comment = __pyx_state[0]; __pyx_result.name = __pyx_state[1]; __pyx_result.quality = __pyx_state[2]; __pyx_result.sequence = __pyx_state[3]
+*     if len(__pyx_state) > 4 and hasattr(__pyx_result, '__dict__'):             # <<<<<<<<<<<<<<
+*         __pyx_result.__dict__.update(__pyx_state[4])
+*/
+if (unlikely(__pyx_v___pyx_state == Py_None)) {
+PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
+__PYX_ERR(1, 13, __pyx_L1_error)
+}
+__pyx_t_3 = __Pyx_PyTuple_GET_SIZE(__pyx_v___pyx_state); if (unlikely(__pyx_t_3 == ((Py_ssize_t)-1))) __PYX_ERR(1, 13, __pyx_L1_error)
+__pyx_t_4 = (__pyx_t_3 > 4);
+if (__pyx_t_4) {
+} else {
+__pyx_t_2 = __pyx_t_4;
+goto __pyx_L4_bool_binop_done;
+}
+__pyx_t_4 = __Pyx_HasAttr(((PyObject *)__pyx_v___pyx_result), __pyx_n_s_dict); if (unlikely(__pyx_t_4 == ((int)-1))) __PYX_ERR(1, 13, __pyx_L1_error)
+__pyx_t_2 = __pyx_t_4;
+__pyx_L4_bool_binop_done:;
+if (__pyx_t_2) {
+/* "(tree fragment)":14
+*     __pyx_result.comment = __pyx_state[0]; __pyx_result.name = __pyx_state[1]; __pyx_result.quality = __pyx_state[2]; __pyx_result.sequence = __pyx_state[3]
+*     if len(__pyx_state) > 4 and hasattr(__pyx_result, '__dict__'):
+*         __pyx_result.__dict__.update(__pyx_state[4])             # <<<<<<<<<<<<<<
+*/
+__pyx_t_5 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v___pyx_result), __pyx_n_s_dict); if (unlikely(!__pyx_t_5)) __PYX_ERR(1, 14, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_5);
+__pyx_t_6 = __Pyx_PyObject_GetAttrStr(__pyx_t_5, __pyx_n_s_update); if (unlikely(!__pyx_t_6)) __PYX_ERR(1, 14, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_6);
+__Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
+if (unlikely(__pyx_v___pyx_state == Py_None)) {
+PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
+__PYX_ERR(1, 14, __pyx_L1_error)
+}
+__pyx_t_5 = __Pyx_GetItemInt_Tuple(__pyx_v___pyx_state, 4, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(1, 14, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_5);
+__pyx_t_7 = NULL;
+__pyx_t_8 = 0;
+#if CYTHON_UNPACK_METHODS
+if (likely(PyMethod_Check(__pyx_t_6))) {
+__pyx_t_7 = PyMethod_GET_SELF(__pyx_t_6);
+if (likely(__pyx_t_7)) {
+PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_6);
+__Pyx_INCREF(__pyx_t_7);
+__Pyx_INCREF(function);
+__Pyx_DECREF_SET(__pyx_t_6, function);
+__pyx_t_8 = 1;
+}
+}
+#endif
+{
+PyObject *__pyx_callargs[2] = {__pyx_t_7, __pyx_t_5};
+__pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_6, __pyx_callargs+1-__pyx_t_8, 1+__pyx_t_8);
+__Pyx_XDECREF(__pyx_t_7); __pyx_t_7 = 0;
+__Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
+if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 14, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
+}
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+/* "(tree fragment)":13
+* cdef __pyx_unpickle_FastxRecord__set_state(FastxRecord __pyx_result, tuple __pyx_state):
+*     __pyx_result.comment = __pyx_state[0]; __pyx_result.name = __pyx_state[1]; __pyx_result.quality = __pyx_state[2]; __pyx_result.sequence = __pyx_state[3]
+*     if len(__pyx_state) > 4 and hasattr(__pyx_result, '__dict__'):             # <<<<<<<<<<<<<<
+*         __pyx_result.__dict__.update(__pyx_state[4])
+*/
+}
+/* "(tree fragment)":11
+*         __pyx_unpickle_FastxRecord__set_state(<FastxRecord> __pyx_result, __pyx_state)
+*     return __pyx_result
+* cdef __pyx_unpickle_FastxRecord__set_state(FastxRecord __pyx_result, tuple __pyx_state):             # <<<<<<<<<<<<<<
+*     __pyx_result.comment = __pyx_state[0]; __pyx_result.name = __pyx_state[1]; __pyx_result.quality = __pyx_state[2]; __pyx_result.sequence = __pyx_state[3]
+*     if len(__pyx_state) > 4 and hasattr(__pyx_result, '__dict__'):
+*/
+/* function exit code */
+__pyx_r = Py_None; __Pyx_INCREF(Py_None);
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_XDECREF(__pyx_t_5);
+__Pyx_XDECREF(__pyx_t_6);
+__Pyx_XDECREF(__pyx_t_7);
+__Pyx_AddTraceback("pysam.libcfaidx.__pyx_unpickle_FastxRecord__set_state", __pyx_clineno, __pyx_lineno, __pyx_filename);
+__pyx_r = 0;
+__pyx_L0:;
+__Pyx_XGIVEREF(__pyx_r);
+__Pyx_TraceReturn(__pyx_r, 0);
+__Pyx_RefNannyFinishContext();
+return __pyx_r;
+}
+static struct __pyx_vtabstruct_5pysam_9libcfaidx_FastaFile __pyx_vtable_5pysam_9libcfaidx_FastaFile;
+static PyObject *__pyx_tp_new_5pysam_9libcfaidx_FastaFile(PyTypeObject *t, PyObject *a, PyObject *k) {
+struct __pyx_obj_5pysam_9libcfaidx_FastaFile *p;
+PyObject *o;
+#if CYTHON_COMPILING_IN_LIMITED_API
+allocfunc alloc_func = (allocfunc)PyType_GetSlot(t, Py_tp_alloc);
+o = alloc_func(t, 0);
+#else
+if (likely(!__Pyx_PyType_HasFeature(t, Py_TPFLAGS_IS_ABSTRACT))) {
+o = (*t->tp_alloc)(t, 0);
+} else {
+o = (PyObject *) PyBaseObject_Type.tp_new(t, __pyx_empty_tuple, 0);
+}
+if (unlikely(!o)) return 0;
+#endif
+p = ((struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)o);
+p->__pyx_vtab = __pyx_vtabptr_5pysam_9libcfaidx_FastaFile;
+p->_filename = Py_None; Py_INCREF(Py_None);
+p->_references = Py_None; Py_INCREF(Py_None);
+p->_lengths = Py_None; Py_INCREF(Py_None);
+p->reference2length = Py_None; Py_INCREF(Py_None);
+if (unlikely(__pyx_pw_5pysam_9libcfaidx_9FastaFile_1__cinit__(o, a, k) < 0)) goto bad;
+return o;
+bad:
+Py_DECREF(o); o = 0;
+return NULL;
+}
+static void __pyx_tp_dealloc_5pysam_9libcfaidx_FastaFile(PyObject *o) {
+struct __pyx_obj_5pysam_9libcfaidx_FastaFile *p = (struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)o;
+#if CYTHON_USE_TP_FINALIZE
+if (unlikely((PY_VERSION_HEX >= 0x03080000 || __Pyx_PyType_HasFeature(Py_TYPE(o), Py_TPFLAGS_HAVE_FINALIZE)) && __Pyx_PyObject_GetSlot(o, tp_finalize, destructor)) && !__Pyx_PyObject_GC_IsFinalized(o)) {
+if (__Pyx_PyObject_GetSlot(o, tp_dealloc, destructor) == __pyx_tp_dealloc_5pysam_9libcfaidx_FastaFile) {
+if (PyObject_CallFinalizerFromDealloc(o)) return;
+}
+}
+#endif
+PyObject_GC_UnTrack(o);
+{
+PyObject *etype, *eval, *etb;
+PyErr_Fetch(&etype, &eval, &etb);
+__Pyx_SET_REFCNT(o, Py_REFCNT(o) + 1);
+__pyx_pw_5pysam_9libcfaidx_9FastaFile_11__dealloc__(o);
+__Pyx_SET_REFCNT(o, Py_REFCNT(o) - 1);
+PyErr_Restore(etype, eval, etb);
+}
+Py_CLEAR(p->_filename);
+Py_CLEAR(p->_references);
+Py_CLEAR(p->_lengths);
+Py_CLEAR(p->reference2length);
+#if CYTHON_USE_TYPE_SLOTS || CYTHON_COMPILING_IN_PYPY
+(*Py_TYPE(o)->tp_free)(o);
+#else
+{
+freefunc tp_free = (freefunc)PyType_GetSlot(Py_TYPE(o), Py_tp_free);
+if (tp_free) tp_free(o);
+}
+#endif
+}
+static int __pyx_tp_traverse_5pysam_9libcfaidx_FastaFile(PyObject *o, visitproc v, void *a) {
+int e;
+struct __pyx_obj_5pysam_9libcfaidx_FastaFile *p = (struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)o;
+if (p->_filename) {
+e = (*v)(p->_filename, a); if (e) return e;
+}
+if (p->_references) {
+e = (*v)(p->_references, a); if (e) return e;
+}
+if (p->_lengths) {
+e = (*v)(p->_lengths, a); if (e) return e;
+}
+if (p->reference2length) {
+e = (*v)(p->reference2length, a); if (e) return e;
+}
+return 0;
+}
+static int __pyx_tp_clear_5pysam_9libcfaidx_FastaFile(PyObject *o) {
+PyObject* tmp;
+struct __pyx_obj_5pysam_9libcfaidx_FastaFile *p = (struct __pyx_obj_5pysam_9libcfaidx_FastaFile *)o;
+tmp = ((PyObject*)p->_filename);
+p->_filename = Py_None; Py_INCREF(Py_None);
+Py_XDECREF(tmp);
+tmp = ((PyObject*)p->_references);
+p->_references = Py_None; Py_INCREF(Py_None);
+Py_XDECREF(tmp);
+tmp = ((PyObject*)p->_lengths);
+p->_lengths = Py_None; Py_INCREF(Py_None);
+Py_XDECREF(tmp);
+tmp = ((PyObject*)p->reference2length);
+p->reference2length = Py_None; Py_INCREF(Py_None);
+Py_XDECREF(tmp);
+return 0;
+}
+static PyObject *__pyx_sq_item_5pysam_9libcfaidx_FastaFile(PyObject *o, Py_ssize_t i) {
+PyObject *r;
+PyObject *x = PyInt_FromSsize_t(i); if(!x) return 0;
+r = Py_TYPE(o)->tp_as_mapping->mp_subscript(o, x);
+Py_DECREF(x);
+return r;
+}
+static PyObject *__pyx_getprop_5pysam_9libcfaidx_9FastaFile_closed(PyObject *o, CYTHON_UNUSED void *x) {
+return __pyx_pw_5pysam_9libcfaidx_9FastaFile_6closed_1__get__(o);
+}
+static PyObject *__pyx_getprop_5pysam_9libcfaidx_9FastaFile_filename(PyObject *o, CYTHON_UNUSED void *x) {
+return __pyx_pw_5pysam_9libcfaidx_9FastaFile_8filename_1__get__(o);
+}
+static PyObject *__pyx_getprop_5pysam_9libcfaidx_9FastaFile_references(PyObject *o, CYTHON_UNUSED void *x) {
+return __pyx_pw_5pysam_9libcfaidx_9FastaFile_10references_1__get__(o);
+}
+static PyObject *__pyx_getprop_5pysam_9libcfaidx_9FastaFile_nreferences(PyObject *o, CYTHON_UNUSED void *x) {
+return __pyx_pw_5pysam_9libcfaidx_9FastaFile_11nreferences_1__get__(o);
+}
+static PyObject *__pyx_getprop_5pysam_9libcfaidx_9FastaFile_lengths(PyObject *o, CYTHON_UNUSED void *x) {
+return __pyx_pw_5pysam_9libcfaidx_9FastaFile_7lengths_1__get__(o);
+}
+static PyMethodDef __pyx_methods_5pysam_9libcfaidx_FastaFile[] = {
+{"is_open", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastaFile_3is_open, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastaFile_2is_open},
+{"_open", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastaFile_7_open, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastaFile_6_open},
+{"close", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastaFile_9close, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastaFile_8close},
+{"__enter__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastaFile_13__enter__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastaFile_12__enter__},
+{"__exit__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastaFile_15__exit__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastaFile_14__exit__},
+{"fetch", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastaFile_17fetch, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastaFile_16fetch},
+{"get_reference_length", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastaFile_19get_reference_length, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastaFile_18get_reference_length},
+{"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastaFile_25__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastaFile_24__reduce_cython__},
+{"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastaFile_27__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastaFile_26__setstate_cython__},
+{0, 0, 0, 0}
+};
+static struct PyGetSetDef __pyx_getsets_5pysam_9libcfaidx_FastaFile[] = {
+{(char *)"closed", __pyx_getprop_5pysam_9libcfaidx_9FastaFile_closed, 0, (char *)PyDoc_STR("bool indicating the current state of the file object.\n        This is a read-only attribute; the close() method changes the value.\n        "), 0},
+{(char *)"filename", __pyx_getprop_5pysam_9libcfaidx_9FastaFile_filename, 0, (char *)PyDoc_STR("filename associated with this object. This is a read-only attribute."), 0},
+{(char *)"references", __pyx_getprop_5pysam_9libcfaidx_9FastaFile_references, 0, (char *)PyDoc_STR("tuple with the names of :term:`reference` sequences."), 0},
+{(char *)"nreferences", __pyx_getprop_5pysam_9libcfaidx_9FastaFile_nreferences, 0, (char *)PyDoc_STR("int with the number of :term:`reference` sequences in the file.\n        This is a read-only attribute."), 0},
+{(char *)"lengths", __pyx_getprop_5pysam_9libcfaidx_9FastaFile_lengths, 0, (char *)PyDoc_STR("tuple with the lengths of :term:`reference` sequences."), 0},
+{0, 0, 0, 0, 0}
+};
+#if CYTHON_USE_TYPE_SPECS
+static PyType_Slot __pyx_type_5pysam_9libcfaidx_FastaFile_slots[] = {
+{Py_tp_dealloc, (void *)__pyx_tp_dealloc_5pysam_9libcfaidx_FastaFile},
+{Py_sq_length, (void *)__pyx_pw_5pysam_9libcfaidx_9FastaFile_5__len__},
+{Py_sq_item, (void *)__pyx_sq_item_5pysam_9libcfaidx_FastaFile},
+{Py_sq_contains, (void *)__pyx_pw_5pysam_9libcfaidx_9FastaFile_23__contains__},
+{Py_mp_length, (void *)__pyx_pw_5pysam_9libcfaidx_9FastaFile_5__len__},
+{Py_mp_subscript, (void *)__pyx_pw_5pysam_9libcfaidx_9FastaFile_21__getitem__},
+{Py_tp_doc, (void *)PyDoc_STR("Random access to fasta formatted files that\n    have been indexed by :term:`faidx`.\n\n    The file is automatically opened. The index file of file\n    ``<filename>`` is expected to be called ``<filename>.fai``.\n\n    Parameters\n    ----------\n\n    filename : string\n        Filename of fasta file to be opened.\n\n    filepath_index : string\n        Optional, filename of the index. By default this is\n        the filename + \".fai\".\n\n    filepath_index_compressed : string\n        Optional, filename of the index if fasta file is. By default this is\n        the filename + \".gzi\".\n\n    Raises\n    ------\n\n    ValueError\n        if index file is missing\n\n    IOError\n        if file could not be opened\n\n    ")},
+{Py_tp_traverse, (void *)__pyx_tp_traverse_5pysam_9libcfaidx_FastaFile},
+{Py_tp_clear, (void *)__pyx_tp_clear_5pysam_9libcfaidx_FastaFile},
+{Py_tp_methods, (void *)__pyx_methods_5pysam_9libcfaidx_FastaFile},
+{Py_tp_getset, (void *)__pyx_getsets_5pysam_9libcfaidx_FastaFile},
+{Py_tp_new, (void *)__pyx_tp_new_5pysam_9libcfaidx_FastaFile},
+{0, 0},
+};
+static PyType_Spec __pyx_type_5pysam_9libcfaidx_FastaFile_spec = {
+"pysam.libcfaidx.FastaFile",
+sizeof(struct __pyx_obj_5pysam_9libcfaidx_FastaFile),
+0,
+Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC,
+__pyx_type_5pysam_9libcfaidx_FastaFile_slots,
+};
+#else
+static PySequenceMethods __pyx_tp_as_sequence_FastaFile = {
+__pyx_pw_5pysam_9libcfaidx_9FastaFile_5__len__, /*sq_length*/
+0, /*sq_concat*/
+0, /*sq_repeat*/
+__pyx_sq_item_5pysam_9libcfaidx_FastaFile, /*sq_item*/
+0, /*sq_slice*/
+0, /*sq_ass_item*/
+0, /*sq_ass_slice*/
+__pyx_pw_5pysam_9libcfaidx_9FastaFile_23__contains__, /*sq_contains*/
+0, /*sq_inplace_concat*/
+0, /*sq_inplace_repeat*/
+};
+static PyMappingMethods __pyx_tp_as_mapping_FastaFile = {
+__pyx_pw_5pysam_9libcfaidx_9FastaFile_5__len__, /*mp_length*/
+__pyx_pw_5pysam_9libcfaidx_9FastaFile_21__getitem__, /*mp_subscript*/
+0, /*mp_ass_subscript*/
+};
+static PyTypeObject __pyx_type_5pysam_9libcfaidx_FastaFile = {
+PyVarObject_HEAD_INIT(0, 0)
+"pysam.libcfaidx.""FastaFile", /*tp_name*/
+sizeof(struct __pyx_obj_5pysam_9libcfaidx_FastaFile), /*tp_basicsize*/
+0, /*tp_itemsize*/
+__pyx_tp_dealloc_5pysam_9libcfaidx_FastaFile, /*tp_dealloc*/
+#if PY_VERSION_HEX < 0x030800b4
+0, /*tp_print*/
+#endif
+#if PY_VERSION_HEX >= 0x030800b4
+0, /*tp_vectorcall_offset*/
+#endif
+0, /*tp_getattr*/
+0, /*tp_setattr*/
+#if PY_MAJOR_VERSION < 3
+0, /*tp_compare*/
+#endif
+#if PY_MAJOR_VERSION >= 3
+0, /*tp_as_async*/
+#endif
+0, /*tp_repr*/
+0, /*tp_as_number*/
+&__pyx_tp_as_sequence_FastaFile, /*tp_as_sequence*/
+&__pyx_tp_as_mapping_FastaFile, /*tp_as_mapping*/
+0, /*tp_hash*/
+0, /*tp_call*/
+0, /*tp_str*/
+0, /*tp_getattro*/
+0, /*tp_setattro*/
+0, /*tp_as_buffer*/
+Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
+PyDoc_STR("Random access to fasta formatted files that\n    have been indexed by :term:`faidx`.\n\n    The file is automatically opened. The index file of file\n    ``<filename>`` is expected to be called ``<filename>.fai``.\n\n    Parameters\n    ----------\n\n    filename : string\n        Filename of fasta file to be opened.\n\n    filepath_index : string\n        Optional, filename of the index. By default this is\n        the filename + \".fai\".\n\n    filepath_index_compressed : string\n        Optional, filename of the index if fasta file is. By default this is\n        the filename + \".gzi\".\n\n    Raises\n    ------\n\n    ValueError\n        if index file is missing\n\n    IOError\n        if file could not be opened\n\n    "), /*tp_doc*/
+__pyx_tp_traverse_5pysam_9libcfaidx_FastaFile, /*tp_traverse*/
+__pyx_tp_clear_5pysam_9libcfaidx_FastaFile, /*tp_clear*/
+0, /*tp_richcompare*/
+0, /*tp_weaklistoffset*/
+0, /*tp_iter*/
+0, /*tp_iternext*/
+__pyx_methods_5pysam_9libcfaidx_FastaFile, /*tp_methods*/
+0, /*tp_members*/
+__pyx_getsets_5pysam_9libcfaidx_FastaFile, /*tp_getset*/
+0, /*tp_base*/
+0, /*tp_dict*/
+0, /*tp_descr_get*/
+0, /*tp_descr_set*/
+#if !CYTHON_USE_TYPE_SPECS
+0, /*tp_dictoffset*/
+#endif
+0, /*tp_init*/
+0, /*tp_alloc*/
+__pyx_tp_new_5pysam_9libcfaidx_FastaFile, /*tp_new*/
+0, /*tp_free*/
+0, /*tp_is_gc*/
+0, /*tp_bases*/
+0, /*tp_mro*/
+0, /*tp_cache*/
+0, /*tp_subclasses*/
+0, /*tp_weaklist*/
+0, /*tp_del*/
+0, /*tp_version_tag*/
+#if PY_VERSION_HEX >= 0x030400a1
+#if CYTHON_USE_TP_FINALIZE
+0, /*tp_finalize*/
+#else
+NULL, /*tp_finalize*/
+#endif
+#endif
+#if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
+0, /*tp_vectorcall*/
+#endif
+#if __PYX_NEED_TP_PRINT_SLOT == 1
+0, /*tp_print*/
+#endif
+#if PY_VERSION_HEX >= 0x030C0000
+0, /*tp_watched*/
+#endif
+#if PY_VERSION_HEX >= 0x030d00A4
+0, /*tp_versions_used*/
+#endif
+#if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
+0, /*tp_pypy_flags*/
+#endif
+};
+#endif
+static struct __pyx_vtabstruct_5pysam_9libcfaidx_FastqProxy __pyx_vtable_5pysam_9libcfaidx_FastqProxy;
+static PyObject *__pyx_tp_new_5pysam_9libcfaidx_FastqProxy(PyTypeObject *t, CYTHON_UNUSED PyObject *a, CYTHON_UNUSED PyObject *k) {
+struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *p;
+PyObject *o;
+#if CYTHON_COMPILING_IN_LIMITED_API
+allocfunc alloc_func = (allocfunc)PyType_GetSlot(t, Py_tp_alloc);
+o = alloc_func(t, 0);
+#else
+if (likely(!__Pyx_PyType_HasFeature(t, Py_TPFLAGS_IS_ABSTRACT))) {
+o = (*t->tp_alloc)(t, 0);
+} else {
+o = (PyObject *) PyBaseObject_Type.tp_new(t, __pyx_empty_tuple, 0);
+}
+if (unlikely(!o)) return 0;
+#endif
+p = ((struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *)o);
+p->__pyx_vtab = __pyx_vtabptr_5pysam_9libcfaidx_FastqProxy;
+return o;
+}
+static void __pyx_tp_dealloc_5pysam_9libcfaidx_FastqProxy(PyObject *o) {
+#if CYTHON_USE_TP_FINALIZE
+if (unlikely((PY_VERSION_HEX >= 0x03080000 || __Pyx_PyType_HasFeature(Py_TYPE(o), Py_TPFLAGS_HAVE_FINALIZE)) && __Pyx_PyObject_GetSlot(o, tp_finalize, destructor)) && (!PyType_IS_GC(Py_TYPE(o)) || !__Pyx_PyObject_GC_IsFinalized(o))) {
+if (__Pyx_PyObject_GetSlot(o, tp_dealloc, destructor) == __pyx_tp_dealloc_5pysam_9libcfaidx_FastqProxy) {
+if (PyObject_CallFinalizerFromDealloc(o)) return;
+}
+}
+#endif
+#if CYTHON_USE_TYPE_SLOTS || CYTHON_COMPILING_IN_PYPY
+(*Py_TYPE(o)->tp_free)(o);
+#else
+{
+freefunc tp_free = (freefunc)PyType_GetSlot(Py_TYPE(o), Py_tp_free);
+if (tp_free) tp_free(o);
+}
+#endif
+}
+static PyObject *__pyx_getprop_5pysam_9libcfaidx_10FastqProxy_name(PyObject *o, CYTHON_UNUSED void *x) {
+return __pyx_pw_5pysam_9libcfaidx_10FastqProxy_4name_1__get__(o);
+}
+static PyObject *__pyx_getprop_5pysam_9libcfaidx_10FastqProxy_sequence(PyObject *o, CYTHON_UNUSED void *x) {
+return __pyx_pw_5pysam_9libcfaidx_10FastqProxy_8sequence_1__get__(o);
+}
+static PyObject *__pyx_getprop_5pysam_9libcfaidx_10FastqProxy_comment(PyObject *o, CYTHON_UNUSED void *x) {
+return __pyx_pw_5pysam_9libcfaidx_10FastqProxy_7comment_1__get__(o);
+}
+static PyObject *__pyx_getprop_5pysam_9libcfaidx_10FastqProxy_quality(PyObject *o, CYTHON_UNUSED void *x) {
+return __pyx_pw_5pysam_9libcfaidx_10FastqProxy_7quality_1__get__(o);
+}
+static PyMethodDef __pyx_methods_5pysam_9libcfaidx_FastqProxy[] = {
+{"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_10FastqProxy_7__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_10FastqProxy_6__reduce_cython__},
+{"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_10FastqProxy_9__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_10FastqProxy_8__setstate_cython__},
+{0, 0, 0, 0}
+};
+static struct PyGetSetDef __pyx_getsets_5pysam_9libcfaidx_FastqProxy[] = {
+{(char *)"name", __pyx_getprop_5pysam_9libcfaidx_10FastqProxy_name, 0, (char *)PyDoc_STR("The name of each entry in the fastq file."), 0},
+{(char *)"sequence", __pyx_getprop_5pysam_9libcfaidx_10FastqProxy_sequence, 0, (char *)PyDoc_STR("The sequence of each entry in the fastq file."), 0},
+{(char *)"comment", __pyx_getprop_5pysam_9libcfaidx_10FastqProxy_comment, 0, (char *)0, 0},
+{(char *)"quality", __pyx_getprop_5pysam_9libcfaidx_10FastqProxy_quality, 0, (char *)PyDoc_STR("The quality score of each entry in the fastq file, represented as a string."), 0},
+{0, 0, 0, 0, 0}
+};
+#if CYTHON_USE_TYPE_SPECS
+static PyType_Slot __pyx_type_5pysam_9libcfaidx_FastqProxy_slots[] = {
+{Py_tp_dealloc, (void *)__pyx_tp_dealloc_5pysam_9libcfaidx_FastqProxy},
+{Py_tp_str, (void *)__pyx_pw_5pysam_9libcfaidx_10FastqProxy_3__str__},
+{Py_tp_doc, (void *)PyDoc_STR("FastqProxy()\nA single entry in a fastq file.")},
+{Py_tp_methods, (void *)__pyx_methods_5pysam_9libcfaidx_FastqProxy},
+{Py_tp_getset, (void *)__pyx_getsets_5pysam_9libcfaidx_FastqProxy},
+{Py_tp_init, (void *)__pyx_pw_5pysam_9libcfaidx_10FastqProxy_1__init__},
+{Py_tp_new, (void *)__pyx_tp_new_5pysam_9libcfaidx_FastqProxy},
+{0, 0},
+};
+static PyType_Spec __pyx_type_5pysam_9libcfaidx_FastqProxy_spec = {
+"pysam.libcfaidx.FastqProxy",
+sizeof(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy),
+0,
+Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE,
+__pyx_type_5pysam_9libcfaidx_FastqProxy_slots,
+};
+#else
+static PyTypeObject __pyx_type_5pysam_9libcfaidx_FastqProxy = {
+PyVarObject_HEAD_INIT(0, 0)
+"pysam.libcfaidx.""FastqProxy", /*tp_name*/
+sizeof(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy), /*tp_basicsize*/
+0, /*tp_itemsize*/
+__pyx_tp_dealloc_5pysam_9libcfaidx_FastqProxy, /*tp_dealloc*/
+#if PY_VERSION_HEX < 0x030800b4
+0, /*tp_print*/
+#endif
+#if PY_VERSION_HEX >= 0x030800b4
+0, /*tp_vectorcall_offset*/
+#endif
+0, /*tp_getattr*/
+0, /*tp_setattr*/
+#if PY_MAJOR_VERSION < 3
+0, /*tp_compare*/
+#endif
+#if PY_MAJOR_VERSION >= 3
+0, /*tp_as_async*/
+#endif
+0, /*tp_repr*/
+0, /*tp_as_number*/
+0, /*tp_as_sequence*/
+0, /*tp_as_mapping*/
+0, /*tp_hash*/
+0, /*tp_call*/
+__pyx_pw_5pysam_9libcfaidx_10FastqProxy_3__str__, /*tp_str*/
+0, /*tp_getattro*/
+0, /*tp_setattro*/
+0, /*tp_as_buffer*/
+Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE, /*tp_flags*/
+PyDoc_STR("FastqProxy()\nA single entry in a fastq file."), /*tp_doc*/
+0, /*tp_traverse*/
+0, /*tp_clear*/
+0, /*tp_richcompare*/
+0, /*tp_weaklistoffset*/
+0, /*tp_iter*/
+0, /*tp_iternext*/
+__pyx_methods_5pysam_9libcfaidx_FastqProxy, /*tp_methods*/
+0, /*tp_members*/
+__pyx_getsets_5pysam_9libcfaidx_FastqProxy, /*tp_getset*/
+0, /*tp_base*/
+0, /*tp_dict*/
+0, /*tp_descr_get*/
+0, /*tp_descr_set*/
+#if !CYTHON_USE_TYPE_SPECS
+0, /*tp_dictoffset*/
+#endif
+__pyx_pw_5pysam_9libcfaidx_10FastqProxy_1__init__, /*tp_init*/
+0, /*tp_alloc*/
+__pyx_tp_new_5pysam_9libcfaidx_FastqProxy, /*tp_new*/
+0, /*tp_free*/
+0, /*tp_is_gc*/
+0, /*tp_bases*/
+0, /*tp_mro*/
+0, /*tp_cache*/
+0, /*tp_subclasses*/
+0, /*tp_weaklist*/
+0, /*tp_del*/
+0, /*tp_version_tag*/
+#if PY_VERSION_HEX >= 0x030400a1
+#if CYTHON_USE_TP_FINALIZE
+0, /*tp_finalize*/
+#else
+NULL, /*tp_finalize*/
+#endif
+#endif
+#if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
+0, /*tp_vectorcall*/
+#endif
+#if __PYX_NEED_TP_PRINT_SLOT == 1
+0, /*tp_print*/
+#endif
+#if PY_VERSION_HEX >= 0x030C0000
+0, /*tp_watched*/
+#endif
+#if PY_VERSION_HEX >= 0x030d00A4
+0, /*tp_versions_used*/
+#endif
+#if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
+0, /*tp_pypy_flags*/
+#endif
+};
+#endif
+static struct __pyx_vtabstruct_5pysam_9libcfaidx_FastxRecord __pyx_vtable_5pysam_9libcfaidx_FastxRecord;
+static PyObject *__pyx_tp_new_5pysam_9libcfaidx_FastxRecord(PyTypeObject *t, CYTHON_UNUSED PyObject *a, CYTHON_UNUSED PyObject *k) {
+struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *p;
+PyObject *o;
+#if CYTHON_COMPILING_IN_LIMITED_API
+allocfunc alloc_func = (allocfunc)PyType_GetSlot(t, Py_tp_alloc);
+o = alloc_func(t, 0);
+#else
+if (likely(!__Pyx_PyType_HasFeature(t, Py_TPFLAGS_IS_ABSTRACT))) {
+o = (*t->tp_alloc)(t, 0);
+} else {
+o = (PyObject *) PyBaseObject_Type.tp_new(t, __pyx_empty_tuple, 0);
+}
+if (unlikely(!o)) return 0;
+#endif
+p = ((struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)o);
+p->__pyx_vtab = __pyx_vtabptr_5pysam_9libcfaidx_FastxRecord;
+p->comment = ((PyObject*)Py_None); Py_INCREF(Py_None);
+p->quality = ((PyObject*)Py_None); Py_INCREF(Py_None);
+p->sequence = ((PyObject*)Py_None); Py_INCREF(Py_None);
+p->name = ((PyObject*)Py_None); Py_INCREF(Py_None);
+return o;
+}
+static void __pyx_tp_dealloc_5pysam_9libcfaidx_FastxRecord(PyObject *o) {
+struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *p = (struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *)o;
+#if CYTHON_USE_TP_FINALIZE
+if (unlikely((PY_VERSION_HEX >= 0x03080000 || __Pyx_PyType_HasFeature(Py_TYPE(o), Py_TPFLAGS_HAVE_FINALIZE)) && __Pyx_PyObject_GetSlot(o, tp_finalize, destructor)) && (!PyType_IS_GC(Py_TYPE(o)) || !__Pyx_PyObject_GC_IsFinalized(o))) {
+if (__Pyx_PyObject_GetSlot(o, tp_dealloc, destructor) == __pyx_tp_dealloc_5pysam_9libcfaidx_FastxRecord) {
+if (PyObject_CallFinalizerFromDealloc(o)) return;
+}
+}
+#endif
+Py_CLEAR(p->comment);
+Py_CLEAR(p->quality);
+Py_CLEAR(p->sequence);
+Py_CLEAR(p->name);
+#if CYTHON_USE_TYPE_SLOTS || CYTHON_COMPILING_IN_PYPY
+(*Py_TYPE(o)->tp_free)(o);
+#else
+{
+freefunc tp_free = (freefunc)PyType_GetSlot(Py_TYPE(o), Py_tp_free);
+if (tp_free) tp_free(o);
+}
+#endif
+}
+static PyObject *__pyx_getprop_5pysam_9libcfaidx_11FastxRecord_comment(PyObject *o, CYTHON_UNUSED void *x) {
+return __pyx_pw_5pysam_9libcfaidx_11FastxRecord_7comment_1__get__(o);
+}
+static int __pyx_setprop_5pysam_9libcfaidx_11FastxRecord_comment(PyObject *o, PyObject *v, CYTHON_UNUSED void *x) {
+if (v) {
+return __pyx_pw_5pysam_9libcfaidx_11FastxRecord_7comment_3__set__(o, v);
+}
+else {
+return __pyx_pw_5pysam_9libcfaidx_11FastxRecord_7comment_5__del__(o);
+}
+}
+static PyObject *__pyx_getprop_5pysam_9libcfaidx_11FastxRecord_quality(PyObject *o, CYTHON_UNUSED void *x) {
+return __pyx_pw_5pysam_9libcfaidx_11FastxRecord_7quality_1__get__(o);
+}
+static int __pyx_setprop_5pysam_9libcfaidx_11FastxRecord_quality(PyObject *o, PyObject *v, CYTHON_UNUSED void *x) {
+if (v) {
+return __pyx_pw_5pysam_9libcfaidx_11FastxRecord_7quality_3__set__(o, v);
+}
+else {
+return __pyx_pw_5pysam_9libcfaidx_11FastxRecord_7quality_5__del__(o);
+}
+}
+static PyObject *__pyx_getprop_5pysam_9libcfaidx_11FastxRecord_sequence(PyObject *o, CYTHON_UNUSED void *x) {
+return __pyx_pw_5pysam_9libcfaidx_11FastxRecord_8sequence_1__get__(o);
+}
+static int __pyx_setprop_5pysam_9libcfaidx_11FastxRecord_sequence(PyObject *o, PyObject *v, CYTHON_UNUSED void *x) {
+if (v) {
+return __pyx_pw_5pysam_9libcfaidx_11FastxRecord_8sequence_3__set__(o, v);
+}
+else {
+return __pyx_pw_5pysam_9libcfaidx_11FastxRecord_8sequence_5__del__(o);
+}
+}
+static PyObject *__pyx_getprop_5pysam_9libcfaidx_11FastxRecord_name(PyObject *o, CYTHON_UNUSED void *x) {
+return __pyx_pw_5pysam_9libcfaidx_11FastxRecord_4name_1__get__(o);
+}
+static int __pyx_setprop_5pysam_9libcfaidx_11FastxRecord_name(PyObject *o, PyObject *v, CYTHON_UNUSED void *x) {
+if (v) {
+return __pyx_pw_5pysam_9libcfaidx_11FastxRecord_4name_3__set__(o, v);
+}
+else {
+return __pyx_pw_5pysam_9libcfaidx_11FastxRecord_4name_5__del__(o);
+}
+}
+static PyMethodDef __pyx_methods_5pysam_9libcfaidx_FastxRecord[] = {
+{"__copy__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_11FastxRecord_3__copy__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_11FastxRecord_2__copy__},
+{"__deepcopy__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_11FastxRecord_5__deepcopy__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_11FastxRecord_4__deepcopy__},
+{"set_name", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_11FastxRecord_7set_name, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_11FastxRecord_6set_name},
+{"set_comment", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_11FastxRecord_9set_comment, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_11FastxRecord_8set_comment},
+{"set_sequence", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_11FastxRecord_11set_sequence, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_11FastxRecord_10set_sequence},
+{"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_11FastxRecord_17__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_11FastxRecord_16__reduce_cython__},
+{"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_11FastxRecord_19__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_11FastxRecord_18__setstate_cython__},
+{0, 0, 0, 0}
+};
+static struct PyGetSetDef __pyx_getsets_5pysam_9libcfaidx_FastxRecord[] = {
+{(char *)"comment", __pyx_getprop_5pysam_9libcfaidx_11FastxRecord_comment, __pyx_setprop_5pysam_9libcfaidx_11FastxRecord_comment, (char *)PyDoc_STR("comment: unicode"), 0},
+{(char *)"quality", __pyx_getprop_5pysam_9libcfaidx_11FastxRecord_quality, __pyx_setprop_5pysam_9libcfaidx_11FastxRecord_quality, (char *)PyDoc_STR("quality: unicode"), 0},
+{(char *)"sequence", __pyx_getprop_5pysam_9libcfaidx_11FastxRecord_sequence, __pyx_setprop_5pysam_9libcfaidx_11FastxRecord_sequence, (char *)PyDoc_STR("sequence: unicode"), 0},
+{(char *)"name", __pyx_getprop_5pysam_9libcfaidx_11FastxRecord_name, __pyx_setprop_5pysam_9libcfaidx_11FastxRecord_name, (char *)PyDoc_STR("name: unicode"), 0},
+{0, 0, 0, 0, 0}
+};
+#if CYTHON_USE_TYPE_SPECS
+static PyType_Slot __pyx_type_5pysam_9libcfaidx_FastxRecord_slots[] = {
+{Py_tp_dealloc, (void *)__pyx_tp_dealloc_5pysam_9libcfaidx_FastxRecord},
+{Py_tp_str, (void *)__pyx_pw_5pysam_9libcfaidx_11FastxRecord_13__str__},
+{Py_tp_doc, (void *)PyDoc_STR("FastxRecord(name=None, comment=None, sequence=None, quality=None, FastqProxy proxy=None)\nA fasta/fastq record.\n\n    A record must contain a name and a sequence. If either of them are\n    None, a ValueError is raised on writing.\n\n    ")},
+{Py_tp_methods, (void *)__pyx_methods_5pysam_9libcfaidx_FastxRecord},
+{Py_tp_getset, (void *)__pyx_getsets_5pysam_9libcfaidx_FastxRecord},
+{Py_tp_init, (void *)__pyx_pw_5pysam_9libcfaidx_11FastxRecord_1__init__},
+{Py_tp_new, (void *)__pyx_tp_new_5pysam_9libcfaidx_FastxRecord},
+{0, 0},
+};
+static PyType_Spec __pyx_type_5pysam_9libcfaidx_FastxRecord_spec = {
+"pysam.libcfaidx.FastxRecord",
+sizeof(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord),
+0,
+Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE,
+__pyx_type_5pysam_9libcfaidx_FastxRecord_slots,
+};
+#else
+static PyTypeObject __pyx_type_5pysam_9libcfaidx_FastxRecord = {
+PyVarObject_HEAD_INIT(0, 0)
+"pysam.libcfaidx.""FastxRecord", /*tp_name*/
+sizeof(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord), /*tp_basicsize*/
+0, /*tp_itemsize*/
+__pyx_tp_dealloc_5pysam_9libcfaidx_FastxRecord, /*tp_dealloc*/
+#if PY_VERSION_HEX < 0x030800b4
+0, /*tp_print*/
+#endif
+#if PY_VERSION_HEX >= 0x030800b4
+0, /*tp_vectorcall_offset*/
+#endif
+0, /*tp_getattr*/
+0, /*tp_setattr*/
+#if PY_MAJOR_VERSION < 3
+0, /*tp_compare*/
+#endif
+#if PY_MAJOR_VERSION >= 3
+0, /*tp_as_async*/
+#endif
+0, /*tp_repr*/
+0, /*tp_as_number*/
+0, /*tp_as_sequence*/
+0, /*tp_as_mapping*/
+0, /*tp_hash*/
+0, /*tp_call*/
+__pyx_pw_5pysam_9libcfaidx_11FastxRecord_13__str__, /*tp_str*/
+0, /*tp_getattro*/
+0, /*tp_setattro*/
+0, /*tp_as_buffer*/
+Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE, /*tp_flags*/
+PyDoc_STR("FastxRecord(name=None, comment=None, sequence=None, quality=None, FastqProxy proxy=None)\nA fasta/fastq record.\n\n    A record must contain a name and a sequence. If either of them are\n    None, a ValueError is raised on writing.\n\n    "), /*tp_doc*/
+0, /*tp_traverse*/
+0, /*tp_clear*/
+0, /*tp_richcompare*/
+0, /*tp_weaklistoffset*/
+0, /*tp_iter*/
+0, /*tp_iternext*/
+__pyx_methods_5pysam_9libcfaidx_FastxRecord, /*tp_methods*/
+0, /*tp_members*/
+__pyx_getsets_5pysam_9libcfaidx_FastxRecord, /*tp_getset*/
+0, /*tp_base*/
+0, /*tp_dict*/
+0, /*tp_descr_get*/
+0, /*tp_descr_set*/
+#if !CYTHON_USE_TYPE_SPECS
+0, /*tp_dictoffset*/
+#endif
+__pyx_pw_5pysam_9libcfaidx_11FastxRecord_1__init__, /*tp_init*/
+0, /*tp_alloc*/
+__pyx_tp_new_5pysam_9libcfaidx_FastxRecord, /*tp_new*/
+0, /*tp_free*/
+0, /*tp_is_gc*/
+0, /*tp_bases*/
+0, /*tp_mro*/
+0, /*tp_cache*/
+0, /*tp_subclasses*/
+0, /*tp_weaklist*/
+0, /*tp_del*/
+0, /*tp_version_tag*/
+#if PY_VERSION_HEX >= 0x030400a1
+#if CYTHON_USE_TP_FINALIZE
+0, /*tp_finalize*/
+#else
+NULL, /*tp_finalize*/
+#endif
+#endif
+#if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
+0, /*tp_vectorcall*/
+#endif
+#if __PYX_NEED_TP_PRINT_SLOT == 1
+0, /*tp_print*/
+#endif
+#if PY_VERSION_HEX >= 0x030C0000
+0, /*tp_watched*/
+#endif
+#if PY_VERSION_HEX >= 0x030d00A4
+0, /*tp_versions_used*/
+#endif
+#if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
+0, /*tp_pypy_flags*/
+#endif
+};
+#endif
+static struct __pyx_vtabstruct_5pysam_9libcfaidx_FastxFile __pyx_vtable_5pysam_9libcfaidx_FastxFile;
+static PyObject *__pyx_tp_new_5pysam_9libcfaidx_FastxFile(PyTypeObject *t, PyObject *a, PyObject *k) {
+struct __pyx_obj_5pysam_9libcfaidx_FastxFile *p;
+PyObject *o;
+#if CYTHON_COMPILING_IN_LIMITED_API
+allocfunc alloc_func = (allocfunc)PyType_GetSlot(t, Py_tp_alloc);
+o = alloc_func(t, 0);
+#else
+if (likely(!__Pyx_PyType_HasFeature(t, Py_TPFLAGS_IS_ABSTRACT))) {
+o = (*t->tp_alloc)(t, 0);
+} else {
+o = (PyObject *) PyBaseObject_Type.tp_new(t, __pyx_empty_tuple, 0);
+}
+if (unlikely(!o)) return 0;
+#endif
+p = ((struct __pyx_obj_5pysam_9libcfaidx_FastxFile *)o);
+p->__pyx_vtab = __pyx_vtabptr_5pysam_9libcfaidx_FastxFile;
+p->_filename = Py_None; Py_INCREF(Py_None);
+if (unlikely(__pyx_pw_5pysam_9libcfaidx_9FastxFile_1__cinit__(o, a, k) < 0)) goto bad;
+return o;
+bad:
+Py_DECREF(o); o = 0;
+return NULL;
+}
+static void __pyx_tp_dealloc_5pysam_9libcfaidx_FastxFile(PyObject *o) {
+struct __pyx_obj_5pysam_9libcfaidx_FastxFile *p = (struct __pyx_obj_5pysam_9libcfaidx_FastxFile *)o;
+#if CYTHON_USE_TP_FINALIZE
+if (unlikely((PY_VERSION_HEX >= 0x03080000 || __Pyx_PyType_HasFeature(Py_TYPE(o), Py_TPFLAGS_HAVE_FINALIZE)) && __Pyx_PyObject_GetSlot(o, tp_finalize, destructor)) && !__Pyx_PyObject_GC_IsFinalized(o)) {
+if (__Pyx_PyObject_GetSlot(o, tp_dealloc, destructor) == __pyx_tp_dealloc_5pysam_9libcfaidx_FastxFile) {
+if (PyObject_CallFinalizerFromDealloc(o)) return;
+}
+}
+#endif
+PyObject_GC_UnTrack(o);
+{
+PyObject *etype, *eval, *etb;
+PyErr_Fetch(&etype, &eval, &etb);
+__Pyx_SET_REFCNT(o, Py_REFCNT(o) + 1);
+__pyx_pw_5pysam_9libcfaidx_9FastxFile_9__dealloc__(o);
+__Pyx_SET_REFCNT(o, Py_REFCNT(o) - 1);
+PyErr_Restore(etype, eval, etb);
+}
+Py_CLEAR(p->_filename);
+#if CYTHON_USE_TYPE_SLOTS || CYTHON_COMPILING_IN_PYPY
+(*Py_TYPE(o)->tp_free)(o);
+#else
+{
+freefunc tp_free = (freefunc)PyType_GetSlot(Py_TYPE(o), Py_tp_free);
+if (tp_free) tp_free(o);
+}
+#endif
+}
+static int __pyx_tp_traverse_5pysam_9libcfaidx_FastxFile(PyObject *o, visitproc v, void *a) {
+int e;
+struct __pyx_obj_5pysam_9libcfaidx_FastxFile *p = (struct __pyx_obj_5pysam_9libcfaidx_FastxFile *)o;
+if (p->_filename) {
+e = (*v)(p->_filename, a); if (e) return e;
+}
+return 0;
+}
+static int __pyx_tp_clear_5pysam_9libcfaidx_FastxFile(PyObject *o) {
+PyObject* tmp;
+struct __pyx_obj_5pysam_9libcfaidx_FastxFile *p = (struct __pyx_obj_5pysam_9libcfaidx_FastxFile *)o;
+tmp = ((PyObject*)p->_filename);
+p->_filename = Py_None; Py_INCREF(Py_None);
+Py_XDECREF(tmp);
+return 0;
+}
+static PyObject *__pyx_getprop_5pysam_9libcfaidx_9FastxFile_closed(PyObject *o, CYTHON_UNUSED void *x) {
+return __pyx_pw_5pysam_9libcfaidx_9FastxFile_6closed_1__get__(o);
+}
+static PyObject *__pyx_getprop_5pysam_9libcfaidx_9FastxFile_filename(PyObject *o, CYTHON_UNUSED void *x) {
+return __pyx_pw_5pysam_9libcfaidx_9FastxFile_8filename_1__get__(o);
+}
+static PyObject *__pyx_specialmethod___pyx_pw_5pysam_9libcfaidx_9FastxFile_17__next__(PyObject *self, CYTHON_UNUSED PyObject *arg) {
+PyObject *res = __pyx_pw_5pysam_9libcfaidx_9FastxFile_17__next__(self);
+if (!res && !PyErr_Occurred()) { PyErr_SetNone(PyExc_StopIteration); }
+return res;
+}
+static PyMethodDef __pyx_methods_5pysam_9libcfaidx_FastxFile[] = {
+{"is_open", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastxFile_3is_open, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastxFile_2is_open},
+{"_open", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastxFile_5_open, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastxFile_4_open},
+{"close", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastxFile_7close, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastxFile_6close},
+{"__enter__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastxFile_11__enter__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastxFile_10__enter__},
+{"__exit__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastxFile_13__exit__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastxFile_12__exit__},
+{"__next__", (PyCFunction)__pyx_specialmethod___pyx_pw_5pysam_9libcfaidx_9FastxFile_17__next__, METH_NOARGS|METH_COEXIST, __pyx_doc_5pysam_9libcfaidx_9FastxFile_16__next__},
+{"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastxFile_19__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastxFile_18__reduce_cython__},
+{"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastxFile_21__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastxFile_20__setstate_cython__},
+{0, 0, 0, 0}
+};
+static struct PyGetSetDef __pyx_getsets_5pysam_9libcfaidx_FastxFile[] = {
+{(char *)"closed", __pyx_getprop_5pysam_9libcfaidx_9FastxFile_closed, 0, (char *)PyDoc_STR("bool indicating the current state of the file object.\n        This is a read-only attribute; the close() method changes the value.\n        "), 0},
+{(char *)"filename", __pyx_getprop_5pysam_9libcfaidx_9FastxFile_filename, 0, (char *)PyDoc_STR("string with the filename associated with this object."), 0},
+{0, 0, 0, 0, 0}
+};
+#if CYTHON_USE_TYPE_SPECS
+static PyType_Slot __pyx_type_5pysam_9libcfaidx_FastxFile_slots[] = {
+{Py_tp_dealloc, (void *)__pyx_tp_dealloc_5pysam_9libcfaidx_FastxFile},
+{Py_tp_doc, (void *)PyDoc_STR("Stream access to :term:`fasta` or :term:`fastq` formatted files.\n\n    The file is automatically opened.\n\n    Entries in the file can be both fastq or fasta formatted or even a\n    mixture of the two.\n\n    This file object permits iterating over all entries in the\n    file. Random access is not implemented. The iteration returns\n    objects of type :class:`FastqProxy`\n\n    Parameters\n    ----------\n\n    filename : string\n        Filename of fasta/fastq file to be opened.\n\n    persist : bool\n\n        If True (default) make a copy of the entry in the file during\n        iteration. If set to False, no copy will be made. This will\n        permit much faster iteration, but an entry will not persist\n        when the iteration continues and an entry is read-only.\n\n    Notes\n    -----\n    Prior to version 0.8.2, this class was called FastqFile.\n\n    Raises\n    ------\n\n    IOError\n        if file could not be opened\n\n\n    Examples\n    --------\n    >>> with pysam.FastxFile(filename) as fh:\n    ...    for entry in fh:\n    ...        print(entry.name)\n    ...        print(entry.sequence)\n    ...        print(entry.comment)\n    ...        print(entry.quality)\n    >>> with pysam.FastxFile(filename) as fin, open(out_filename, mode='w') as fout:\n    ...    for entry in fin:\n    ...        fout.write(str(entry) + '\\n')\n\n    ")},
+{Py_tp_traverse, (void *)__pyx_tp_traverse_5pysam_9libcfaidx_FastxFile},
+{Py_tp_clear, (void *)__pyx_tp_clear_5pysam_9libcfaidx_FastxFile},
+{Py_tp_iter, (void *)__pyx_pw_5pysam_9libcfaidx_9FastxFile_15__iter__},
+{Py_tp_iternext, (void *)__pyx_pw_5pysam_9libcfaidx_9FastxFile_17__next__},
+{Py_tp_methods, (void *)__pyx_methods_5pysam_9libcfaidx_FastxFile},
+{Py_tp_getset, (void *)__pyx_getsets_5pysam_9libcfaidx_FastxFile},
+{Py_tp_new, (void *)__pyx_tp_new_5pysam_9libcfaidx_FastxFile},
+{0, 0},
+};
+static PyType_Spec __pyx_type_5pysam_9libcfaidx_FastxFile_spec = {
+"pysam.libcfaidx.FastxFile",
+sizeof(struct __pyx_obj_5pysam_9libcfaidx_FastxFile),
+0,
+Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC,
+__pyx_type_5pysam_9libcfaidx_FastxFile_slots,
+};
+#else
+static PyTypeObject __pyx_type_5pysam_9libcfaidx_FastxFile = {
+PyVarObject_HEAD_INIT(0, 0)
+"pysam.libcfaidx.""FastxFile", /*tp_name*/
+sizeof(struct __pyx_obj_5pysam_9libcfaidx_FastxFile), /*tp_basicsize*/
+0, /*tp_itemsize*/
+__pyx_tp_dealloc_5pysam_9libcfaidx_FastxFile, /*tp_dealloc*/
+#if PY_VERSION_HEX < 0x030800b4
+0, /*tp_print*/
+#endif
+#if PY_VERSION_HEX >= 0x030800b4
+0, /*tp_vectorcall_offset*/
+#endif
+0, /*tp_getattr*/
+0, /*tp_setattr*/
+#if PY_MAJOR_VERSION < 3
+0, /*tp_compare*/
+#endif
+#if PY_MAJOR_VERSION >= 3
+0, /*tp_as_async*/
+#endif
+0, /*tp_repr*/
+0, /*tp_as_number*/
+0, /*tp_as_sequence*/
+0, /*tp_as_mapping*/
+0, /*tp_hash*/
+0, /*tp_call*/
+0, /*tp_str*/
+0, /*tp_getattro*/
+0, /*tp_setattro*/
+0, /*tp_as_buffer*/
+Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
+PyDoc_STR("Stream access to :term:`fasta` or :term:`fastq` formatted files.\n\n    The file is automatically opened.\n\n    Entries in the file can be both fastq or fasta formatted or even a\n    mixture of the two.\n\n    This file object permits iterating over all entries in the\n    file. Random access is not implemented. The iteration returns\n    objects of type :class:`FastqProxy`\n\n    Parameters\n    ----------\n\n    filename : string\n        Filename of fasta/fastq file to be opened.\n\n    persist : bool\n\n        If True (default) make a copy of the entry in the file during\n        iteration. If set to False, no copy will be made. This will\n        permit much faster iteration, but an entry will not persist\n        when the iteration continues and an entry is read-only.\n\n    Notes\n    -----\n    Prior to version 0.8.2, this class was called FastqFile.\n\n    Raises\n    ------\n\n    IOError\n        if file could not be opened\n\n\n    Examples\n    --------\n    >>> with pysam.FastxFile(filename) as fh:\n    ...    for entry in fh:\n    ...        print(entry.name)\n    ...        print(entry.sequence)\n    ...        print(entry.comment)\n    ...        print(entry.quality)\n    >>> with pysam.FastxFile(filename) as fin, open(out_filename, mode='w') as fout:\n    ...    for entry in fin:\n    ...        fout.write(str(entry) + '\\n')\n\n    "), /*tp_doc*/
+__pyx_tp_traverse_5pysam_9libcfaidx_FastxFile, /*tp_traverse*/
+__pyx_tp_clear_5pysam_9libcfaidx_FastxFile, /*tp_clear*/
+0, /*tp_richcompare*/
+0, /*tp_weaklistoffset*/
+__pyx_pw_5pysam_9libcfaidx_9FastxFile_15__iter__, /*tp_iter*/
+__pyx_pw_5pysam_9libcfaidx_9FastxFile_17__next__, /*tp_iternext*/
+__pyx_methods_5pysam_9libcfaidx_FastxFile, /*tp_methods*/
+0, /*tp_members*/
+__pyx_getsets_5pysam_9libcfaidx_FastxFile, /*tp_getset*/
+0, /*tp_base*/
+0, /*tp_dict*/
+0, /*tp_descr_get*/
+0, /*tp_descr_set*/
+#if !CYTHON_USE_TYPE_SPECS
+0, /*tp_dictoffset*/
+#endif
+0, /*tp_init*/
+0, /*tp_alloc*/
+__pyx_tp_new_5pysam_9libcfaidx_FastxFile, /*tp_new*/
+0, /*tp_free*/
+0, /*tp_is_gc*/
+0, /*tp_bases*/
+0, /*tp_mro*/
+0, /*tp_cache*/
+0, /*tp_subclasses*/
+0, /*tp_weaklist*/
+0, /*tp_del*/
+0, /*tp_version_tag*/
+#if PY_VERSION_HEX >= 0x030400a1
+#if CYTHON_USE_TP_FINALIZE
+0, /*tp_finalize*/
+#else
+NULL, /*tp_finalize*/
+#endif
+#endif
+#if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
+0, /*tp_vectorcall*/
+#endif
+#if __PYX_NEED_TP_PRINT_SLOT == 1
+0, /*tp_print*/
+#endif
+#if PY_VERSION_HEX >= 0x030C0000
+0, /*tp_watched*/
+#endif
+#if PY_VERSION_HEX >= 0x030d00A4
+0, /*tp_versions_used*/
+#endif
+#if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
+0, /*tp_pypy_flags*/
+#endif
+};
+#endif
+static struct __pyx_vtabstruct_5pysam_9libcfaidx_FastqFile __pyx_vtable_5pysam_9libcfaidx_FastqFile;
+static PyObject *__pyx_tp_new_5pysam_9libcfaidx_FastqFile(PyTypeObject *t, PyObject *a, PyObject *k) {
+struct __pyx_obj_5pysam_9libcfaidx_FastqFile *p;
+PyObject *o = __pyx_tp_new_5pysam_9libcfaidx_FastxFile(t, a, k);
+if (unlikely(!o)) return 0;
+p = ((struct __pyx_obj_5pysam_9libcfaidx_FastqFile *)o);
+p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_5pysam_9libcfaidx_FastxFile*)__pyx_vtabptr_5pysam_9libcfaidx_FastqFile;
+return o;
+}
+static PyMethodDef __pyx_methods_5pysam_9libcfaidx_FastqFile[] = {
+{"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastqFile_1__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastqFile___reduce_cython__},
+{"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9FastqFile_3__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9FastqFile_2__setstate_cython__},
+{0, 0, 0, 0}
+};
+#if CYTHON_USE_TYPE_SPECS
+static PyType_Slot __pyx_type_5pysam_9libcfaidx_FastqFile_slots[] = {
+{Py_tp_doc, (void *)PyDoc_STR("FastqFile is deprecated: use FastxFile instead")},
+{Py_tp_traverse, (void *)__pyx_tp_traverse_5pysam_9libcfaidx_FastxFile},
+{Py_tp_clear, (void *)__pyx_tp_clear_5pysam_9libcfaidx_FastxFile},
+{Py_tp_methods, (void *)__pyx_methods_5pysam_9libcfaidx_FastqFile},
+{Py_tp_new, (void *)__pyx_tp_new_5pysam_9libcfaidx_FastqFile},
+{0, 0},
+};
+static PyType_Spec __pyx_type_5pysam_9libcfaidx_FastqFile_spec = {
+"pysam.libcfaidx.FastqFile",
+sizeof(struct __pyx_obj_5pysam_9libcfaidx_FastqFile),
+0,
+Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC,
+__pyx_type_5pysam_9libcfaidx_FastqFile_slots,
+};
+#else
+static PyTypeObject __pyx_type_5pysam_9libcfaidx_FastqFile = {
+PyVarObject_HEAD_INIT(0, 0)
+"pysam.libcfaidx.""FastqFile", /*tp_name*/
+sizeof(struct __pyx_obj_5pysam_9libcfaidx_FastqFile), /*tp_basicsize*/
+0, /*tp_itemsize*/
+__pyx_tp_dealloc_5pysam_9libcfaidx_FastxFile, /*tp_dealloc*/
+#if PY_VERSION_HEX < 0x030800b4
+0, /*tp_print*/
+#endif
+#if PY_VERSION_HEX >= 0x030800b4
+0, /*tp_vectorcall_offset*/
+#endif
+0, /*tp_getattr*/
+0, /*tp_setattr*/
+#if PY_MAJOR_VERSION < 3
+0, /*tp_compare*/
+#endif
+#if PY_MAJOR_VERSION >= 3
+0, /*tp_as_async*/
+#endif
+0, /*tp_repr*/
+0, /*tp_as_number*/
+0, /*tp_as_sequence*/
+0, /*tp_as_mapping*/
+0, /*tp_hash*/
+0, /*tp_call*/
+0, /*tp_str*/
+0, /*tp_getattro*/
+0, /*tp_setattro*/
+0, /*tp_as_buffer*/
+Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
+PyDoc_STR("FastqFile is deprecated: use FastxFile instead"), /*tp_doc*/
+__pyx_tp_traverse_5pysam_9libcfaidx_FastxFile, /*tp_traverse*/
+__pyx_tp_clear_5pysam_9libcfaidx_FastxFile, /*tp_clear*/
+0, /*tp_richcompare*/
+0, /*tp_weaklistoffset*/
+#if CYTHON_COMPILING_IN_PYPY || 0
+__pyx_pw_5pysam_9libcfaidx_9FastxFile_15__iter__, /*tp_iter*/
+#else
+0, /*tp_iter*/
+#endif
+#if CYTHON_COMPILING_IN_PYPY || 0
+__pyx_pw_5pysam_9libcfaidx_9FastxFile_17__next__, /*tp_iternext*/
+#else
+0, /*tp_iternext*/
+#endif
+__pyx_methods_5pysam_9libcfaidx_FastqFile, /*tp_methods*/
+0, /*tp_members*/
+0, /*tp_getset*/
+0, /*tp_base*/
+0, /*tp_dict*/
+0, /*tp_descr_get*/
+0, /*tp_descr_set*/
+#if !CYTHON_USE_TYPE_SPECS
+0, /*tp_dictoffset*/
+#endif
+0, /*tp_init*/
+0, /*tp_alloc*/
+__pyx_tp_new_5pysam_9libcfaidx_FastqFile, /*tp_new*/
+0, /*tp_free*/
+0, /*tp_is_gc*/
+0, /*tp_bases*/
+0, /*tp_mro*/
+0, /*tp_cache*/
+0, /*tp_subclasses*/
+0, /*tp_weaklist*/
+0, /*tp_del*/
+0, /*tp_version_tag*/
+#if PY_VERSION_HEX >= 0x030400a1
+#if CYTHON_USE_TP_FINALIZE
+0, /*tp_finalize*/
+#else
+NULL, /*tp_finalize*/
+#endif
+#endif
+#if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
+0, /*tp_vectorcall*/
+#endif
+#if __PYX_NEED_TP_PRINT_SLOT == 1
+0, /*tp_print*/
+#endif
+#if PY_VERSION_HEX >= 0x030C0000
+0, /*tp_watched*/
+#endif
+#if PY_VERSION_HEX >= 0x030d00A4
+0, /*tp_versions_used*/
+#endif
+#if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
+0, /*tp_pypy_flags*/
+#endif
+};
+#endif
+static struct __pyx_vtabstruct_5pysam_9libcfaidx_Fastafile __pyx_vtable_5pysam_9libcfaidx_Fastafile;
+static PyObject *__pyx_tp_new_5pysam_9libcfaidx_Fastafile(PyTypeObject *t, PyObject *a, PyObject *k) {
+struct __pyx_obj_5pysam_9libcfaidx_Fastafile *p;
+PyObject *o = __pyx_tp_new_5pysam_9libcfaidx_FastaFile(t, a, k);
+if (unlikely(!o)) return 0;
+p = ((struct __pyx_obj_5pysam_9libcfaidx_Fastafile *)o);
+p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_5pysam_9libcfaidx_FastaFile*)__pyx_vtabptr_5pysam_9libcfaidx_Fastafile;
+return o;
+}
+static PyMethodDef __pyx_methods_5pysam_9libcfaidx_Fastafile[] = {
+{"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9Fastafile_1__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9Fastafile___reduce_cython__},
+{"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libcfaidx_9Fastafile_3__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libcfaidx_9Fastafile_2__setstate_cython__},
+{0, 0, 0, 0}
+};
+#if CYTHON_USE_TYPE_SPECS
+static PyType_Slot __pyx_type_5pysam_9libcfaidx_Fastafile_slots[] = {
+{Py_tp_doc, (void *)PyDoc_STR("Fastafile is deprecated: use FastaFile instead")},
+{Py_tp_traverse, (void *)__pyx_tp_traverse_5pysam_9libcfaidx_FastaFile},
+{Py_tp_clear, (void *)__pyx_tp_clear_5pysam_9libcfaidx_FastaFile},
+{Py_tp_methods, (void *)__pyx_methods_5pysam_9libcfaidx_Fastafile},
+{Py_tp_new, (void *)__pyx_tp_new_5pysam_9libcfaidx_Fastafile},
+{0, 0},
+};
+static PyType_Spec __pyx_type_5pysam_9libcfaidx_Fastafile_spec = {
+"pysam.libcfaidx.Fastafile",
+sizeof(struct __pyx_obj_5pysam_9libcfaidx_Fastafile),
+0,
+Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC,
+__pyx_type_5pysam_9libcfaidx_Fastafile_slots,
+};
+#else
+static PyTypeObject __pyx_type_5pysam_9libcfaidx_Fastafile = {
+PyVarObject_HEAD_INIT(0, 0)
+"pysam.libcfaidx.""Fastafile", /*tp_name*/
+sizeof(struct __pyx_obj_5pysam_9libcfaidx_Fastafile), /*tp_basicsize*/
+0, /*tp_itemsize*/
+__pyx_tp_dealloc_5pysam_9libcfaidx_FastaFile, /*tp_dealloc*/
+#if PY_VERSION_HEX < 0x030800b4
+0, /*tp_print*/
+#endif
+#if PY_VERSION_HEX >= 0x030800b4
+0, /*tp_vectorcall_offset*/
+#endif
+0, /*tp_getattr*/
+0, /*tp_setattr*/
+#if PY_MAJOR_VERSION < 3
+0, /*tp_compare*/
+#endif
+#if PY_MAJOR_VERSION >= 3
+0, /*tp_as_async*/
+#endif
+0, /*tp_repr*/
+0, /*tp_as_number*/
+0, /*tp_as_sequence*/
+0, /*tp_as_mapping*/
+0, /*tp_hash*/
+0, /*tp_call*/
+0, /*tp_str*/
+0, /*tp_getattro*/
+0, /*tp_setattro*/
+0, /*tp_as_buffer*/
+Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
+PyDoc_STR("Fastafile is deprecated: use FastaFile instead"), /*tp_doc*/
+__pyx_tp_traverse_5pysam_9libcfaidx_FastaFile, /*tp_traverse*/
+__pyx_tp_clear_5pysam_9libcfaidx_FastaFile, /*tp_clear*/
+0, /*tp_richcompare*/
+0, /*tp_weaklistoffset*/
+0, /*tp_iter*/
+0, /*tp_iternext*/
+__pyx_methods_5pysam_9libcfaidx_Fastafile, /*tp_methods*/
+0, /*tp_members*/
+0, /*tp_getset*/
+0, /*tp_base*/
+0, /*tp_dict*/
+0, /*tp_descr_get*/
+0, /*tp_descr_set*/
+#if !CYTHON_USE_TYPE_SPECS
+0, /*tp_dictoffset*/
+#endif
+0, /*tp_init*/
+0, /*tp_alloc*/
+__pyx_tp_new_5pysam_9libcfaidx_Fastafile, /*tp_new*/
+0, /*tp_free*/
+0, /*tp_is_gc*/
+0, /*tp_bases*/
+0, /*tp_mro*/
+0, /*tp_cache*/
+0, /*tp_subclasses*/
+0, /*tp_weaklist*/
+0, /*tp_del*/
+0, /*tp_version_tag*/
+#if PY_VERSION_HEX >= 0x030400a1
+#if CYTHON_USE_TP_FINALIZE
+0, /*tp_finalize*/
+#else
+NULL, /*tp_finalize*/
+#endif
+#endif
+#if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
+0, /*tp_vectorcall*/
+#endif
+#if __PYX_NEED_TP_PRINT_SLOT == 1
+0, /*tp_print*/
+#endif
+#if PY_VERSION_HEX >= 0x030C0000
+0, /*tp_watched*/
+#endif
+#if PY_VERSION_HEX >= 0x030d00A4
+0, /*tp_versions_used*/
+#endif
+#if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
+0, /*tp_pypy_flags*/
+#endif
+};
+#endif
+static PyMethodDef __pyx_methods[] = {
+{0, 0, 0, 0}
+};
+#ifndef CYTHON_SMALL_CODE
+#if defined(__clang__)
+#define CYTHON_SMALL_CODE
+#elif defined(__GNUC__) && (__GNUC__ > 4 || (__GNUC__ == 4 && __GNUC_MINOR__ >= 3))
+#define CYTHON_SMALL_CODE __attribute__((cold))
+#else
+#define CYTHON_SMALL_CODE
+#endif
+#endif
+/* #### Code section: pystring_table ### */
+static int __Pyx_CreateStringTabAndInitStrings(void) {
+__Pyx_StringTabEntry __pyx_string_tab[] = {
+{&__pyx_n_s_FastaFile, __pyx_k_FastaFile, sizeof(__pyx_k_FastaFile), 0, 0, 1, 1},
+{&__pyx_n_u_FastaFile, __pyx_k_FastaFile, sizeof(__pyx_k_FastaFile), 0, 1, 0, 1},
+{&__pyx_n_s_FastaFile___enter, __pyx_k_FastaFile___enter, sizeof(__pyx_k_FastaFile___enter), 0, 0, 1, 1},
+{&__pyx_n_s_FastaFile___exit, __pyx_k_FastaFile___exit, sizeof(__pyx_k_FastaFile___exit), 0, 0, 1, 1},
+{&__pyx_n_s_FastaFile___reduce_cython, __pyx_k_FastaFile___reduce_cython, sizeof(__pyx_k_FastaFile___reduce_cython), 0, 0, 1, 1},
+{&__pyx_n_s_FastaFile___setstate_cython, __pyx_k_FastaFile___setstate_cython, sizeof(__pyx_k_FastaFile___setstate_cython), 0, 0, 1, 1},
+{&__pyx_n_s_FastaFile__open, __pyx_k_FastaFile__open, sizeof(__pyx_k_FastaFile__open), 0, 0, 1, 1},
+{&__pyx_n_s_FastaFile_close, __pyx_k_FastaFile_close, sizeof(__pyx_k_FastaFile_close), 0, 0, 1, 1},
+{&__pyx_n_s_FastaFile_fetch, __pyx_k_FastaFile_fetch, sizeof(__pyx_k_FastaFile_fetch), 0, 0, 1, 1},
+{&__pyx_n_s_FastaFile_get_reference_length, __pyx_k_FastaFile_get_reference_length, sizeof(__pyx_k_FastaFile_get_reference_length), 0, 0, 1, 1},
+{&__pyx_n_s_FastaFile_is_open, __pyx_k_FastaFile_is_open, sizeof(__pyx_k_FastaFile_is_open), 0, 0, 1, 1},
+{&__pyx_n_s_Fastafile, __pyx_k_Fastafile, sizeof(__pyx_k_Fastafile), 0, 0, 1, 1},
+{&__pyx_n_u_Fastafile, __pyx_k_Fastafile, sizeof(__pyx_k_Fastafile), 0, 1, 0, 1},
+{&__pyx_n_s_Fastafile___reduce_cython, __pyx_k_Fastafile___reduce_cython, sizeof(__pyx_k_Fastafile___reduce_cython), 0, 0, 1, 1},
+{&__pyx_n_s_Fastafile___setstate_cython, __pyx_k_Fastafile___setstate_cython, sizeof(__pyx_k_Fastafile___setstate_cython), 0, 0, 1, 1},
+{&__pyx_n_s_FastqFile, __pyx_k_FastqFile, sizeof(__pyx_k_FastqFile), 0, 0, 1, 1},
+{&__pyx_n_u_FastqFile, __pyx_k_FastqFile, sizeof(__pyx_k_FastqFile), 0, 1, 0, 1},
+{&__pyx_n_s_FastqFile___reduce_cython, __pyx_k_FastqFile___reduce_cython, sizeof(__pyx_k_FastqFile___reduce_cython), 0, 0, 1, 1},
+{&__pyx_n_s_FastqFile___setstate_cython, __pyx_k_FastqFile___setstate_cython, sizeof(__pyx_k_FastqFile___setstate_cython), 0, 0, 1, 1},
+{&__pyx_n_s_FastqProxy, __pyx_k_FastqProxy, sizeof(__pyx_k_FastqProxy), 0, 0, 1, 1},
+{&__pyx_n_u_FastqProxy, __pyx_k_FastqProxy, sizeof(__pyx_k_FastqProxy), 0, 1, 0, 1},
+{&__pyx_n_s_FastqProxy___reduce_cython, __pyx_k_FastqProxy___reduce_cython, sizeof(__pyx_k_FastqProxy___reduce_cython), 0, 0, 1, 1},
+{&__pyx_n_s_FastqProxy___setstate_cython, __pyx_k_FastqProxy___setstate_cython, sizeof(__pyx_k_FastqProxy___setstate_cython), 0, 0, 1, 1},
+{&__pyx_n_s_FastqProxy_get_quality_array, __pyx_k_FastqProxy_get_quality_array, sizeof(__pyx_k_FastqProxy_get_quality_array), 0, 0, 1, 1},
+{&__pyx_n_s_FastxFile, __pyx_k_FastxFile, sizeof(__pyx_k_FastxFile), 0, 0, 1, 1},
+{&__pyx_n_u_FastxFile, __pyx_k_FastxFile, sizeof(__pyx_k_FastxFile), 0, 1, 0, 1},
+{&__pyx_n_s_FastxFile___enter, __pyx_k_FastxFile___enter, sizeof(__pyx_k_FastxFile___enter), 0, 0, 1, 1},
+{&__pyx_n_s_FastxFile___exit, __pyx_k_FastxFile___exit, sizeof(__pyx_k_FastxFile___exit), 0, 0, 1, 1},
+{&__pyx_n_s_FastxFile___reduce_cython, __pyx_k_FastxFile___reduce_cython, sizeof(__pyx_k_FastxFile___reduce_cython), 0, 0, 1, 1},
+{&__pyx_n_s_FastxFile___setstate_cython, __pyx_k_FastxFile___setstate_cython, sizeof(__pyx_k_FastxFile___setstate_cython), 0, 0, 1, 1},
+{&__pyx_n_s_FastxFile__open, __pyx_k_FastxFile__open, sizeof(__pyx_k_FastxFile__open), 0, 0, 1, 1},
+{&__pyx_n_s_FastxFile_close, __pyx_k_FastxFile_close, sizeof(__pyx_k_FastxFile_close), 0, 0, 1, 1},
+{&__pyx_n_s_FastxFile_is_open, __pyx_k_FastxFile_is_open, sizeof(__pyx_k_FastxFile_is_open), 0, 0, 1, 1},
+{&__pyx_n_s_FastxRecord, __pyx_k_FastxRecord, sizeof(__pyx_k_FastxRecord), 0, 0, 1, 1},
+{&__pyx_n_u_FastxRecord, __pyx_k_FastxRecord, sizeof(__pyx_k_FastxRecord), 0, 1, 0, 1},
+{&__pyx_n_s_FastxRecord___copy, __pyx_k_FastxRecord___copy, sizeof(__pyx_k_FastxRecord___copy), 0, 0, 1, 1},
+{&__pyx_n_s_FastxRecord___deepcopy, __pyx_k_FastxRecord___deepcopy, sizeof(__pyx_k_FastxRecord___deepcopy), 0, 0, 1, 1},
+{&__pyx_n_s_FastxRecord___reduce_cython, __pyx_k_FastxRecord___reduce_cython, sizeof(__pyx_k_FastxRecord___reduce_cython), 0, 0, 1, 1},
+{&__pyx_n_s_FastxRecord___setstate_cython, __pyx_k_FastxRecord___setstate_cython, sizeof(__pyx_k_FastxRecord___setstate_cython), 0, 0, 1, 1},
+{&__pyx_n_s_FastxRecord_get_quality_array, __pyx_k_FastxRecord_get_quality_array, sizeof(__pyx_k_FastxRecord_get_quality_array), 0, 0, 1, 1},
+{&__pyx_kp_u_FastxRecord_must_have_a_name_and, __pyx_k_FastxRecord_must_have_a_name_and, sizeof(__pyx_k_FastxRecord_must_have_a_name_and), 0, 1, 0, 0},
+{&__pyx_n_s_FastxRecord_set_comment, __pyx_k_FastxRecord_set_comment, sizeof(__pyx_k_FastxRecord_set_comment), 0, 0, 1, 1},
+{&__pyx_n_s_FastxRecord_set_name, __pyx_k_FastxRecord_set_name, sizeof(__pyx_k_FastxRecord_set_name), 0, 0, 1, 1},
+{&__pyx_n_s_FastxRecord_set_sequence, __pyx_k_FastxRecord_set_sequence, sizeof(__pyx_k_FastxRecord_set_sequence), 0, 0, 1, 1},
+{&__pyx_n_s_IOError, __pyx_k_IOError, sizeof(__pyx_k_IOError), 0, 0, 1, 1},
+{&__pyx_kp_u_I_O_operation_on_closed_file, __pyx_k_I_O_operation_on_closed_file, sizeof(__pyx_k_I_O_operation_on_closed_file), 0, 1, 0, 0},
+{&__pyx_kp_s_Incompatible_checksums_0x_x_vs_0, __pyx_k_Incompatible_checksums_0x_x_vs_0, sizeof(__pyx_k_Incompatible_checksums_0x_x_vs_0), 0, 0, 1, 0},
+{&__pyx_n_s_KeyError, __pyx_k_KeyError, sizeof(__pyx_k_KeyError), 0, 0, 1, 1},
+{&__pyx_n_s_MemoryError, __pyx_k_MemoryError, sizeof(__pyx_k_MemoryError), 0, 0, 1, 1},
+{&__pyx_kp_u_None, __pyx_k_None, sizeof(__pyx_k_None), 0, 1, 0, 0},
+{&__pyx_n_s_PickleError, __pyx_k_PickleError, sizeof(__pyx_k_PickleError), 0, 0, 1, 1},
+{&__pyx_n_s_StopIteration, __pyx_k_StopIteration, sizeof(__pyx_k_StopIteration), 0, 0, 1, 1},
+{&__pyx_n_s_TypeError, __pyx_k_TypeError, sizeof(__pyx_k_TypeError), 0, 0, 1, 1},
+{&__pyx_n_s_ValueError, __pyx_k_ValueError, sizeof(__pyx_k_ValueError), 0, 0, 1, 1},
+{&__pyx_kp_u__11, __pyx_k__11, sizeof(__pyx_k__11), 0, 1, 0, 0},
+{&__pyx_kp_u__16, __pyx_k__16, sizeof(__pyx_k__16), 0, 1, 0, 0},
+{&__pyx_kp_u__17, __pyx_k__17, sizeof(__pyx_k__17), 0, 1, 0, 0},
+{&__pyx_kp_u__18, __pyx_k__18, sizeof(__pyx_k__18), 0, 1, 0, 0},
+{&__pyx_kp_u__19, __pyx_k__19, sizeof(__pyx_k__19), 0, 1, 0, 0},
+{&__pyx_kp_b__4, __pyx_k__4, sizeof(__pyx_k__4), 0, 0, 0, 0},
+{&__pyx_kp_u__47, __pyx_k__47, sizeof(__pyx_k__47), 0, 1, 0, 0},
+{&__pyx_n_s__48, __pyx_k__48, sizeof(__pyx_k__48), 0, 0, 1, 1},
+{&__pyx_n_s__68, __pyx_k__68, sizeof(__pyx_k__68), 0, 0, 1, 1},
+{&__pyx_n_s_all, __pyx_k_all, sizeof(__pyx_k_all), 0, 0, 1, 1},
+{&__pyx_n_s_append, __pyx_k_append, sizeof(__pyx_k_append), 0, 0, 1, 1},
+{&__pyx_n_s_asyncio_coroutines, __pyx_k_asyncio_coroutines, sizeof(__pyx_k_asyncio_coroutines), 0, 0, 1, 1},
+{&__pyx_n_s_bindex_filename, __pyx_k_bindex_filename, sizeof(__pyx_k_bindex_filename), 0, 0, 1, 1},
+{&__pyx_n_s_bindex_filename_compressed, __pyx_k_bindex_filename_compressed, sizeof(__pyx_k_bindex_filename_compressed), 0, 0, 1, 1},
+{&__pyx_kp_u_calling_len_on_closed_file, __pyx_k_calling_len_on_closed_file, sizeof(__pyx_k_calling_len_on_closed_file), 0, 1, 0, 0},
+{&__pyx_kp_u_can_not_write_record_without_a_s, __pyx_k_can_not_write_record_without_a_s, sizeof(__pyx_k_can_not_write_record_without_a_s), 0, 1, 0, 0},
+{&__pyx_kp_u_can_not_write_record_without_nam, __pyx_k_can_not_write_record_without_nam, sizeof(__pyx_k_can_not_write_record_without_nam), 0, 1, 0, 0},
+{&__pyx_n_s_cfilename, __pyx_k_cfilename, sizeof(__pyx_k_cfilename), 0, 0, 1, 1},
+{&__pyx_n_s_cindexname, __pyx_k_cindexname, sizeof(__pyx_k_cindexname), 0, 0, 1, 1},
+{&__pyx_n_s_cindexname_compressed, __pyx_k_cindexname_compressed, sizeof(__pyx_k_cindexname_compressed), 0, 0, 1, 1},
+{&__pyx_n_s_class_getitem, __pyx_k_class_getitem, sizeof(__pyx_k_class_getitem), 0, 0, 1, 1},
+{&__pyx_n_s_cline_in_traceback, __pyx_k_cline_in_traceback, sizeof(__pyx_k_cline_in_traceback), 0, 0, 1, 1},
+{&__pyx_n_s_close, __pyx_k_close, sizeof(__pyx_k_close), 0, 0, 1, 1},
+{&__pyx_n_s_comment, __pyx_k_comment, sizeof(__pyx_k_comment), 0, 0, 1, 1},
+{&__pyx_n_s_contig, __pyx_k_contig, sizeof(__pyx_k_contig), 0, 0, 1, 1},
+{&__pyx_n_s_contig_b, __pyx_k_contig_b, sizeof(__pyx_k_contig_b), 0, 0, 1, 1},
+{&__pyx_n_s_copy, __pyx_k_copy, sizeof(__pyx_k_copy), 0, 0, 1, 1},
+{&__pyx_n_s_deepcopy, __pyx_k_deepcopy, sizeof(__pyx_k_deepcopy), 0, 0, 1, 1},
+{&__pyx_n_s_dict, __pyx_k_dict, sizeof(__pyx_k_dict), 0, 0, 1, 1},
+{&__pyx_n_s_dict_2, __pyx_k_dict_2, sizeof(__pyx_k_dict_2), 0, 0, 1, 1},
+{&__pyx_kp_u_disable, __pyx_k_disable, sizeof(__pyx_k_disable), 0, 1, 0, 0},
+{&__pyx_kp_u_do_not_instantiate_FastqProxy_di, __pyx_k_do_not_instantiate_FastqProxy_di, sizeof(__pyx_k_do_not_instantiate_FastqProxy_di), 0, 1, 0, 0},
+{&__pyx_kp_u_enable, __pyx_k_enable, sizeof(__pyx_k_enable), 0, 1, 0, 0},
+{&__pyx_n_s_end, __pyx_k_end, sizeof(__pyx_k_end), 0, 0, 1, 1},
+{&__pyx_n_s_enter, __pyx_k_enter, sizeof(__pyx_k_enter), 0, 0, 1, 1},
+{&__pyx_kp_u_error_when_opening_file_s, __pyx_k_error_when_opening_file_s, sizeof(__pyx_k_error_when_opening_file_s), 0, 1, 0, 0},
+{&__pyx_n_s_exc_type, __pyx_k_exc_type, sizeof(__pyx_k_exc_type), 0, 0, 1, 1},
+{&__pyx_n_s_exc_value, __pyx_k_exc_value, sizeof(__pyx_k_exc_value), 0, 0, 1, 1},
+{&__pyx_n_s_exists, __pyx_k_exists, sizeof(__pyx_k_exists), 0, 0, 1, 1},
+{&__pyx_n_s_exit, __pyx_k_exit, sizeof(__pyx_k_exit), 0, 0, 1, 1},
+{&__pyx_kp_u_failure_when_retrieving_sequence, __pyx_k_failure_when_retrieving_sequence, sizeof(__pyx_k_failure_when_retrieving_sequence), 0, 1, 0, 0},
+{&__pyx_n_s_fetch, __pyx_k_fetch, sizeof(__pyx_k_fetch), 0, 0, 1, 1},
+{&__pyx_kp_u_file_s_not_found, __pyx_k_file_s_not_found, sizeof(__pyx_k_file_s_not_found), 0, 1, 0, 0},
+{&__pyx_n_s_filename, __pyx_k_filename, sizeof(__pyx_k_filename), 0, 0, 1, 1},
+{&__pyx_kp_u_filename_does_not_exist, __pyx_k_filename_does_not_exist, sizeof(__pyx_k_filename_does_not_exist), 0, 1, 0, 0},
+{&__pyx_n_s_filepath_index, __pyx_k_filepath_index, sizeof(__pyx_k_filepath_index), 0, 0, 1, 1},
+{&__pyx_n_s_filepath_index_compressed, __pyx_k_filepath_index_compressed, sizeof(__pyx_k_filepath_index_compressed), 0, 0, 1, 1},
+{&__pyx_n_s_format, __pyx_k_format, sizeof(__pyx_k_format), 0, 0, 1, 1},
+{&__pyx_kp_u_gc, __pyx_k_gc, sizeof(__pyx_k_gc), 0, 1, 0, 0},
+{&__pyx_n_s_get_quality_array, __pyx_k_get_quality_array, sizeof(__pyx_k_get_quality_array), 0, 0, 1, 1},
+{&__pyx_n_s_get_reference_length, __pyx_k_get_reference_length, sizeof(__pyx_k_get_reference_length), 0, 0, 1, 1},
+{&__pyx_n_s_getstate, __pyx_k_getstate, sizeof(__pyx_k_getstate), 0, 0, 1, 1},
+{&__pyx_n_s_import, __pyx_k_import, sizeof(__pyx_k_import), 0, 0, 1, 1},
+{&__pyx_n_s_initializing, __pyx_k_initializing, sizeof(__pyx_k_initializing), 0, 0, 1, 1},
+{&__pyx_n_s_is_coroutine, __pyx_k_is_coroutine, sizeof(__pyx_k_is_coroutine), 0, 0, 1, 1},
+{&__pyx_n_s_is_open, __pyx_k_is_open, sizeof(__pyx_k_is_open), 0, 0, 1, 1},
+{&__pyx_kp_u_isenabled, __pyx_k_isenabled, sizeof(__pyx_k_isenabled), 0, 1, 0, 0},
+{&__pyx_n_s_length, __pyx_k_length, sizeof(__pyx_k_length), 0, 0, 1, 1},
+{&__pyx_n_s_main, __pyx_k_main, sizeof(__pyx_k_main), 0, 0, 1, 1},
+{&__pyx_n_s_memo, __pyx_k_memo, sizeof(__pyx_k_memo), 0, 0, 1, 1},
+{&__pyx_n_s_name, __pyx_k_name, sizeof(__pyx_k_name), 0, 0, 1, 1},
+{&__pyx_n_s_name_2, __pyx_k_name_2, sizeof(__pyx_k_name_2), 0, 0, 1, 1},
+{&__pyx_n_s_new, __pyx_k_new, sizeof(__pyx_k_new), 0, 0, 1, 1},
+{&__pyx_kp_s_no_default___reduce___due_to_non, __pyx_k_no_default___reduce___due_to_non, sizeof(__pyx_k_no_default___reduce___due_to_non), 0, 0, 1, 0},
+{&__pyx_kp_u_no_sequence_region_supplied, __pyx_k_no_sequence_region_supplied, sizeof(__pyx_k_no_sequence_region_supplied), 0, 1, 0, 0},
+{&__pyx_n_s_nreferences, __pyx_k_nreferences, sizeof(__pyx_k_nreferences), 0, 0, 1, 1},
+{&__pyx_n_s_offset, __pyx_k_offset, sizeof(__pyx_k_offset), 0, 0, 1, 1},
+{&__pyx_n_s_open, __pyx_k_open, sizeof(__pyx_k_open), 0, 0, 1, 1},
+{&__pyx_n_s_os, __pyx_k_os, sizeof(__pyx_k_os), 0, 0, 1, 1},
+{&__pyx_n_s_path, __pyx_k_path, sizeof(__pyx_k_path), 0, 0, 1, 1},
+{&__pyx_n_s_persist, __pyx_k_persist, sizeof(__pyx_k_persist), 0, 0, 1, 1},
+{&__pyx_n_s_pickle, __pyx_k_pickle, sizeof(__pyx_k_pickle), 0, 0, 1, 1},
+{&__pyx_n_s_proxy, __pyx_k_proxy, sizeof(__pyx_k_proxy), 0, 0, 1, 1},
+{&__pyx_n_s_pysam_libcfaidx, __pyx_k_pysam_libcfaidx, sizeof(__pyx_k_pysam_libcfaidx), 0, 0, 1, 1},
+{&__pyx_kp_s_pysam_libcfaidx_pyx, __pyx_k_pysam_libcfaidx_pyx, sizeof(__pyx_k_pysam_libcfaidx_pyx), 0, 0, 1, 0},
+{&__pyx_n_s_pyx_PickleError, __pyx_k_pyx_PickleError, sizeof(__pyx_k_pyx_PickleError), 0, 0, 1, 1},
+{&__pyx_n_s_pyx_checksum, __pyx_k_pyx_checksum, sizeof(__pyx_k_pyx_checksum), 0, 0, 1, 1},
+{&__pyx_n_s_pyx_result, __pyx_k_pyx_result, sizeof(__pyx_k_pyx_result), 0, 0, 1, 1},
+{&__pyx_n_s_pyx_state, __pyx_k_pyx_state, sizeof(__pyx_k_pyx_state), 0, 0, 1, 1},
+{&__pyx_n_s_pyx_type, __pyx_k_pyx_type, sizeof(__pyx_k_pyx_type), 0, 0, 1, 1},
+{&__pyx_n_s_pyx_unpickle_FastxRecord, __pyx_k_pyx_unpickle_FastxRecord, sizeof(__pyx_k_pyx_unpickle_FastxRecord), 0, 0, 1, 1},
+{&__pyx_n_s_pyx_vtable, __pyx_k_pyx_vtable, sizeof(__pyx_k_pyx_vtable), 0, 0, 1, 1},
+{&__pyx_n_s_quality, __pyx_k_quality, sizeof(__pyx_k_quality), 0, 0, 1, 1},
+{&__pyx_n_s_re, __pyx_k_re, sizeof(__pyx_k_re), 0, 0, 1, 1},
+{&__pyx_n_s_reduce, __pyx_k_reduce, sizeof(__pyx_k_reduce), 0, 0, 1, 1},
+{&__pyx_n_s_reduce_cython, __pyx_k_reduce_cython, sizeof(__pyx_k_reduce_cython), 0, 0, 1, 1},
+{&__pyx_n_s_reduce_ex, __pyx_k_reduce_ex, sizeof(__pyx_k_reduce_ex), 0, 0, 1, 1},
+{&__pyx_n_s_ref, __pyx_k_ref, sizeof(__pyx_k_ref), 0, 0, 1, 1},
+{&__pyx_n_s_reference, __pyx_k_reference, sizeof(__pyx_k_reference), 0, 0, 1, 1},
+{&__pyx_n_s_references, __pyx_k_references, sizeof(__pyx_k_references), 0, 0, 1, 1},
+{&__pyx_n_s_region, __pyx_k_region, sizeof(__pyx_k_region), 0, 0, 1, 1},
+{&__pyx_n_s_rend, __pyx_k_rend, sizeof(__pyx_k_rend), 0, 0, 1, 1},
+{&__pyx_n_s_rstart, __pyx_k_rstart, sizeof(__pyx_k_rstart), 0, 0, 1, 1},
+{&__pyx_kp_u_s, __pyx_k_s, sizeof(__pyx_k_s), 0, 1, 0, 0},
+{&__pyx_n_s_s_2, __pyx_k_s_2, sizeof(__pyx_k_s_2), 0, 0, 1, 1},
+{&__pyx_n_s_self, __pyx_k_self, sizeof(__pyx_k_self), 0, 0, 1, 1},
+{&__pyx_kp_s_self__delegate_cannot_be_convert, __pyx_k_self__delegate_cannot_be_convert, sizeof(__pyx_k_self__delegate_cannot_be_convert), 0, 0, 1, 0},
+{&__pyx_n_s_seq, __pyx_k_seq, sizeof(__pyx_k_seq), 0, 0, 1, 1},
+{&__pyx_n_s_sequence, __pyx_k_sequence, sizeof(__pyx_k_sequence), 0, 0, 1, 1},
+{&__pyx_kp_u_sequence_and_quality_length_do_n, __pyx_k_sequence_and_quality_length_do_n, sizeof(__pyx_k_sequence_and_quality_length_do_n), 0, 1, 0, 0},
+{&__pyx_kp_u_sequence_s_not_present, __pyx_k_sequence_s_not_present, sizeof(__pyx_k_sequence_s_not_present), 0, 1, 0, 0},
+{&__pyx_n_s_set_comment, __pyx_k_set_comment, sizeof(__pyx_k_set_comment), 0, 0, 1, 1},
+{&__pyx_n_s_set_name, __pyx_k_set_name, sizeof(__pyx_k_set_name), 0, 0, 1, 1},
+{&__pyx_n_s_set_sequence, __pyx_k_set_sequence, sizeof(__pyx_k_set_sequence), 0, 0, 1, 1},
+{&__pyx_n_s_setstate, __pyx_k_setstate, sizeof(__pyx_k_setstate), 0, 0, 1, 1},
+{&__pyx_n_s_setstate_cython, __pyx_k_setstate_cython, sizeof(__pyx_k_setstate_cython), 0, 0, 1, 1},
+{&__pyx_n_s_spec, __pyx_k_spec, sizeof(__pyx_k_spec), 0, 0, 1, 1},
+{&__pyx_n_s_ss, __pyx_k_ss, sizeof(__pyx_k_ss), 0, 0, 1, 1},
+{&__pyx_n_s_start, __pyx_k_start, sizeof(__pyx_k_start), 0, 0, 1, 1},
+{&__pyx_n_s_state, __pyx_k_state, sizeof(__pyx_k_state), 0, 0, 1, 1},
+{&__pyx_kp_s_stringsource, __pyx_k_stringsource, sizeof(__pyx_k_stringsource), 0, 0, 1, 0},
+{&__pyx_n_s_sys, __pyx_k_sys, sizeof(__pyx_k_sys), 0, 0, 1, 1},
+{&__pyx_n_s_test, __pyx_k_test, sizeof(__pyx_k_test), 0, 0, 1, 1},
+{&__pyx_n_s_traceback, __pyx_k_traceback, sizeof(__pyx_k_traceback), 0, 0, 1, 1},
+{&__pyx_kp_u_truncated_quality_string_in_0, __pyx_k_truncated_quality_string_in_0, sizeof(__pyx_k_truncated_quality_string_in_0), 0, 1, 0, 0},
+{&__pyx_kp_u_unknown_problem_parsing_0, __pyx_k_unknown_problem_parsing_0, sizeof(__pyx_k_unknown_problem_parsing_0), 0, 1, 0, 0},
+{&__pyx_n_s_update, __pyx_k_update, sizeof(__pyx_k_update), 0, 0, 1, 1},
+{&__pyx_n_s_use_setstate, __pyx_k_use_setstate, sizeof(__pyx_k_use_setstate), 0, 0, 1, 1},
+{&__pyx_n_s_x, __pyx_k_x, sizeof(__pyx_k_x), 0, 0, 1, 1},
+{&__pyx_n_s_zip, __pyx_k_zip, sizeof(__pyx_k_zip), 0, 0, 1, 1},
+{0, 0, 0, 0, 0, 0, 0}
+};
+return __Pyx_InitStrings(__pyx_string_tab);
+}
+/* #### Code section: cached_builtins ### */
+static CYTHON_SMALL_CODE int __Pyx_InitCachedBuiltins(void) {
+__pyx_builtin_ValueError = __Pyx_GetBuiltinName(__pyx_n_s_ValueError); if (!__pyx_builtin_ValueError) __PYX_ERR(0, 129, __pyx_L1_error)
+__pyx_builtin_IOError = __Pyx_GetBuiltinName(__pyx_n_s_IOError); if (!__pyx_builtin_IOError) __PYX_ERR(0, 153, __pyx_L1_error)
+__pyx_builtin_zip = __Pyx_GetBuiltinName(__pyx_n_s_zip); if (!__pyx_builtin_zip) __PYX_ERR(0, 193, __pyx_L1_error)
+__pyx_builtin_KeyError = __Pyx_GetBuiltinName(__pyx_n_s_KeyError); if (!__pyx_builtin_KeyError) __PYX_ERR(0, 301, __pyx_L1_error)
+__pyx_builtin_TypeError = __Pyx_GetBuiltinName(__pyx_n_s_TypeError); if (!__pyx_builtin_TypeError) __PYX_ERR(1, 2, __pyx_L1_error)
+__pyx_builtin_StopIteration = __Pyx_GetBuiltinName(__pyx_n_s_StopIteration); if (!__pyx_builtin_StopIteration) __PYX_ERR(0, 649, __pyx_L1_error)
+__pyx_builtin_MemoryError = __Pyx_GetBuiltinName(__pyx_n_s_MemoryError); if (!__pyx_builtin_MemoryError) __PYX_ERR(3, 120, __pyx_L1_error)
+return 0;
+__pyx_L1_error:;
+return -1;
+}
+/* #### Code section: cached_constants ### */
+static CYTHON_SMALL_CODE int __Pyx_InitCachedConstants(void) {
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__Pyx_InitCachedConstants", 0);
+/* "pysam/libcfaidx.pyx":129
+*     def __len__(self):
+*         if self.fastafile == NULL:
+*             raise ValueError("calling len() on closed file")             # <<<<<<<<<<<<<<
+*
+*         return faidx_nseq(self.fastafile)
+*/
+__pyx_tuple__2 = PyTuple_Pack(1, __pyx_kp_u_calling_len_on_closed_file); if (unlikely(!__pyx_tuple__2)) __PYX_ERR(0, 129, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__2);
+__Pyx_GIVEREF(__pyx_tuple__2);
+/* "pysam/libcfaidx.pyx":281
+*
+*         if not self.is_open():
+*             raise ValueError("I/O operation on closed file" )             # <<<<<<<<<<<<<<
+*
+*         cdef int length
+*/
+__pyx_tuple__9 = PyTuple_Pack(1, __pyx_kp_u_I_O_operation_on_closed_file); if (unlikely(!__pyx_tuple__9)) __PYX_ERR(0, 281, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__9);
+__Pyx_GIVEREF(__pyx_tuple__9);
+/* "pysam/libcfaidx.pyx":291
+*
+*         if contig is None:
+*             raise ValueError("no sequence/region supplied.")             # <<<<<<<<<<<<<<
+*
+*         if rstart == rend:
+*/
+__pyx_tuple__10 = PyTuple_Pack(1, __pyx_kp_u_no_sequence_region_supplied); if (unlikely(!__pyx_tuple__10)) __PYX_ERR(0, 291, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__10);
+__Pyx_GIVEREF(__pyx_tuple__10);
+/* "pysam/libcfaidx.pyx":358
+*     """A single entry in a fastq file."""
+*     def __init__(self):
+*         raise ValueError("do not instantiate FastqProxy directly")             # <<<<<<<<<<<<<<
+*
+*     property name:
+*/
+__pyx_tuple__15 = PyTuple_Pack(1, __pyx_kp_u_do_not_instantiate_FastqProxy_di); if (unlikely(!__pyx_tuple__15)) __PYX_ERR(0, 358, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__15);
+__Pyx_GIVEREF(__pyx_tuple__15);
+/* "pysam/libcfaidx.pyx":443
+*     cdef cython.str to_string(self):
+*         if self.name is None:
+*             raise ValueError("can not write record without name")             # <<<<<<<<<<<<<<
+*
+*         if self.sequence is None:
+*/
+__pyx_tuple__25 = PyTuple_Pack(1, __pyx_kp_u_can_not_write_record_without_nam); if (unlikely(!__pyx_tuple__25)) __PYX_ERR(0, 443, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__25);
+__Pyx_GIVEREF(__pyx_tuple__25);
+/* "pysam/libcfaidx.pyx":446
+*
+*         if self.sequence is None:
+*             raise ValueError("can not write record without a sequence")             # <<<<<<<<<<<<<<
+*
+*         if self.comment is None:
+*/
+__pyx_tuple__26 = PyTuple_Pack(1, __pyx_kp_u_can_not_write_record_without_a_s); if (unlikely(!__pyx_tuple__26)) __PYX_ERR(0, 446, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__26);
+__Pyx_GIVEREF(__pyx_tuple__26);
+/* "pysam/libcfaidx.pyx":465
+*     def set_name(self, name):
+*         if name is None:
+*             raise ValueError("FastxRecord must have a name and not None")             # <<<<<<<<<<<<<<
+*         self.name = name
+*
+*/
+__pyx_tuple__28 = PyTuple_Pack(1, __pyx_kp_u_FastxRecord_must_have_a_name_and); if (unlikely(!__pyx_tuple__28)) __PYX_ERR(0, 465, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__28);
+__Pyx_GIVEREF(__pyx_tuple__28);
+/* "(tree fragment)":4
+*     cdef object __pyx_PickleError
+*     cdef object __pyx_result
+*     if __pyx_checksum not in (0x1bdb611, 0xb688a86, 0x43fd151):             # <<<<<<<<<<<<<<
+*         from pickle import PickleError as __pyx_PickleError
+*         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0x1bdb611, 0xb688a86, 0x43fd151) = (comment, name, quality, sequence))" % __pyx_checksum
+*/
+__pyx_tuple__46 = PyTuple_Pack(3, __pyx_int_29210129, __pyx_int_191400582, __pyx_int_71291217); if (unlikely(!__pyx_tuple__46)) __PYX_ERR(1, 4, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__46);
+__Pyx_GIVEREF(__pyx_tuple__46);
+/* "pysam/libcfaidx.pyx":123
+*         self._open(*args, **kwargs)
+*
+*     def is_open(self):             # <<<<<<<<<<<<<<
+*         '''return true if samfile has been opened.'''
+*         return self.fastafile != NULL
+*/
+__pyx_tuple__49 = PyTuple_Pack(1, __pyx_n_s_self); if (unlikely(!__pyx_tuple__49)) __PYX_ERR(0, 123, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__49);
+__Pyx_GIVEREF(__pyx_tuple__49);
+__pyx_codeobj_ = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__49, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libcfaidx_pyx, __pyx_n_s_is_open, 123, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj_)) __PYX_ERR(0, 123, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":133
+*         return faidx_nseq(self.fastafile)
+*
+*     def _open(self, filename, filepath_index=None, filepath_index_compressed=None):             # <<<<<<<<<<<<<<
+*         '''open an indexed fasta file.
+*
+*/
+__pyx_tuple__50 = PyTuple_Pack(13, __pyx_n_s_self, __pyx_n_s_filename, __pyx_n_s_filepath_index, __pyx_n_s_filepath_index_compressed, __pyx_n_s_cfilename, __pyx_n_s_cindexname, __pyx_n_s_cindexname_compressed, __pyx_n_s_bindex_filename, __pyx_n_s_bindex_filename_compressed, __pyx_n_s_nreferences, __pyx_n_s_x, __pyx_n_s_s_2, __pyx_n_s_ss); if (unlikely(!__pyx_tuple__50)) __PYX_ERR(0, 133, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__50);
+__Pyx_GIVEREF(__pyx_tuple__50);
+__pyx_codeobj__3 = (PyObject*)__Pyx_PyCode_New(4, 0, 0, 13, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__50, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libcfaidx_pyx, __pyx_n_s_open, 133, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__3)) __PYX_ERR(0, 133, __pyx_L1_error)
+__pyx_tuple__51 = PyTuple_Pack(2, Py_None, Py_None); if (unlikely(!__pyx_tuple__51)) __PYX_ERR(0, 133, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__51);
+__Pyx_GIVEREF(__pyx_tuple__51);
+/* "pysam/libcfaidx.pyx":195
+*         self.reference2length = dict(zip(self._references, self._lengths))
+*
+*     def close(self):             # <<<<<<<<<<<<<<
+*         """close the file."""
+*         if self.fastafile != NULL:
+*/
+__pyx_codeobj__5 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__49, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libcfaidx_pyx, __pyx_n_s_close, 195, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__5)) __PYX_ERR(0, 195, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":207
+*
+*     # context manager interface
+*     def __enter__(self):             # <<<<<<<<<<<<<<
+*         return self
+*
+*/
+__pyx_codeobj__6 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__49, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libcfaidx_pyx, __pyx_n_s_enter, 207, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__6)) __PYX_ERR(0, 207, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":210
+*         return self
+*
+*     def __exit__(self, exc_type, exc_value, traceback):             # <<<<<<<<<<<<<<
+*         self.close()
+*         return False
+*/
+__pyx_tuple__52 = PyTuple_Pack(4, __pyx_n_s_self, __pyx_n_s_exc_type, __pyx_n_s_exc_value, __pyx_n_s_traceback); if (unlikely(!__pyx_tuple__52)) __PYX_ERR(0, 210, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__52);
+__Pyx_GIVEREF(__pyx_tuple__52);
+__pyx_codeobj__7 = (PyObject*)__Pyx_PyCode_New(4, 0, 0, 4, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__52, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libcfaidx_pyx, __pyx_n_s_exit, 210, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__7)) __PYX_ERR(0, 210, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":242
+*             return self._lengths
+*
+*     def fetch(self,             # <<<<<<<<<<<<<<
+*               reference=None,
+*               start=None,
+*/
+__pyx_tuple__53 = PyTuple_Pack(12, __pyx_n_s_self, __pyx_n_s_reference, __pyx_n_s_start, __pyx_n_s_end, __pyx_n_s_region, __pyx_n_s_length, __pyx_n_s_seq, __pyx_n_s_ref, __pyx_n_s_rstart, __pyx_n_s_rend, __pyx_n_s_contig, __pyx_n_s_contig_b); if (unlikely(!__pyx_tuple__53)) __PYX_ERR(0, 242, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__53);
+__Pyx_GIVEREF(__pyx_tuple__53);
+__pyx_codeobj__8 = (PyObject*)__Pyx_PyCode_New(5, 0, 0, 12, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__53, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libcfaidx_pyx, __pyx_n_s_fetch, 242, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__8)) __PYX_ERR(0, 242, __pyx_L1_error)
+__pyx_tuple__54 = PyTuple_Pack(4, Py_None, Py_None, Py_None, Py_None); if (unlikely(!__pyx_tuple__54)) __PYX_ERR(0, 242, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__54);
+__Pyx_GIVEREF(__pyx_tuple__54);
+/* "pysam/libcfaidx.pyx":343
+*         return seq
+*
+*     def get_reference_length(self, reference):             # <<<<<<<<<<<<<<
+*         '''return the length of reference.'''
+*         return self.reference2length[reference]
+*/
+__pyx_tuple__55 = PyTuple_Pack(2, __pyx_n_s_self, __pyx_n_s_reference); if (unlikely(!__pyx_tuple__55)) __PYX_ERR(0, 343, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__55);
+__Pyx_GIVEREF(__pyx_tuple__55);
+__pyx_codeobj__12 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__55, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libcfaidx_pyx, __pyx_n_s_get_reference_length, 343, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__12)) __PYX_ERR(0, 343, __pyx_L1_error)
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):
+*/
+__pyx_codeobj__13 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__49, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_reduce_cython, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__13)) __PYX_ERR(1, 1, __pyx_L1_error)
+/* "(tree fragment)":3
+* def __reduce_cython__(self):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+*/
+__pyx_tuple__56 = PyTuple_Pack(2, __pyx_n_s_self, __pyx_n_s_pyx_state); if (unlikely(!__pyx_tuple__56)) __PYX_ERR(1, 3, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__56);
+__Pyx_GIVEREF(__pyx_tuple__56);
+__pyx_codeobj__14 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__56, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_setstate_cython, 3, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__14)) __PYX_ERR(1, 3, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":404
+*         return self.to_string()
+*
+*     cpdef array.array get_quality_array(self, int offset=33):             # <<<<<<<<<<<<<<
+*         '''return quality values as integer array after subtracting offset.'''
+*         if self.quality is None:
+*/
+__pyx_tuple__57 = PyTuple_Pack(2, __pyx_n_s_self, __pyx_n_s_offset); if (unlikely(!__pyx_tuple__57)) __PYX_ERR(0, 404, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__57);
+__Pyx_GIVEREF(__pyx_tuple__57);
+__pyx_codeobj__20 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__57, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libcfaidx_pyx, __pyx_n_s_get_quality_array, 404, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__20)) __PYX_ERR(0, 404, __pyx_L1_error)
+__pyx_tuple__58 = PyTuple_Pack(1, __pyx_int_33); if (unlikely(!__pyx_tuple__58)) __PYX_ERR(0, 404, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__58);
+__Pyx_GIVEREF(__pyx_tuple__58);
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     raise TypeError, "self._delegate cannot be converted to a Python object for pickling"
+* def __setstate_cython__(self, __pyx_state):
+*/
+__pyx_codeobj__21 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__49, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_reduce_cython, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__21)) __PYX_ERR(1, 1, __pyx_L1_error)
+/* "(tree fragment)":3
+* def __reduce_cython__(self):
+*     raise TypeError, "self._delegate cannot be converted to a Python object for pickling"
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     raise TypeError, "self._delegate cannot be converted to a Python object for pickling"
+*/
+__pyx_codeobj__22 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__56, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_setstate_cython, 3, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__22)) __PYX_ERR(1, 3, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":435
+*             self.name = name
+*
+*     def __copy__(self):             # <<<<<<<<<<<<<<
+*         return FastxRecord(self.name, self.comment, self.sequence, self.quality)
+*
+*/
+__pyx_codeobj__23 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__49, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libcfaidx_pyx, __pyx_n_s_copy, 435, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__23)) __PYX_ERR(0, 435, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":438
+*         return FastxRecord(self.name, self.comment, self.sequence, self.quality)
+*
+*     def __deepcopy__(self, memo):             # <<<<<<<<<<<<<<
+*         return FastxRecord(self.name, self.comment, self.sequence, self.quality)
+*
+*/
+__pyx_tuple__59 = PyTuple_Pack(2, __pyx_n_s_self, __pyx_n_s_memo); if (unlikely(!__pyx_tuple__59)) __PYX_ERR(0, 438, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__59);
+__Pyx_GIVEREF(__pyx_tuple__59);
+__pyx_codeobj__24 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__59, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libcfaidx_pyx, __pyx_n_s_deepcopy, 438, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__24)) __PYX_ERR(0, 438, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":463
+*         return self.to_string()
+*
+*     def set_name(self, name):             # <<<<<<<<<<<<<<
+*         if name is None:
+*             raise ValueError("FastxRecord must have a name and not None")
+*/
+__pyx_tuple__60 = PyTuple_Pack(2, __pyx_n_s_self, __pyx_n_s_name); if (unlikely(!__pyx_tuple__60)) __PYX_ERR(0, 463, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__60);
+__Pyx_GIVEREF(__pyx_tuple__60);
+__pyx_codeobj__27 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__60, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libcfaidx_pyx, __pyx_n_s_set_name, 463, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__27)) __PYX_ERR(0, 463, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":468
+*         self.name = name
+*
+*     def set_comment(self, comment):             # <<<<<<<<<<<<<<
+*         self.comment = comment
+*
+*/
+__pyx_tuple__61 = PyTuple_Pack(2, __pyx_n_s_self, __pyx_n_s_comment); if (unlikely(!__pyx_tuple__61)) __PYX_ERR(0, 468, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__61);
+__Pyx_GIVEREF(__pyx_tuple__61);
+__pyx_codeobj__29 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__61, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libcfaidx_pyx, __pyx_n_s_set_comment, 468, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__29)) __PYX_ERR(0, 468, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":471
+*         self.comment = comment
+*
+*     def set_sequence(self, sequence, quality=None):             # <<<<<<<<<<<<<<
+*         """set sequence of this record.
+*
+*/
+__pyx_tuple__62 = PyTuple_Pack(3, __pyx_n_s_self, __pyx_n_s_sequence, __pyx_n_s_quality); if (unlikely(!__pyx_tuple__62)) __PYX_ERR(0, 471, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__62);
+__Pyx_GIVEREF(__pyx_tuple__62);
+__pyx_codeobj__30 = (PyObject*)__Pyx_PyCode_New(3, 0, 0, 3, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__62, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libcfaidx_pyx, __pyx_n_s_set_sequence, 471, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__30)) __PYX_ERR(0, 471, __pyx_L1_error)
+__pyx_tuple__63 = PyTuple_Pack(1, Py_None); if (unlikely(!__pyx_tuple__63)) __PYX_ERR(0, 471, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__63);
+__Pyx_GIVEREF(__pyx_tuple__63);
+/* "pysam/libcfaidx.pyx":488
+*         return self.to_string()
+*
+*     cpdef array.array get_quality_array(self, int offset=33):             # <<<<<<<<<<<<<<
+*         '''return quality values as array after subtracting offset.'''
+*         if self.quality is None:
+*/
+__pyx_codeobj__31 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__57, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libcfaidx_pyx, __pyx_n_s_get_quality_array, 488, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__31)) __PYX_ERR(0, 488, __pyx_L1_error)
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     cdef tuple state
+*     cdef object _dict
+*/
+__pyx_tuple__64 = PyTuple_Pack(4, __pyx_n_s_self, __pyx_n_s_state, __pyx_n_s_dict_2, __pyx_n_s_use_setstate); if (unlikely(!__pyx_tuple__64)) __PYX_ERR(1, 1, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__64);
+__Pyx_GIVEREF(__pyx_tuple__64);
+__pyx_codeobj__32 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 4, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__64, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_reduce_cython, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__32)) __PYX_ERR(1, 1, __pyx_L1_error)
+/* "(tree fragment)":16
+*     else:
+*         return __pyx_unpickle_FastxRecord, (type(self), 0x1bdb611, state)
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     __pyx_unpickle_FastxRecord__set_state(self, __pyx_state)
+*/
+__pyx_codeobj__33 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__56, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_setstate_cython, 16, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__33)) __PYX_ERR(1, 16, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":551
+*         self._open(*args, **kwargs)
+*
+*     def is_open(self):             # <<<<<<<<<<<<<<
+*         '''return true if samfile has been opened.'''
+*         return self.entry != NULL
+*/
+__pyx_codeobj__34 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__49, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libcfaidx_pyx, __pyx_n_s_is_open, 551, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__34)) __PYX_ERR(0, 551, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":555
+*         return self.entry != NULL
+*
+*     def _open(self, filename, persist=True):             # <<<<<<<<<<<<<<
+*         '''open a fastq/fasta file in *filename*
+*
+*/
+__pyx_tuple__65 = PyTuple_Pack(4, __pyx_n_s_self, __pyx_n_s_filename, __pyx_n_s_persist, __pyx_n_s_cfilename); if (unlikely(!__pyx_tuple__65)) __PYX_ERR(0, 555, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__65);
+__Pyx_GIVEREF(__pyx_tuple__65);
+__pyx_codeobj__35 = (PyObject*)__Pyx_PyCode_New(3, 0, 0, 4, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__65, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libcfaidx_pyx, __pyx_n_s_open, 555, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__35)) __PYX_ERR(0, 555, __pyx_L1_error)
+__pyx_tuple__66 = PyTuple_Pack(1, Py_True); if (unlikely(!__pyx_tuple__66)) __PYX_ERR(0, 555, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__66);
+__Pyx_GIVEREF(__pyx_tuple__66);
+/* "pysam/libcfaidx.pyx":588
+*         self._filename = filename
+*
+*     def close(self):             # <<<<<<<<<<<<<<
+*         '''close the file.'''
+*         if self.fastqfile != NULL:
+*/
+__pyx_codeobj__36 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__49, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libcfaidx_pyx, __pyx_n_s_close, 588, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__36)) __PYX_ERR(0, 588, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":604
+*
+*     # context manager interface
+*     def __enter__(self):             # <<<<<<<<<<<<<<
+*         return self
+*
+*/
+__pyx_codeobj__37 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__49, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libcfaidx_pyx, __pyx_n_s_enter, 604, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__37)) __PYX_ERR(0, 604, __pyx_L1_error)
+/* "pysam/libcfaidx.pyx":607
+*         return self
+*
+*     def __exit__(self, exc_type, exc_value, traceback):             # <<<<<<<<<<<<<<
+*         self.close()
+*         return False
+*/
+__pyx_codeobj__38 = (PyObject*)__Pyx_PyCode_New(4, 0, 0, 4, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__52, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libcfaidx_pyx, __pyx_n_s_exit, 607, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__38)) __PYX_ERR(0, 607, __pyx_L1_error)
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):
+*/
+__pyx_codeobj__39 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__49, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_reduce_cython, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__39)) __PYX_ERR(1, 1, __pyx_L1_error)
+/* "(tree fragment)":3
+* def __reduce_cython__(self):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+*/
+__pyx_codeobj__40 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__56, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_setstate_cython, 3, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__40)) __PYX_ERR(1, 3, __pyx_L1_error)
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):
+*/
+__pyx_codeobj__41 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__49, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_reduce_cython, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__41)) __PYX_ERR(1, 1, __pyx_L1_error)
+/* "(tree fragment)":3
+* def __reduce_cython__(self):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+*/
+__pyx_codeobj__42 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__56, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_setstate_cython, 3, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__42)) __PYX_ERR(1, 3, __pyx_L1_error)
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):
+*/
+__pyx_codeobj__43 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__49, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_reduce_cython, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__43)) __PYX_ERR(1, 1, __pyx_L1_error)
+/* "(tree fragment)":3
+* def __reduce_cython__(self):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+*/
+__pyx_codeobj__44 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__56, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_setstate_cython, 3, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__44)) __PYX_ERR(1, 3, __pyx_L1_error)
+/* "(tree fragment)":1
+* def __pyx_unpickle_FastxRecord(__pyx_type, long __pyx_checksum, __pyx_state):             # <<<<<<<<<<<<<<
+*     cdef object __pyx_PickleError
+*     cdef object __pyx_result
+*/
+__pyx_tuple__67 = PyTuple_Pack(5, __pyx_n_s_pyx_type, __pyx_n_s_pyx_checksum, __pyx_n_s_pyx_state, __pyx_n_s_pyx_PickleError, __pyx_n_s_pyx_result); if (unlikely(!__pyx_tuple__67)) __PYX_ERR(1, 1, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_tuple__67);
+__Pyx_GIVEREF(__pyx_tuple__67);
+__pyx_codeobj__45 = (PyObject*)__Pyx_PyCode_New(3, 0, 0, 5, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__67, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_pyx_unpickle_FastxRecord, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__45)) __PYX_ERR(1, 1, __pyx_L1_error)
+__Pyx_RefNannyFinishContext();
+return 0;
+__pyx_L1_error:;
+__Pyx_RefNannyFinishContext();
+return -1;
+}
+/* #### Code section: init_constants ### */
+static CYTHON_SMALL_CODE int __Pyx_InitConstants(void) {
+if (__Pyx_CreateStringTabAndInitStrings() < 0) __PYX_ERR(0, 1, __pyx_L1_error);
+__pyx_int_33 = PyInt_FromLong(33); if (unlikely(!__pyx_int_33)) __PYX_ERR(0, 1, __pyx_L1_error)
+__pyx_int_29210129 = PyInt_FromLong(29210129L); if (unlikely(!__pyx_int_29210129)) __PYX_ERR(0, 1, __pyx_L1_error)
+__pyx_int_71291217 = PyInt_FromLong(71291217L); if (unlikely(!__pyx_int_71291217)) __PYX_ERR(0, 1, __pyx_L1_error)
+__pyx_int_191400582 = PyInt_FromLong(191400582L); if (unlikely(!__pyx_int_191400582)) __PYX_ERR(0, 1, __pyx_L1_error)
+return 0;
+__pyx_L1_error:;
+return -1;
+}
+/* #### Code section: init_globals ### */
+static CYTHON_SMALL_CODE int __Pyx_InitGlobals(void) {
+return 0;
+}
+/* #### Code section: init_module ### */
+static CYTHON_SMALL_CODE int __Pyx_modinit_global_init_code(void); /*proto*/
+static CYTHON_SMALL_CODE int __Pyx_modinit_variable_export_code(void); /*proto*/
+static CYTHON_SMALL_CODE int __Pyx_modinit_function_export_code(void); /*proto*/
+static CYTHON_SMALL_CODE int __Pyx_modinit_type_init_code(void); /*proto*/
+static CYTHON_SMALL_CODE int __Pyx_modinit_type_import_code(void); /*proto*/
+static CYTHON_SMALL_CODE int __Pyx_modinit_variable_import_code(void); /*proto*/
+static CYTHON_SMALL_CODE int __Pyx_modinit_function_import_code(void); /*proto*/
+static int __Pyx_modinit_global_init_code(void) {
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__Pyx_modinit_global_init_code", 0);
+/*--- Global init code ---*/
+__Pyx_RefNannyFinishContext();
+return 0;
+}
+static int __Pyx_modinit_variable_export_code(void) {
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__Pyx_modinit_variable_export_code", 0);
+/*--- Variable export code ---*/
+__Pyx_RefNannyFinishContext();
+return 0;
+}
+static int __Pyx_modinit_function_export_code(void) {
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__Pyx_modinit_function_export_code", 0);
+/*--- Function export code ---*/
+__Pyx_RefNannyFinishContext();
+return 0;
+}
+static int __Pyx_modinit_type_init_code(void) {
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__Pyx_modinit_type_init_code", 0);
+/*--- Type init code ---*/
+__pyx_vtabptr_5pysam_9libcfaidx_FastaFile = &__pyx_vtable_5pysam_9libcfaidx_FastaFile;
+__pyx_vtable_5pysam_9libcfaidx_FastaFile._fetch = (char *(*)(struct __pyx_obj_5pysam_9libcfaidx_FastaFile *, char *, int, int, int *))__pyx_f_5pysam_9libcfaidx_9FastaFile__fetch;
+#if CYTHON_USE_TYPE_SPECS
+__pyx_ptype_5pysam_9libcfaidx_FastaFile = (PyTypeObject *) __Pyx_PyType_FromModuleAndSpec(__pyx_m, &__pyx_type_5pysam_9libcfaidx_FastaFile_spec, NULL); if (unlikely(!__pyx_ptype_5pysam_9libcfaidx_FastaFile)) __PYX_ERR(0, 83, __pyx_L1_error)
+if (__Pyx_fix_up_extension_type_from_spec(&__pyx_type_5pysam_9libcfaidx_FastaFile_spec, __pyx_ptype_5pysam_9libcfaidx_FastaFile) < 0) __PYX_ERR(0, 83, __pyx_L1_error)
+#else
+__pyx_ptype_5pysam_9libcfaidx_FastaFile = &__pyx_type_5pysam_9libcfaidx_FastaFile;
+#endif
+#if !CYTHON_COMPILING_IN_LIMITED_API
+#endif
+#if !CYTHON_USE_TYPE_SPECS
+if (__Pyx_PyType_Ready(__pyx_ptype_5pysam_9libcfaidx_FastaFile) < 0) __PYX_ERR(0, 83, __pyx_L1_error)
+#endif
+#if PY_MAJOR_VERSION < 3
+__pyx_ptype_5pysam_9libcfaidx_FastaFile->tp_print = 0;
+#endif
+#if !CYTHON_COMPILING_IN_LIMITED_API
+if ((CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP) && likely(!__pyx_ptype_5pysam_9libcfaidx_FastaFile->tp_dictoffset && __pyx_ptype_5pysam_9libcfaidx_FastaFile->tp_getattro == PyObject_GenericGetAttr)) {
+__pyx_ptype_5pysam_9libcfaidx_FastaFile->tp_getattro = __Pyx_PyObject_GenericGetAttr;
+}
+#endif
+#if CYTHON_UPDATE_DESCRIPTOR_DOC
+{
+PyObject *wrapper = PyObject_GetAttrString((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastaFile, "__contains__"); if (unlikely(!wrapper)) __PYX_ERR(0, 83, __pyx_L1_error)
+if (__Pyx_IS_TYPE(wrapper, &PyWrapperDescr_Type)) {
+__pyx_wrapperbase_5pysam_9libcfaidx_9FastaFile_22__contains__ = *((PyWrapperDescrObject *)wrapper)->d_base;
+__pyx_wrapperbase_5pysam_9libcfaidx_9FastaFile_22__contains__.doc = __pyx_doc_5pysam_9libcfaidx_9FastaFile_22__contains__;
+((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_5pysam_9libcfaidx_9FastaFile_22__contains__;
+}
+}
+#endif
+if (__Pyx_SetVtable(__pyx_ptype_5pysam_9libcfaidx_FastaFile, __pyx_vtabptr_5pysam_9libcfaidx_FastaFile) < 0) __PYX_ERR(0, 83, __pyx_L1_error)
+#if !CYTHON_COMPILING_IN_LIMITED_API
+if (__Pyx_MergeVtables(__pyx_ptype_5pysam_9libcfaidx_FastaFile) < 0) __PYX_ERR(0, 83, __pyx_L1_error)
+#endif
+if (PyObject_SetAttr(__pyx_m, __pyx_n_s_FastaFile, (PyObject *) __pyx_ptype_5pysam_9libcfaidx_FastaFile) < 0) __PYX_ERR(0, 83, __pyx_L1_error)
+#if !CYTHON_COMPILING_IN_LIMITED_API
+if (__Pyx_setup_reduce((PyObject *) __pyx_ptype_5pysam_9libcfaidx_FastaFile) < 0) __PYX_ERR(0, 83, __pyx_L1_error)
+#endif
+__pyx_vtabptr_5pysam_9libcfaidx_FastqProxy = &__pyx_vtable_5pysam_9libcfaidx_FastqProxy;
+__pyx_vtable_5pysam_9libcfaidx_FastqProxy.to_string = (PyObject *(*)(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *))__pyx_f_5pysam_9libcfaidx_10FastqProxy_to_string;
+__pyx_vtable_5pysam_9libcfaidx_FastqProxy.tostring = (PyObject *(*)(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *))__pyx_f_5pysam_9libcfaidx_10FastqProxy_tostring;
+__pyx_vtable_5pysam_9libcfaidx_FastqProxy.get_quality_array = (arrayobject *(*)(struct __pyx_obj_5pysam_9libcfaidx_FastqProxy *, int __pyx_skip_dispatch, struct __pyx_opt_args_5pysam_9libcfaidx_10FastqProxy_get_quality_array *__pyx_optional_args))__pyx_f_5pysam_9libcfaidx_10FastqProxy_get_quality_array;
+#if CYTHON_USE_TYPE_SPECS
+__pyx_ptype_5pysam_9libcfaidx_FastqProxy = (PyTypeObject *) __Pyx_PyType_FromModuleAndSpec(__pyx_m, &__pyx_type_5pysam_9libcfaidx_FastqProxy_spec, NULL); if (unlikely(!__pyx_ptype_5pysam_9libcfaidx_FastqProxy)) __PYX_ERR(0, 355, __pyx_L1_error)
+if (__Pyx_fix_up_extension_type_from_spec(&__pyx_type_5pysam_9libcfaidx_FastqProxy_spec, __pyx_ptype_5pysam_9libcfaidx_FastqProxy) < 0) __PYX_ERR(0, 355, __pyx_L1_error)
+#else
+__pyx_ptype_5pysam_9libcfaidx_FastqProxy = &__pyx_type_5pysam_9libcfaidx_FastqProxy;
+#endif
+#if !CYTHON_COMPILING_IN_LIMITED_API
+#endif
+#if !CYTHON_USE_TYPE_SPECS
+if (__Pyx_PyType_Ready(__pyx_ptype_5pysam_9libcfaidx_FastqProxy) < 0) __PYX_ERR(0, 355, __pyx_L1_error)
+#endif
+#if PY_MAJOR_VERSION < 3
+__pyx_ptype_5pysam_9libcfaidx_FastqProxy->tp_print = 0;
+#endif
+#if !CYTHON_COMPILING_IN_LIMITED_API
+if ((CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP) && likely(!__pyx_ptype_5pysam_9libcfaidx_FastqProxy->tp_dictoffset && __pyx_ptype_5pysam_9libcfaidx_FastqProxy->tp_getattro == PyObject_GenericGetAttr)) {
+__pyx_ptype_5pysam_9libcfaidx_FastqProxy->tp_getattro = __Pyx_PyObject_GenericGetAttr;
+}
+#endif
+if (__Pyx_SetVtable(__pyx_ptype_5pysam_9libcfaidx_FastqProxy, __pyx_vtabptr_5pysam_9libcfaidx_FastqProxy) < 0) __PYX_ERR(0, 355, __pyx_L1_error)
+#if !CYTHON_COMPILING_IN_LIMITED_API
+if (__Pyx_MergeVtables(__pyx_ptype_5pysam_9libcfaidx_FastqProxy) < 0) __PYX_ERR(0, 355, __pyx_L1_error)
+#endif
+if (PyObject_SetAttr(__pyx_m, __pyx_n_s_FastqProxy, (PyObject *) __pyx_ptype_5pysam_9libcfaidx_FastqProxy) < 0) __PYX_ERR(0, 355, __pyx_L1_error)
+#if !CYTHON_COMPILING_IN_LIMITED_API
+if (__Pyx_setup_reduce((PyObject *) __pyx_ptype_5pysam_9libcfaidx_FastqProxy) < 0) __PYX_ERR(0, 355, __pyx_L1_error)
+#endif
+__pyx_vtabptr_5pysam_9libcfaidx_FastxRecord = &__pyx_vtable_5pysam_9libcfaidx_FastxRecord;
+__pyx_vtable_5pysam_9libcfaidx_FastxRecord.to_string = (PyObject *(*)(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *))__pyx_f_5pysam_9libcfaidx_11FastxRecord_to_string;
+__pyx_vtable_5pysam_9libcfaidx_FastxRecord.tostring = (PyObject *(*)(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *))__pyx_f_5pysam_9libcfaidx_11FastxRecord_tostring;
+__pyx_vtable_5pysam_9libcfaidx_FastxRecord.get_quality_array = (arrayobject *(*)(struct __pyx_obj_5pysam_9libcfaidx_FastxRecord *, int __pyx_skip_dispatch, struct __pyx_opt_args_5pysam_9libcfaidx_11FastxRecord_get_quality_array *__pyx_optional_args))__pyx_f_5pysam_9libcfaidx_11FastxRecord_get_quality_array;
+#if CYTHON_USE_TYPE_SPECS
+__pyx_ptype_5pysam_9libcfaidx_FastxRecord = (PyTypeObject *) __Pyx_PyType_FromModuleAndSpec(__pyx_m, &__pyx_type_5pysam_9libcfaidx_FastxRecord_spec, NULL); if (unlikely(!__pyx_ptype_5pysam_9libcfaidx_FastxRecord)) __PYX_ERR(0, 411, __pyx_L1_error)
+if (__Pyx_fix_up_extension_type_from_spec(&__pyx_type_5pysam_9libcfaidx_FastxRecord_spec, __pyx_ptype_5pysam_9libcfaidx_FastxRecord) < 0) __PYX_ERR(0, 411, __pyx_L1_error)
+#else
+__pyx_ptype_5pysam_9libcfaidx_FastxRecord = &__pyx_type_5pysam_9libcfaidx_FastxRecord;
+#endif
+#if !CYTHON_COMPILING_IN_LIMITED_API
+#endif
+#if !CYTHON_USE_TYPE_SPECS
+if (__Pyx_PyType_Ready(__pyx_ptype_5pysam_9libcfaidx_FastxRecord) < 0) __PYX_ERR(0, 411, __pyx_L1_error)
+#endif
+#if PY_MAJOR_VERSION < 3
+__pyx_ptype_5pysam_9libcfaidx_FastxRecord->tp_print = 0;
+#endif
+#if !CYTHON_COMPILING_IN_LIMITED_API
+if ((CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP) && likely(!__pyx_ptype_5pysam_9libcfaidx_FastxRecord->tp_dictoffset && __pyx_ptype_5pysam_9libcfaidx_FastxRecord->tp_getattro == PyObject_GenericGetAttr)) {
+__pyx_ptype_5pysam_9libcfaidx_FastxRecord->tp_getattro = __Pyx_PyObject_GenericGetAttr;
+}
+#endif
+if (__Pyx_SetVtable(__pyx_ptype_5pysam_9libcfaidx_FastxRecord, __pyx_vtabptr_5pysam_9libcfaidx_FastxRecord) < 0) __PYX_ERR(0, 411, __pyx_L1_error)
+#if !CYTHON_COMPILING_IN_LIMITED_API
+if (__Pyx_MergeVtables(__pyx_ptype_5pysam_9libcfaidx_FastxRecord) < 0) __PYX_ERR(0, 411, __pyx_L1_error)
+#endif
+if (PyObject_SetAttr(__pyx_m, __pyx_n_s_FastxRecord, (PyObject *) __pyx_ptype_5pysam_9libcfaidx_FastxRecord) < 0) __PYX_ERR(0, 411, __pyx_L1_error)
+#if !CYTHON_COMPILING_IN_LIMITED_API
+if (__Pyx_setup_reduce((PyObject *) __pyx_ptype_5pysam_9libcfaidx_FastxRecord) < 0) __PYX_ERR(0, 411, __pyx_L1_error)
+#endif
+__pyx_vtabptr_5pysam_9libcfaidx_FastxFile = &__pyx_vtable_5pysam_9libcfaidx_FastxFile;
+__pyx_vtable_5pysam_9libcfaidx_FastxFile.getCurrent = (kseq_t *(*)(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *))__pyx_f_5pysam_9libcfaidx_9FastxFile_getCurrent;
+__pyx_vtable_5pysam_9libcfaidx_FastxFile.cnext = (int (*)(struct __pyx_obj_5pysam_9libcfaidx_FastxFile *))__pyx_f_5pysam_9libcfaidx_9FastxFile_cnext;
+#if CYTHON_USE_TYPE_SPECS
+__pyx_ptype_5pysam_9libcfaidx_FastxFile = (PyTypeObject *) __Pyx_PyType_FromModuleAndSpec(__pyx_m, &__pyx_type_5pysam_9libcfaidx_FastxFile_spec, NULL); if (unlikely(!__pyx_ptype_5pysam_9libcfaidx_FastxFile)) __PYX_ERR(0, 496, __pyx_L1_error)
+if (__Pyx_fix_up_extension_type_from_spec(&__pyx_type_5pysam_9libcfaidx_FastxFile_spec, __pyx_ptype_5pysam_9libcfaidx_FastxFile) < 0) __PYX_ERR(0, 496, __pyx_L1_error)
+#else
+__pyx_ptype_5pysam_9libcfaidx_FastxFile = &__pyx_type_5pysam_9libcfaidx_FastxFile;
+#endif
+#if !CYTHON_COMPILING_IN_LIMITED_API
+#endif
+#if !CYTHON_USE_TYPE_SPECS
+if (__Pyx_PyType_Ready(__pyx_ptype_5pysam_9libcfaidx_FastxFile) < 0) __PYX_ERR(0, 496, __pyx_L1_error)
+#endif
+#if PY_MAJOR_VERSION < 3
+__pyx_ptype_5pysam_9libcfaidx_FastxFile->tp_print = 0;
+#endif
+#if !CYTHON_COMPILING_IN_LIMITED_API
+if ((CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP) && likely(!__pyx_ptype_5pysam_9libcfaidx_FastxFile->tp_dictoffset && __pyx_ptype_5pysam_9libcfaidx_FastxFile->tp_getattro == PyObject_GenericGetAttr)) {
+__pyx_ptype_5pysam_9libcfaidx_FastxFile->tp_getattro = __Pyx_PyObject_GenericGetAttr;
+}
+#endif
+#if CYTHON_UPDATE_DESCRIPTOR_DOC
+{
+PyObject *wrapper = PyObject_GetAttrString((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastxFile, "__next__"); if (unlikely(!wrapper)) __PYX_ERR(0, 496, __pyx_L1_error)
+if (__Pyx_IS_TYPE(wrapper, &PyWrapperDescr_Type)) {
+__pyx_wrapperbase_5pysam_9libcfaidx_9FastxFile_16__next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
+__pyx_wrapperbase_5pysam_9libcfaidx_9FastxFile_16__next__.doc = __pyx_doc_5pysam_9libcfaidx_9FastxFile_16__next__;
+((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_5pysam_9libcfaidx_9FastxFile_16__next__;
+}
+}
+#endif
+if (__Pyx_SetVtable(__pyx_ptype_5pysam_9libcfaidx_FastxFile, __pyx_vtabptr_5pysam_9libcfaidx_FastxFile) < 0) __PYX_ERR(0, 496, __pyx_L1_error)
+#if !CYTHON_COMPILING_IN_LIMITED_API
+if (__Pyx_MergeVtables(__pyx_ptype_5pysam_9libcfaidx_FastxFile) < 0) __PYX_ERR(0, 496, __pyx_L1_error)
+#endif
+if (PyObject_SetAttr(__pyx_m, __pyx_n_s_FastxFile, (PyObject *) __pyx_ptype_5pysam_9libcfaidx_FastxFile) < 0) __PYX_ERR(0, 496, __pyx_L1_error)
+#if !CYTHON_COMPILING_IN_LIMITED_API
+if (__Pyx_setup_reduce((PyObject *) __pyx_ptype_5pysam_9libcfaidx_FastxFile) < 0) __PYX_ERR(0, 496, __pyx_L1_error)
+#endif
+__pyx_vtabptr_5pysam_9libcfaidx_FastqFile = &__pyx_vtable_5pysam_9libcfaidx_FastqFile;
+__pyx_vtable_5pysam_9libcfaidx_FastqFile.__pyx_base = *__pyx_vtabptr_5pysam_9libcfaidx_FastxFile;
+#if CYTHON_USE_TYPE_SPECS
+__pyx_t_1 = PyTuple_Pack(1, (PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastxFile); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 658, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_ptype_5pysam_9libcfaidx_FastqFile = (PyTypeObject *) __Pyx_PyType_FromModuleAndSpec(__pyx_m, &__pyx_type_5pysam_9libcfaidx_FastqFile_spec, __pyx_t_1);
+__Pyx_XDECREF(__pyx_t_1); __pyx_t_1 = 0;
+if (unlikely(!__pyx_ptype_5pysam_9libcfaidx_FastqFile)) __PYX_ERR(0, 658, __pyx_L1_error)
+if (__Pyx_fix_up_extension_type_from_spec(&__pyx_type_5pysam_9libcfaidx_FastqFile_spec, __pyx_ptype_5pysam_9libcfaidx_FastqFile) < 0) __PYX_ERR(0, 658, __pyx_L1_error)
+#else
+__pyx_ptype_5pysam_9libcfaidx_FastqFile = &__pyx_type_5pysam_9libcfaidx_FastqFile;
+#endif
+#if !CYTHON_COMPILING_IN_LIMITED_API
+__pyx_ptype_5pysam_9libcfaidx_FastqFile->tp_base = __pyx_ptype_5pysam_9libcfaidx_FastxFile;
+#endif
+#if !CYTHON_USE_TYPE_SPECS
+if (__Pyx_PyType_Ready(__pyx_ptype_5pysam_9libcfaidx_FastqFile) < 0) __PYX_ERR(0, 658, __pyx_L1_error)
+#endif
+#if PY_MAJOR_VERSION < 3
+__pyx_ptype_5pysam_9libcfaidx_FastqFile->tp_print = 0;
+#endif
+#if !CYTHON_COMPILING_IN_LIMITED_API
+if ((CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP) && likely(!__pyx_ptype_5pysam_9libcfaidx_FastqFile->tp_dictoffset && __pyx_ptype_5pysam_9libcfaidx_FastqFile->tp_getattro == PyObject_GenericGetAttr)) {
+__pyx_ptype_5pysam_9libcfaidx_FastqFile->tp_getattro = __Pyx_PyObject_GenericGetAttr;
+}
+#endif
+if (__Pyx_SetVtable(__pyx_ptype_5pysam_9libcfaidx_FastqFile, __pyx_vtabptr_5pysam_9libcfaidx_FastqFile) < 0) __PYX_ERR(0, 658, __pyx_L1_error)
+#if !CYTHON_COMPILING_IN_LIMITED_API
+if (__Pyx_MergeVtables(__pyx_ptype_5pysam_9libcfaidx_FastqFile) < 0) __PYX_ERR(0, 658, __pyx_L1_error)
+#endif
+if (PyObject_SetAttr(__pyx_m, __pyx_n_s_FastqFile, (PyObject *) __pyx_ptype_5pysam_9libcfaidx_FastqFile) < 0) __PYX_ERR(0, 658, __pyx_L1_error)
+#if !CYTHON_COMPILING_IN_LIMITED_API
+if (__Pyx_setup_reduce((PyObject *) __pyx_ptype_5pysam_9libcfaidx_FastqFile) < 0) __PYX_ERR(0, 658, __pyx_L1_error)
+#endif
+__pyx_vtabptr_5pysam_9libcfaidx_Fastafile = &__pyx_vtable_5pysam_9libcfaidx_Fastafile;
+__pyx_vtable_5pysam_9libcfaidx_Fastafile.__pyx_base = *__pyx_vtabptr_5pysam_9libcfaidx_FastaFile;
+#if CYTHON_USE_TYPE_SPECS
+__pyx_t_1 = PyTuple_Pack(1, (PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastaFile); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 663, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_ptype_5pysam_9libcfaidx_Fastafile = (PyTypeObject *) __Pyx_PyType_FromModuleAndSpec(__pyx_m, &__pyx_type_5pysam_9libcfaidx_Fastafile_spec, __pyx_t_1);
+__Pyx_XDECREF(__pyx_t_1); __pyx_t_1 = 0;
+if (unlikely(!__pyx_ptype_5pysam_9libcfaidx_Fastafile)) __PYX_ERR(0, 663, __pyx_L1_error)
+if (__Pyx_fix_up_extension_type_from_spec(&__pyx_type_5pysam_9libcfaidx_Fastafile_spec, __pyx_ptype_5pysam_9libcfaidx_Fastafile) < 0) __PYX_ERR(0, 663, __pyx_L1_error)
+#else
+__pyx_ptype_5pysam_9libcfaidx_Fastafile = &__pyx_type_5pysam_9libcfaidx_Fastafile;
+#endif
+#if !CYTHON_COMPILING_IN_LIMITED_API
+__pyx_ptype_5pysam_9libcfaidx_Fastafile->tp_base = __pyx_ptype_5pysam_9libcfaidx_FastaFile;
+#endif
+#if !CYTHON_USE_TYPE_SPECS
+if (__Pyx_PyType_Ready(__pyx_ptype_5pysam_9libcfaidx_Fastafile) < 0) __PYX_ERR(0, 663, __pyx_L1_error)
+#endif
+#if PY_MAJOR_VERSION < 3
+__pyx_ptype_5pysam_9libcfaidx_Fastafile->tp_print = 0;
+#endif
+#if !CYTHON_COMPILING_IN_LIMITED_API
+if ((CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP) && likely(!__pyx_ptype_5pysam_9libcfaidx_Fastafile->tp_dictoffset && __pyx_ptype_5pysam_9libcfaidx_Fastafile->tp_getattro == PyObject_GenericGetAttr)) {
+__pyx_ptype_5pysam_9libcfaidx_Fastafile->tp_getattro = __Pyx_PyObject_GenericGetAttr;
+}
+#endif
+if (__Pyx_SetVtable(__pyx_ptype_5pysam_9libcfaidx_Fastafile, __pyx_vtabptr_5pysam_9libcfaidx_Fastafile) < 0) __PYX_ERR(0, 663, __pyx_L1_error)
+#if !CYTHON_COMPILING_IN_LIMITED_API
+if (__Pyx_MergeVtables(__pyx_ptype_5pysam_9libcfaidx_Fastafile) < 0) __PYX_ERR(0, 663, __pyx_L1_error)
+#endif
+if (PyObject_SetAttr(__pyx_m, __pyx_n_s_Fastafile, (PyObject *) __pyx_ptype_5pysam_9libcfaidx_Fastafile) < 0) __PYX_ERR(0, 663, __pyx_L1_error)
+#if !CYTHON_COMPILING_IN_LIMITED_API
+if (__Pyx_setup_reduce((PyObject *) __pyx_ptype_5pysam_9libcfaidx_Fastafile) < 0) __PYX_ERR(0, 663, __pyx_L1_error)
+#endif
+__Pyx_RefNannyFinishContext();
+return 0;
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_RefNannyFinishContext();
+return -1;
+}
+static int __Pyx_modinit_type_import_code(void) {
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__Pyx_modinit_type_import_code", 0);
+/*--- Type import code ---*/
+__pyx_t_1 = PyImport_ImportModule(__Pyx_BUILTIN_MODULE_NAME); if (unlikely(!__pyx_t_1)) __PYX_ERR(5, 9, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_ptype_7cpython_4type_type = __Pyx_ImportType_3_0_11(__pyx_t_1, __Pyx_BUILTIN_MODULE_NAME, "type",
+#if defined(PYPY_VERSION_NUM) && PYPY_VERSION_NUM < 0x050B0000
+sizeof(PyTypeObject), __PYX_GET_STRUCT_ALIGNMENT_3_0_11(PyTypeObject),
+#elif CYTHON_COMPILING_IN_LIMITED_API
+sizeof(PyTypeObject), __PYX_GET_STRUCT_ALIGNMENT_3_0_11(PyTypeObject),
+#else
+sizeof(PyHeapTypeObject), __PYX_GET_STRUCT_ALIGNMENT_3_0_11(PyHeapTypeObject),
+#endif
+__Pyx_ImportType_CheckSize_Warn_3_0_11); if (!__pyx_ptype_7cpython_4type_type) __PYX_ERR(5, 9, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__pyx_t_1 = PyImport_ImportModule(__Pyx_BUILTIN_MODULE_NAME); if (unlikely(!__pyx_t_1)) __PYX_ERR(6, 8, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_ptype_7cpython_4bool_bool = __Pyx_ImportType_3_0_11(__pyx_t_1, __Pyx_BUILTIN_MODULE_NAME, "bool", sizeof(PyBoolObject), __PYX_GET_STRUCT_ALIGNMENT_3_0_11(PyBoolObject),__Pyx_ImportType_CheckSize_Warn_3_0_11); if (!__pyx_ptype_7cpython_4bool_bool) __PYX_ERR(6, 8, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__pyx_t_1 = PyImport_ImportModule(__Pyx_BUILTIN_MODULE_NAME); if (unlikely(!__pyx_t_1)) __PYX_ERR(7, 15, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_ptype_7cpython_7complex_complex = __Pyx_ImportType_3_0_11(__pyx_t_1, __Pyx_BUILTIN_MODULE_NAME, "complex", sizeof(PyComplexObject), __PYX_GET_STRUCT_ALIGNMENT_3_0_11(PyComplexObject),__Pyx_ImportType_CheckSize_Warn_3_0_11); if (!__pyx_ptype_7cpython_7complex_complex) __PYX_ERR(7, 15, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__pyx_t_1 = PyImport_ImportModule("array"); if (unlikely(!__pyx_t_1)) __PYX_ERR(3, 69, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_ptype_7cpython_5array_array = __Pyx_ImportType_3_0_11(__pyx_t_1, "array", "array", sizeof(arrayobject), __PYX_GET_STRUCT_ALIGNMENT_3_0_11(arrayobject),__Pyx_ImportType_CheckSize_Warn_3_0_11); if (!__pyx_ptype_7cpython_5array_array) __PYX_ERR(3, 69, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__pyx_t_1 = PyImport_ImportModule("pysam.libchtslib"); if (unlikely(!__pyx_t_1)) __PYX_ERR(8, 2706, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+__pyx_ptype_5pysam_10libchtslib_HTSFile = __Pyx_ImportType_3_0_11(__pyx_t_1, "pysam.libchtslib", "HTSFile", sizeof(struct __pyx_obj_5pysam_10libchtslib_HTSFile), __PYX_GET_STRUCT_ALIGNMENT_3_0_11(struct __pyx_obj_5pysam_10libchtslib_HTSFile),__Pyx_ImportType_CheckSize_Warn_3_0_11); if (!__pyx_ptype_5pysam_10libchtslib_HTSFile) __PYX_ERR(8, 2706, __pyx_L1_error)
+__pyx_vtabptr_5pysam_10libchtslib_HTSFile = (struct __pyx_vtabstruct_5pysam_10libchtslib_HTSFile*)__Pyx_GetVtable(__pyx_ptype_5pysam_10libchtslib_HTSFile); if (unlikely(!__pyx_vtabptr_5pysam_10libchtslib_HTSFile)) __PYX_ERR(8, 2706, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__Pyx_RefNannyFinishContext();
+return 0;
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_RefNannyFinishContext();
+return -1;
+}
+static int __Pyx_modinit_variable_import_code(void) {
+__Pyx_RefNannyDeclarations
+__Pyx_RefNannySetupContext("__Pyx_modinit_variable_import_code", 0);
+/*--- Variable import code ---*/
+__Pyx_RefNannyFinishContext();
+return 0;
+}
+static int __Pyx_modinit_function_import_code(void) {
+__Pyx_RefNannyDeclarations
+PyObject *__pyx_t_1 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannySetupContext("__Pyx_modinit_function_import_code", 0);
+/*--- Function import code ---*/
+__pyx_t_1 = PyImport_ImportModule("pysam.libcutils"); if (!__pyx_t_1) __PYX_ERR(0, 1, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_1);
+if (__Pyx_ImportFunction_3_0_11(__pyx_t_1, "parse_region", (void (**)(void))&__pyx_f_5pysam_9libcutils_parse_region, "PyObject *(int __pyx_skip_dispatch, struct __pyx_opt_args_5pysam_9libcutils_parse_region *__pyx_optional_args)") < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+if (__Pyx_ImportFunction_3_0_11(__pyx_t_1, "qualitystring_to_array", (void (**)(void))&__pyx_f_5pysam_9libcutils_qualitystring_to_array, "arrayobject *(PyObject *, int __pyx_skip_dispatch, struct __pyx_opt_args_5pysam_9libcutils_qualitystring_to_array *__pyx_optional_args)") < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+if (__Pyx_ImportFunction_3_0_11(__pyx_t_1, "charptr_to_str", (void (**)(void))&__pyx_f_5pysam_9libcutils_charptr_to_str, "PyObject *(char const *, struct __pyx_opt_args_5pysam_9libcutils_charptr_to_str *__pyx_optional_args)") < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+if (__Pyx_ImportFunction_3_0_11(__pyx_t_1, "force_str", (void (**)(void))&__pyx_f_5pysam_9libcutils_force_str, "PyObject *(PyObject *, struct __pyx_opt_args_5pysam_9libcutils_force_str *__pyx_optional_args)") < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+if (__Pyx_ImportFunction_3_0_11(__pyx_t_1, "force_bytes", (void (**)(void))&__pyx_f_5pysam_9libcutils_force_bytes, "PyObject *(PyObject *, struct __pyx_opt_args_5pysam_9libcutils_force_bytes *__pyx_optional_args)") < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+if (__Pyx_ImportFunction_3_0_11(__pyx_t_1, "encode_filename", (void (**)(void))&__pyx_f_5pysam_9libcutils_encode_filename, "PyObject *(PyObject *)") < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+if (__Pyx_ImportFunction_3_0_11(__pyx_t_1, "from_string_and_size", (void (**)(void))&__pyx_f_5pysam_9libcutils_from_string_and_size, "PyObject *(char const *, size_t)") < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+__Pyx_RefNannyFinishContext();
+return 0;
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_1);
+__Pyx_RefNannyFinishContext();
+return -1;
+}
+#if PY_MAJOR_VERSION >= 3
+#if CYTHON_PEP489_MULTI_PHASE_INIT
+static PyObject* __pyx_pymod_create(PyObject *spec, PyModuleDef *def); /*proto*/
+static int __pyx_pymod_exec_libcfaidx(PyObject* module); /*proto*/
+static PyModuleDef_Slot __pyx_moduledef_slots[] = {
+{Py_mod_create, (void*)__pyx_pymod_create},
+{Py_mod_exec, (void*)__pyx_pymod_exec_libcfaidx},
+{0, NULL}
+};
+#endif
+#ifdef __cplusplus
+namespace {
+struct PyModuleDef __pyx_moduledef =
+#else
+static struct PyModuleDef __pyx_moduledef =
+#endif
+{
+PyModuleDef_HEAD_INIT,
+"libcfaidx",
+0, /* m_doc */
+#if CYTHON_PEP489_MULTI_PHASE_INIT
+0, /* m_size */
+#elif CYTHON_USE_MODULE_STATE
+sizeof(__pyx_mstate), /* m_size */
+#else
+-1, /* m_size */
+#endif
+__pyx_methods /* m_methods */,
+#if CYTHON_PEP489_MULTI_PHASE_INIT
+__pyx_moduledef_slots, /* m_slots */
+#else
+NULL, /* m_reload */
+#endif
+#if CYTHON_USE_MODULE_STATE
+__pyx_m_traverse, /* m_traverse */
+__pyx_m_clear, /* m_clear */
+NULL /* m_free */
+#else
+NULL, /* m_traverse */
+NULL, /* m_clear */
+NULL /* m_free */
+#endif
+};
+#ifdef __cplusplus
+} /* anonymous namespace */
+#endif
+#endif
+#ifndef CYTHON_NO_PYINIT_EXPORT
+#define __Pyx_PyMODINIT_FUNC PyMODINIT_FUNC
+#elif PY_MAJOR_VERSION < 3
+#ifdef __cplusplus
+#define __Pyx_PyMODINIT_FUNC extern "C" void
+#else
+#define __Pyx_PyMODINIT_FUNC void
+#endif
+#else
+#ifdef __cplusplus
+#define __Pyx_PyMODINIT_FUNC extern "C" PyObject *
+#else
+#define __Pyx_PyMODINIT_FUNC PyObject *
+#endif
+#endif
+#if PY_MAJOR_VERSION < 3
+__Pyx_PyMODINIT_FUNC initlibcfaidx(void) CYTHON_SMALL_CODE; /*proto*/
+__Pyx_PyMODINIT_FUNC initlibcfaidx(void)
+#else
+__Pyx_PyMODINIT_FUNC PyInit_libcfaidx(void) CYTHON_SMALL_CODE; /*proto*/
+__Pyx_PyMODINIT_FUNC PyInit_libcfaidx(void)
+#if CYTHON_PEP489_MULTI_PHASE_INIT
+{
+return PyModuleDef_Init(&__pyx_moduledef);
+}
+static CYTHON_SMALL_CODE int __Pyx_check_single_interpreter(void) {
+#if PY_VERSION_HEX >= 0x030700A1
+static PY_INT64_T main_interpreter_id = -1;
+PY_INT64_T current_id = PyInterpreterState_GetID(PyThreadState_Get()->interp);
+if (main_interpreter_id == -1) {
+main_interpreter_id = current_id;
+return (unlikely(current_id == -1)) ? -1 : 0;
+} else if (unlikely(main_interpreter_id != current_id))
+#else
+static PyInterpreterState *main_interpreter = NULL;
+PyInterpreterState *current_interpreter = PyThreadState_Get()->interp;
+if (!main_interpreter) {
+main_interpreter = current_interpreter;
+} else if (unlikely(main_interpreter != current_interpreter))
+#endif
+{
+PyErr_SetString(
+PyExc_ImportError,
+"Interpreter change detected - this module can only be loaded into one interpreter per process.");
+return -1;
+}
+return 0;
+}
+#if CYTHON_COMPILING_IN_LIMITED_API
+static CYTHON_SMALL_CODE int __Pyx_copy_spec_to_module(PyObject *spec, PyObject *module, const char* from_name, const char* to_name, int allow_none)
+#else
+static CYTHON_SMALL_CODE int __Pyx_copy_spec_to_module(PyObject *spec, PyObject *moddict, const char* from_name, const char* to_name, int allow_none)
+#endif
+{
+PyObject *value = PyObject_GetAttrString(spec, from_name);
+int result = 0;
+if (likely(value)) {
+if (allow_none || value != Py_None) {
+#if CYTHON_COMPILING_IN_LIMITED_API
+result = PyModule_AddObject(module, to_name, value);
+#else
+result = PyDict_SetItemString(moddict, to_name, value);
+#endif
+}
+Py_DECREF(value);
+} else if (PyErr_ExceptionMatches(PyExc_AttributeError)) {
+PyErr_Clear();
+} else {
+result = -1;
+}
+return result;
+}
+static CYTHON_SMALL_CODE PyObject* __pyx_pymod_create(PyObject *spec, PyModuleDef *def) {
+PyObject *module = NULL, *moddict, *modname;
+CYTHON_UNUSED_VAR(def);
+if (__Pyx_check_single_interpreter())
+return NULL;
+if (__pyx_m)
+return __Pyx_NewRef(__pyx_m);
+modname = PyObject_GetAttrString(spec, "name");
+if (unlikely(!modname)) goto bad;
+module = PyModule_NewObject(modname);
+Py_DECREF(modname);
+if (unlikely(!module)) goto bad;
+#if CYTHON_COMPILING_IN_LIMITED_API
+moddict = module;
+#else
+moddict = PyModule_GetDict(module);
+if (unlikely(!moddict)) goto bad;
+#endif
+if (unlikely(__Pyx_copy_spec_to_module(spec, moddict, "loader", "__loader__", 1) < 0)) goto bad;
+if (unlikely(__Pyx_copy_spec_to_module(spec, moddict, "origin", "__file__", 1) < 0)) goto bad;
+if (unlikely(__Pyx_copy_spec_to_module(spec, moddict, "parent", "__package__", 1) < 0)) goto bad;
+if (unlikely(__Pyx_copy_spec_to_module(spec, moddict, "submodule_search_locations", "__path__", 0) < 0)) goto bad;
+return module;
+bad:
+Py_XDECREF(module);
+return NULL;
+}
+static CYTHON_SMALL_CODE int __pyx_pymod_exec_libcfaidx(PyObject *__pyx_pyinit_module)
+#endif
+#endif
+{
+int stringtab_initialized = 0;
+#if CYTHON_USE_MODULE_STATE
+int pystate_addmodule_run = 0;
+#endif
+__Pyx_TraceDeclarations
+PyObject *__pyx_t_1 = NULL;
+PyObject *__pyx_t_2 = NULL;
+int __pyx_lineno = 0;
+const char *__pyx_filename = NULL;
+int __pyx_clineno = 0;
+__Pyx_RefNannyDeclarations
+#if CYTHON_PEP489_MULTI_PHASE_INIT
+if (__pyx_m) {
+if (__pyx_m == __pyx_pyinit_module) return 0;
+PyErr_SetString(PyExc_RuntimeError, "Module 'libcfaidx' has already been imported. Re-initialisation is not supported.");
+return -1;
+}
+#elif PY_MAJOR_VERSION >= 3
+if (__pyx_m) return __Pyx_NewRef(__pyx_m);
+#endif
+/*--- Module creation code ---*/
+#if CYTHON_PEP489_MULTI_PHASE_INIT
+__pyx_m = __pyx_pyinit_module;
+Py_INCREF(__pyx_m);
+#else
+#if PY_MAJOR_VERSION < 3
+__pyx_m = Py_InitModule4("libcfaidx", __pyx_methods, 0, 0, PYTHON_API_VERSION); Py_XINCREF(__pyx_m);
+if (unlikely(!__pyx_m)) __PYX_ERR(0, 1, __pyx_L1_error)
+#elif CYTHON_USE_MODULE_STATE
+__pyx_t_1 = PyModule_Create(&__pyx_moduledef); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1, __pyx_L1_error)
+{
+int add_module_result = PyState_AddModule(__pyx_t_1, &__pyx_moduledef);
+__pyx_t_1 = 0; /* transfer ownership from __pyx_t_1 to "libcfaidx" pseudovariable */
+if (unlikely((add_module_result < 0))) __PYX_ERR(0, 1, __pyx_L1_error)
+pystate_addmodule_run = 1;
+}
+#else
+__pyx_m = PyModule_Create(&__pyx_moduledef);
+if (unlikely(!__pyx_m)) __PYX_ERR(0, 1, __pyx_L1_error)
+#endif
+#endif
+CYTHON_UNUSED_VAR(__pyx_t_1);
+__pyx_d = PyModule_GetDict(__pyx_m); if (unlikely(!__pyx_d)) __PYX_ERR(0, 1, __pyx_L1_error)
+Py_INCREF(__pyx_d);
+__pyx_b = __Pyx_PyImport_AddModuleRef(__Pyx_BUILTIN_MODULE_NAME); if (unlikely(!__pyx_b)) __PYX_ERR(0, 1, __pyx_L1_error)
+__pyx_cython_runtime = __Pyx_PyImport_AddModuleRef((const char *) "cython_runtime"); if (unlikely(!__pyx_cython_runtime)) __PYX_ERR(0, 1, __pyx_L1_error)
+if (PyObject_SetAttrString(__pyx_m, "__builtins__", __pyx_b) < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+#if CYTHON_REFNANNY
+__Pyx_RefNanny = __Pyx_RefNannyImportAPI("refnanny");
+if (!__Pyx_RefNanny) {
+PyErr_Clear();
+__Pyx_RefNanny = __Pyx_RefNannyImportAPI("Cython.Runtime.refnanny");
+if (!__Pyx_RefNanny)
+Py_FatalError("failed to import 'refnanny' module");
+}
+#endif
+__Pyx_RefNannySetupContext("__Pyx_PyMODINIT_FUNC PyInit_libcfaidx(void)", 0);
+if (__Pyx_check_binary_version(__PYX_LIMITED_VERSION_HEX, __Pyx_get_runtime_version(), CYTHON_COMPILING_IN_LIMITED_API) < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+#ifdef __Pxy_PyFrame_Initialize_Offsets
+__Pxy_PyFrame_Initialize_Offsets();
+#endif
+__pyx_empty_tuple = PyTuple_New(0); if (unlikely(!__pyx_empty_tuple)) __PYX_ERR(0, 1, __pyx_L1_error)
+__pyx_empty_bytes = PyBytes_FromStringAndSize("", 0); if (unlikely(!__pyx_empty_bytes)) __PYX_ERR(0, 1, __pyx_L1_error)
+__pyx_empty_unicode = PyUnicode_FromStringAndSize("", 0); if (unlikely(!__pyx_empty_unicode)) __PYX_ERR(0, 1, __pyx_L1_error)
+#ifdef __Pyx_CyFunction_USED
+if (__pyx_CyFunction_init(__pyx_m) < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+#endif
+#ifdef __Pyx_FusedFunction_USED
+if (__pyx_FusedFunction_init(__pyx_m) < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+#endif
+#ifdef __Pyx_Coroutine_USED
+if (__pyx_Coroutine_init(__pyx_m) < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+#endif
+#ifdef __Pyx_Generator_USED
+if (__pyx_Generator_init(__pyx_m) < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+#endif
+#ifdef __Pyx_AsyncGen_USED
+if (__pyx_AsyncGen_init(__pyx_m) < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+#endif
+#ifdef __Pyx_StopAsyncIteration_USED
+if (__pyx_StopAsyncIteration_init(__pyx_m) < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+#endif
+/*--- Library function declarations ---*/
+/*--- Threads initialization code ---*/
+#if defined(WITH_THREAD) && PY_VERSION_HEX < 0x030700F0 && defined(__PYX_FORCE_INIT_THREADS) && __PYX_FORCE_INIT_THREADS
+PyEval_InitThreads();
+#endif
+/*--- Initialize various global constants etc. ---*/
+if (__Pyx_InitConstants() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+stringtab_initialized = 1;
+if (__Pyx_InitGlobals() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+#if PY_MAJOR_VERSION < 3 && (__PYX_DEFAULT_STRING_ENCODING_IS_ASCII || __PYX_DEFAULT_STRING_ENCODING_IS_DEFAULT)
+if (__Pyx_init_sys_getdefaultencoding_params() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+#endif
+if (__pyx_module_is_main_pysam__libcfaidx) {
+if (PyObject_SetAttr(__pyx_m, __pyx_n_s_name_2, __pyx_n_s_main) < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+}
+#if PY_MAJOR_VERSION >= 3
+{
+PyObject *modules = PyImport_GetModuleDict(); if (unlikely(!modules)) __PYX_ERR(0, 1, __pyx_L1_error)
+if (!PyDict_GetItemString(modules, "pysam.libcfaidx")) {
+if (unlikely((PyDict_SetItemString(modules, "pysam.libcfaidx", __pyx_m) < 0))) __PYX_ERR(0, 1, __pyx_L1_error)
+}
+}
+#endif
+/*--- Builtin init code ---*/
+if (__Pyx_InitCachedBuiltins() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+/*--- Constants init code ---*/
+if (__Pyx_InitCachedConstants() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+/*--- Global type/function init code ---*/
+(void)__Pyx_modinit_global_init_code();
+(void)__Pyx_modinit_variable_export_code();
+(void)__Pyx_modinit_function_export_code();
+if (unlikely((__Pyx_modinit_type_init_code() < 0))) __PYX_ERR(0, 1, __pyx_L1_error)
+if (unlikely((__Pyx_modinit_type_import_code() < 0))) __PYX_ERR(0, 1, __pyx_L1_error)
+(void)__Pyx_modinit_variable_import_code();
+if (unlikely((__Pyx_modinit_function_import_code() < 0))) __PYX_ERR(0, 1, __pyx_L1_error)
+/*--- Execution code ---*/
+#if defined(__Pyx_Generator_USED) || defined(__Pyx_Coroutine_USED)
+if (__Pyx_patch_abc() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+#endif
+__Pyx_TraceCall("__Pyx_PyMODINIT_FUNC PyInit_libcfaidx(void)", __pyx_f[0], 1, 0, __PYX_ERR(0, 1, __pyx_L1_error));
+/* "pysam/libcfaidx.pyx":48
+* #
+* ###############################################################################
+* import sys             # <<<<<<<<<<<<<<
+* import os
+* import re
+*/
+__pyx_t_2 = __Pyx_ImportDottedModule(__pyx_n_s_sys, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 48, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (PyDict_SetItem(__pyx_d, __pyx_n_s_sys, __pyx_t_2) < 0) __PYX_ERR(0, 48, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":49
+* ###############################################################################
+* import sys
+* import os             # <<<<<<<<<<<<<<
+* import re
+*
+*/
+__pyx_t_2 = __Pyx_ImportDottedModule(__pyx_n_s_os, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 49, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (PyDict_SetItem(__pyx_d, __pyx_n_s_os, __pyx_t_2) < 0) __PYX_ERR(0, 49, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":50
+* import sys
+* import os
+* import re             # <<<<<<<<<<<<<<
+*
+*
+*/
+__pyx_t_2 = __Pyx_ImportDottedModule(__pyx_n_s_re, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 50, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (PyDict_SetItem(__pyx_d, __pyx_n_s_re, __pyx_t_2) < 0) __PYX_ERR(0, 50, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":123
+*         self._open(*args, **kwargs)
+*
+*     def is_open(self):             # <<<<<<<<<<<<<<
+*         '''return true if samfile has been opened.'''
+*         return self.fastafile != NULL
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_9FastaFile_3is_open, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastaFile_is_open, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj_)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 123, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastaFile, __pyx_n_s_is_open, __pyx_t_2) < 0) __PYX_ERR(0, 123, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+PyType_Modified(__pyx_ptype_5pysam_9libcfaidx_FastaFile);
+/* "pysam/libcfaidx.pyx":133
+*         return faidx_nseq(self.fastafile)
+*
+*     def _open(self, filename, filepath_index=None, filepath_index_compressed=None):             # <<<<<<<<<<<<<<
+*         '''open an indexed fasta file.
+*
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_9FastaFile_7_open, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastaFile__open, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__3)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 133, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_CyFunction_SetDefaultsTuple(__pyx_t_2, __pyx_tuple__51);
+if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastaFile, __pyx_n_s_open, __pyx_t_2) < 0) __PYX_ERR(0, 133, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+PyType_Modified(__pyx_ptype_5pysam_9libcfaidx_FastaFile);
+/* "pysam/libcfaidx.pyx":195
+*         self.reference2length = dict(zip(self._references, self._lengths))
+*
+*     def close(self):             # <<<<<<<<<<<<<<
+*         """close the file."""
+*         if self.fastafile != NULL:
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_9FastaFile_9close, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastaFile_close, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__5)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 195, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastaFile, __pyx_n_s_close, __pyx_t_2) < 0) __PYX_ERR(0, 195, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+PyType_Modified(__pyx_ptype_5pysam_9libcfaidx_FastaFile);
+/* "pysam/libcfaidx.pyx":207
+*
+*     # context manager interface
+*     def __enter__(self):             # <<<<<<<<<<<<<<
+*         return self
+*
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_9FastaFile_13__enter__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastaFile___enter, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__6)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 207, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastaFile, __pyx_n_s_enter, __pyx_t_2) < 0) __PYX_ERR(0, 207, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+PyType_Modified(__pyx_ptype_5pysam_9libcfaidx_FastaFile);
+/* "pysam/libcfaidx.pyx":210
+*         return self
+*
+*     def __exit__(self, exc_type, exc_value, traceback):             # <<<<<<<<<<<<<<
+*         self.close()
+*         return False
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_9FastaFile_15__exit__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastaFile___exit, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__7)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 210, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastaFile, __pyx_n_s_exit, __pyx_t_2) < 0) __PYX_ERR(0, 210, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+PyType_Modified(__pyx_ptype_5pysam_9libcfaidx_FastaFile);
+/* "pysam/libcfaidx.pyx":242
+*             return self._lengths
+*
+*     def fetch(self,             # <<<<<<<<<<<<<<
+*               reference=None,
+*               start=None,
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_9FastaFile_17fetch, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastaFile_fetch, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__8)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 242, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_CyFunction_SetDefaultsTuple(__pyx_t_2, __pyx_tuple__54);
+if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastaFile, __pyx_n_s_fetch, __pyx_t_2) < 0) __PYX_ERR(0, 242, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+PyType_Modified(__pyx_ptype_5pysam_9libcfaidx_FastaFile);
+/* "pysam/libcfaidx.pyx":343
+*         return seq
+*
+*     def get_reference_length(self, reference):             # <<<<<<<<<<<<<<
+*         '''return the length of reference.'''
+*         return self.reference2length[reference]
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_9FastaFile_19get_reference_length, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastaFile_get_reference_length, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__12)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 343, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastaFile, __pyx_n_s_get_reference_length, __pyx_t_2) < 0) __PYX_ERR(0, 343, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+PyType_Modified(__pyx_ptype_5pysam_9libcfaidx_FastaFile);
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_9FastaFile_25__reduce_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastaFile___reduce_cython, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__13)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 1, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (PyDict_SetItem(__pyx_d, __pyx_n_s_reduce_cython, __pyx_t_2) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+/* "(tree fragment)":3
+* def __reduce_cython__(self):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_9FastaFile_27__setstate_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastaFile___setstate_cython, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__14)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 3, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (PyDict_SetItem(__pyx_d, __pyx_n_s_setstate_cython, __pyx_t_2) < 0) __PYX_ERR(1, 3, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":404
+*         return self.to_string()
+*
+*     cpdef array.array get_quality_array(self, int offset=33):             # <<<<<<<<<<<<<<
+*         '''return quality values as integer array after subtracting offset.'''
+*         if self.quality is None:
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_10FastqProxy_5get_quality_array, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastqProxy_get_quality_array, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__20)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 404, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_CyFunction_SetDefaultsTuple(__pyx_t_2, __pyx_tuple__58);
+if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastqProxy, __pyx_n_s_get_quality_array, __pyx_t_2) < 0) __PYX_ERR(0, 404, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+PyType_Modified(__pyx_ptype_5pysam_9libcfaidx_FastqProxy);
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     raise TypeError, "self._delegate cannot be converted to a Python object for pickling"
+* def __setstate_cython__(self, __pyx_state):
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_10FastqProxy_7__reduce_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastqProxy___reduce_cython, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__21)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 1, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (PyDict_SetItem(__pyx_d, __pyx_n_s_reduce_cython, __pyx_t_2) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+/* "(tree fragment)":3
+* def __reduce_cython__(self):
+*     raise TypeError, "self._delegate cannot be converted to a Python object for pickling"
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     raise TypeError, "self._delegate cannot be converted to a Python object for pickling"
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_10FastqProxy_9__setstate_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastqProxy___setstate_cython, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__22)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 3, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (PyDict_SetItem(__pyx_d, __pyx_n_s_setstate_cython, __pyx_t_2) < 0) __PYX_ERR(1, 3, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":435
+*             self.name = name
+*
+*     def __copy__(self):             # <<<<<<<<<<<<<<
+*         return FastxRecord(self.name, self.comment, self.sequence, self.quality)
+*
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_11FastxRecord_3__copy__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastxRecord___copy, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__23)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 435, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastxRecord, __pyx_n_s_copy, __pyx_t_2) < 0) __PYX_ERR(0, 435, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+PyType_Modified(__pyx_ptype_5pysam_9libcfaidx_FastxRecord);
+/* "pysam/libcfaidx.pyx":438
+*         return FastxRecord(self.name, self.comment, self.sequence, self.quality)
+*
+*     def __deepcopy__(self, memo):             # <<<<<<<<<<<<<<
+*         return FastxRecord(self.name, self.comment, self.sequence, self.quality)
+*
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_11FastxRecord_5__deepcopy__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastxRecord___deepcopy, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__24)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 438, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastxRecord, __pyx_n_s_deepcopy, __pyx_t_2) < 0) __PYX_ERR(0, 438, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+PyType_Modified(__pyx_ptype_5pysam_9libcfaidx_FastxRecord);
+/* "pysam/libcfaidx.pyx":463
+*         return self.to_string()
+*
+*     def set_name(self, name):             # <<<<<<<<<<<<<<
+*         if name is None:
+*             raise ValueError("FastxRecord must have a name and not None")
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_11FastxRecord_7set_name, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastxRecord_set_name, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__27)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 463, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastxRecord, __pyx_n_s_set_name, __pyx_t_2) < 0) __PYX_ERR(0, 463, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+PyType_Modified(__pyx_ptype_5pysam_9libcfaidx_FastxRecord);
+/* "pysam/libcfaidx.pyx":468
+*         self.name = name
+*
+*     def set_comment(self, comment):             # <<<<<<<<<<<<<<
+*         self.comment = comment
+*
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_11FastxRecord_9set_comment, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastxRecord_set_comment, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__29)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 468, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastxRecord, __pyx_n_s_set_comment, __pyx_t_2) < 0) __PYX_ERR(0, 468, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+PyType_Modified(__pyx_ptype_5pysam_9libcfaidx_FastxRecord);
+/* "pysam/libcfaidx.pyx":471
+*         self.comment = comment
+*
+*     def set_sequence(self, sequence, quality=None):             # <<<<<<<<<<<<<<
+*         """set sequence of this record.
+*
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_11FastxRecord_11set_sequence, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastxRecord_set_sequence, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__30)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 471, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_CyFunction_SetDefaultsTuple(__pyx_t_2, __pyx_tuple__63);
+if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastxRecord, __pyx_n_s_set_sequence, __pyx_t_2) < 0) __PYX_ERR(0, 471, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+PyType_Modified(__pyx_ptype_5pysam_9libcfaidx_FastxRecord);
+/* "pysam/libcfaidx.pyx":488
+*         return self.to_string()
+*
+*     cpdef array.array get_quality_array(self, int offset=33):             # <<<<<<<<<<<<<<
+*         '''return quality values as array after subtracting offset.'''
+*         if self.quality is None:
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_11FastxRecord_15get_quality_array, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastxRecord_get_quality_array, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__31)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 488, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_CyFunction_SetDefaultsTuple(__pyx_t_2, __pyx_tuple__58);
+if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastxRecord, __pyx_n_s_get_quality_array, __pyx_t_2) < 0) __PYX_ERR(0, 488, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+PyType_Modified(__pyx_ptype_5pysam_9libcfaidx_FastxRecord);
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     cdef tuple state
+*     cdef object _dict
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_11FastxRecord_17__reduce_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastxRecord___reduce_cython, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__32)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 1, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastxRecord, __pyx_n_s_reduce_cython, __pyx_t_2) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+PyType_Modified(__pyx_ptype_5pysam_9libcfaidx_FastxRecord);
+/* "(tree fragment)":16
+*     else:
+*         return __pyx_unpickle_FastxRecord, (type(self), 0x1bdb611, state)
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     __pyx_unpickle_FastxRecord__set_state(self, __pyx_state)
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_11FastxRecord_19__setstate_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastxRecord___setstate_cython, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__33)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 16, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastxRecord, __pyx_n_s_setstate_cython, __pyx_t_2) < 0) __PYX_ERR(1, 16, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+PyType_Modified(__pyx_ptype_5pysam_9libcfaidx_FastxRecord);
+/* "pysam/libcfaidx.pyx":551
+*         self._open(*args, **kwargs)
+*
+*     def is_open(self):             # <<<<<<<<<<<<<<
+*         '''return true if samfile has been opened.'''
+*         return self.entry != NULL
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_9FastxFile_3is_open, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastxFile_is_open, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__34)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 551, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastxFile, __pyx_n_s_is_open, __pyx_t_2) < 0) __PYX_ERR(0, 551, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+PyType_Modified(__pyx_ptype_5pysam_9libcfaidx_FastxFile);
+/* "pysam/libcfaidx.pyx":555
+*         return self.entry != NULL
+*
+*     def _open(self, filename, persist=True):             # <<<<<<<<<<<<<<
+*         '''open a fastq/fasta file in *filename*
+*
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_9FastxFile_5_open, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastxFile__open, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__35)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 555, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_CyFunction_SetDefaultsTuple(__pyx_t_2, __pyx_tuple__66);
+if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastxFile, __pyx_n_s_open, __pyx_t_2) < 0) __PYX_ERR(0, 555, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+PyType_Modified(__pyx_ptype_5pysam_9libcfaidx_FastxFile);
+/* "pysam/libcfaidx.pyx":588
+*         self._filename = filename
+*
+*     def close(self):             # <<<<<<<<<<<<<<
+*         '''close the file.'''
+*         if self.fastqfile != NULL:
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_9FastxFile_7close, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastxFile_close, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__36)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 588, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastxFile, __pyx_n_s_close, __pyx_t_2) < 0) __PYX_ERR(0, 588, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+PyType_Modified(__pyx_ptype_5pysam_9libcfaidx_FastxFile);
+/* "pysam/libcfaidx.pyx":604
+*
+*     # context manager interface
+*     def __enter__(self):             # <<<<<<<<<<<<<<
+*         return self
+*
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_9FastxFile_11__enter__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastxFile___enter, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__37)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 604, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastxFile, __pyx_n_s_enter, __pyx_t_2) < 0) __PYX_ERR(0, 604, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+PyType_Modified(__pyx_ptype_5pysam_9libcfaidx_FastxFile);
+/* "pysam/libcfaidx.pyx":607
+*         return self
+*
+*     def __exit__(self, exc_type, exc_value, traceback):             # <<<<<<<<<<<<<<
+*         self.close()
+*         return False
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_9FastxFile_13__exit__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastxFile___exit, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__38)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 607, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libcfaidx_FastxFile, __pyx_n_s_exit, __pyx_t_2) < 0) __PYX_ERR(0, 607, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+PyType_Modified(__pyx_ptype_5pysam_9libcfaidx_FastxFile);
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_9FastxFile_19__reduce_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastxFile___reduce_cython, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__39)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 1, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (PyDict_SetItem(__pyx_d, __pyx_n_s_reduce_cython, __pyx_t_2) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+/* "(tree fragment)":3
+* def __reduce_cython__(self):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_9FastxFile_21__setstate_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastxFile___setstate_cython, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__40)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 3, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (PyDict_SetItem(__pyx_d, __pyx_n_s_setstate_cython, __pyx_t_2) < 0) __PYX_ERR(1, 3, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_9FastqFile_1__reduce_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastqFile___reduce_cython, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__41)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 1, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (PyDict_SetItem(__pyx_d, __pyx_n_s_reduce_cython, __pyx_t_2) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+/* "(tree fragment)":3
+* def __reduce_cython__(self):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_9FastqFile_3__setstate_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_FastqFile___setstate_cython, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__42)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 3, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (PyDict_SetItem(__pyx_d, __pyx_n_s_setstate_cython, __pyx_t_2) < 0) __PYX_ERR(1, 3, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+/* "(tree fragment)":1
+* def __reduce_cython__(self):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_9Fastafile_1__reduce_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_Fastafile___reduce_cython, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__43)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 1, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (PyDict_SetItem(__pyx_d, __pyx_n_s_reduce_cython, __pyx_t_2) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+/* "(tree fragment)":3
+* def __reduce_cython__(self):
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+* def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
+*     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_9Fastafile_3__setstate_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_Fastafile___setstate_cython, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__44)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 3, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (PyDict_SetItem(__pyx_d, __pyx_n_s_setstate_cython, __pyx_t_2) < 0) __PYX_ERR(1, 3, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":667
+*     pass
+*
+* __all__ = ["FastaFile",             # <<<<<<<<<<<<<<
+*            "FastqFile",
+*            "FastxFile",
+*/
+__pyx_t_2 = PyList_New(6); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 667, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+__Pyx_INCREF(__pyx_n_u_FastaFile);
+__Pyx_GIVEREF(__pyx_n_u_FastaFile);
+if (__Pyx_PyList_SET_ITEM(__pyx_t_2, 0, __pyx_n_u_FastaFile)) __PYX_ERR(0, 667, __pyx_L1_error);
+__Pyx_INCREF(__pyx_n_u_FastqFile);
+__Pyx_GIVEREF(__pyx_n_u_FastqFile);
+if (__Pyx_PyList_SET_ITEM(__pyx_t_2, 1, __pyx_n_u_FastqFile)) __PYX_ERR(0, 667, __pyx_L1_error);
+__Pyx_INCREF(__pyx_n_u_FastxFile);
+__Pyx_GIVEREF(__pyx_n_u_FastxFile);
+if (__Pyx_PyList_SET_ITEM(__pyx_t_2, 2, __pyx_n_u_FastxFile)) __PYX_ERR(0, 667, __pyx_L1_error);
+__Pyx_INCREF(__pyx_n_u_Fastafile);
+__Pyx_GIVEREF(__pyx_n_u_Fastafile);
+if (__Pyx_PyList_SET_ITEM(__pyx_t_2, 3, __pyx_n_u_Fastafile)) __PYX_ERR(0, 667, __pyx_L1_error);
+__Pyx_INCREF(__pyx_n_u_FastxRecord);
+__Pyx_GIVEREF(__pyx_n_u_FastxRecord);
+if (__Pyx_PyList_SET_ITEM(__pyx_t_2, 4, __pyx_n_u_FastxRecord)) __PYX_ERR(0, 667, __pyx_L1_error);
+__Pyx_INCREF(__pyx_n_u_FastqProxy);
+__Pyx_GIVEREF(__pyx_n_u_FastqProxy);
+if (__Pyx_PyList_SET_ITEM(__pyx_t_2, 5, __pyx_n_u_FastqProxy)) __PYX_ERR(0, 667, __pyx_L1_error);
+if (PyDict_SetItem(__pyx_d, __pyx_n_s_all, __pyx_t_2) < 0) __PYX_ERR(0, 667, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+/* "(tree fragment)":1
+* def __pyx_unpickle_FastxRecord(__pyx_type, long __pyx_checksum, __pyx_state):             # <<<<<<<<<<<<<<
+*     cdef object __pyx_PickleError
+*     cdef object __pyx_result
+*/
+__pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libcfaidx_1__pyx_unpickle_FastxRecord, 0, __pyx_n_s_pyx_unpickle_FastxRecord, NULL, __pyx_n_s_pysam_libcfaidx, __pyx_d, ((PyObject *)__pyx_codeobj__45)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 1, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (PyDict_SetItem(__pyx_d, __pyx_n_s_pyx_unpickle_FastxRecord, __pyx_t_2) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+/* "pysam/libcfaidx.pyx":1
+* # cython: embedsignature=True             # <<<<<<<<<<<<<<
+* # cython: profile=True
+* ###############################################################################
+*/
+__pyx_t_2 = __Pyx_PyDict_NewPresized(0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1, __pyx_L1_error)
+__Pyx_GOTREF(__pyx_t_2);
+if (PyDict_SetItem(__pyx_d, __pyx_n_s_test, __pyx_t_2) < 0) __PYX_ERR(0, 1, __pyx_L1_error)
+__Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+__Pyx_TraceReturn(Py_None, 0);
+/*--- Wrapped vars code ---*/
+goto __pyx_L0;
+__pyx_L1_error:;
+__Pyx_XDECREF(__pyx_t_2);
+if (__pyx_m) {
+if (__pyx_d && stringtab_initialized) {
+__Pyx_AddTraceback("init pysam.libcfaidx", __pyx_clineno, __pyx_lineno, __pyx_filename);
+}
+#if !CYTHON_USE_MODULE_STATE
+Py_CLEAR(__pyx_m);
+#else
+Py_DECREF(__pyx_m);
+if (pystate_addmodule_run) {
+PyObject *tp, *value, *tb;
+PyErr_Fetch(&tp, &value, &tb);
+PyState_RemoveModule(&__pyx_moduledef);
+PyErr_Restore(tp, value, tb);
+}
+#endif
+} else if (!PyErr_Occurred()) {
+PyErr_SetString(PyExc_ImportError, "init pysam.libcfaidx");
+}
+__pyx_L0:;
+__Pyx_RefNannyFinishContext();
+#if CYTHON_PEP489_MULTI_PHASE_INIT
+return (__pyx_m != NULL) ? 0 : -1;
+#elif PY_MAJOR_VERSION >= 3
+return __pyx_m;
+#else
+return;
+#endif
+}
+/* #### Code section: cleanup_globals ### */
+/* #### Code section: cleanup_module ### */
+/* #### Code section: main_method ### */
+/* #### Code section: utility_code_pragmas ### */
+#ifdef _MSC_VER
+#pragma warning( push )
+/* Warning 4127: conditional expression is constant
+* Cython uses constant conditional expressions to allow in inline functions to be optimized at
+* compile-time, so this warning is not useful
+*/
+#pragma warning( disable : 4127 )
+#endif
+/* #### Code section: utility_code_def ### */
+/* --- Runtime support code --- */
+/* Refnanny */
+#if CYTHON_REFNANNY
+static __Pyx_RefNannyAPIStruct *__Pyx_RefNannyImportAPI(const char *modname) {
+PyObject *m = NULL, *p = NULL;
+void *r = NULL;
+m = PyImport_ImportModule(modname);
+if (!m) goto end;
+p = PyObject_GetAttrString(m, "RefNannyAPI");
+if (!p) goto end;
+r = PyLong_AsVoidPtr(p);
+end:
+Py_XDECREF(p);
+Py_XDECREF(m);
+return (__Pyx_RefNannyAPIStruct *)r;
+}
+#endif
+/* PyErrExceptionMatches */
+#if CYTHON_FAST_THREAD_STATE
+static int __Pyx_PyErr_ExceptionMatchesTuple(PyObject *exc_type, PyObject *tuple) {
+Py_ssize_t i, n;
+n = PyTuple_GET_SIZE(tuple);
+#if PY_MAJOR_VERSION >= 3
+for (i=0; i<n; i++) {
+if (exc_type == PyTuple_GET_ITEM(tuple, i)) return 1;
+}
+#endif
+for (i=0; i<n; i++) {
+if (__Pyx_PyErr_GivenExceptionMatches(exc_type, PyTuple_GET_ITEM(tuple, i))) return 1;
+}
+return 0;
+}
+static CYTHON_INLINE int __Pyx_PyErr_ExceptionMatchesInState(PyThreadState* tstate, PyObject* err) {
+int result;
+PyObject *exc_type;
+#if PY_VERSION_HEX >= 0x030C00A6
+PyObject *current_exception = tstate->current_exception;
+if (unlikely(!current_exception)) return 0;
+exc_type = (PyObject*) Py_TYPE(current_exception);
+if (exc_type == err) return 1;
+#else
+exc_type = tstate->curexc_type;
+if (exc_type == err) return 1;
+if (unlikely(!exc_type)) return 0;
+#endif
+#if CYTHON_AVOID_BORROWED_REFS
+Py_INCREF(exc_type);
+#endif
+if (unlikely(PyTuple_Check(err))) {
+result = __Pyx_PyErr_ExceptionMatchesTuple(exc_type, err);
+} else {
+result = __Pyx_PyErr_GivenExceptionMatches(exc_type, err);
+}
+#if CYTHON_AVOID_BORROWED_REFS
+Py_DECREF(exc_type);
+#endif
+return result;
+}
+#endif
+/* PyErrFetchRestore */
+#if CYTHON_FAST_THREAD_STATE
+static CYTHON_INLINE void __Pyx_ErrRestoreInState(PyThreadState *tstate, PyObject *type, PyObject *value, PyObject *tb) {
+#if PY_VERSION_HEX >= 0x030C00A6
+PyObject *tmp_value;
+assert(type == NULL || (value != NULL && type == (PyObject*) Py_TYPE(value)));
+if (value) {
+#if CYTHON_COMPILING_IN_CPYTHON
+if (unlikely(((PyBaseExceptionObject*) value)->traceback != tb))
+#endif
+PyException_SetTraceback(value, tb);
+}
+tmp_value = tstate->current_exception;
+tstate->current_exception = value;
+Py_XDECREF(tmp_value);
+Py_XDECREF(type);
+Py_XDECREF(tb);
+#else
+PyObject *tmp_type, *tmp_value, *tmp_tb;
+tmp_type = tstate->curexc_type;
+tmp_value = tstate->curexc_value;
+tmp_tb = tstate->curexc_traceback;
+tstate->curexc_type = type;
+tstate->curexc_value = value;
+tstate->curexc_traceback = tb;
+Py_XDECREF(tmp_type);
+Py_XDECREF(tmp_value);
+Py_XDECREF(tmp_tb);
+#endif
+}
+static CYTHON_INLINE void __Pyx_ErrFetchInState(PyThreadState *tstate, PyObject **type, PyObject **value, PyObject **tb) {
+#if PY_VERSION_HEX >= 0x030C00A6
+PyObject* exc_value;
+exc_value = tstate->current_exception;
+tstate->current_exception = 0;
+*value = exc_value;
+*type = NULL;
+*tb = NULL;
+if (exc_value) {
+*type = (PyObject*) Py_TYPE(exc_value);
+Py_INCREF(*type);
+#if CYTHON_COMPILING_IN_CPYTHON
+*tb = ((PyBaseExceptionObject*) exc_value)->traceback;
+Py_XINCREF(*tb);
+#else
+*tb = PyException_GetTraceback(exc_value);
+#endif
+}
+#else
+*type = tstate->curexc_type;
+*value = tstate->curexc_value;
+*tb = tstate->curexc_traceback;
+tstate->curexc_type = 0;
+tstate->curexc_value = 0;
+tstate->curexc_traceback = 0;
+#endif
+}
+#endif
+/* PyObjectGetAttrStr */
+#if CYTHON_USE_TYPE_SLOTS
+static CYTHON_INLINE PyObject* __Pyx_PyObject_GetAttrStr(PyObject* obj, PyObject* attr_name) {
+PyTypeObject* tp = Py_TYPE(obj);
+if (likely(tp->tp_getattro))
+return tp->tp_getattro(obj, attr_name);
+#if PY_MAJOR_VERSION < 3
+if (likely(tp->tp_getattr))
+return tp->tp_getattr(obj, PyString_AS_STRING(attr_name));
+#endif
+return PyObject_GetAttr(obj, attr_name);
+}
+#endif
+/* PyObjectGetAttrStrNoError */
+#if __PYX_LIMITED_VERSION_HEX < 0x030d00A1
+static void __Pyx_PyObject_GetAttrStr_ClearAttributeError(void) {
+__Pyx_PyThreadState_declare
+__Pyx_PyThreadState_assign
+if (likely(__Pyx_PyErr_ExceptionMatches(PyExc_AttributeError)))
+__Pyx_PyErr_Clear();
+}
+#endif
+static CYTHON_INLINE PyObject* __Pyx_PyObject_GetAttrStrNoError(PyObject* obj, PyObject* attr_name) {
+PyObject *result;
+#if __PYX_LIMITED_VERSION_HEX >= 0x030d00A1
+(void) PyObject_GetOptionalAttr(obj, attr_name, &result);
+return result;
+#else
+#if CYTHON_COMPILING_IN_CPYTHON && CYTHON_USE_TYPE_SLOTS && PY_VERSION_HEX >= 0x030700B1
+PyTypeObject* tp = Py_TYPE(obj);
+if (likely(tp->tp_getattro == PyObject_GenericGetAttr)) {
+return _PyObject_GenericGetAttrWithDict(obj, attr_name, NULL, 1);
+}
+#endif
+result = __Pyx_PyObject_GetAttrStr(obj, attr_name);
+if (unlikely(!result)) {
+__Pyx_PyObject_GetAttrStr_ClearAttributeError();
+}
+return result;
+#endif
+}
+/* GetBuiltinName */
+static PyObject *__Pyx_GetBuiltinName(PyObject *name) {
+PyObject* result = __Pyx_PyObject_GetAttrStrNoError(__pyx_b, name);
+if (unlikely(!result) && !PyErr_Occurred()) {
+PyErr_Format(PyExc_NameError,
+#if PY_MAJOR_VERSION >= 3
+"name '%U' is not defined", name);
+#else
+"name '%.200s' is not defined", PyString_AS_STRING(name));
+#endif
+}
+return result;
+}
+/* TupleAndListFromArray */
+#if CYTHON_COMPILING_IN_CPYTHON
+static CYTHON_INLINE void __Pyx_copy_object_array(PyObject *const *CYTHON_RESTRICT src, PyObject** CYTHON_RESTRICT dest, Py_ssize_t length) {
+PyObject *v;
+Py_ssize_t i;
+for (i = 0; i < length; i++) {
+v = dest[i] = src[i];
+Py_INCREF(v);
+}
+}
+static CYTHON_INLINE PyObject *
+__Pyx_PyTuple_FromArray(PyObject *const *src, Py_ssize_t n)
+{
+PyObject *res;
+if (n <= 0) {
+Py_INCREF(__pyx_empty_tuple);
+return __pyx_empty_tuple;
+}
+res = PyTuple_New(n);
+if (unlikely(res == NULL)) return NULL;
+__Pyx_copy_object_array(src, ((PyTupleObject*)res)->ob_item, n);
+return res;
+}
+static CYTHON_INLINE PyObject *
+__Pyx_PyList_FromArray(PyObject *const *src, Py_ssize_t n)
+{
+PyObject *res;
+if (n <= 0) {
+return PyList_New(0);
+}
+res = PyList_New(n);
+if (unlikely(res == NULL)) return NULL;
+__Pyx_copy_object_array(src, ((PyListObject*)res)->ob_item, n);
+return res;
+}
+#endif
+/* BytesEquals */
+static CYTHON_INLINE int __Pyx_PyBytes_Equals(PyObject* s1, PyObject* s2, int equals) {
+#if CYTHON_COMPILING_IN_PYPY || CYTHON_COMPILING_IN_LIMITED_API
+return PyObject_RichCompareBool(s1, s2, equals);
+#else
+if (s1 == s2) {
+return (equals == Py_EQ);
+} else if (PyBytes_CheckExact(s1) & PyBytes_CheckExact(s2)) {
+const char *ps1, *ps2;
+Py_ssize_t length = PyBytes_GET_SIZE(s1);
+if (length != PyBytes_GET_SIZE(s2))
+return (equals == Py_NE);
+ps1 = PyBytes_AS_STRING(s1);
+ps2 = PyBytes_AS_STRING(s2);
+if (ps1[0] != ps2[0]) {
+return (equals == Py_NE);
+} else if (length == 1) {
+return (equals == Py_EQ);
+} else {
+int result;
+#if CYTHON_USE_UNICODE_INTERNALS && (PY_VERSION_HEX < 0x030B0000)
+Py_hash_t hash1, hash2;
+hash1 = ((PyBytesObject*)s1)->ob_shash;
+hash2 = ((PyBytesObject*)s2)->ob_shash;
+if (hash1 != hash2 && hash1 != -1 && hash2 != -1) {
+return (equals == Py_NE);
+}
+#endif
+result = memcmp(ps1, ps2, (size_t)length);
+return (equals == Py_EQ) ? (result == 0) : (result != 0);
+}
+} else if ((s1 == Py_None) & PyBytes_CheckExact(s2)) {
+return (equals == Py_NE);
+} else if ((s2 == Py_None) & PyBytes_CheckExact(s1)) {
+return (equals == Py_NE);
+} else {
+int result;
+PyObject* py_result = PyObject_RichCompare(s1, s2, equals);
+if (!py_result)
+return -1;
+result = __Pyx_PyObject_IsTrue(py_result);
+Py_DECREF(py_result);
+return result;
+}
+#endif
+}
+/* UnicodeEquals */
+static CYTHON_INLINE int __Pyx_PyUnicode_Equals(PyObject* s1, PyObject* s2, int equals) {
+#if CYTHON_COMPILING_IN_PYPY || CYTHON_COMPILING_IN_LIMITED_API
+return PyObject_RichCompareBool(s1, s2, equals);
+#else
+#if PY_MAJOR_VERSION < 3
+PyObject* owned_ref = NULL;
+#endif
+int s1_is_unicode, s2_is_unicode;
+if (s1 == s2) {
+goto return_eq;
+}
+s1_is_unicode = PyUnicode_CheckExact(s1);
+s2_is_unicode = PyUnicode_CheckExact(s2);
+#if PY_MAJOR_VERSION < 3
+if ((s1_is_unicode & (!s2_is_unicode)) && PyString_CheckExact(s2)) {
+owned_ref = PyUnicode_FromObject(s2);
+if (unlikely(!owned_ref))
+return -1;
+s2 = owned_ref;
+s2_is_unicode = 1;
+} else if ((s2_is_unicode & (!s1_is_unicode)) && PyString_CheckExact(s1)) {
+owned_ref = PyUnicode_FromObject(s1);
+if (unlikely(!owned_ref))
+return -1;
+s1 = owned_ref;
+s1_is_unicode = 1;
+} else if (((!s2_is_unicode) & (!s1_is_unicode))) {
+return __Pyx_PyBytes_Equals(s1, s2, equals);
+}
+#endif
+if (s1_is_unicode & s2_is_unicode) {
+Py_ssize_t length;
+int kind;
+void *data1, *data2;
+if (unlikely(__Pyx_PyUnicode_READY(s1) < 0) || unlikely(__Pyx_PyUnicode_READY(s2) < 0))
+return -1;
+length = __Pyx_PyUnicode_GET_LENGTH(s1);
+if (length != __Pyx_PyUnicode_GET_LENGTH(s2)) {
+goto return_ne;
+}
+#if CYTHON_USE_UNICODE_INTERNALS
+{
+Py_hash_t hash1, hash2;
+#if CYTHON_PEP393_ENABLED
+hash1 = ((PyASCIIObject*)s1)->hash;
+hash2 = ((PyASCIIObject*)s2)->hash;
+#else
+hash1 = ((PyUnicodeObject*)s1)->hash;
+hash2 = ((PyUnicodeObject*)s2)->hash;
+#endif
+if (hash1 != hash2 && hash1 != -1 && hash2 != -1) {
+goto return_ne;
+}
+}
+#endif
+kind = __Pyx_PyUnicode_KIND(s1);
+if (kind != __Pyx_PyUnicode_KIND(s2)) {
+goto return_ne;
+}
+data1 = __Pyx_PyUnicode_DATA(s1);
+data2 = __Pyx_PyUnicode_DATA(s2);
+if (__Pyx_PyUnicode_READ(kind, data1, 0) != __Pyx_PyUnicode_READ(kind, data2, 0)) {
+goto return_ne;
+} else if (length == 1) {
+goto return_eq;
+} else {
+int result = memcmp(data1, data2, (size_t)(length * kind));
+#if PY_MAJOR_VERSION < 3
+Py_XDECREF(owned_ref);
+#endif
+return (equals == Py_EQ) ? (result == 0) : (result != 0);
+}
+} else if ((s1 == Py_None) & s2_is_unicode) {
+goto return_ne;
+} else if ((s2 == Py_None) & s1_is_unicode) {
+goto return_ne;
+} else {
+int result;
+PyObject* py_result = PyObject_RichCompare(s1, s2, equals);
+#if PY_MAJOR_VERSION < 3
+Py_XDECREF(owned_ref);
+#endif
+if (!py_result)
+return -1;
+result = __Pyx_PyObject_IsTrue(py_result);
+Py_DECREF(py_result);
+return result;
+}
+return_eq:
+#if PY_MAJOR_VERSION < 3
+Py_XDECREF(owned_ref);
+#endif
+return (equals == Py_EQ);
+return_ne:
+#if PY_MAJOR_VERSION < 3
+Py_XDECREF(owned_ref);
+#endif
+return (equals == Py_NE);
+#endif
+}
+/* fastcall */
+#if CYTHON_METH_FASTCALL
+static CYTHON_INLINE PyObject * __Pyx_GetKwValue_FASTCALL(PyObject *kwnames, PyObject *const *kwvalues, PyObject *s)
+{
+Py_ssize_t i, n = PyTuple_GET_SIZE(kwnames);
+for (i = 0; i < n; i++)
+{
+if (s == PyTuple_GET_ITEM(kwnames, i)) return kwvalues[i];
+}
+for (i = 0; i < n; i++)
+{
+int eq = __Pyx_PyUnicode_Equals(s, PyTuple_GET_ITEM(kwnames, i), Py_EQ);
+if (unlikely(eq != 0)) {
+if (unlikely(eq < 0)) return NULL;
+return kwvalues[i];
+}
+}
+return NULL;
+}
+#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX >= 0x030d0000
+CYTHON_UNUSED static PyObject *__Pyx_KwargsAsDict_FASTCALL(PyObject *kwnames, PyObject *const *kwvalues) {
+Py_ssize_t i, nkwargs = PyTuple_GET_SIZE(kwnames);
+PyObject *dict;
+dict = PyDict_New();
+if (unlikely(!dict))
+return NULL;
+for (i=0; i<nkwargs; i++) {
+PyObject *key = PyTuple_GET_ITEM(kwnames, i);
+if (unlikely(PyDict_SetItem(dict, key, kwvalues[i]) < 0))
+goto bad;
+}
+return dict;
+bad:
+Py_DECREF(dict);
+return NULL;
+}
+#endif
+#endif
+/* Profile */
+#if CYTHON_PROFILE
+static int __Pyx_TraceSetupAndCall(PyCodeObject** code,
+PyFrameObject** frame,
+PyThreadState* tstate,
+const char *funcname,
+const char *srcfile,
+int firstlineno) {
+PyObject *type, *value, *traceback;
+int retval;
+if (*frame == NULL || !CYTHON_PROFILE_REUSE_FRAME) {
+if (*code == NULL) {
+*code = __Pyx_createFrameCodeObject(funcname, srcfile, firstlineno);
+if (*code == NULL) return 0;
+}
+*frame = PyFrame_New(
+tstate,                          /*PyThreadState *tstate*/
+*code,                           /*PyCodeObject *code*/
+__pyx_d,                  /*PyObject *globals*/
+0                                /*PyObject *locals*/
+);
+if (*frame == NULL) return 0;
+if (CYTHON_TRACE && (*frame)->f_trace == NULL) {
+Py_INCREF(Py_None);
+(*frame)->f_trace = Py_None;
+}
+#if PY_VERSION_HEX < 0x030400B1
+} else {
+(*frame)->f_tstate = tstate;
+#endif
+}
+__Pyx_PyFrame_SetLineNumber(*frame, firstlineno);
+retval = 1;
+__Pyx_EnterTracing(tstate);
+__Pyx_ErrFetchInState(tstate, &type, &value, &traceback);
+#if CYTHON_TRACE
+if (tstate->c_tracefunc)
+retval = tstate->c_tracefunc(tstate->c_traceobj, *frame, PyTrace_CALL, NULL) == 0;
+if (retval && tstate->c_profilefunc)
+#endif
+retval = tstate->c_profilefunc(tstate->c_profileobj, *frame, PyTrace_CALL, NULL) == 0;
+__Pyx_LeaveTracing(tstate);
+if (retval) {
+__Pyx_ErrRestoreInState(tstate, type, value, traceback);
+return __Pyx_IsTracing(tstate, 0, 0) && retval;
+} else {
+Py_XDECREF(type);
+Py_XDECREF(value);
+Py_XDECREF(traceback);
+return -1;
+}
+}
+static PyCodeObject *__Pyx_createFrameCodeObject(const char *funcname, const char *srcfile, int firstlineno) {
+PyCodeObject *py_code = 0;
+#if PY_MAJOR_VERSION >= 3
+py_code = PyCode_NewEmpty(srcfile, funcname, firstlineno);
+if (likely(py_code)) {
+py_code->co_flags |= CO_OPTIMIZED | CO_NEWLOCALS;
+}
+#else
+PyObject *py_srcfile = 0;
+PyObject *py_funcname = 0;
+py_funcname = PyString_FromString(funcname);
+if (unlikely(!py_funcname)) goto bad;
+py_srcfile = PyString_FromString(srcfile);
+if (unlikely(!py_srcfile)) goto bad;
+py_code = PyCode_New(
+0,
+0,
+0,
+CO_OPTIMIZED | CO_NEWLOCALS,
+__pyx_empty_bytes,     /*PyObject *code,*/
+__pyx_empty_tuple,     /*PyObject *consts,*/
+__pyx_empty_tuple,     /*PyObject *names,*/
+__pyx_empty_tuple,     /*PyObject *varnames,*/
+__pyx_empty_tuple,     /*PyObject *freevars,*/
+__pyx_empty_tuple,     /*PyObject *cellvars,*/
+py_srcfile,       /*PyObject *filename,*/
+py_funcname,      /*PyObject *name,*/
+firstlineno,
+__pyx_empty_bytes      /*PyObject *lnotab*/
+);
+bad:
+Py_XDECREF(py_srcfile);
+Py_XDECREF(py_funcname);
+#endif
+return py_code;
+}
+#endif
+/* KeywordStringCheck */
+static int __Pyx_CheckKeywordStrings(
+PyObject *kw,
+const char* function_name,
+int kw_allowed)
+{
+PyObject* key = 0;
+Py_ssize_t pos = 0;
+#if CYTHON_COMPILING_IN_PYPY
+if (!kw_allowed && PyDict_Next(kw, &pos, &key, 0))
+goto invalid_keyword;
+return 1;
+#else
+if (CYTHON_METH_FASTCALL && likely(PyTuple_Check(kw))) {
+Py_ssize_t kwsize;
+#if CYTHON_ASSUME_SAFE_MACROS
+kwsize = PyTuple_GET_SIZE(kw);
+#else
+kwsize = PyTuple_Size(kw);
+if (kwsize < 0) return 0;
+#endif
+if (unlikely(kwsize == 0))
+return 1;
+if (!kw_allowed) {
+#if CYTHON_ASSUME_SAFE_MACROS
+key = PyTuple_GET_ITEM(kw, 0);
+#else
+key = PyTuple_GetItem(kw, pos);
+if (!key) return 0;
+#endif
+goto invalid_keyword;
+}
+#if PY_VERSION_HEX < 0x03090000
+for (pos = 0; pos < kwsize; pos++) {
+#if CYTHON_ASSUME_SAFE_MACROS
+key = PyTuple_GET_ITEM(kw, pos);
+#else
+key = PyTuple_GetItem(kw, pos);
+if (!key) return 0;
+#endif
+if (unlikely(!PyUnicode_Check(key)))
+goto invalid_keyword_type;
+}
+#endif
+return 1;
+}
+while (PyDict_Next(kw, &pos, &key, 0)) {
+#if PY_MAJOR_VERSION < 3
+if (unlikely(!PyString_Check(key)))
+#endif
+if (unlikely(!PyUnicode_Check(key)))
+goto invalid_keyword_type;
+}
+if (!kw_allowed && unlikely(key))
+goto invalid_keyword;
+return 1;
+invalid_keyword_type:
+PyErr_Format(PyExc_TypeError,
+"%.200s() keywords must be strings", function_name);
+return 0;
+#endif
+invalid_keyword:
+#if PY_MAJOR_VERSION < 3
+PyErr_Format(PyExc_TypeError,
+"%.200s() got an unexpected keyword argument '%.200s'",
+function_name, PyString_AsString(key));
+#else
+PyErr_Format(PyExc_TypeError,
+"%s() got an unexpected keyword argument '%U'",
+function_name, key);
+#endif
+return 0;
+}
+/* PyObjectCall */
+#if CYTHON_COMPILING_IN_CPYTHON
+static CYTHON_INLINE PyObject* __Pyx_PyObject_Call(PyObject *func, PyObject *arg, PyObject *kw) {
+PyObject *result;
+ternaryfunc call = Py_TYPE(func)->tp_call;
+if (unlikely(!call))
+return PyObject_Call(func, arg, kw);
+#if PY_MAJOR_VERSION < 3
+if (unlikely(Py_EnterRecursiveCall((char*)" while calling a Python object")))
+return NULL;
+#else
+if (unlikely(Py_EnterRecursiveCall(" while calling a Python object")))
+return NULL;
+#endif
+result = (*call)(func, arg, kw);
+Py_LeaveRecursiveCall();
+if (unlikely(!result) && unlikely(!PyErr_Occurred())) {
+PyErr_SetString(
+PyExc_SystemError,
+"NULL result without error in PyObject_Call");
+}
+return result;
+}
+#endif
+/* RaiseArgTupleInvalid */
+static void __Pyx_RaiseArgtupleInvalid(
+const char* func_name,
+int exact,
+Py_ssize_t num_min,
+Py_ssize_t num_max,
+Py_ssize_t num_found)
+{
+Py_ssize_t num_expected;
+const char *more_or_less;
+if (num_found < num_min) {
+num_expected = num_min;
+more_or_less = "at least";
+} else {
+num_expected = num_max;
+more_or_less = "at most";
+}
+if (exact) {
+more_or_less = "exactly";
+}
+PyErr_Format(PyExc_TypeError,
+"%.200s() takes %.8s %" CYTHON_FORMAT_SSIZE_T "d positional argument%.1s (%" CYTHON_FORMAT_SSIZE_T "d given)",
+func_name, more_or_less, num_expected,
+(num_expected == 1) ? "" : "s", num_found);
+}
+/* RaiseException */
+#if PY_MAJOR_VERSION < 3
+static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb, PyObject *cause) {
+__Pyx_PyThreadState_declare
+CYTHON_UNUSED_VAR(cause);
+Py_XINCREF(type);
+if (!value || value == Py_None)
+value = NULL;
+else
+Py_INCREF(value);
+if (!tb || tb == Py_None)
+tb = NULL;
+else {
+Py_INCREF(tb);
+if (!PyTraceBack_Check(tb)) {
+PyErr_SetString(PyExc_TypeError,
+"raise: arg 3 must be a traceback or None");
+goto raise_error;
+}
+}
+if (PyType_Check(type)) {
+#if CYTHON_COMPILING_IN_PYPY
+if (!value) {
+Py_INCREF(Py_None);
+value = Py_None;
+}
+#endif
+PyErr_NormalizeException(&type, &value, &tb);
+} else {
+if (value) {
+PyErr_SetString(PyExc_TypeError,
+"instance exception may not have a separate value");
+goto raise_error;
+}
+value = type;
+type = (PyObject*) Py_TYPE(type);
+Py_INCREF(type);
+if (!PyType_IsSubtype((PyTypeObject *)type, (PyTypeObject *)PyExc_BaseException)) {
+PyErr_SetString(PyExc_TypeError,
+"raise: exception class must be a subclass of BaseException");
+goto raise_error;
+}
+}
+__Pyx_PyThreadState_assign
+__Pyx_ErrRestore(type, value, tb);
+return;
+raise_error:
+Py_XDECREF(value);
+Py_XDECREF(type);
+Py_XDECREF(tb);
+return;
+}
+#else
+static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb, PyObject *cause) {
+PyObject* owned_instance = NULL;
+if (tb == Py_None) {
+tb = 0;
+} else if (tb && !PyTraceBack_Check(tb)) {
+PyErr_SetString(PyExc_TypeError,
+"raise: arg 3 must be a traceback or None");
+goto bad;
+}
+if (value == Py_None)
+value = 0;
+if (PyExceptionInstance_Check(type)) {
+if (value) {
+PyErr_SetString(PyExc_TypeError,
+"instance exception may not have a separate value");
+goto bad;
+}
+value = type;
+type = (PyObject*) Py_TYPE(value);
+} else if (PyExceptionClass_Check(type)) {
+PyObject *instance_class = NULL;
+if (value && PyExceptionInstance_Check(value)) {
+instance_class = (PyObject*) Py_TYPE(value);
+if (instance_class != type) {
+int is_subclass = PyObject_IsSubclass(instance_class, type);
+if (!is_subclass) {
+instance_class = NULL;
+} else if (unlikely(is_subclass == -1)) {
+goto bad;
+} else {
+type = instance_class;
+}
+}
+}
+if (!instance_class) {
+PyObject *args;
+if (!value)
+args = PyTuple_New(0);
+else if (PyTuple_Check(value)) {
+Py_INCREF(value);
+args = value;
+} else
+args = PyTuple_Pack(1, value);
+if (!args)
+goto bad;
+owned_instance = PyObject_Call(type, args, NULL);
+Py_DECREF(args);
+if (!owned_instance)
+goto bad;
+value = owned_instance;
+if (!PyExceptionInstance_Check(value)) {
+PyErr_Format(PyExc_TypeError,
+"calling %R should have returned an instance of "
+"BaseException, not %R",
+type, Py_TYPE(value));
+goto bad;
+}
+}
+} else {
+PyErr_SetString(PyExc_TypeError,
+"raise: exception class must be a subclass of BaseException");
+goto bad;
+}
+if (cause) {
+PyObject *fixed_cause;
+if (cause == Py_None) {
+fixed_cause = NULL;
+} else if (PyExceptionClass_Check(cause)) {
+fixed_cause = PyObject_CallObject(cause, NULL);
+if (fixed_cause == NULL)
+goto bad;
+} else if (PyExceptionInstance_Check(cause)) {
+fixed_cause = cause;
+Py_INCREF(fixed_cause);
+} else {
+PyErr_SetString(PyExc_TypeError,
+"exception causes must derive from "
+"BaseException");
+goto bad;
+}
+PyException_SetCause(value, fixed_cause);
+}
+PyErr_SetObject(type, value);
+if (tb) {
+#if PY_VERSION_HEX >= 0x030C00A6
+PyException_SetTraceback(value, tb);
+#elif CYTHON_FAST_THREAD_STATE
+PyThreadState *tstate = __Pyx_PyThreadState_Current;
+PyObject* tmp_tb = tstate->curexc_traceback;
+if (tb != tmp_tb) {
+Py_INCREF(tb);
+tstate->curexc_traceback = tb;
+Py_XDECREF(tmp_tb);
+}
+#else
+PyObject *tmp_type, *tmp_value, *tmp_tb;
+PyErr_Fetch(&tmp_type, &tmp_value, &tmp_tb);
+Py_INCREF(tb);
+PyErr_Restore(tmp_type, tmp_value, tb);
+Py_XDECREF(tmp_tb);
+#endif
+}
+bad:
+Py_XDECREF(owned_instance);
+return;
+}
+#endif
+/* RaiseDoubleKeywords */
+static void __Pyx_RaiseDoubleKeywordsError(
+const char* func_name,
+PyObject* kw_name)
+{
+PyErr_Format(PyExc_TypeError,
+#if PY_MAJOR_VERSION >= 3
+"%s() got multiple values for keyword argument '%U'", func_name, kw_name);
+#else
+"%s() got multiple values for keyword argument '%s'", func_name,
+PyString_AsString(kw_name));
+#endif
+}
+/* ParseKeywords */
+static int __Pyx_ParseOptionalKeywords(
+PyObject *kwds,
+PyObject *const *kwvalues,
+PyObject **argnames[],
+PyObject *kwds2,
+PyObject *values[],
+Py_ssize_t num_pos_args,
+const char* function_name)
+{
+PyObject *key = 0, *value = 0;
+Py_ssize_t pos = 0;
+PyObject*** name;
+PyObject*** first_kw_arg = argnames + num_pos_args;
+int kwds_is_tuple = CYTHON_METH_FASTCALL && likely(PyTuple_Check(kwds));
+while (1) {
+Py_XDECREF(key); key = NULL;
+Py_XDECREF(value); value = NULL;
+if (kwds_is_tuple) {
+Py_ssize_t size;
+#if CYTHON_ASSUME_SAFE_MACROS
+size = PyTuple_GET_SIZE(kwds);
+#else
+size = PyTuple_Size(kwds);
+if (size < 0) goto bad;
+#endif
+if (pos >= size) break;
+#if CYTHON_AVOID_BORROWED_REFS
+key = __Pyx_PySequence_ITEM(kwds, pos);
+if (!key) goto bad;
+#elif CYTHON_ASSUME_SAFE_MACROS
+key = PyTuple_GET_ITEM(kwds, pos);
+#else
+key = PyTuple_GetItem(kwds, pos);
+if (!key) goto bad;
+#endif
+value = kwvalues[pos];
+pos++;
+}
+else
+{
+if (!PyDict_Next(kwds, &pos, &key, &value)) break;
+#if CYTHON_AVOID_BORROWED_REFS
+Py_INCREF(key);
+#endif
+}
+name = first_kw_arg;
+while (*name && (**name != key)) name++;
+if (*name) {
+values[name-argnames] = value;
+#if CYTHON_AVOID_BORROWED_REFS
+Py_INCREF(value);
+Py_DECREF(key);
+#endif
+key = NULL;
+value = NULL;
+continue;
+}
+#if !CYTHON_AVOID_BORROWED_REFS
+Py_INCREF(key);
+#endif
+Py_INCREF(value);
+name = first_kw_arg;
+#if PY_MAJOR_VERSION < 3
+if (likely(PyString_Check(key))) {
+while (*name) {
+if ((CYTHON_COMPILING_IN_PYPY || PyString_GET_SIZE(**name) == PyString_GET_SIZE(key))
+&& _PyString_Eq(**name, key)) {
+values[name-argnames] = value;
+#if CYTHON_AVOID_BORROWED_REFS
+value = NULL;
+#endif
+break;
+}
+name++;
+}
+if (*name) continue;
+else {
+PyObject*** argname = argnames;
+while (argname != first_kw_arg) {
+if ((**argname == key) || (
+(CYTHON_COMPILING_IN_PYPY || PyString_GET_SIZE(**argname) == PyString_GET_SIZE(key))
+&& _PyString_Eq(**argname, key))) {
+goto arg_passed_twice;
+}
+argname++;
+}
+}
+} else
+#endif
+if (likely(PyUnicode_Check(key))) {
+while (*name) {
+int cmp = (
+#if !CYTHON_COMPILING_IN_PYPY && PY_MAJOR_VERSION >= 3
+(__Pyx_PyUnicode_GET_LENGTH(**name) != __Pyx_PyUnicode_GET_LENGTH(key)) ? 1 :
+#endif
+PyUnicode_Compare(**name, key)
+);
+if (cmp < 0 && unlikely(PyErr_Occurred())) goto bad;
+if (cmp == 0) {
+values[name-argnames] = value;
+#if CYTHON_AVOID_BORROWED_REFS
+value = NULL;
+#endif
+break;
+}
+name++;
+}
+if (*name) continue;
+else {
+PyObject*** argname = argnames;
+while (argname != first_kw_arg) {
+int cmp = (**argname == key) ? 0 :
+#if !CYTHON_COMPILING_IN_PYPY && PY_MAJOR_VERSION >= 3
+(__Pyx_PyUnicode_GET_LENGTH(**argname) != __Pyx_PyUnicode_GET_LENGTH(key)) ? 1 :
+#endif
+PyUnicode_Compare(**argname, key);
+if (cmp < 0 && unlikely(PyErr_Occurred())) goto bad;
+if (cmp == 0) goto arg_passed_twice;
+argname++;
+}
+}
+} else
+goto invalid_keyword_type;
+if (kwds2) {
+if (unlikely(PyDict_SetItem(kwds2, key, value))) goto bad;
+} else {
+goto invalid_keyword;
+}
+}
+Py_XDECREF(key);
+Py_XDECREF(value);
+return 0;
+arg_passed_twice:
+__Pyx_RaiseDoubleKeywordsError(function_name, key);
+goto bad;
+invalid_keyword_type:
+PyErr_Format(PyExc_TypeError,
+"%.200s() keywords must be strings", function_name);
+goto bad;
+invalid_keyword:
+#if PY_MAJOR_VERSION < 3
+PyErr_Format(PyExc_TypeError,
+"%.200s() got an unexpected keyword argument '%.200s'",
+function_name, PyString_AsString(key));
+#else
+PyErr_Format(PyExc_TypeError,
+"%s() got an unexpected keyword argument '%U'",
+function_name, key);
+#endif
+bad:
+Py_XDECREF(key);
+Py_XDECREF(value);
+return -1;
+}
+/* PyFunctionFastCall */
+#if CYTHON_FAST_PYCALL && !CYTHON_VECTORCALL
+static PyObject* __Pyx_PyFunction_FastCallNoKw(PyCodeObject *co, PyObject **args, Py_ssize_t na,
+PyObject *globals) {
+PyFrameObject *f;
+PyThreadState *tstate = __Pyx_PyThreadState_Current;
+PyObject **fastlocals;
+Py_ssize_t i;
+PyObject *result;
+assert(globals != NULL);
+/* XXX Perhaps we should create a specialized
+PyFrame_New() that doesn't take locals, but does
+take builtins without sanity checking them.
+*/
+assert(tstate != NULL);
+f = PyFrame_New(tstate, co, globals, NULL);
+if (f == NULL) {
+return NULL;
+}
+fastlocals = __Pyx_PyFrame_GetLocalsplus(f);
+for (i = 0; i < na; i++) {
+Py_INCREF(*args);
+fastlocals[i] = *args++;
+}
+result = PyEval_EvalFrameEx(f,0);
+++tstate->recursion_depth;
+Py_DECREF(f);
+--tstate->recursion_depth;
+return result;
+}
+static PyObject *__Pyx_PyFunction_FastCallDict(PyObject *func, PyObject **args, Py_ssize_t nargs, PyObject *kwargs) {
+PyCodeObject *co = (PyCodeObject *)PyFunction_GET_CODE(func);
+PyObject *globals = PyFunction_GET_GLOBALS(func);
+PyObject *argdefs = PyFunction_GET_DEFAULTS(func);
+PyObject *closure;
+#if PY_MAJOR_VERSION >= 3
+PyObject *kwdefs;
+#endif
+PyObject *kwtuple, **k;
+PyObject **d;
+Py_ssize_t nd;
+Py_ssize_t nk;
+PyObject *result;
+assert(kwargs == NULL || PyDict_Check(kwargs));
+nk = kwargs ? PyDict_Size(kwargs) : 0;
+#if PY_MAJOR_VERSION < 3
+if (unlikely(Py_EnterRecursiveCall((char*)" while calling a Python object"))) {
+return NULL;
+}
+#else
+if (unlikely(Py_EnterRecursiveCall(" while calling a Python object"))) {
+return NULL;
+}
+#endif
+if (
+#if PY_MAJOR_VERSION >= 3
+co->co_kwonlyargcount == 0 &&
+#endif
+likely(kwargs == NULL || nk == 0) &&
+co->co_flags == (CO_OPTIMIZED | CO_NEWLOCALS | CO_NOFREE)) {
+if (argdefs == NULL && co->co_argcount == nargs) {
+result = __Pyx_PyFunction_FastCallNoKw(co, args, nargs, globals);
+goto done;
+}
+else if (nargs == 0 && argdefs != NULL
+&& co->co_argcount == Py_SIZE(argdefs)) {
+/* function called with no arguments, but all parameters have
+a default value: use default values as arguments .*/
+args = &PyTuple_GET_ITEM(argdefs, 0);
+result =__Pyx_PyFunction_FastCallNoKw(co, args, Py_SIZE(argdefs), globals);
+goto done;
+}
+}
+if (kwargs != NULL) {
+Py_ssize_t pos, i;
+kwtuple = PyTuple_New(2 * nk);
+if (kwtuple == NULL) {
+result = NULL;
+goto done;
+}
+k = &PyTuple_GET_ITEM(kwtuple, 0);
+pos = i = 0;
+while (PyDict_Next(kwargs, &pos, &k[i], &k[i+1])) {
+Py_INCREF(k[i]);
+Py_INCREF(k[i+1]);
+i += 2;
+}
+nk = i / 2;
+}
+else {
+kwtuple = NULL;
+k = NULL;
+}
+closure = PyFunction_GET_CLOSURE(func);
+#if PY_MAJOR_VERSION >= 3
+kwdefs = PyFunction_GET_KW_DEFAULTS(func);
+#endif
+if (argdefs != NULL) {
+d = &PyTuple_GET_ITEM(argdefs, 0);
+nd = Py_SIZE(argdefs);
+}
+else {
+d = NULL;
+nd = 0;
+}
+#if PY_MAJOR_VERSION >= 3
+result = PyEval_EvalCodeEx((PyObject*)co, globals, (PyObject *)NULL,
+args, (int)nargs,
+k, (int)nk,
+d, (int)nd, kwdefs, closure);
+#else
+result = PyEval_EvalCodeEx(co, globals, (PyObject *)NULL,
+args, (int)nargs,
+k, (int)nk,
+d, (int)nd, closure);
+#endif
+Py_XDECREF(kwtuple);
+done:
+Py_LeaveRecursiveCall();
+return result;
+}
+#endif
+/* PyObjectCallMethO */
+#if CYTHON_COMPILING_IN_CPYTHON
+static CYTHON_INLINE PyObject* __Pyx_PyObject_CallMethO(PyObject *func, PyObject *arg) {
+PyObject *self, *result;
+PyCFunction cfunc;
+cfunc = __Pyx_CyOrPyCFunction_GET_FUNCTION(func);
+self = __Pyx_CyOrPyCFunction_GET_SELF(func);
+#if PY_MAJOR_VERSION < 3
+if (unlikely(Py_EnterRecursiveCall((char*)" while calling a Python object")))
+return NULL;
+#else
+if (unlikely(Py_EnterRecursiveCall(" while calling a Python object")))
+return NULL;
+#endif
+result = cfunc(self, arg);
+Py_LeaveRecursiveCall();
+if (unlikely(!result) && unlikely(!PyErr_Occurred())) {
+PyErr_SetString(
+PyExc_SystemError,
+"NULL result without error in PyObject_Call");
+}
+return result;
+}
+#endif
+/* PyObjectFastCall */
+#if PY_VERSION_HEX < 0x03090000 || CYTHON_COMPILING_IN_LIMITED_API
+static PyObject* __Pyx_PyObject_FastCall_fallback(PyObject *func, PyObject **args, size_t nargs, PyObject *kwargs) {
+PyObject *argstuple;
+PyObject *result = 0;
+size_t i;
+argstuple = PyTuple_New((Py_ssize_t)nargs);
+if (unlikely(!argstuple)) return NULL;
+for (i = 0; i < nargs; i++) {
+Py_INCREF(args[i]);
+if (__Pyx_PyTuple_SET_ITEM(argstuple, (Py_ssize_t)i, args[i]) < 0) goto bad;
+}
+result = __Pyx_PyObject_Call(func, argstuple, kwargs);
+bad:
+Py_DECREF(argstuple);
+return result;
+}
+#endif
+static CYTHON_INLINE PyObject* __Pyx_PyObject_FastCallDict(PyObject *func, PyObject **args, size_t _nargs, PyObject *kwargs) {
+Py_ssize_t nargs = __Pyx_PyVectorcall_NARGS(_nargs);
+#if CYTHON_COMPILING_IN_CPYTHON
+if (nargs == 0 && kwargs == NULL) {
+if (__Pyx_CyOrPyCFunction_Check(func) && likely( __Pyx_CyOrPyCFunction_GET_FLAGS(func) & METH_NOARGS))
+return __Pyx_PyObject_CallMethO(func, NULL);
+}
+else if (nargs == 1 && kwargs == NULL) {
+if (__Pyx_CyOrPyCFunction_Check(func) && likely( __Pyx_CyOrPyCFunction_GET_FLAGS(func) & METH_O))
+return __Pyx_PyObject_CallMethO(func, args[0]);
+}
+#endif
+#if PY_VERSION_HEX < 0x030800B1
+#if CYTHON_FAST_PYCCALL
+if (PyCFunction_Check(func)) {
+if (kwargs) {
+return _PyCFunction_FastCallDict(func, args, nargs, kwargs);
+} else {
+return _PyCFunction_FastCallKeywords(func, args, nargs, NULL);
+}
+}
+#if PY_VERSION_HEX >= 0x030700A1
+if (!kwargs && __Pyx_IS_TYPE(func, &PyMethodDescr_Type)) {
+return _PyMethodDescr_FastCallKeywords(func, args, nargs, NULL);
+}
+#endif
+#endif
+#if CYTHON_FAST_PYCALL
+if (PyFunction_Check(func)) {
+return __Pyx_PyFunction_FastCallDict(func, args, nargs, kwargs);
+}
+#endif
+#endif
+if (kwargs == NULL) {
+#if CYTHON_VECTORCALL
+#if PY_VERSION_HEX < 0x03090000
+vectorcallfunc f = _PyVectorcall_Function(func);
+#else
+vectorcallfunc f = PyVectorcall_Function(func);
+#endif
+if (f) {
+return f(func, args, (size_t)nargs, NULL);
+}
+#elif defined(__Pyx_CyFunction_USED) && CYTHON_BACKPORT_VECTORCALL
+if (__Pyx_CyFunction_CheckExact(func)) {
+__pyx_vectorcallfunc f = __Pyx_CyFunction_func_vectorcall(func);
+if (f) return f(func, args, (size_t)nargs, NULL);
+}
+#endif
+}
+if (nargs == 0) {
+return __Pyx_PyObject_Call(func, __pyx_empty_tuple, kwargs);
+}
+#if PY_VERSION_HEX >= 0x03090000 && !CYTHON_COMPILING_IN_LIMITED_API
+return PyObject_VectorcallDict(func, args, (size_t)nargs, kwargs);
+#else
+return __Pyx_PyObject_FastCall_fallback(func, args, (size_t)nargs, kwargs);
+#endif
+}
+/* PyDictVersioning */
+#if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_TYPE_SLOTS
+static CYTHON_INLINE PY_UINT64_T __Pyx_get_tp_dict_version(PyObject *obj) {
+PyObject *dict = Py_TYPE(obj)->tp_dict;
+return likely(dict) ? __PYX_GET_DICT_VERSION(dict) : 0;
+}
+static CYTHON_INLINE PY_UINT64_T __Pyx_get_object_dict_version(PyObject *obj) {
+PyObject **dictptr = NULL;
+Py_ssize_t offset = Py_TYPE(obj)->tp_dictoffset;
+if (offset) {
+#if CYTHON_COMPILING_IN_CPYTHON
+dictptr = (likely(offset > 0)) ? (PyObject **) ((char *)obj + offset) : _PyObject_GetDictPtr(obj);
+#else
+dictptr = _PyObject_GetDictPtr(obj);
+#endif
+}
+return (dictptr && *dictptr) ? __PYX_GET_DICT_VERSION(*dictptr) : 0;
+}
+static CYTHON_INLINE int __Pyx_object_dict_version_matches(PyObject* obj, PY_UINT64_T tp_dict_version, PY_UINT64_T obj_dict_version) {
+PyObject *dict = Py_TYPE(obj)->tp_dict;
+if (unlikely(!dict) || unlikely(tp_dict_version != __PYX_GET_DICT_VERSION(dict)))
+return 0;
+return obj_dict_version == __Pyx_get_object_dict_version(obj);
+}
+#endif
+/* GetModuleGlobalName */
+#if CYTHON_USE_DICT_VERSIONS
+static PyObject *__Pyx__GetModuleGlobalName(PyObject *name, PY_UINT64_T *dict_version, PyObject **dict_cached_value)
+#else
+static CYTHON_INLINE PyObject *__Pyx__GetModuleGlobalName(PyObject *name)
+#endif
+{
+PyObject *result;
+#if !CYTHON_AVOID_BORROWED_REFS
+#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX >= 0x030500A1 && PY_VERSION_HEX < 0x030d0000
+result = _PyDict_GetItem_KnownHash(__pyx_d, name, ((PyASCIIObject *) name)->hash);
+__PYX_UPDATE_DICT_CACHE(__pyx_d, result, *dict_cached_value, *dict_version)
+if (likely(result)) {
+return __Pyx_NewRef(result);
+} else if (unlikely(PyErr_Occurred())) {
+return NULL;
+}
+#elif CYTHON_COMPILING_IN_LIMITED_API
+if (unlikely(!__pyx_m)) {
+return NULL;
+}
+result = PyObject_GetAttr(__pyx_m, name);
+if (likely(result)) {
+return result;
+}
+#else
+result = PyDict_GetItem(__pyx_d, name);
+__PYX_UPDATE_DICT_CACHE(__pyx_d, result, *dict_cached_value, *dict_version)
+if (likely(result)) {
+return __Pyx_NewRef(result);
+}
+#endif
+#else
+result = PyObject_GetItem(__pyx_d, name);
+__PYX_UPDATE_DICT_CACHE(__pyx_d, result, *dict_cached_value, *dict_version)
+if (likely(result)) {
+return __Pyx_NewRef(result);
+}
+PyErr_Clear();
+#endif
+return __Pyx_GetBuiltinName(name);
+}
+/* PyObjectCallOneArg */
+static CYTHON_INLINE PyObject* __Pyx_PyObject_CallOneArg(PyObject *func, PyObject *arg) {
+PyObject *args[2] = {NULL, arg};
+return __Pyx_PyObject_FastCall(func, args+1, 1 | __Pyx_PY_VECTORCALL_ARGUMENTS_OFFSET);
+}
+/* PyObjectCall2Args */
+static CYTHON_INLINE PyObject* __Pyx_PyObject_Call2Args(PyObject* function, PyObject* arg1, PyObject* arg2) {
+PyObject *args[3] = {NULL, arg1, arg2};
+return __Pyx_PyObject_FastCall(function, args+1, 2 | __Pyx_PY_VECTORCALL_ARGUMENTS_OFFSET);
+}
+/* PyObjectGetMethod */
+static int __Pyx_PyObject_GetMethod(PyObject *obj, PyObject *name, PyObject **method) {
+PyObject *attr;
+#if CYTHON_UNPACK_METHODS && CYTHON_COMPILING_IN_CPYTHON && CYTHON_USE_PYTYPE_LOOKUP
+__Pyx_TypeName type_name;
+PyTypeObject *tp = Py_TYPE(obj);
+PyObject *descr;
+descrgetfunc f = NULL;
+PyObject **dictptr, *dict;
+int meth_found = 0;
+assert (*method == NULL);
+if (unlikely(tp->tp_getattro != PyObject_GenericGetAttr)) {
+attr = __Pyx_PyObject_GetAttrStr(obj, name);
+goto try_unpack;
+}
+if (unlikely(tp->tp_dict == NULL) && unlikely(PyType_Ready(tp) < 0)) {
+return 0;
+}
+descr = _PyType_Lookup(tp, name);
+if (likely(descr != NULL)) {
+Py_INCREF(descr);
+#if defined(Py_TPFLAGS_METHOD_DESCRIPTOR) && Py_TPFLAGS_METHOD_DESCRIPTOR
+if (__Pyx_PyType_HasFeature(Py_TYPE(descr), Py_TPFLAGS_METHOD_DESCRIPTOR))
+#elif PY_MAJOR_VERSION >= 3
+#ifdef __Pyx_CyFunction_USED
+if (likely(PyFunction_Check(descr) || __Pyx_IS_TYPE(descr, &PyMethodDescr_Type) || __Pyx_CyFunction_Check(descr)))
+#else
+if (likely(PyFunction_Check(descr) || __Pyx_IS_TYPE(descr, &PyMethodDescr_Type)))
+#endif
+#else
+#ifdef __Pyx_CyFunction_USED
+if (likely(PyFunction_Check(descr) || __Pyx_CyFunction_Check(descr)))
+#else
+if (likely(PyFunction_Check(descr)))
+#endif
+#endif
+{
+meth_found = 1;
+} else {
+f = Py_TYPE(descr)->tp_descr_get;
+if (f != NULL && PyDescr_IsData(descr)) {
+attr = f(descr, obj, (PyObject *)Py_TYPE(obj));
+Py_DECREF(descr);
+goto try_unpack;
+}
+}
+}
+dictptr = _PyObject_GetDictPtr(obj);
+if (dictptr != NULL && (dict = *dictptr) != NULL) {
+Py_INCREF(dict);
+attr = __Pyx_PyDict_GetItemStr(dict, name);
+if (attr != NULL) {
+Py_INCREF(attr);
+Py_DECREF(dict);
+Py_XDECREF(descr);
+goto try_unpack;
+}
+Py_DECREF(dict);
+}
+if (meth_found) {
+*method = descr;
+return 1;
+}
+if (f != NULL) {
+attr = f(descr, obj, (PyObject *)Py_TYPE(obj));
+Py_DECREF(descr);
+goto try_unpack;
+}
+if (likely(descr != NULL)) {
+*method = descr;
+return 0;
+}
+type_name = __Pyx_PyType_GetName(tp);
+PyErr_Format(PyExc_AttributeError,
+#if PY_MAJOR_VERSION >= 3
+"'" __Pyx_FMT_TYPENAME "' object has no attribute '%U'",
+type_name, name);
+#else
+"'" __Pyx_FMT_TYPENAME "' object has no attribute '%.400s'",
+type_name, PyString_AS_STRING(name));
+#endif
+__Pyx_DECREF_TypeName(type_name);
+return 0;
+#else
+attr = __Pyx_PyObject_GetAttrStr(obj, name);
+goto try_unpack;
+#endif
+try_unpack:
+#if CYTHON_UNPACK_METHODS
+if (likely(attr) && PyMethod_Check(attr) && likely(PyMethod_GET_SELF(attr) == obj)) {
+PyObject *function = PyMethod_GET_FUNCTION(attr);
+Py_INCREF(function);
+Py_DECREF(attr);
+*method = function;
+return 1;
+}
+#endif
+*method = attr;
+return 0;
+}
+/* PyObjectCallMethod1 */
+#if !(CYTHON_VECTORCALL && __PYX_LIMITED_VERSION_HEX >= 0x030C00A2)
+static PyObject* __Pyx__PyObject_CallMethod1(PyObject* method, PyObject* arg) {
+PyObject *result = __Pyx_PyObject_CallOneArg(method, arg);
+Py_DECREF(method);
+return result;
+}
+#endif
+static PyObject* __Pyx_PyObject_CallMethod1(PyObject* obj, PyObject* method_name, PyObject* arg) {
+#if CYTHON_VECTORCALL && __PYX_LIMITED_VERSION_HEX >= 0x030C00A2
+PyObject *args[2] = {obj, arg};
+(void) __Pyx_PyObject_GetMethod;
+(void) __Pyx_PyObject_CallOneArg;
+(void) __Pyx_PyObject_Call2Args;
+return PyObject_VectorcallMethod(method_name, args, 2 | PY_VECTORCALL_ARGUMENTS_OFFSET, NULL);
+#else
+PyObject *method = NULL, *result;
+int is_method = __Pyx_PyObject_GetMethod(obj, method_name, &method);
+if (likely(is_method)) {
+result = __Pyx_PyObject_Call2Args(method, obj, arg);
+Py_DECREF(method);
+return result;
+}
+if (unlikely(!method)) return NULL;
+return __Pyx__PyObject_CallMethod1(method, arg);
+#endif
+}
+/* append */
+static CYTHON_INLINE int __Pyx_PyObject_Append(PyObject* L, PyObject* x) {
+if (likely(PyList_CheckExact(L))) {
+if (unlikely(__Pyx_PyList_Append(L, x) < 0)) return -1;
+} else {
+PyObject* retval = __Pyx_PyObject_CallMethod1(L, __pyx_n_s_append, x);
+if (unlikely(!retval))
+return -1;
+Py_DECREF(retval);
+}
+return 0;
+}
+/* WriteUnraisableException */
+static void __Pyx_WriteUnraisable(const char *name, int clineno,
+int lineno, const char *filename,
+int full_traceback, int nogil) {
+PyObject *old_exc, *old_val, *old_tb;
+PyObject *ctx;
+__Pyx_PyThreadState_declare
+#ifdef WITH_THREAD
+PyGILState_STATE state;
+if (nogil)
+state = PyGILState_Ensure();
+else state = (PyGILState_STATE)0;
+#endif
+CYTHON_UNUSED_VAR(clineno);
+CYTHON_UNUSED_VAR(lineno);
+CYTHON_UNUSED_VAR(filename);
+CYTHON_MAYBE_UNUSED_VAR(nogil);
+__Pyx_PyThreadState_assign
+__Pyx_ErrFetch(&old_exc, &old_val, &old_tb);
+if (full_traceback) {
+Py_XINCREF(old_exc);
+Py_XINCREF(old_val);
+Py_XINCREF(old_tb);
+__Pyx_ErrRestore(old_exc, old_val, old_tb);
+PyErr_PrintEx(0);
+}
+#if PY_MAJOR_VERSION < 3
+ctx = PyString_FromString(name);
+#else
+ctx = PyUnicode_FromString(name);
+#endif
+__Pyx_ErrRestore(old_exc, old_val, old_tb);
+if (!ctx) {
+PyErr_WriteUnraisable(Py_None);
+} else {
+PyErr_WriteUnraisable(ctx);
+Py_DECREF(ctx);
+}
+#ifdef WITH_THREAD
+if (nogil)
+PyGILState_Release(state);
+#endif
+}
+/* RaiseTooManyValuesToUnpack */
+static CYTHON_INLINE void __Pyx_RaiseTooManyValuesError(Py_ssize_t expected) {
+PyErr_Format(PyExc_ValueError,
+"too many values to unpack (expected %" CYTHON_FORMAT_SSIZE_T "d)", expected);
+}
+/* RaiseNeedMoreValuesToUnpack */
+static CYTHON_INLINE void __Pyx_RaiseNeedMoreValuesError(Py_ssize_t index) {
+PyErr_Format(PyExc_ValueError,
+"need more than %" CYTHON_FORMAT_SSIZE_T "d value%.1s to unpack",
+index, (index == 1) ? "" : "s");
+}
+/* IterFinish */
+static CYTHON_INLINE int __Pyx_IterFinish(void) {
+PyObject* exc_type;
+__Pyx_PyThreadState_declare
+__Pyx_PyThreadState_assign
+exc_type = __Pyx_PyErr_CurrentExceptionType();
+if (unlikely(exc_type)) {
+if (unlikely(!__Pyx_PyErr_GivenExceptionMatches(exc_type, PyExc_StopIteration)))
+return -1;
+__Pyx_PyErr_Clear();
+return 0;
+}
+return 0;
+}
+/* UnpackItemEndCheck */
+static int __Pyx_IternextUnpackEndCheck(PyObject *retval, Py_ssize_t expected) {
+if (unlikely(retval)) {
+Py_DECREF(retval);
+__Pyx_RaiseTooManyValuesError(expected);
+return -1;
+}
+return __Pyx_IterFinish();
+}
+/* GetException */
+#if CYTHON_FAST_THREAD_STATE
+static int __Pyx__GetException(PyThreadState *tstate, PyObject **type, PyObject **value, PyObject **tb)
+#else
+static int __Pyx_GetException(PyObject **type, PyObject **value, PyObject **tb)
+#endif
+{
+PyObject *local_type = NULL, *local_value, *local_tb = NULL;
+#if CYTHON_FAST_THREAD_STATE
+PyObject *tmp_type, *tmp_value, *tmp_tb;
+#if PY_VERSION_HEX >= 0x030C00A6
+local_value = tstate->current_exception;
+tstate->current_exception = 0;
+if (likely(local_value)) {
+local_type = (PyObject*) Py_TYPE(local_value);
+Py_INCREF(local_type);
+local_tb = PyException_GetTraceback(local_value);
+}
+#else
+local_type = tstate->curexc_type;
+local_value = tstate->curexc_value;
+local_tb = tstate->curexc_traceback;
+tstate->curexc_type = 0;
+tstate->curexc_value = 0;
+tstate->curexc_traceback = 0;
+#endif
+#else
+PyErr_Fetch(&local_type, &local_value, &local_tb);
+#endif
+PyErr_NormalizeException(&local_type, &local_value, &local_tb);
+#if CYTHON_FAST_THREAD_STATE && PY_VERSION_HEX >= 0x030C00A6
+if (unlikely(tstate->current_exception))
+#elif CYTHON_FAST_THREAD_STATE
+if (unlikely(tstate->curexc_type))
+#else
+if (unlikely(PyErr_Occurred()))
+#endif
+goto bad;
+#if PY_MAJOR_VERSION >= 3
+if (local_tb) {
+if (unlikely(PyException_SetTraceback(local_value, local_tb) < 0))
+goto bad;
+}
+#endif
+Py_XINCREF(local_tb);
+Py_XINCREF(local_type);
+Py_XINCREF(local_value);
+*type = local_type;
+*value = local_value;
+*tb = local_tb;
+#if CYTHON_FAST_THREAD_STATE
+#if CYTHON_USE_EXC_INFO_STACK
+{
+_PyErr_StackItem *exc_info = tstate->exc_info;
+#if PY_VERSION_HEX >= 0x030B00a4
+tmp_value = exc_info->exc_value;
+exc_info->exc_value = local_value;
+tmp_type = NULL;
+tmp_tb = NULL;
+Py_XDECREF(local_type);
+Py_XDECREF(local_tb);
+#else
+tmp_type = exc_info->exc_type;
+tmp_value = exc_info->exc_value;
+tmp_tb = exc_info->exc_traceback;
+exc_info->exc_type = local_type;
+exc_info->exc_value = local_value;
+exc_info->exc_traceback = local_tb;
+#endif
+}
+#else
+tmp_type = tstate->exc_type;
+tmp_value = tstate->exc_value;
+tmp_tb = tstate->exc_traceback;
+tstate->exc_type = local_type;
+tstate->exc_value = local_value;
+tstate->exc_traceback = local_tb;
+#endif
+Py_XDECREF(tmp_type);
+Py_XDECREF(tmp_value);
+Py_XDECREF(tmp_tb);
+#else
+PyErr_SetExcInfo(local_type, local_value, local_tb);
+#endif
+return 0;
+bad:
+*type = 0;
+*value = 0;
+*tb = 0;
+Py_XDECREF(local_type);
+Py_XDECREF(local_value);
+Py_XDECREF(local_tb);
+return -1;
+}
+/* SwapException */
+#if CYTHON_FAST_THREAD_STATE
+static CYTHON_INLINE void __Pyx__ExceptionSwap(PyThreadState *tstate, PyObject **type, PyObject **value, PyObject **tb) {
+PyObject *tmp_type, *tmp_value, *tmp_tb;
+#if CYTHON_USE_EXC_INFO_STACK && PY_VERSION_HEX >= 0x030B00a4
+_PyErr_StackItem *exc_info = tstate->exc_info;
+tmp_value = exc_info->exc_value;
+exc_info->exc_value = *value;
+if (tmp_value == NULL || tmp_value == Py_None) {
+Py_XDECREF(tmp_value);
+tmp_value = NULL;
+tmp_type = NULL;
+tmp_tb = NULL;
+} else {
+tmp_type = (PyObject*) Py_TYPE(tmp_value);
+Py_INCREF(tmp_type);
+#if CYTHON_COMPILING_IN_CPYTHON
+tmp_tb = ((PyBaseExceptionObject*) tmp_value)->traceback;
+Py_XINCREF(tmp_tb);
+#else
+tmp_tb = PyException_GetTraceback(tmp_value);
+#endif
+}
+#elif CYTHON_USE_EXC_INFO_STACK
+_PyErr_StackItem *exc_info = tstate->exc_info;
+tmp_type = exc_info->exc_type;
+tmp_value = exc_info->exc_value;
+tmp_tb = exc_info->exc_traceback;
+exc_info->exc_type = *type;
+exc_info->exc_value = *value;
+exc_info->exc_traceback = *tb;
+#else
+tmp_type = tstate->exc_type;
+tmp_value = tstate->exc_value;
+tmp_tb = tstate->exc_traceback;
+tstate->exc_type = *type;
+tstate->exc_value = *value;
+tstate->exc_traceback = *tb;
+#endif
+*type = tmp_type;
+*value = tmp_value;
+*tb = tmp_tb;
+}
+#else
+static CYTHON_INLINE void __Pyx_ExceptionSwap(PyObject **type, PyObject **value, PyObject **tb) {
+PyObject *tmp_type, *tmp_value, *tmp_tb;
+PyErr_GetExcInfo(&tmp_type, &tmp_value, &tmp_tb);
+PyErr_SetExcInfo(*type, *value, *tb);
+*type = tmp_type;
+*value = tmp_value;
+*tb = tmp_tb;
+}
+#endif
+/* GetTopmostException */
+#if CYTHON_USE_EXC_INFO_STACK && CYTHON_FAST_THREAD_STATE
+static _PyErr_StackItem *
+__Pyx_PyErr_GetTopmostException(PyThreadState *tstate)
+{
+_PyErr_StackItem *exc_info = tstate->exc_info;
+while ((exc_info->exc_value == NULL || exc_info->exc_value == Py_None) &&
+exc_info->previous_item != NULL)
+{
+exc_info = exc_info->previous_item;
+}
+return exc_info;
+}
+#endif
+/* SaveResetException */
+#if CYTHON_FAST_THREAD_STATE
+static CYTHON_INLINE void __Pyx__ExceptionSave(PyThreadState *tstate, PyObject **type, PyObject **value, PyObject **tb) {
+#if CYTHON_USE_EXC_INFO_STACK && PY_VERSION_HEX >= 0x030B00a4
+_PyErr_StackItem *exc_info = __Pyx_PyErr_GetTopmostException(tstate);
+PyObject *exc_value = exc_info->exc_value;
+if (exc_value == NULL || exc_value == Py_None) {
+*value = NULL;
+*type = NULL;
+*tb = NULL;
+} else {
+*value = exc_value;
+Py_INCREF(*value);
+*type = (PyObject*) Py_TYPE(exc_value);
+Py_INCREF(*type);
+*tb = PyException_GetTraceback(exc_value);
+}
+#elif CYTHON_USE_EXC_INFO_STACK
+_PyErr_StackItem *exc_info = __Pyx_PyErr_GetTopmostException(tstate);
+*type = exc_info->exc_type;
+*value = exc_info->exc_value;
+*tb = exc_info->exc_traceback;
+Py_XINCREF(*type);
+Py_XINCREF(*value);
+Py_XINCREF(*tb);
+#else
+*type = tstate->exc_type;
+*value = tstate->exc_value;
+*tb = tstate->exc_traceback;
+Py_XINCREF(*type);
+Py_XINCREF(*value);
+Py_XINCREF(*tb);
+#endif
+}
+static CYTHON_INLINE void __Pyx__ExceptionReset(PyThreadState *tstate, PyObject *type, PyObject *value, PyObject *tb) {
+#if CYTHON_USE_EXC_INFO_STACK && PY_VERSION_HEX >= 0x030B00a4
+_PyErr_StackItem *exc_info = tstate->exc_info;
+PyObject *tmp_value = exc_info->exc_value;
+exc_info->exc_value = value;
+Py_XDECREF(tmp_value);
+Py_XDECREF(type);
+Py_XDECREF(tb);
+#else
+PyObject *tmp_type, *tmp_value, *tmp_tb;
+#if CYTHON_USE_EXC_INFO_STACK
+_PyErr_StackItem *exc_info = tstate->exc_info;
+tmp_type = exc_info->exc_type;
+tmp_value = exc_info->exc_value;
+tmp_tb = exc_info->exc_traceback;
+exc_info->exc_type = type;
+exc_info->exc_value = value;
+exc_info->exc_traceback = tb;
+#else
+tmp_type = tstate->exc_type;
+tmp_value = tstate->exc_value;
+tmp_tb = tstate->exc_traceback;
+tstate->exc_type = type;
+tstate->exc_value = value;
+tstate->exc_traceback = tb;
+#endif
+Py_XDECREF(tmp_type);
+Py_XDECREF(tmp_value);
+Py_XDECREF(tmp_tb);
+#endif
+}
+#endif
+/* GetItemInt */
+static PyObject *__Pyx_GetItemInt_Generic(PyObject *o, PyObject* j) {
+PyObject *r;
+if (unlikely(!j)) return NULL;
+r = PyObject_GetItem(o, j);
+Py_DECREF(j);
+return r;
+}
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_List_Fast(PyObject *o, Py_ssize_t i,
+CYTHON_NCP_UNUSED int wraparound,
+CYTHON_NCP_UNUSED int boundscheck) {
+#if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
+Py_ssize_t wrapped_i = i;
+if (wraparound & unlikely(i < 0)) {
+wrapped_i += PyList_GET_SIZE(o);
+}
+if ((!boundscheck) || likely(__Pyx_is_valid_index(wrapped_i, PyList_GET_SIZE(o)))) {
+PyObject *r = PyList_GET_ITEM(o, wrapped_i);
+Py_INCREF(r);
+return r;
+}
+return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
+#else
+return PySequence_GetItem(o, i);
+#endif
+}
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Tuple_Fast(PyObject *o, Py_ssize_t i,
+CYTHON_NCP_UNUSED int wraparound,
+CYTHON_NCP_UNUSED int boundscheck) {
+#if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
+Py_ssize_t wrapped_i = i;
+if (wraparound & unlikely(i < 0)) {
+wrapped_i += PyTuple_GET_SIZE(o);
+}
+if ((!boundscheck) || likely(__Pyx_is_valid_index(wrapped_i, PyTuple_GET_SIZE(o)))) {
+PyObject *r = PyTuple_GET_ITEM(o, wrapped_i);
+Py_INCREF(r);
+return r;
+}
+return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
+#else
+return PySequence_GetItem(o, i);
+#endif
+}
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Fast(PyObject *o, Py_ssize_t i, int is_list,
+CYTHON_NCP_UNUSED int wraparound,
+CYTHON_NCP_UNUSED int boundscheck) {
+#if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS && CYTHON_USE_TYPE_SLOTS
+if (is_list || PyList_CheckExact(o)) {
+Py_ssize_t n = ((!wraparound) | likely(i >= 0)) ? i : i + PyList_GET_SIZE(o);
+if ((!boundscheck) || (likely(__Pyx_is_valid_index(n, PyList_GET_SIZE(o))))) {
+PyObject *r = PyList_GET_ITEM(o, n);
+Py_INCREF(r);
+return r;
+}
+}
+else if (PyTuple_CheckExact(o)) {
+Py_ssize_t n = ((!wraparound) | likely(i >= 0)) ? i : i + PyTuple_GET_SIZE(o);
+if ((!boundscheck) || likely(__Pyx_is_valid_index(n, PyTuple_GET_SIZE(o)))) {
+PyObject *r = PyTuple_GET_ITEM(o, n);
+Py_INCREF(r);
+return r;
+}
+} else {
+PyMappingMethods *mm = Py_TYPE(o)->tp_as_mapping;
+PySequenceMethods *sm = Py_TYPE(o)->tp_as_sequence;
+if (mm && mm->mp_subscript) {
+PyObject *r, *key = PyInt_FromSsize_t(i);
+if (unlikely(!key)) return NULL;
+r = mm->mp_subscript(o, key);
+Py_DECREF(key);
+return r;
+}
+if (likely(sm && sm->sq_item)) {
+if (wraparound && unlikely(i < 0) && likely(sm->sq_length)) {
+Py_ssize_t l = sm->sq_length(o);
+if (likely(l >= 0)) {
+i += l;
+} else {
+if (!PyErr_ExceptionMatches(PyExc_OverflowError))
+return NULL;
+PyErr_Clear();
+}
+}
+return sm->sq_item(o, i);
+}
+}
+#else
+if (is_list || !PyMapping_Check(o)) {
+return PySequence_GetItem(o, i);
+}
+#endif
+return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
+}
+/* ObjectGetItem */
+#if CYTHON_USE_TYPE_SLOTS
+static PyObject *__Pyx_PyObject_GetIndex(PyObject *obj, PyObject *index) {
+PyObject *runerr = NULL;
+Py_ssize_t key_value;
+key_value = __Pyx_PyIndex_AsSsize_t(index);
+if (likely(key_value != -1 || !(runerr = PyErr_Occurred()))) {
+return __Pyx_GetItemInt_Fast(obj, key_value, 0, 1, 1);
+}
+if (PyErr_GivenExceptionMatches(runerr, PyExc_OverflowError)) {
+__Pyx_TypeName index_type_name = __Pyx_PyType_GetName(Py_TYPE(index));
+PyErr_Clear();
+PyErr_Format(PyExc_IndexError,
+"cannot fit '" __Pyx_FMT_TYPENAME "' into an index-sized integer", index_type_name);
+__Pyx_DECREF_TypeName(index_type_name);
+}
+return NULL;
+}
+static PyObject *__Pyx_PyObject_GetItem_Slow(PyObject *obj, PyObject *key) {
+__Pyx_TypeName obj_type_name;
+if (likely(PyType_Check(obj))) {
+PyObject *meth = __Pyx_PyObject_GetAttrStrNoError(obj, __pyx_n_s_class_getitem);
+if (!meth) {
+PyErr_Clear();
+} else {
+PyObject *result = __Pyx_PyObject_CallOneArg(meth, key);
+Py_DECREF(meth);
+return result;
+}
+}
+obj_type_name = __Pyx_PyType_GetName(Py_TYPE(obj));
+PyErr_Format(PyExc_TypeError,
+"'" __Pyx_FMT_TYPENAME "' object is not subscriptable", obj_type_name);
+__Pyx_DECREF_TypeName(obj_type_name);
+return NULL;
+}
+static PyObject *__Pyx_PyObject_GetItem(PyObject *obj, PyObject *key) {
+PyTypeObject *tp = Py_TYPE(obj);
+PyMappingMethods *mm = tp->tp_as_mapping;
+PySequenceMethods *sm = tp->tp_as_sequence;
+if (likely(mm && mm->mp_subscript)) {
+return mm->mp_subscript(obj, key);
+}
+if (likely(sm && sm->sq_item)) {
+return __Pyx_PyObject_GetIndex(obj, key);
+}
+return __Pyx_PyObject_GetItem_Slow(obj, key);
+}
+#endif
+/* PyObjectFormatAndDecref */
+static CYTHON_INLINE PyObject* __Pyx_PyObject_FormatSimpleAndDecref(PyObject* s, PyObject* f) {
+if (unlikely(!s)) return NULL;
+if (likely(PyUnicode_CheckExact(s))) return s;
+#if PY_MAJOR_VERSION < 3
+if (likely(PyString_CheckExact(s))) {
+PyObject *result = PyUnicode_FromEncodedObject(s, NULL, "strict");
+Py_DECREF(s);
+return result;
+}
+#endif
+return __Pyx_PyObject_FormatAndDecref(s, f);
+}
+static CYTHON_INLINE PyObject* __Pyx_PyObject_FormatAndDecref(PyObject* s, PyObject* f) {
+PyObject *result;
+if (unlikely(!s)) return NULL;
+result = PyObject_Format(s, f);
+Py_DECREF(s);
+return result;
+}
+/* JoinPyUnicode */
+static PyObject* __Pyx_PyUnicode_Join(PyObject* value_tuple, Py_ssize_t value_count, Py_ssize_t result_ulength,
+Py_UCS4 max_char) {
+#if CYTHON_USE_UNICODE_INTERNALS && CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
+PyObject *result_uval;
+int result_ukind, kind_shift;
+Py_ssize_t i, char_pos;
+void *result_udata;
+CYTHON_MAYBE_UNUSED_VAR(max_char);
+#if CYTHON_PEP393_ENABLED
+result_uval = PyUnicode_New(result_ulength, max_char);
+if (unlikely(!result_uval)) return NULL;
+result_ukind = (max_char <= 255) ? PyUnicode_1BYTE_KIND : (max_char <= 65535) ? PyUnicode_2BYTE_KIND : PyUnicode_4BYTE_KIND;
+kind_shift = (result_ukind == PyUnicode_4BYTE_KIND) ? 2 : result_ukind - 1;
+result_udata = PyUnicode_DATA(result_uval);
+#else
+result_uval = PyUnicode_FromUnicode(NULL, result_ulength);
+if (unlikely(!result_uval)) return NULL;
+result_ukind = sizeof(Py_UNICODE);
+kind_shift = (result_ukind == 4) ? 2 : result_ukind - 1;
+result_udata = PyUnicode_AS_UNICODE(result_uval);
+#endif
+assert(kind_shift == 2 || kind_shift == 1 || kind_shift == 0);
+char_pos = 0;
+for (i=0; i < value_count; i++) {
+int ukind;
+Py_ssize_t ulength;
+void *udata;
+PyObject *uval = PyTuple_GET_ITEM(value_tuple, i);
+if (unlikely(__Pyx_PyUnicode_READY(uval)))
+goto bad;
+ulength = __Pyx_PyUnicode_GET_LENGTH(uval);
+if (unlikely(!ulength))
+continue;
+if (unlikely((PY_SSIZE_T_MAX >> kind_shift) - ulength < char_pos))
+goto overflow;
+ukind = __Pyx_PyUnicode_KIND(uval);
+udata = __Pyx_PyUnicode_DATA(uval);
+if (!CYTHON_PEP393_ENABLED || ukind == result_ukind) {
+memcpy((char *)result_udata + (char_pos << kind_shift), udata, (size_t) (ulength << kind_shift));
+} else {
+#if PY_VERSION_HEX >= 0x030d0000
+if (unlikely(PyUnicode_CopyCharacters(result_uval, char_pos, uval, 0, ulength) < 0)) goto bad;
+#elif CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX >= 0x030300F0 || defined(_PyUnicode_FastCopyCharacters)
+_PyUnicode_FastCopyCharacters(result_uval, char_pos, uval, 0, ulength);
+#else
+Py_ssize_t j;
+for (j=0; j < ulength; j++) {
+Py_UCS4 uchar = __Pyx_PyUnicode_READ(ukind, udata, j);
+__Pyx_PyUnicode_WRITE(result_ukind, result_udata, char_pos+j, uchar);
+}
+#endif
+}
+char_pos += ulength;
+}
+return result_uval;
+overflow:
+PyErr_SetString(PyExc_OverflowError, "join() result is too long for a Python string");
+bad:
+Py_DECREF(result_uval);
+return NULL;
+#else
+CYTHON_UNUSED_VAR(max_char);
+CYTHON_UNUSED_VAR(result_ulength);
+CYTHON_UNUSED_VAR(value_count);
+return PyUnicode_Join(__pyx_empty_unicode, value_tuple);
+#endif
+}
+/* ExtTypeTest */
+static CYTHON_INLINE int __Pyx_TypeTest(PyObject *obj, PyTypeObject *type) {
+__Pyx_TypeName obj_type_name;
+__Pyx_TypeName type_name;
+if (unlikely(!type)) {
+PyErr_SetString(PyExc_SystemError, "Missing type object");
+return 0;
+}
+if (likely(__Pyx_TypeCheck(obj, type)))
+return 1;
+obj_type_name = __Pyx_PyType_GetName(Py_TYPE(obj));
+type_name = __Pyx_PyType_GetName(type);
+PyErr_Format(PyExc_TypeError,
+"Cannot convert " __Pyx_FMT_TYPENAME " to " __Pyx_FMT_TYPENAME,
+obj_type_name, type_name);
+__Pyx_DECREF_TypeName(obj_type_name);
+__Pyx_DECREF_TypeName(type_name);
+return 0;
+}
+/* ArgTypeTest */
+static int __Pyx__ArgTypeTest(PyObject *obj, PyTypeObject *type, const char *name, int exact)
+{
+__Pyx_TypeName type_name;
+__Pyx_TypeName obj_type_name;
+if (unlikely(!type)) {
+PyErr_SetString(PyExc_SystemError, "Missing type object");
+return 0;
+}
+else if (exact) {
+#if PY_MAJOR_VERSION == 2
+if ((type == &PyBaseString_Type) && likely(__Pyx_PyBaseString_CheckExact(obj))) return 1;
+#endif
+}
+else {
+if (likely(__Pyx_TypeCheck(obj, type))) return 1;
+}
+type_name = __Pyx_PyType_GetName(type);
+obj_type_name = __Pyx_PyType_GetName(Py_TYPE(obj));
+PyErr_Format(PyExc_TypeError,
+"Argument '%.200s' has incorrect type (expected " __Pyx_FMT_TYPENAME
+", got " __Pyx_FMT_TYPENAME ")", name, type_name, obj_type_name);
+__Pyx_DECREF_TypeName(type_name);
+__Pyx_DECREF_TypeName(obj_type_name);
+return 0;
+}
+/* RaiseUnexpectedTypeError */
+static int
+__Pyx_RaiseUnexpectedTypeError(const char *expected, PyObject *obj)
+{
+__Pyx_TypeName obj_type_name = __Pyx_PyType_GetName(Py_TYPE(obj));
+PyErr_Format(PyExc_TypeError, "Expected %s, got " __Pyx_FMT_TYPENAME,
+expected, obj_type_name);
+__Pyx_DECREF_TypeName(obj_type_name);
+return 0;
+}
+/* PyUnicode_Unicode */
+static CYTHON_INLINE PyObject* __Pyx_PyUnicode_Unicode(PyObject *obj) {
+if (unlikely(obj == Py_None))
+obj = __pyx_kp_u_None;
+return __Pyx_NewRef(obj);
+}
+/* GetAttr3 */
+#if __PYX_LIMITED_VERSION_HEX < 0x030d00A1
+static PyObject *__Pyx_GetAttr3Default(PyObject *d) {
+__Pyx_PyThreadState_declare
+__Pyx_PyThreadState_assign
+if (unlikely(!__Pyx_PyErr_ExceptionMatches(PyExc_AttributeError)))
+return NULL;
+__Pyx_PyErr_Clear();
+Py_INCREF(d);
+return d;
+}
+#endif
+static CYTHON_INLINE PyObject *__Pyx_GetAttr3(PyObject *o, PyObject *n, PyObject *d) {
+PyObject *r;
+#if __PYX_LIMITED_VERSION_HEX >= 0x030d00A1
+int res = PyObject_GetOptionalAttr(o, n, &r);
+return (res != 0) ? r : __Pyx_NewRef(d);
+#else
+#if CYTHON_USE_TYPE_SLOTS
+if (likely(PyString_Check(n))) {
+r = __Pyx_PyObject_GetAttrStrNoError(o, n);
+if (unlikely(!r) && likely(!PyErr_Occurred())) {
+r = __Pyx_NewRef(d);
+}
+return r;
+}
+#endif
+r = PyObject_GetAttr(o, n);
+return (likely(r)) ? r : __Pyx_GetAttr3Default(d);
+#endif
+}
+/* Import */
+static PyObject *__Pyx_Import(PyObject *name, PyObject *from_list, int level) {
+PyObject *module = 0;
+PyObject *empty_dict = 0;
+PyObject *empty_list = 0;
+#if PY_MAJOR_VERSION < 3
+PyObject *py_import;
+py_import = __Pyx_PyObject_GetAttrStr(__pyx_b, __pyx_n_s_import);
+if (unlikely(!py_import))
+goto bad;
+if (!from_list) {
+empty_list = PyList_New(0);
+if (unlikely(!empty_list))
+goto bad;
+from_list = empty_list;
+}
+#endif
+empty_dict = PyDict_New();
+if (unlikely(!empty_dict))
+goto bad;
+{
+#if PY_MAJOR_VERSION >= 3
+if (level == -1) {
+if (strchr(__Pyx_MODULE_NAME, '.') != NULL) {
+module = PyImport_ImportModuleLevelObject(
+name, __pyx_d, empty_dict, from_list, 1);
+if (unlikely(!module)) {
+if (unlikely(!PyErr_ExceptionMatches(PyExc_ImportError)))
+goto bad;
+PyErr_Clear();
+}
+}
+level = 0;
+}
+#endif
+if (!module) {
+#if PY_MAJOR_VERSION < 3
+PyObject *py_level = PyInt_FromLong(level);
+if (unlikely(!py_level))
+goto bad;
+module = PyObject_CallFunctionObjArgs(py_import,
+name, __pyx_d, empty_dict, from_list, py_level, (PyObject *)NULL);
+Py_DECREF(py_level);
+#else
+module = PyImport_ImportModuleLevelObject(
+name, __pyx_d, empty_dict, from_list, level);
+#endif
+}
+}
+bad:
+Py_XDECREF(empty_dict);
+Py_XDECREF(empty_list);
+#if PY_MAJOR_VERSION < 3
+Py_XDECREF(py_import);
+#endif
+return module;
+}
+/* ImportFrom */
+static PyObject* __Pyx_ImportFrom(PyObject* module, PyObject* name) {
+PyObject* value = __Pyx_PyObject_GetAttrStr(module, name);
+if (unlikely(!value) && PyErr_ExceptionMatches(PyExc_AttributeError)) {
+const char* module_name_str = 0;
+PyObject* module_name = 0;
+PyObject* module_dot = 0;
+PyObject* full_name = 0;
+PyErr_Clear();
+module_name_str = PyModule_GetName(module);
+if (unlikely(!module_name_str)) { goto modbad; }
+module_name = PyUnicode_FromString(module_name_str);
+if (unlikely(!module_name)) { goto modbad; }
+module_dot = PyUnicode_Concat(module_name, __pyx_kp_u__47);
+if (unlikely(!module_dot)) { goto modbad; }
+full_name = PyUnicode_Concat(module_dot, name);
+if (unlikely(!full_name)) { goto modbad; }
+#if PY_VERSION_HEX < 0x030700A1 || (CYTHON_COMPILING_IN_PYPY && PYPY_VERSION_NUM  < 0x07030400)
+{
+PyObject *modules = PyImport_GetModuleDict();
+if (unlikely(!modules))
+goto modbad;
+value = PyObject_GetItem(modules, full_name);
+}
+#else
+value = PyImport_GetModule(full_name);
+#endif
+modbad:
+Py_XDECREF(full_name);
+Py_XDECREF(module_dot);
+Py_XDECREF(module_name);
+}
+if (unlikely(!value)) {
+PyErr_Format(PyExc_ImportError,
+#if PY_MAJOR_VERSION < 3
+"cannot import name %.230s", PyString_AS_STRING(name));
+#else
+"cannot import name %S", name);
+#endif
+}
+return value;
+}
+/* GetAttr */
+static CYTHON_INLINE PyObject *__Pyx_GetAttr(PyObject *o, PyObject *n) {
+#if CYTHON_USE_TYPE_SLOTS
+#if PY_MAJOR_VERSION >= 3
+if (likely(PyUnicode_Check(n)))
+#else
+if (likely(PyString_Check(n)))
+#endif
+return __Pyx_PyObject_GetAttrStr(o, n);
+#endif
+return PyObject_GetAttr(o, n);
+}
+/* HasAttr */
+static CYTHON_INLINE int __Pyx_HasAttr(PyObject *o, PyObject *n) {
+PyObject *r;
+if (unlikely(!__Pyx_PyBaseString_Check(n))) {
+PyErr_SetString(PyExc_TypeError,
+"hasattr(): attribute name must be string");
+return -1;
+}
+r = __Pyx_GetAttr(o, n);
+if (!r) {
+PyErr_Clear();
+return 0;
+} else {
+Py_DECREF(r);
+return 1;
+}
+}
+/* FixUpExtensionType */
+#if CYTHON_USE_TYPE_SPECS
+static int __Pyx_fix_up_extension_type_from_spec(PyType_Spec *spec, PyTypeObject *type) {
+#if PY_VERSION_HEX > 0x030900B1 || CYTHON_COMPILING_IN_LIMITED_API
+CYTHON_UNUSED_VAR(spec);
+CYTHON_UNUSED_VAR(type);
+#else
+const PyType_Slot *slot = spec->slots;
+while (slot && slot->slot && slot->slot != Py_tp_members)
+slot++;
+if (slot && slot->slot == Py_tp_members) {
+int changed = 0;
+#if !(PY_VERSION_HEX <= 0x030900b1 && CYTHON_COMPILING_IN_CPYTHON)
+const
+#endif
+PyMemberDef *memb = (PyMemberDef*) slot->pfunc;
+while (memb && memb->name) {
+if (memb->name[0] == '_' && memb->name[1] == '_') {
+#if PY_VERSION_HEX < 0x030900b1
+if (strcmp(memb->name, "__weaklistoffset__") == 0) {
+assert(memb->type == T_PYSSIZET);
+assert(memb->flags == READONLY);
+type->tp_weaklistoffset = memb->offset;
+changed = 1;
+}
+else if (strcmp(memb->name, "__dictoffset__") == 0) {
+assert(memb->type == T_PYSSIZET);
+assert(memb->flags == READONLY);
+type->tp_dictoffset = memb->offset;
+changed = 1;
+}
+#if CYTHON_METH_FASTCALL
+else if (strcmp(memb->name, "__vectorcalloffset__") == 0) {
+assert(memb->type == T_PYSSIZET);
+assert(memb->flags == READONLY);
+#if PY_VERSION_HEX >= 0x030800b4
+type->tp_vectorcall_offset = memb->offset;
+#else
+type->tp_print = (printfunc) memb->offset;
+#endif
+changed = 1;
+}
+#endif
+#else
+if ((0));
+#endif
+#if PY_VERSION_HEX <= 0x030900b1 && CYTHON_COMPILING_IN_CPYTHON
+else if (strcmp(memb->name, "__module__") == 0) {
+PyObject *descr;
+assert(memb->type == T_OBJECT);
+assert(memb->flags == 0 || memb->flags == READONLY);
+descr = PyDescr_NewMember(type, memb);
+if (unlikely(!descr))
+return -1;
+if (unlikely(PyDict_SetItem(type->tp_dict, PyDescr_NAME(descr), descr) < 0)) {
+Py_DECREF(descr);
+return -1;
+}
+Py_DECREF(descr);
+changed = 1;
+}
+#endif
+}
+memb++;
+}
+if (changed)
+PyType_Modified(type);
+}
+#endif
+return 0;
+}
+#endif
+/* PyObjectCallNoArg */
+static CYTHON_INLINE PyObject* __Pyx_PyObject_CallNoArg(PyObject *func) {
+PyObject *arg[2] = {NULL, NULL};
+return __Pyx_PyObject_FastCall(func, arg + 1, 0 | __Pyx_PY_VECTORCALL_ARGUMENTS_OFFSET);
+}
+/* PyObjectCallMethod0 */
+static PyObject* __Pyx_PyObject_CallMethod0(PyObject* obj, PyObject* method_name) {
+PyObject *method = NULL, *result = NULL;
+int is_method = __Pyx_PyObject_GetMethod(obj, method_name, &method);
+if (likely(is_method)) {
+result = __Pyx_PyObject_CallOneArg(method, obj);
+Py_DECREF(method);
+return result;
+}
+if (unlikely(!method)) goto bad;
+result = __Pyx_PyObject_CallNoArg(method);
+Py_DECREF(method);
+bad:
+return result;
+}
+/* ValidateBasesTuple */
+#if CYTHON_COMPILING_IN_CPYTHON || CYTHON_COMPILING_IN_LIMITED_API || CYTHON_USE_TYPE_SPECS
+static int __Pyx_validate_bases_tuple(const char *type_name, Py_ssize_t dictoffset, PyObject *bases) {
+Py_ssize_t i, n;
+#if CYTHON_ASSUME_SAFE_MACROS
+n = PyTuple_GET_SIZE(bases);
+#else
+n = PyTuple_Size(bases);
+if (n < 0) return -1;
+#endif
+for (i = 1; i < n; i++)
+{
+#if CYTHON_AVOID_BORROWED_REFS
+PyObject *b0 = PySequence_GetItem(bases, i);
+if (!b0) return -1;
+#elif CYTHON_ASSUME_SAFE_MACROS
+PyObject *b0 = PyTuple_GET_ITEM(bases, i);
+#else
+PyObject *b0 = PyTuple_GetItem(bases, i);
+if (!b0) return -1;
+#endif
+PyTypeObject *b;
+#if PY_MAJOR_VERSION < 3
+if (PyClass_Check(b0))
+{
+PyErr_Format(PyExc_TypeError, "base class '%.200s' is an old-style class",
+PyString_AS_STRING(((PyClassObject*)b0)->cl_name));
+#if CYTHON_AVOID_BORROWED_REFS
+Py_DECREF(b0);
+#endif
+return -1;
+}
+#endif
+b = (PyTypeObject*) b0;
+if (!__Pyx_PyType_HasFeature(b, Py_TPFLAGS_HEAPTYPE))
+{
+__Pyx_TypeName b_name = __Pyx_PyType_GetName(b);
+PyErr_Format(PyExc_TypeError,
+"base class '" __Pyx_FMT_TYPENAME "' is not a heap type", b_name);
+__Pyx_DECREF_TypeName(b_name);
+#if CYTHON_AVOID_BORROWED_REFS
+Py_DECREF(b0);
+#endif
+return -1;
+}
+if (dictoffset == 0)
+{
+Py_ssize_t b_dictoffset = 0;
+#if CYTHON_USE_TYPE_SLOTS || CYTHON_COMPILING_IN_PYPY
+b_dictoffset = b->tp_dictoffset;
+#else
+PyObject *py_b_dictoffset = PyObject_GetAttrString((PyObject*)b, "__dictoffset__");
+if (!py_b_dictoffset) goto dictoffset_return;
+b_dictoffset = PyLong_AsSsize_t(py_b_dictoffset);
+Py_DECREF(py_b_dictoffset);
+if (b_dictoffset == -1 && PyErr_Occurred()) goto dictoffset_return;
+#endif
+if (b_dictoffset) {
+{
+__Pyx_TypeName b_name = __Pyx_PyType_GetName(b);
+PyErr_Format(PyExc_TypeError,
+"extension type '%.200s' has no __dict__ slot, "
+"but base type '" __Pyx_FMT_TYPENAME "' has: "
+"either add 'cdef dict __dict__' to the extension type "
+"or add '__slots__ = [...]' to the base type",
+type_name, b_name);
+__Pyx_DECREF_TypeName(b_name);
+}
+#if !(CYTHON_USE_TYPE_SLOTS || CYTHON_COMPILING_IN_PYPY)
+dictoffset_return:
+#endif
+#if CYTHON_AVOID_BORROWED_REFS
+Py_DECREF(b0);
+#endif
+return -1;
+}
+}
+#if CYTHON_AVOID_BORROWED_REFS
+Py_DECREF(b0);
+#endif
+}
+return 0;
+}
+#endif
+/* PyType_Ready */
+static int __Pyx_PyType_Ready(PyTypeObject *t) {
+#if CYTHON_USE_TYPE_SPECS || !(CYTHON_COMPILING_IN_CPYTHON || CYTHON_COMPILING_IN_LIMITED_API) || defined(PYSTON_MAJOR_VERSION)
+(void)__Pyx_PyObject_CallMethod0;
+#if CYTHON_USE_TYPE_SPECS
+(void)__Pyx_validate_bases_tuple;
+#endif
+return PyType_Ready(t);
+#else
+int r;
+PyObject *bases = __Pyx_PyType_GetSlot(t, tp_bases, PyObject*);
+if (bases && unlikely(__Pyx_validate_bases_tuple(t->tp_name, t->tp_dictoffset, bases) == -1))
+return -1;
+#if PY_VERSION_HEX >= 0x03050000 && !defined(PYSTON_MAJOR_VERSION)
+{
+int gc_was_enabled;
+#if PY_VERSION_HEX >= 0x030A00b1
+gc_was_enabled = PyGC_Disable();
+(void)__Pyx_PyObject_CallMethod0;
+#else
+PyObject *ret, *py_status;
+PyObject *gc = NULL;
+#if PY_VERSION_HEX >= 0x030700a1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM+0 >= 0x07030400)
+gc = PyImport_GetModule(__pyx_kp_u_gc);
+#endif
+if (unlikely(!gc)) gc = PyImport_Import(__pyx_kp_u_gc);
+if (unlikely(!gc)) return -1;
+py_status = __Pyx_PyObject_CallMethod0(gc, __pyx_kp_u_isenabled);
+if (unlikely(!py_status)) {
+Py_DECREF(gc);
+return -1;
+}
+gc_was_enabled = __Pyx_PyObject_IsTrue(py_status);
+Py_DECREF(py_status);
+if (gc_was_enabled > 0) {
+ret = __Pyx_PyObject_CallMethod0(gc, __pyx_kp_u_disable);
+if (unlikely(!ret)) {
+Py_DECREF(gc);
+return -1;
+}
+Py_DECREF(ret);
+} else if (unlikely(gc_was_enabled == -1)) {
+Py_DECREF(gc);
+return -1;
+}
+#endif
+t->tp_flags |= Py_TPFLAGS_HEAPTYPE;
+#if PY_VERSION_HEX >= 0x030A0000
+t->tp_flags |= Py_TPFLAGS_IMMUTABLETYPE;
+#endif
+#else
+(void)__Pyx_PyObject_CallMethod0;
+#endif
+r = PyType_Ready(t);
+#if PY_VERSION_HEX >= 0x03050000 && !defined(PYSTON_MAJOR_VERSION)
+t->tp_flags &= ~Py_TPFLAGS_HEAPTYPE;
+#if PY_VERSION_HEX >= 0x030A00b1
+if (gc_was_enabled)
+PyGC_Enable();
+#else
+if (gc_was_enabled) {
+PyObject *tp, *v, *tb;
+PyErr_Fetch(&tp, &v, &tb);
+ret = __Pyx_PyObject_CallMethod0(gc, __pyx_kp_u_enable);
+if (likely(ret || r == -1)) {
+Py_XDECREF(ret);
+PyErr_Restore(tp, v, tb);
+} else {
+Py_XDECREF(tp);
+Py_XDECREF(v);
+Py_XDECREF(tb);
+r = -1;
+}
+}
+Py_DECREF(gc);
+#endif
+}
+#endif
+return r;
+#endif
+}
+/* PyObject_GenericGetAttrNoDict */
+#if CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP && PY_VERSION_HEX < 0x03070000
+static PyObject *__Pyx_RaiseGenericGetAttributeError(PyTypeObject *tp, PyObject *attr_name) {
+__Pyx_TypeName type_name = __Pyx_PyType_GetName(tp);
+PyErr_Format(PyExc_AttributeError,
+#if PY_MAJOR_VERSION >= 3
+"'" __Pyx_FMT_TYPENAME "' object has no attribute '%U'",
+type_name, attr_name);
+#else
+"'" __Pyx_FMT_TYPENAME "' object has no attribute '%.400s'",
+type_name, PyString_AS_STRING(attr_name));
+#endif
+__Pyx_DECREF_TypeName(type_name);
+return NULL;
+}
+static CYTHON_INLINE PyObject* __Pyx_PyObject_GenericGetAttrNoDict(PyObject* obj, PyObject* attr_name) {
+PyObject *descr;
+PyTypeObject *tp = Py_TYPE(obj);
+if (unlikely(!PyString_Check(attr_name))) {
+return PyObject_GenericGetAttr(obj, attr_name);
+}
+assert(!tp->tp_dictoffset);
+descr = _PyType_Lookup(tp, attr_name);
+if (unlikely(!descr)) {
+return __Pyx_RaiseGenericGetAttributeError(tp, attr_name);
+}
+Py_INCREF(descr);
+#if PY_MAJOR_VERSION < 3
+if (likely(PyType_HasFeature(Py_TYPE(descr), Py_TPFLAGS_HAVE_CLASS)))
+#endif
+{
+descrgetfunc f = Py_TYPE(descr)->tp_descr_get;
+if (unlikely(f)) {
+PyObject *res = f(descr, obj, (PyObject *)tp);
+Py_DECREF(descr);
+return res;
+}
+}
+return descr;
+}
+#endif
+/* PyObject_GenericGetAttr */
+#if CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP && PY_VERSION_HEX < 0x03070000
+static PyObject* __Pyx_PyObject_GenericGetAttr(PyObject* obj, PyObject* attr_name) {
+if (unlikely(Py_TYPE(obj)->tp_dictoffset)) {
+return PyObject_GenericGetAttr(obj, attr_name);
+}
+return __Pyx_PyObject_GenericGetAttrNoDict(obj, attr_name);
+}
+#endif
+/* SetVTable */
+static int __Pyx_SetVtable(PyTypeObject *type, void *vtable) {
+PyObject *ob = PyCapsule_New(vtable, 0, 0);
+if (unlikely(!ob))
+goto bad;
+#if CYTHON_COMPILING_IN_LIMITED_API
+if (unlikely(PyObject_SetAttr((PyObject *) type, __pyx_n_s_pyx_vtable, ob) < 0))
+#else
+if (unlikely(PyDict_SetItem(type->tp_dict, __pyx_n_s_pyx_vtable, ob) < 0))
+#endif
+goto bad;
+Py_DECREF(ob);
+return 0;
+bad:
+Py_XDECREF(ob);
+return -1;
+}
+/* GetVTable */
+static void* __Pyx_GetVtable(PyTypeObject *type) {
+void* ptr;
+#if CYTHON_COMPILING_IN_LIMITED_API
+PyObject *ob = PyObject_GetAttr((PyObject *)type, __pyx_n_s_pyx_vtable);
+#else
+PyObject *ob = PyObject_GetItem(type->tp_dict, __pyx_n_s_pyx_vtable);
+#endif
+if (!ob)
+goto bad;
+ptr = PyCapsule_GetPointer(ob, 0);
+if (!ptr && !PyErr_Occurred())
+PyErr_SetString(PyExc_RuntimeError, "invalid vtable found for imported type");
+Py_DECREF(ob);
+return ptr;
+bad:
+Py_XDECREF(ob);
+return NULL;
+}
+/* MergeVTables */
+#if !CYTHON_COMPILING_IN_LIMITED_API
+static int __Pyx_MergeVtables(PyTypeObject *type) {
+int i;
+void** base_vtables;
+__Pyx_TypeName tp_base_name;
+__Pyx_TypeName base_name;
+void* unknown = (void*)-1;
+PyObject* bases = type->tp_bases;
+int base_depth = 0;
+{
+PyTypeObject* base = type->tp_base;
+while (base) {
+base_depth += 1;
+base = base->tp_base;
+}
+}
+base_vtables = (void**) malloc(sizeof(void*) * (size_t)(base_depth + 1));
+base_vtables[0] = unknown;
+for (i = 1; i < PyTuple_GET_SIZE(bases); i++) {
+void* base_vtable = __Pyx_GetVtable(((PyTypeObject*)PyTuple_GET_ITEM(bases, i)));
+if (base_vtable != NULL) {
+int j;
+PyTypeObject* base = type->tp_base;
+for (j = 0; j < base_depth; j++) {
+if (base_vtables[j] == unknown) {
+base_vtables[j] = __Pyx_GetVtable(base);
+base_vtables[j + 1] = unknown;
+}
+if (base_vtables[j] == base_vtable) {
+break;
+} else if (base_vtables[j] == NULL) {
+goto bad;
+}
+base = base->tp_base;
+}
+}
+}
+PyErr_Clear();
+free(base_vtables);
+return 0;
+bad:
+tp_base_name = __Pyx_PyType_GetName(type->tp_base);
+base_name = __Pyx_PyType_GetName((PyTypeObject*)PyTuple_GET_ITEM(bases, i));
+PyErr_Format(PyExc_TypeError,
+"multiple bases have vtable conflict: '" __Pyx_FMT_TYPENAME "' and '" __Pyx_FMT_TYPENAME "'", tp_base_name, base_name);
+__Pyx_DECREF_TypeName(tp_base_name);
+__Pyx_DECREF_TypeName(base_name);
+free(base_vtables);
+return -1;
+}
+#endif
+/* SetupReduce */
+#if !CYTHON_COMPILING_IN_LIMITED_API
+static int __Pyx_setup_reduce_is_named(PyObject* meth, PyObject* name) {
+int ret;
+PyObject *name_attr;
+name_attr = __Pyx_PyObject_GetAttrStrNoError(meth, __pyx_n_s_name_2);
+if (likely(name_attr)) {
+ret = PyObject_RichCompareBool(name_attr, name, Py_EQ);
+} else {
+ret = -1;
+}
+if (unlikely(ret < 0)) {
+PyErr_Clear();
+ret = 0;
+}
+Py_XDECREF(name_attr);
+return ret;
+}
+static int __Pyx_setup_reduce(PyObject* type_obj) {
+int ret = 0;
+PyObject *object_reduce = NULL;
+PyObject *object_getstate = NULL;
+PyObject *object_reduce_ex = NULL;
+PyObject *reduce = NULL;
+PyObject *reduce_ex = NULL;
+PyObject *reduce_cython = NULL;
+PyObject *setstate = NULL;
+PyObject *setstate_cython = NULL;
+PyObject *getstate = NULL;
+#if CYTHON_USE_PYTYPE_LOOKUP
+getstate = _PyType_Lookup((PyTypeObject*)type_obj, __pyx_n_s_getstate);
+#else
+getstate = __Pyx_PyObject_GetAttrStrNoError(type_obj, __pyx_n_s_getstate);
+if (!getstate && PyErr_Occurred()) {
+goto __PYX_BAD;
+}
+#endif
+if (getstate) {
+#if CYTHON_USE_PYTYPE_LOOKUP
+object_getstate = _PyType_Lookup(&PyBaseObject_Type, __pyx_n_s_getstate);
+#else
+object_getstate = __Pyx_PyObject_GetAttrStrNoError((PyObject*)&PyBaseObject_Type, __pyx_n_s_getstate);
+if (!object_getstate && PyErr_Occurred()) {
+goto __PYX_BAD;
+}
+#endif
+if (object_getstate != getstate) {
+goto __PYX_GOOD;
+}
+}
+#if CYTHON_USE_PYTYPE_LOOKUP
+object_reduce_ex = _PyType_Lookup(&PyBaseObject_Type, __pyx_n_s_reduce_ex); if (!object_reduce_ex) goto __PYX_BAD;
+#else
+object_reduce_ex = __Pyx_PyObject_GetAttrStr((PyObject*)&PyBaseObject_Type, __pyx_n_s_reduce_ex); if (!object_reduce_ex) goto __PYX_BAD;
+#endif
+reduce_ex = __Pyx_PyObject_GetAttrStr(type_obj, __pyx_n_s_reduce_ex); if (unlikely(!reduce_ex)) goto __PYX_BAD;
+if (reduce_ex == object_reduce_ex) {
+#if CYTHON_USE_PYTYPE_LOOKUP
+object_reduce = _PyType_Lookup(&PyBaseObject_Type, __pyx_n_s_reduce); if (!object_reduce) goto __PYX_BAD;
+#else
+object_reduce = __Pyx_PyObject_GetAttrStr((PyObject*)&PyBaseObject_Type, __pyx_n_s_reduce); if (!object_reduce) goto __PYX_BAD;
+#endif
+reduce = __Pyx_PyObject_GetAttrStr(type_obj, __pyx_n_s_reduce); if (unlikely(!reduce)) goto __PYX_BAD;
+if (reduce == object_reduce || __Pyx_setup_reduce_is_named(reduce, __pyx_n_s_reduce_cython)) {
+reduce_cython = __Pyx_PyObject_GetAttrStrNoError(type_obj, __pyx_n_s_reduce_cython);
+if (likely(reduce_cython)) {
+ret = PyDict_SetItem(((PyTypeObject*)type_obj)->tp_dict, __pyx_n_s_reduce, reduce_cython); if (unlikely(ret < 0)) goto __PYX_BAD;
+ret = PyDict_DelItem(((PyTypeObject*)type_obj)->tp_dict, __pyx_n_s_reduce_cython); if (unlikely(ret < 0)) goto __PYX_BAD;
+} else if (reduce == object_reduce || PyErr_Occurred()) {
+goto __PYX_BAD;
+}
+setstate = __Pyx_PyObject_GetAttrStrNoError(type_obj, __pyx_n_s_setstate);
+if (!setstate) PyErr_Clear();
+if (!setstate || __Pyx_setup_reduce_is_named(setstate, __pyx_n_s_setstate_cython)) {
+setstate_cython = __Pyx_PyObject_GetAttrStrNoError(type_obj, __pyx_n_s_setstate_cython);
+if (likely(setstate_cython)) {
+ret = PyDict_SetItem(((PyTypeObject*)type_obj)->tp_dict, __pyx_n_s_setstate, setstate_cython); if (unlikely(ret < 0)) goto __PYX_BAD;
+ret = PyDict_DelItem(((PyTypeObject*)type_obj)->tp_dict, __pyx_n_s_setstate_cython); if (unlikely(ret < 0)) goto __PYX_BAD;
+} else if (!setstate || PyErr_Occurred()) {
+goto __PYX_BAD;
+}
+}
+PyType_Modified((PyTypeObject*)type_obj);
+}
+}
+goto __PYX_GOOD;
+__PYX_BAD:
+if (!PyErr_Occurred()) {
+__Pyx_TypeName type_obj_name =
+__Pyx_PyType_GetName((PyTypeObject*)type_obj);
+PyErr_Format(PyExc_RuntimeError,
+"Unable to initialize pickling for " __Pyx_FMT_TYPENAME, type_obj_name);
+__Pyx_DECREF_TypeName(type_obj_name);
+}
+ret = -1;
+__PYX_GOOD:
+#if !CYTHON_USE_PYTYPE_LOOKUP
+Py_XDECREF(object_reduce);
+Py_XDECREF(object_reduce_ex);
+Py_XDECREF(object_getstate);
+Py_XDECREF(getstate);
+#endif
+Py_XDECREF(reduce);
+Py_XDECREF(reduce_ex);
+Py_XDECREF(reduce_cython);
+Py_XDECREF(setstate);
+Py_XDECREF(setstate_cython);
+return ret;
+}
+#endif
+/* TypeImport */
+#ifndef __PYX_HAVE_RT_ImportType_3_0_11
+#define __PYX_HAVE_RT_ImportType_3_0_11
+static PyTypeObject *__Pyx_ImportType_3_0_11(PyObject *module, const char *module_name, const char *class_name,
+size_t size, size_t alignment, enum __Pyx_ImportType_CheckSize_3_0_11 check_size)
+{
+PyObject *result = 0;
+char warning[200];
+Py_ssize_t basicsize;
+Py_ssize_t itemsize;
+#if CYTHON_COMPILING_IN_LIMITED_API
+PyObject *py_basicsize;
+PyObject *py_itemsize;
+#endif
+result = PyObject_GetAttrString(module, class_name);
+if (!result)
+goto bad;
+if (!PyType_Check(result)) {
+PyErr_Format(PyExc_TypeError,
+"%.200s.%.200s is not a type object",
+module_name, class_name);
+goto bad;
+}
+#if !CYTHON_COMPILING_IN_LIMITED_API
+basicsize = ((PyTypeObject *)result)->tp_basicsize;
+itemsize = ((PyTypeObject *)result)->tp_itemsize;
+#else
+py_basicsize = PyObject_GetAttrString(result, "__basicsize__");
+if (!py_basicsize)
+goto bad;
+basicsize = PyLong_AsSsize_t(py_basicsize);
+Py_DECREF(py_basicsize);
+py_basicsize = 0;
+if (basicsize == (Py_ssize_t)-1 && PyErr_Occurred())
+goto bad;
+py_itemsize = PyObject_GetAttrString(result, "__itemsize__");
+if (!py_itemsize)
+goto bad;
+itemsize = PyLong_AsSsize_t(py_itemsize);
+Py_DECREF(py_itemsize);
+py_itemsize = 0;
+if (itemsize == (Py_ssize_t)-1 && PyErr_Occurred())
+goto bad;
+#endif
+if (itemsize) {
+if (size % alignment) {
+alignment = size % alignment;
+}
+if (itemsize < (Py_ssize_t)alignment)
+itemsize = (Py_ssize_t)alignment;
+}
+if ((size_t)(basicsize + itemsize) < size) {
+PyErr_Format(PyExc_ValueError,
+"%.200s.%.200s size changed, may indicate binary incompatibility. "
+"Expected %zd from C header, got %zd from PyObject",
+module_name, class_name, size, basicsize+itemsize);
+goto bad;
+}
+if (check_size == __Pyx_ImportType_CheckSize_Error_3_0_11 &&
+((size_t)basicsize > size || (size_t)(basicsize + itemsize) < size)) {
+PyErr_Format(PyExc_ValueError,
+"%.200s.%.200s size changed, may indicate binary incompatibility. "
+"Expected %zd from C header, got %zd-%zd from PyObject",
+module_name, class_name, size, basicsize, basicsize+itemsize);
+goto bad;
+}
+else if (check_size == __Pyx_ImportType_CheckSize_Warn_3_0_11 && (size_t)basicsize > size) {
+PyOS_snprintf(warning, sizeof(warning),
+"%s.%s size changed, may indicate binary incompatibility. "
+"Expected %zd from C header, got %zd from PyObject",
+module_name, class_name, size, basicsize);
+if (PyErr_WarnEx(NULL, warning, 0) < 0) goto bad;
+}
+return (PyTypeObject *)result;
+bad:
+Py_XDECREF(result);
+return NULL;
+}
+#endif
+/* ImportDottedModule */
+#if PY_MAJOR_VERSION >= 3
+static PyObject *__Pyx__ImportDottedModule_Error(PyObject *name, PyObject *parts_tuple, Py_ssize_t count) {
+PyObject *partial_name = NULL, *slice = NULL, *sep = NULL;
+if (unlikely(PyErr_Occurred())) {
+PyErr_Clear();
+}
+if (likely(PyTuple_GET_SIZE(parts_tuple) == count)) {
+partial_name = name;
+} else {
+slice = PySequence_GetSlice(parts_tuple, 0, count);
+if (unlikely(!slice))
+goto bad;
+sep = PyUnicode_FromStringAndSize(".", 1);
+if (unlikely(!sep))
+goto bad;
+partial_name = PyUnicode_Join(sep, slice);
+}
+PyErr_Format(
+#if PY_MAJOR_VERSION < 3
+PyExc_ImportError,
+"No module named '%s'", PyString_AS_STRING(partial_name));
+#else
+#if PY_VERSION_HEX >= 0x030600B1
+PyExc_ModuleNotFoundError,
+#else
+PyExc_ImportError,
+#endif
+"No module named '%U'", partial_name);
+#endif
+bad:
+Py_XDECREF(sep);
+Py_XDECREF(slice);
+Py_XDECREF(partial_name);
+return NULL;
+}
+#endif
+#if PY_MAJOR_VERSION >= 3
+static PyObject *__Pyx__ImportDottedModule_Lookup(PyObject *name) {
+PyObject *imported_module;
+#if PY_VERSION_HEX < 0x030700A1 || (CYTHON_COMPILING_IN_PYPY && PYPY_VERSION_NUM  < 0x07030400)
+PyObject *modules = PyImport_GetModuleDict();
+if (unlikely(!modules))
+return NULL;
+imported_module = __Pyx_PyDict_GetItemStr(modules, name);
+Py_XINCREF(imported_module);
+#else
+imported_module = PyImport_GetModule(name);
+#endif
+return imported_module;
+}
+#endif
+#if PY_MAJOR_VERSION >= 3
+static PyObject *__Pyx_ImportDottedModule_WalkParts(PyObject *module, PyObject *name, PyObject *parts_tuple) {
+Py_ssize_t i, nparts;
+nparts = PyTuple_GET_SIZE(parts_tuple);
+for (i=1; i < nparts && module; i++) {
+PyObject *part, *submodule;
+#if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
+part = PyTuple_GET_ITEM(parts_tuple, i);
+#else
+part = PySequence_ITEM(parts_tuple, i);
+#endif
+submodule = __Pyx_PyObject_GetAttrStrNoError(module, part);
+#if !(CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS)
+Py_DECREF(part);
+#endif
+Py_DECREF(module);
+module = submodule;
+}
+if (unlikely(!module)) {
+return __Pyx__ImportDottedModule_Error(name, parts_tuple, i);
+}
+return module;
+}
+#endif
+static PyObject *__Pyx__ImportDottedModule(PyObject *name, PyObject *parts_tuple) {
+#if PY_MAJOR_VERSION < 3
+PyObject *module, *from_list, *star = __pyx_n_s__48;
+CYTHON_UNUSED_VAR(parts_tuple);
+from_list = PyList_New(1);
+if (unlikely(!from_list))
+return NULL;
+Py_INCREF(star);
+PyList_SET_ITEM(from_list, 0, star);
+module = __Pyx_Import(name, from_list, 0);
+Py_DECREF(from_list);
+return module;
+#else
+PyObject *imported_module;
+PyObject *module = __Pyx_Import(name, NULL, 0);
+if (!parts_tuple || unlikely(!module))
+return module;
+imported_module = __Pyx__ImportDottedModule_Lookup(name);
+if (likely(imported_module)) {
+Py_DECREF(module);
+return imported_module;
+}
+PyErr_Clear();
+return __Pyx_ImportDottedModule_WalkParts(module, name, parts_tuple);
+#endif
+}
+static PyObject *__Pyx_ImportDottedModule(PyObject *name, PyObject *parts_tuple) {
+#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX >= 0x030400B1
+PyObject *module = __Pyx__ImportDottedModule_Lookup(name);
+if (likely(module)) {
+PyObject *spec = __Pyx_PyObject_GetAttrStrNoError(module, __pyx_n_s_spec);
+if (likely(spec)) {
+PyObject *unsafe = __Pyx_PyObject_GetAttrStrNoError(spec, __pyx_n_s_initializing);
+if (likely(!unsafe || !__Pyx_PyObject_IsTrue(unsafe))) {
+Py_DECREF(spec);
+spec = NULL;
+}
+Py_XDECREF(unsafe);
+}
+if (likely(!spec)) {
+PyErr_Clear();
+return module;
+}
+Py_DECREF(spec);
+Py_DECREF(module);
+} else if (PyErr_Occurred()) {
+PyErr_Clear();
+}
+#endif
+return __Pyx__ImportDottedModule(name, parts_tuple);
+}
+/* FetchSharedCythonModule */
+static PyObject *__Pyx_FetchSharedCythonABIModule(void) {
+return __Pyx_PyImport_AddModuleRef((char*) __PYX_ABI_MODULE_NAME);
+}
+/* FetchCommonType */
+static int __Pyx_VerifyCachedType(PyObject *cached_type,
+const char *name,
+Py_ssize_t basicsize,
+Py_ssize_t expected_basicsize) {
+if (!PyType_Check(cached_type)) {
+PyErr_Format(PyExc_TypeError,
+"Shared Cython type %.200s is not a type object", name);
+return -1;
+}
+if (basicsize != expected_basicsize) {
+PyErr_Format(PyExc_TypeError,
+"Shared Cython type %.200s has the wrong size, try recompiling",
+name);
+return -1;
+}
+return 0;
+}
+#if !CYTHON_USE_TYPE_SPECS
+static PyTypeObject* __Pyx_FetchCommonType(PyTypeObject* type) {
+PyObject* abi_module;
+const char* object_name;
+PyTypeObject *cached_type = NULL;
+abi_module = __Pyx_FetchSharedCythonABIModule();
+if (!abi_module) return NULL;
+object_name = strrchr(type->tp_name, '.');
+object_name = object_name ? object_name+1 : type->tp_name;
+cached_type = (PyTypeObject*) PyObject_GetAttrString(abi_module, object_name);
+if (cached_type) {
+if (__Pyx_VerifyCachedType(
+(PyObject *)cached_type,
+object_name,
+cached_type->tp_basicsize,
+type->tp_basicsize) < 0) {
+goto bad;
+}
+goto done;
+}
+if (!PyErr_ExceptionMatches(PyExc_AttributeError)) goto bad;
+PyErr_Clear();
+if (PyType_Ready(type) < 0) goto bad;
+if (PyObject_SetAttrString(abi_module, object_name, (PyObject *)type) < 0)
+goto bad;
+Py_INCREF(type);
+cached_type = type;
+done:
+Py_DECREF(abi_module);
+return cached_type;
+bad:
+Py_XDECREF(cached_type);
+cached_type = NULL;
+goto done;
+}
+#else
+static PyTypeObject *__Pyx_FetchCommonTypeFromSpec(PyObject *module, PyType_Spec *spec, PyObject *bases) {
+PyObject *abi_module, *cached_type = NULL;
+const char* object_name = strrchr(spec->name, '.');
+object_name = object_name ? object_name+1 : spec->name;
+abi_module = __Pyx_FetchSharedCythonABIModule();
+if (!abi_module) return NULL;
+cached_type = PyObject_GetAttrString(abi_module, object_name);
+if (cached_type) {
+Py_ssize_t basicsize;
+#if CYTHON_COMPILING_IN_LIMITED_API
+PyObject *py_basicsize;
+py_basicsize = PyObject_GetAttrString(cached_type, "__basicsize__");
+if (unlikely(!py_basicsize)) goto bad;
+basicsize = PyLong_AsSsize_t(py_basicsize);
+Py_DECREF(py_basicsize);
+py_basicsize = 0;
+if (unlikely(basicsize == (Py_ssize_t)-1) && PyErr_Occurred()) goto bad;
+#else
+basicsize = likely(PyType_Check(cached_type)) ? ((PyTypeObject*) cached_type)->tp_basicsize : -1;
+#endif
+if (__Pyx_VerifyCachedType(
+cached_type,
+object_name,
+basicsize,
+spec->basicsize) < 0) {
+goto bad;
+}
+goto done;
+}
+if (!PyErr_ExceptionMatches(PyExc_AttributeError)) goto bad;
+PyErr_Clear();
+CYTHON_UNUSED_VAR(module);
+cached_type = __Pyx_PyType_FromModuleAndSpec(abi_module, spec, bases);
+if (unlikely(!cached_type)) goto bad;
+if (unlikely(__Pyx_fix_up_extension_type_from_spec(spec, (PyTypeObject *) cached_type) < 0)) goto bad;
+if (PyObject_SetAttrString(abi_module, object_name, cached_type) < 0) goto bad;
+done:
+Py_DECREF(abi_module);
+assert(cached_type == NULL || PyType_Check(cached_type));
+return (PyTypeObject *) cached_type;
+bad:
+Py_XDECREF(cached_type);
+cached_type = NULL;
+goto done;
+}
+#endif
+/* PyVectorcallFastCallDict */
+#if CYTHON_METH_FASTCALL
+static PyObject *__Pyx_PyVectorcall_FastCallDict_kw(PyObject *func, __pyx_vectorcallfunc vc, PyObject *const *args, size_t nargs, PyObject *kw)
+{
+PyObject *res = NULL;
+PyObject *kwnames;
+PyObject **newargs;
+PyObject **kwvalues;
+Py_ssize_t i, pos;
+size_t j;
+PyObject *key, *value;
+unsigned long keys_are_strings;
+Py_ssize_t nkw = PyDict_GET_SIZE(kw);
+newargs = (PyObject **)PyMem_Malloc((nargs + (size_t)nkw) * sizeof(args[0]));
+if (unlikely(newargs == NULL)) {
+PyErr_NoMemory();
+return NULL;
+}
+for (j = 0; j < nargs; j++) newargs[j] = args[j];
+kwnames = PyTuple_New(nkw);
+if (unlikely(kwnames == NULL)) {
+PyMem_Free(newargs);
+return NULL;
+}
+kwvalues = newargs + nargs;
+pos = i = 0;
+keys_are_strings = Py_TPFLAGS_UNICODE_SUBCLASS;
+while (PyDict_Next(kw, &pos, &key, &value)) {
+keys_are_strings &= Py_TYPE(key)->tp_flags;
+Py_INCREF(key);
+Py_INCREF(value);
+PyTuple_SET_ITEM(kwnames, i, key);
+kwvalues[i] = value;
+i++;
+}
+if (unlikely(!keys_are_strings)) {
+PyErr_SetString(PyExc_TypeError, "keywords must be strings");
+goto cleanup;
+}
+res = vc(func, newargs, nargs, kwnames);
+cleanup:
+Py_DECREF(kwnames);
+for (i = 0; i < nkw; i++)
+Py_DECREF(kwvalues[i]);
+PyMem_Free(newargs);
+return res;
+}
+static CYTHON_INLINE PyObject *__Pyx_PyVectorcall_FastCallDict(PyObject *func, __pyx_vectorcallfunc vc, PyObject *const *args, size_t nargs, PyObject *kw)
+{
+if (likely(kw == NULL) || PyDict_GET_SIZE(kw) == 0) {
+return vc(func, args, nargs, NULL);
+}
+return __Pyx_PyVectorcall_FastCallDict_kw(func, vc, args, nargs, kw);
+}
+#endif
+/* CythonFunctionShared */
+#if CYTHON_COMPILING_IN_LIMITED_API
+static CYTHON_INLINE int __Pyx__IsSameCyOrCFunction(PyObject *func, void *cfunc) {
+if (__Pyx_CyFunction_Check(func)) {
+return PyCFunction_GetFunction(((__pyx_CyFunctionObject*)func)->func) == (PyCFunction) cfunc;
+} else if (PyCFunction_Check(func)) {
+return PyCFunction_GetFunction(func) == (PyCFunction) cfunc;
+}
+return 0;
+}
+#else
+static CYTHON_INLINE int __Pyx__IsSameCyOrCFunction(PyObject *func, void *cfunc) {
+return __Pyx_CyOrPyCFunction_Check(func) && __Pyx_CyOrPyCFunction_GET_FUNCTION(func) == (PyCFunction) cfunc;
+}
+#endif
+static CYTHON_INLINE void __Pyx__CyFunction_SetClassObj(__pyx_CyFunctionObject* f, PyObject* classobj) {
+#if PY_VERSION_HEX < 0x030900B1 || CYTHON_COMPILING_IN_LIMITED_API
+__Pyx_Py_XDECREF_SET(
+__Pyx_CyFunction_GetClassObj(f),
+((classobj) ? __Pyx_NewRef(classobj) : NULL));
+#else
+__Pyx_Py_XDECREF_SET(
+((PyCMethodObject *) (f))->mm_class,
+(PyTypeObject*)((classobj) ? __Pyx_NewRef(classobj) : NULL));
+#endif
+}
+static PyObject *
+__Pyx_CyFunction_get_doc(__pyx_CyFunctionObject *op, void *closure)
+{
+CYTHON_UNUSED_VAR(closure);
+if (unlikely(op->func_doc == NULL)) {
+#if CYTHON_COMPILING_IN_LIMITED_API
+op->func_doc = PyObject_GetAttrString(op->func, "__doc__");
+if (unlikely(!op->func_doc)) return NULL;
+#else
+if (((PyCFunctionObject*)op)->m_ml->ml_doc) {
+#if PY_MAJOR_VERSION >= 3
+op->func_doc = PyUnicode_FromString(((PyCFunctionObject*)op)->m_ml->ml_doc);
+#else
+op->func_doc = PyString_FromString(((PyCFunctionObject*)op)->m_ml->ml_doc);
+#endif
+if (unlikely(op->func_doc == NULL))
+return NULL;
+} else {
+Py_INCREF(Py_None);
+return Py_None;
+}
+#endif
+}
+Py_INCREF(op->func_doc);
+return op->func_doc;
+}
+static int
+__Pyx_CyFunction_set_doc(__pyx_CyFunctionObject *op, PyObject *value, void *context)
+{
+CYTHON_UNUSED_VAR(context);
+if (value == NULL) {
+value = Py_None;
+}
+Py_INCREF(value);
+__Pyx_Py_XDECREF_SET(op->func_doc, value);
+return 0;
+}
+static PyObject *
+__Pyx_CyFunction_get_name(__pyx_CyFunctionObject *op, void *context)
+{
+CYTHON_UNUSED_VAR(context);
+if (unlikely(op->func_name == NULL)) {
+#if CYTHON_COMPILING_IN_LIMITED_API
+op->func_name = PyObject_GetAttrString(op->func, "__name__");
+#elif PY_MAJOR_VERSION >= 3
+op->func_name = PyUnicode_InternFromString(((PyCFunctionObject*)op)->m_ml->ml_name);
+#else
+op->func_name = PyString_InternFromString(((PyCFunctionObject*)op)->m_ml->ml_name);
+#endif
+if (unlikely(op->func_name == NULL))
+return NULL;
+}
+Py_INCREF(op->func_name);
+return op->func_name;
+}
+static int
+__Pyx_CyFunction_set_name(__pyx_CyFunctionObject *op, PyObject *value, void *context)
+{
+CYTHON_UNUSED_VAR(context);
+#if PY_MAJOR_VERSION >= 3
+if (unlikely(value == NULL || !PyUnicode_Check(value)))
+#else
+if (unlikely(value == NULL || !PyString_Check(value)))
+#endif
+{
+PyErr_SetString(PyExc_TypeError,
+"__name__ must be set to a string object");
+return -1;
+}
+Py_INCREF(value);
+__Pyx_Py_XDECREF_SET(op->func_name, value);
+return 0;
+}
+static PyObject *
+__Pyx_CyFunction_get_qualname(__pyx_CyFunctionObject *op, void *context)
+{
+CYTHON_UNUSED_VAR(context);
+Py_INCREF(op->func_qualname);
+return op->func_qualname;
+}
+static int
+__Pyx_CyFunction_set_qualname(__pyx_CyFunctionObject *op, PyObject *value, void *context)
+{
+CYTHON_UNUSED_VAR(context);
+#if PY_MAJOR_VERSION >= 3
+if (unlikely(value == NULL || !PyUnicode_Check(value)))
+#else
+if (unlikely(value == NULL || !PyString_Check(value)))
+#endif
+{
+PyErr_SetString(PyExc_TypeError,
+"__qualname__ must be set to a string object");
+return -1;
+}
+Py_INCREF(value);
+__Pyx_Py_XDECREF_SET(op->func_qualname, value);
+return 0;
+}
+static PyObject *
+__Pyx_CyFunction_get_dict(__pyx_CyFunctionObject *op, void *context)
+{
+CYTHON_UNUSED_VAR(context);
+if (unlikely(op->func_dict == NULL)) {
+op->func_dict = PyDict_New();
+if (unlikely(op->func_dict == NULL))
+return NULL;
+}
+Py_INCREF(op->func_dict);
+return op->func_dict;
+}
+static int
+__Pyx_CyFunction_set_dict(__pyx_CyFunctionObject *op, PyObject *value, void *context)
+{
+CYTHON_UNUSED_VAR(context);
+if (unlikely(value == NULL)) {
+PyErr_SetString(PyExc_TypeError,
+"function's dictionary may not be deleted");
+return -1;
+}
+if (unlikely(!PyDict_Check(value))) {
+PyErr_SetString(PyExc_TypeError,
+"setting function's dictionary to a non-dict");
+return -1;
+}
+Py_INCREF(value);
+__Pyx_Py_XDECREF_SET(op->func_dict, value);
+return 0;
+}
+static PyObject *
+__Pyx_CyFunction_get_globals(__pyx_CyFunctionObject *op, void *context)
+{
+CYTHON_UNUSED_VAR(context);
+Py_INCREF(op->func_globals);
+return op->func_globals;
+}
+static PyObject *
+__Pyx_CyFunction_get_closure(__pyx_CyFunctionObject *op, void *context)
+{
+CYTHON_UNUSED_VAR(op);
+CYTHON_UNUSED_VAR(context);
+Py_INCREF(Py_None);
+return Py_None;
+}
+static PyObject *
+__Pyx_CyFunction_get_code(__pyx_CyFunctionObject *op, void *context)
+{
+PyObject* result = (op->func_code) ? op->func_code : Py_None;
+CYTHON_UNUSED_VAR(context);
+Py_INCREF(result);
+return result;
+}
+static int
+__Pyx_CyFunction_init_defaults(__pyx_CyFunctionObject *op) {
+int result = 0;
+PyObject *res = op->defaults_getter((PyObject *) op);
+if (unlikely(!res))
+return -1;
+#if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
+op->defaults_tuple = PyTuple_GET_ITEM(res, 0);
+Py_INCREF(op->defaults_tuple);
+op->defaults_kwdict = PyTuple_GET_ITEM(res, 1);
+Py_INCREF(op->defaults_kwdict);
+#else
+op->defaults_tuple = __Pyx_PySequence_ITEM(res, 0);
+if (unlikely(!op->defaults_tuple)) result = -1;
+else {
+op->defaults_kwdict = __Pyx_PySequence_ITEM(res, 1);
+if (unlikely(!op->defaults_kwdict)) result = -1;
+}
+#endif
+Py_DECREF(res);
+return result;
+}
+static int
+__Pyx_CyFunction_set_defaults(__pyx_CyFunctionObject *op, PyObject* value, void *context) {
+CYTHON_UNUSED_VAR(context);
+if (!value) {
+value = Py_None;
+} else if (unlikely(value != Py_None && !PyTuple_Check(value))) {
+PyErr_SetString(PyExc_TypeError,
+"__defaults__ must be set to a tuple object");
+return -1;
+}
+PyErr_WarnEx(PyExc_RuntimeWarning, "changes to cyfunction.__defaults__ will not "
+"currently affect the values used in function calls", 1);
+Py_INCREF(value);
+__Pyx_Py_XDECREF_SET(op->defaults_tuple, value);
+return 0;
+}
+static PyObject *
+__Pyx_CyFunction_get_defaults(__pyx_CyFunctionObject *op, void *context) {
+PyObject* result = op->defaults_tuple;
+CYTHON_UNUSED_VAR(context);
+if (unlikely(!result)) {
+if (op->defaults_getter) {
+if (unlikely(__Pyx_CyFunction_init_defaults(op) < 0)) return NULL;
+result = op->defaults_tuple;
+} else {
+result = Py_None;
+}
+}
+Py_INCREF(result);
+return result;
+}
+static int
+__Pyx_CyFunction_set_kwdefaults(__pyx_CyFunctionObject *op, PyObject* value, void *context) {
+CYTHON_UNUSED_VAR(context);
+if (!value) {
+value = Py_None;
+} else if (unlikely(value != Py_None && !PyDict_Check(value))) {
+PyErr_SetString(PyExc_TypeError,
+"__kwdefaults__ must be set to a dict object");
+return -1;
+}
+PyErr_WarnEx(PyExc_RuntimeWarning, "changes to cyfunction.__kwdefaults__ will not "
+"currently affect the values used in function calls", 1);
+Py_INCREF(value);
+__Pyx_Py_XDECREF_SET(op->defaults_kwdict, value);
+return 0;
+}
+static PyObject *
+__Pyx_CyFunction_get_kwdefaults(__pyx_CyFunctionObject *op, void *context) {
+PyObject* result = op->defaults_kwdict;
+CYTHON_UNUSED_VAR(context);
+if (unlikely(!result)) {
+if (op->defaults_getter) {
+if (unlikely(__Pyx_CyFunction_init_defaults(op) < 0)) return NULL;
+result = op->defaults_kwdict;
+} else {
+result = Py_None;
+}
+}
+Py_INCREF(result);
+return result;
+}
+static int
+__Pyx_CyFunction_set_annotations(__pyx_CyFunctionObject *op, PyObject* value, void *context) {
+CYTHON_UNUSED_VAR(context);
+if (!value || value == Py_None) {
+value = NULL;
+} else if (unlikely(!PyDict_Check(value))) {
+PyErr_SetString(PyExc_TypeError,
+"__annotations__ must be set to a dict object");
+return -1;
+}
+Py_XINCREF(value);
+__Pyx_Py_XDECREF_SET(op->func_annotations, value);
+return 0;
+}
+static PyObject *
+__Pyx_CyFunction_get_annotations(__pyx_CyFunctionObject *op, void *context) {
+PyObject* result = op->func_annotations;
+CYTHON_UNUSED_VAR(context);
+if (unlikely(!result)) {
+result = PyDict_New();
+if (unlikely(!result)) return NULL;
+op->func_annotations = result;
+}
+Py_INCREF(result);
+return result;
+}
+static PyObject *
+__Pyx_CyFunction_get_is_coroutine(__pyx_CyFunctionObject *op, void *context) {
+int is_coroutine;
+CYTHON_UNUSED_VAR(context);
+if (op->func_is_coroutine) {
+return __Pyx_NewRef(op->func_is_coroutine);
+}
+is_coroutine = op->flags & __Pyx_CYFUNCTION_COROUTINE;
+#if PY_VERSION_HEX >= 0x03050000
+if (is_coroutine) {
+PyObject *module, *fromlist, *marker = __pyx_n_s_is_coroutine;
+fromlist = PyList_New(1);
+if (unlikely(!fromlist)) return NULL;
+Py_INCREF(marker);
+#if CYTHON_ASSUME_SAFE_MACROS
+PyList_SET_ITEM(fromlist, 0, marker);
+#else
+if (unlikely(PyList_SetItem(fromlist, 0, marker) < 0)) {
+Py_DECREF(marker);
+Py_DECREF(fromlist);
+return NULL;
+}
+#endif
+module = PyImport_ImportModuleLevelObject(__pyx_n_s_asyncio_coroutines, NULL, NULL, fromlist, 0);
+Py_DECREF(fromlist);
+if (unlikely(!module)) goto ignore;
+op->func_is_coroutine = __Pyx_PyObject_GetAttrStr(module, marker);
+Py_DECREF(module);
+if (likely(op->func_is_coroutine)) {
+return __Pyx_NewRef(op->func_is_coroutine);
+}
+ignore:
+PyErr_Clear();
+}
+#endif
+op->func_is_coroutine = __Pyx_PyBool_FromLong(is_coroutine);
+return __Pyx_NewRef(op->func_is_coroutine);
+}
+#if CYTHON_COMPILING_IN_LIMITED_API
+static PyObject *
+__Pyx_CyFunction_get_module(__pyx_CyFunctionObject *op, void *context) {
+CYTHON_UNUSED_VAR(context);
+return PyObject_GetAttrString(op->func, "__module__");
+}
+static int
+__Pyx_CyFunction_set_module(__pyx_CyFunctionObject *op, PyObject* value, void *context) {
+CYTHON_UNUSED_VAR(context);
+return PyObject_SetAttrString(op->func, "__module__", value);
+}
+#endif
+static PyGetSetDef __pyx_CyFunction_getsets[] = {
+{(char *) "func_doc", (getter)__Pyx_CyFunction_get_doc, (setter)__Pyx_CyFunction_set_doc, 0, 0},
+{(char *) "__doc__",  (getter)__Pyx_CyFunction_get_doc, (setter)__Pyx_CyFunction_set_doc, 0, 0},
+{(char *) "func_name", (getter)__Pyx_CyFunction_get_name, (setter)__Pyx_CyFunction_set_name, 0, 0},
+{(char *) "__name__", (getter)__Pyx_CyFunction_get_name, (setter)__Pyx_CyFunction_set_name, 0, 0},
+{(char *) "__qualname__", (getter)__Pyx_CyFunction_get_qualname, (setter)__Pyx_CyFunction_set_qualname, 0, 0},
+{(char *) "func_dict", (getter)__Pyx_CyFunction_get_dict, (setter)__Pyx_CyFunction_set_dict, 0, 0},
+{(char *) "__dict__", (getter)__Pyx_CyFunction_get_dict, (setter)__Pyx_CyFunction_set_dict, 0, 0},
+{(char *) "func_globals", (getter)__Pyx_CyFunction_get_globals, 0, 0, 0},
+{(char *) "__globals__", (getter)__Pyx_CyFunction_get_globals, 0, 0, 0},
+{(char *) "func_closure", (getter)__Pyx_CyFunction_get_closure, 0, 0, 0},
+{(char *) "__closure__", (getter)__Pyx_CyFunction_get_closure, 0, 0, 0},
+{(char *) "func_code", (getter)__Pyx_CyFunction_get_code, 0, 0, 0},
+{(char *) "__code__", (getter)__Pyx_CyFunction_get_code, 0, 0, 0},
+{(char *) "func_defaults", (getter)__Pyx_CyFunction_get_defaults, (setter)__Pyx_CyFunction_set_defaults, 0, 0},
+{(char *) "__defaults__", (getter)__Pyx_CyFunction_get_defaults, (setter)__Pyx_CyFunction_set_defaults, 0, 0},
+{(char *) "__kwdefaults__", (getter)__Pyx_CyFunction_get_kwdefaults, (setter)__Pyx_CyFunction_set_kwdefaults, 0, 0},
+{(char *) "__annotations__", (getter)__Pyx_CyFunction_get_annotations, (setter)__Pyx_CyFunction_set_annotations, 0, 0},
+{(char *) "_is_coroutine", (getter)__Pyx_CyFunction_get_is_coroutine, 0, 0, 0},
+#if CYTHON_COMPILING_IN_LIMITED_API
+{"__module__", (getter)__Pyx_CyFunction_get_module, (setter)__Pyx_CyFunction_set_module, 0, 0},
+#endif
+{0, 0, 0, 0, 0}
+};
+static PyMemberDef __pyx_CyFunction_members[] = {
+#if !CYTHON_COMPILING_IN_LIMITED_API
+{(char *) "__module__", T_OBJECT, offsetof(PyCFunctionObject, m_module), 0, 0},
+#endif
+#if CYTHON_USE_TYPE_SPECS
+{(char *) "__dictoffset__", T_PYSSIZET, offsetof(__pyx_CyFunctionObject, func_dict), READONLY, 0},
+#if CYTHON_METH_FASTCALL
+#if CYTHON_BACKPORT_VECTORCALL
+{(char *) "__vectorcalloffset__", T_PYSSIZET, offsetof(__pyx_CyFunctionObject, func_vectorcall), READONLY, 0},
+#else
+#if !CYTHON_COMPILING_IN_LIMITED_API
+{(char *) "__vectorcalloffset__", T_PYSSIZET, offsetof(PyCFunctionObject, vectorcall), READONLY, 0},
+#endif
+#endif
+#endif
+#if PY_VERSION_HEX < 0x030500A0 || CYTHON_COMPILING_IN_LIMITED_API
+{(char *) "__weaklistoffset__", T_PYSSIZET, offsetof(__pyx_CyFunctionObject, func_weakreflist), READONLY, 0},
+#else
+{(char *) "__weaklistoffset__", T_PYSSIZET, offsetof(PyCFunctionObject, m_weakreflist), READONLY, 0},
+#endif
+#endif
+{0, 0, 0,  0, 0}
+};
+static PyObject *
+__Pyx_CyFunction_reduce(__pyx_CyFunctionObject *m, PyObject *args)
+{
+CYTHON_UNUSED_VAR(args);
+#if PY_MAJOR_VERSION >= 3
+Py_INCREF(m->func_qualname);
+return m->func_qualname;
+#else
+return PyString_FromString(((PyCFunctionObject*)m)->m_ml->ml_name);
+#endif
+}
+static PyMethodDef __pyx_CyFunction_methods[] = {
+{"__reduce__", (PyCFunction)__Pyx_CyFunction_reduce, METH_VARARGS, 0},
+{0, 0, 0, 0}
+};
+#if PY_VERSION_HEX < 0x030500A0 || CYTHON_COMPILING_IN_LIMITED_API
+#define __Pyx_CyFunction_weakreflist(cyfunc) ((cyfunc)->func_weakreflist)
+#else
+#define __Pyx_CyFunction_weakreflist(cyfunc) (((PyCFunctionObject*)cyfunc)->m_weakreflist)
+#endif
+static PyObject *__Pyx_CyFunction_Init(__pyx_CyFunctionObject *op, PyMethodDef *ml, int flags, PyObject* qualname,
+PyObject *closure, PyObject *module, PyObject* globals, PyObject* code) {
+#if !CYTHON_COMPILING_IN_LIMITED_API
+PyCFunctionObject *cf = (PyCFunctionObject*) op;
+#endif
+if (unlikely(op == NULL))
+return NULL;
+#if CYTHON_COMPILING_IN_LIMITED_API
+op->func = PyCFunction_NewEx(ml, (PyObject*)op, module);
+if (unlikely(!op->func)) return NULL;
+#endif
+op->flags = flags;
+__Pyx_CyFunction_weakreflist(op) = NULL;
+#if !CYTHON_COMPILING_IN_LIMITED_API
+cf->m_ml = ml;
+cf->m_self = (PyObject *) op;
+#endif
+Py_XINCREF(closure);
+op->func_closure = closure;
+#if !CYTHON_COMPILING_IN_LIMITED_API
+Py_XINCREF(module);
+cf->m_module = module;
+#endif
+op->func_dict = NULL;
+op->func_name = NULL;
+Py_INCREF(qualname);
+op->func_qualname = qualname;
+op->func_doc = NULL;
+#if PY_VERSION_HEX < 0x030900B1 || CYTHON_COMPILING_IN_LIMITED_API
+op->func_classobj = NULL;
+#else
+((PyCMethodObject*)op)->mm_class = NULL;
+#endif
+op->func_globals = globals;
+Py_INCREF(op->func_globals);
+Py_XINCREF(code);
+op->func_code = code;
+op->defaults_pyobjects = 0;
+op->defaults_size = 0;
+op->defaults = NULL;
+op->defaults_tuple = NULL;
+op->defaults_kwdict = NULL;
+op->defaults_getter = NULL;
+op->func_annotations = NULL;
+op->func_is_coroutine = NULL;
+#if CYTHON_METH_FASTCALL
+switch (ml->ml_flags & (METH_VARARGS | METH_FASTCALL | METH_NOARGS | METH_O | METH_KEYWORDS | METH_METHOD)) {
+case METH_NOARGS:
+__Pyx_CyFunction_func_vectorcall(op) = __Pyx_CyFunction_Vectorcall_NOARGS;
+break;
+case METH_O:
+__Pyx_CyFunction_func_vectorcall(op) = __Pyx_CyFunction_Vectorcall_O;
+break;
+case METH_METHOD | METH_FASTCALL | METH_KEYWORDS:
+__Pyx_CyFunction_func_vectorcall(op) = __Pyx_CyFunction_Vectorcall_FASTCALL_KEYWORDS_METHOD;
+break;
+case METH_FASTCALL | METH_KEYWORDS:
+__Pyx_CyFunction_func_vectorcall(op) = __Pyx_CyFunction_Vectorcall_FASTCALL_KEYWORDS;
+break;
+case METH_VARARGS | METH_KEYWORDS:
+__Pyx_CyFunction_func_vectorcall(op) = NULL;
+break;
+default:
+PyErr_SetString(PyExc_SystemError, "Bad call flags for CyFunction");
+Py_DECREF(op);
+return NULL;
+}
+#endif
+return (PyObject *) op;
+}
+static int
+__Pyx_CyFunction_clear(__pyx_CyFunctionObject *m)
+{
+Py_CLEAR(m->func_closure);
+#if CYTHON_COMPILING_IN_LIMITED_API
+Py_CLEAR(m->func);
+#else
+Py_CLEAR(((PyCFunctionObject*)m)->m_module);
+#endif
+Py_CLEAR(m->func_dict);
+Py_CLEAR(m->func_name);
+Py_CLEAR(m->func_qualname);
+Py_CLEAR(m->func_doc);
+Py_CLEAR(m->func_globals);
+Py_CLEAR(m->func_code);
+#if !CYTHON_COMPILING_IN_LIMITED_API
+#if PY_VERSION_HEX < 0x030900B1
+Py_CLEAR(__Pyx_CyFunction_GetClassObj(m));
+#else
+{
+PyObject *cls = (PyObject*) ((PyCMethodObject *) (m))->mm_class;
+((PyCMethodObject *) (m))->mm_class = NULL;
+Py_XDECREF(cls);
+}
+#endif
+#endif
+Py_CLEAR(m->defaults_tuple);
+Py_CLEAR(m->defaults_kwdict);
+Py_CLEAR(m->func_annotations);
+Py_CLEAR(m->func_is_coroutine);
+if (m->defaults) {
+PyObject **pydefaults = __Pyx_CyFunction_Defaults(PyObject *, m);
+int i;
+for (i = 0; i < m->defaults_pyobjects; i++)
+Py_XDECREF(pydefaults[i]);
+PyObject_Free(m->defaults);
+m->defaults = NULL;
+}
+return 0;
+}
+static void __Pyx__CyFunction_dealloc(__pyx_CyFunctionObject *m)
+{
+if (__Pyx_CyFunction_weakreflist(m) != NULL)
+PyObject_ClearWeakRefs((PyObject *) m);
+__Pyx_CyFunction_clear(m);
+__Pyx_PyHeapTypeObject_GC_Del(m);
+}
+static void __Pyx_CyFunction_dealloc(__pyx_CyFunctionObject *m)
+{
+PyObject_GC_UnTrack(m);
+__Pyx__CyFunction_dealloc(m);
+}
+static int __Pyx_CyFunction_traverse(__pyx_CyFunctionObject *m, visitproc visit, void *arg)
+{
+Py_VISIT(m->func_closure);
+#if CYTHON_COMPILING_IN_LIMITED_API
+Py_VISIT(m->func);
+#else
+Py_VISIT(((PyCFunctionObject*)m)->m_module);
+#endif
+Py_VISIT(m->func_dict);
+Py_VISIT(m->func_name);
+Py_VISIT(m->func_qualname);
+Py_VISIT(m->func_doc);
+Py_VISIT(m->func_globals);
+Py_VISIT(m->func_code);
+#if !CYTHON_COMPILING_IN_LIMITED_API
+Py_VISIT(__Pyx_CyFunction_GetClassObj(m));
+#endif
+Py_VISIT(m->defaults_tuple);
+Py_VISIT(m->defaults_kwdict);
+Py_VISIT(m->func_is_coroutine);
+if (m->defaults) {
+PyObject **pydefaults = __Pyx_CyFunction_Defaults(PyObject *, m);
+int i;
+for (i = 0; i < m->defaults_pyobjects; i++)
+Py_VISIT(pydefaults[i]);
+}
+return 0;
+}
+static PyObject*
+__Pyx_CyFunction_repr(__pyx_CyFunctionObject *op)
+{
+#if PY_MAJOR_VERSION >= 3
+return PyUnicode_FromFormat("<cyfunction %U at %p>",
+op->func_qualname, (void *)op);
+#else
+return PyString_FromFormat("<cyfunction %s at %p>",
+PyString_AsString(op->func_qualname), (void *)op);
+#endif
+}
+static PyObject * __Pyx_CyFunction_CallMethod(PyObject *func, PyObject *self, PyObject *arg, PyObject *kw) {
+#if CYTHON_COMPILING_IN_LIMITED_API
+PyObject *f = ((__pyx_CyFunctionObject*)func)->func;
+PyObject *py_name = NULL;
+PyCFunction meth;
+int flags;
+meth = PyCFunction_GetFunction(f);
+if (unlikely(!meth)) return NULL;
+flags = PyCFunction_GetFlags(f);
+if (unlikely(flags < 0)) return NULL;
+#else
+PyCFunctionObject* f = (PyCFunctionObject*)func;
+PyCFunction meth = f->m_ml->ml_meth;
+int flags = f->m_ml->ml_flags;
+#endif
+Py_ssize_t size;
+switch (flags & (METH_VARARGS | METH_KEYWORDS | METH_NOARGS | METH_O)) {
+case METH_VARARGS:
+if (likely(kw == NULL || PyDict_Size(kw) == 0))
+return (*meth)(self, arg);
+break;
+case METH_VARARGS | METH_KEYWORDS:
+return (*(PyCFunctionWithKeywords)(void*)meth)(self, arg, kw);
+case METH_NOARGS:
+if (likely(kw == NULL || PyDict_Size(kw) == 0)) {
+#if CYTHON_ASSUME_SAFE_MACROS
+size = PyTuple_GET_SIZE(arg);
+#else
+size = PyTuple_Size(arg);
+if (unlikely(size < 0)) return NULL;
+#endif
+if (likely(size == 0))
+return (*meth)(self, NULL);
+#if CYTHON_COMPILING_IN_LIMITED_API
+py_name = __Pyx_CyFunction_get_name((__pyx_CyFunctionObject*)func, NULL);
+if (!py_name) return NULL;
+PyErr_Format(PyExc_TypeError,
+"%.200S() takes no arguments (%" CYTHON_FORMAT_SSIZE_T "d given)",
+py_name, size);
+Py_DECREF(py_name);
+#else
+PyErr_Format(PyExc_TypeError,
+"%.200s() takes no arguments (%" CYTHON_FORMAT_SSIZE_T "d given)",
+f->m_ml->ml_name, size);
+#endif
+return NULL;
+}
+break;
+case METH_O:
+if (likely(kw == NULL || PyDict_Size(kw) == 0)) {
+#if CYTHON_ASSUME_SAFE_MACROS
+size = PyTuple_GET_SIZE(arg);
+#else
+size = PyTuple_Size(arg);
+if (unlikely(size < 0)) return NULL;
+#endif
+if (likely(size == 1)) {
+PyObject *result, *arg0;
+#if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
+arg0 = PyTuple_GET_ITEM(arg, 0);
+#else
+arg0 = __Pyx_PySequence_ITEM(arg, 0); if (unlikely(!arg0)) return NULL;
+#endif
+result = (*meth)(self, arg0);
+#if !(CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS)
+Py_DECREF(arg0);
+#endif
+return result;
+}
+#if CYTHON_COMPILING_IN_LIMITED_API
+py_name = __Pyx_CyFunction_get_name((__pyx_CyFunctionObject*)func, NULL);
+if (!py_name) return NULL;
+PyErr_Format(PyExc_TypeError,
+"%.200S() takes exactly one argument (%" CYTHON_FORMAT_SSIZE_T "d given)",
+py_name, size);
+Py_DECREF(py_name);
+#else
+PyErr_Format(PyExc_TypeError,
+"%.200s() takes exactly one argument (%" CYTHON_FORMAT_SSIZE_T "d given)",
+f->m_ml->ml_name, size);
+#endif
+return NULL;
+}
+break;
+default:
+PyErr_SetString(PyExc_SystemError, "Bad call flags for CyFunction");
+return NULL;
+}
+#if CYTHON_COMPILING_IN_LIMITED_API
+py_name = __Pyx_CyFunction_get_name((__pyx_CyFunctionObject*)func, NULL);
+if (!py_name) return NULL;
+PyErr_Format(PyExc_TypeError, "%.200S() takes no keyword arguments",
+py_name);
+Py_DECREF(py_name);
+#else
+PyErr_Format(PyExc_TypeError, "%.200s() takes no keyword arguments",
+f->m_ml->ml_name);
+#endif
+return NULL;
+}
+static CYTHON_INLINE PyObject *__Pyx_CyFunction_Call(PyObject *func, PyObject *arg, PyObject *kw) {
+PyObject *self, *result;
+#if CYTHON_COMPILING_IN_LIMITED_API
+self = PyCFunction_GetSelf(((__pyx_CyFunctionObject*)func)->func);
+if (unlikely(!self) && PyErr_Occurred()) return NULL;
+#else
+self = ((PyCFunctionObject*)func)->m_self;
+#endif
+result = __Pyx_CyFunction_CallMethod(func, self, arg, kw);
+return result;
+}
+static PyObject *__Pyx_CyFunction_CallAsMethod(PyObject *func, PyObject *args, PyObject *kw) {
+PyObject *result;
+__pyx_CyFunctionObject *cyfunc = (__pyx_CyFunctionObject *) func;
+#if CYTHON_METH_FASTCALL
+__pyx_vectorcallfunc vc = __Pyx_CyFunction_func_vectorcall(cyfunc);
+if (vc) {
+#if CYTHON_ASSUME_SAFE_MACROS
+return __Pyx_PyVectorcall_FastCallDict(func, vc, &PyTuple_GET_ITEM(args, 0), (size_t)PyTuple_GET_SIZE(args), kw);
+#else
+(void) &__Pyx_PyVectorcall_FastCallDict;
+return PyVectorcall_Call(func, args, kw);
+#endif
+}
+#endif
+if ((cyfunc->flags & __Pyx_CYFUNCTION_CCLASS) && !(cyfunc->flags & __Pyx_CYFUNCTION_STATICMETHOD)) {
+Py_ssize_t argc;
+PyObject *new_args;
+PyObject *self;
+#if CYTHON_ASSUME_SAFE_MACROS
+argc = PyTuple_GET_SIZE(args);
+#else
+argc = PyTuple_Size(args);
+if (unlikely(!argc) < 0) return NULL;
+#endif
+new_args = PyTuple_GetSlice(args, 1, argc);
+if (unlikely(!new_args))
+return NULL;
+self = PyTuple_GetItem(args, 0);
+if (unlikely(!self)) {
+Py_DECREF(new_args);
+#if PY_MAJOR_VERSION > 2
+PyErr_Format(PyExc_TypeError,
+"unbound method %.200S() needs an argument",
+cyfunc->func_qualname);
+#else
+PyErr_SetString(PyExc_TypeError,
+"unbound method needs an argument");
+#endif
+return NULL;
+}
+result = __Pyx_CyFunction_CallMethod(func, self, new_args, kw);
+Py_DECREF(new_args);
+} else {
+result = __Pyx_CyFunction_Call(func, args, kw);
+}
+return result;
+}
+#if CYTHON_METH_FASTCALL
+static CYTHON_INLINE int __Pyx_CyFunction_Vectorcall_CheckArgs(__pyx_CyFunctionObject *cyfunc, Py_ssize_t nargs, PyObject *kwnames)
+{
+int ret = 0;
+if ((cyfunc->flags & __Pyx_CYFUNCTION_CCLASS) && !(cyfunc->flags & __Pyx_CYFUNCTION_STATICMETHOD)) {
+if (unlikely(nargs < 1)) {
+PyErr_Format(PyExc_TypeError, "%.200s() needs an argument",
+((PyCFunctionObject*)cyfunc)->m_ml->ml_name);
+return -1;
+}
+ret = 1;
+}
+if (unlikely(kwnames) && unlikely(PyTuple_GET_SIZE(kwnames))) {
+PyErr_Format(PyExc_TypeError,
+"%.200s() takes no keyword arguments", ((PyCFunctionObject*)cyfunc)->m_ml->ml_name);
+return -1;
+}
+return ret;
+}
+static PyObject * __Pyx_CyFunction_Vectorcall_NOARGS(PyObject *func, PyObject *const *args, size_t nargsf, PyObject *kwnames)
+{
+__pyx_CyFunctionObject *cyfunc = (__pyx_CyFunctionObject *)func;
+PyMethodDef* def = ((PyCFunctionObject*)cyfunc)->m_ml;
+#if CYTHON_BACKPORT_VECTORCALL
+Py_ssize_t nargs = (Py_ssize_t)nargsf;
+#else
+Py_ssize_t nargs = PyVectorcall_NARGS(nargsf);
+#endif
+PyObject *self;
+switch (__Pyx_CyFunction_Vectorcall_CheckArgs(cyfunc, nargs, kwnames)) {
+case 1:
+self = args[0];
+args += 1;
+nargs -= 1;
+break;
+case 0:
+self = ((PyCFunctionObject*)cyfunc)->m_self;
+break;
+default:
+return NULL;
+}
+if (unlikely(nargs != 0)) {
+PyErr_Format(PyExc_TypeError,
+"%.200s() takes no arguments (%" CYTHON_FORMAT_SSIZE_T "d given)",
+def->ml_name, nargs);
+return NULL;
+}
+return def->ml_meth(self, NULL);
+}
+static PyObject * __Pyx_CyFunction_Vectorcall_O(PyObject *func, PyObject *const *args, size_t nargsf, PyObject *kwnames)
+{
+__pyx_CyFunctionObject *cyfunc = (__pyx_CyFunctionObject *)func;
+PyMethodDef* def = ((PyCFunctionObject*)cyfunc)->m_ml;
+#if CYTHON_BACKPORT_VECTORCALL
+Py_ssize_t nargs = (Py_ssize_t)nargsf;
+#else
+Py_ssize_t nargs = PyVectorcall_NARGS(nargsf);
+#endif
+PyObject *self;
+switch (__Pyx_CyFunction_Vectorcall_CheckArgs(cyfunc, nargs, kwnames)) {
+case 1:
+self = args[0];
+args += 1;
+nargs -= 1;
+break;
+case 0:
+self = ((PyCFunctionObject*)cyfunc)->m_self;
+break;
+default:
+return NULL;
+}
+if (unlikely(nargs != 1)) {
+PyErr_Format(PyExc_TypeError,
+"%.200s() takes exactly one argument (%" CYTHON_FORMAT_SSIZE_T "d given)",
+def->ml_name, nargs);
+return NULL;
+}
+return def->ml_meth(self, args[0]);
+}
+static PyObject * __Pyx_CyFunction_Vectorcall_FASTCALL_KEYWORDS(PyObject *func, PyObject *const *args, size_t nargsf, PyObject *kwnames)
+{
+__pyx_CyFunctionObject *cyfunc = (__pyx_CyFunctionObject *)func;
+PyMethodDef* def = ((PyCFunctionObject*)cyfunc)->m_ml;
+#if CYTHON_BACKPORT_VECTORCALL
+Py_ssize_t nargs = (Py_ssize_t)nargsf;
+#else
+Py_ssize_t nargs = PyVectorcall_NARGS(nargsf);
+#endif
+PyObject *self;
+switch (__Pyx_CyFunction_Vectorcall_CheckArgs(cyfunc, nargs, NULL)) {
+case 1:
+self = args[0];
+args += 1;
+nargs -= 1;
+break;
+case 0:
+self = ((PyCFunctionObject*)cyfunc)->m_self;
+break;
+default:
+return NULL;
+}
+return ((__Pyx_PyCFunctionFastWithKeywords)(void(*)(void))def->ml_meth)(self, args, nargs, kwnames);
+}
+static PyObject * __Pyx_CyFunction_Vectorcall_FASTCALL_KEYWORDS_METHOD(PyObject *func, PyObject *const *args, size_t nargsf, PyObject *kwnames)
+{
+__pyx_CyFunctionObject *cyfunc = (__pyx_CyFunctionObject *)func;
+PyMethodDef* def = ((PyCFunctionObject*)cyfunc)->m_ml;
+PyTypeObject *cls = (PyTypeObject *) __Pyx_CyFunction_GetClassObj(cyfunc);
+#if CYTHON_BACKPORT_VECTORCALL
+Py_ssize_t nargs = (Py_ssize_t)nargsf;
+#else
+Py_ssize_t nargs = PyVectorcall_NARGS(nargsf);
+#endif
+PyObject *self;
+switch (__Pyx_CyFunction_Vectorcall_CheckArgs(cyfunc, nargs, NULL)) {
+case 1:
+self = args[0];
+args += 1;
+nargs -= 1;
+break;
+case 0:
+self = ((PyCFunctionObject*)cyfunc)->m_self;
+break;
+default:
+return NULL;
+}
+return ((__Pyx_PyCMethod)(void(*)(void))def->ml_meth)(self, cls, args, (size_t)nargs, kwnames);
+}
+#endif
+#if CYTHON_USE_TYPE_SPECS
+static PyType_Slot __pyx_CyFunctionType_slots[] = {
+{Py_tp_dealloc, (void *)__Pyx_CyFunction_dealloc},
+{Py_tp_repr, (void *)__Pyx_CyFunction_repr},
+{Py_tp_call, (void *)__Pyx_CyFunction_CallAsMethod},
+{Py_tp_traverse, (void *)__Pyx_CyFunction_traverse},
+{Py_tp_clear, (void *)__Pyx_CyFunction_clear},
+{Py_tp_methods, (void *)__pyx_CyFunction_methods},
+{Py_tp_members, (void *)__pyx_CyFunction_members},
+{Py_tp_getset, (void *)__pyx_CyFunction_getsets},
+{Py_tp_descr_get, (void *)__Pyx_PyMethod_New},
+{0, 0},
+};
+static PyType_Spec __pyx_CyFunctionType_spec = {
+__PYX_TYPE_MODULE_PREFIX "cython_function_or_method",
+sizeof(__pyx_CyFunctionObject),
+0,
+#ifdef Py_TPFLAGS_METHOD_DESCRIPTOR
+Py_TPFLAGS_METHOD_DESCRIPTOR |
+#endif
+#if (defined(_Py_TPFLAGS_HAVE_VECTORCALL) && CYTHON_METH_FASTCALL)
+_Py_TPFLAGS_HAVE_VECTORCALL |
+#endif
+Py_TPFLAGS_DEFAULT | Py_TPFLAGS_HAVE_GC | Py_TPFLAGS_BASETYPE,
+__pyx_CyFunctionType_slots
+};
+#else
+static PyTypeObject __pyx_CyFunctionType_type = {
+PyVarObject_HEAD_INIT(0, 0)
+__PYX_TYPE_MODULE_PREFIX "cython_function_or_method",
+sizeof(__pyx_CyFunctionObject),
+0,
+(destructor) __Pyx_CyFunction_dealloc,
+#if !CYTHON_METH_FASTCALL
+0,
+#elif CYTHON_BACKPORT_VECTORCALL
+(printfunc)offsetof(__pyx_CyFunctionObject, func_vectorcall),
+#else
+offsetof(PyCFunctionObject, vectorcall),
+#endif
+0,
+0,
+#if PY_MAJOR_VERSION < 3
+0,
+#else
+0,
+#endif
+(reprfunc) __Pyx_CyFunction_repr,
+0,
+0,
+0,
+0,
+__Pyx_CyFunction_CallAsMethod,
+0,
+0,
+0,
+0,
+#ifdef Py_TPFLAGS_METHOD_DESCRIPTOR
+Py_TPFLAGS_METHOD_DESCRIPTOR |
+#endif
+#if defined(_Py_TPFLAGS_HAVE_VECTORCALL) && CYTHON_METH_FASTCALL
+_Py_TPFLAGS_HAVE_VECTORCALL |
+#endif
+Py_TPFLAGS_DEFAULT | Py_TPFLAGS_HAVE_GC | Py_TPFLAGS_BASETYPE,
+0,
+(traverseproc) __Pyx_CyFunction_traverse,
+(inquiry) __Pyx_CyFunction_clear,
+0,
+#if PY_VERSION_HEX < 0x030500A0
+offsetof(__pyx_CyFunctionObject, func_weakreflist),
+#else
+offsetof(PyCFunctionObject, m_weakreflist),
+#endif
+0,
+0,
+__pyx_CyFunction_methods,
+__pyx_CyFunction_members,
+__pyx_CyFunction_getsets,
+0,
+0,
+__Pyx_PyMethod_New,
+0,
+offsetof(__pyx_CyFunctionObject, func_dict),
+0,
+0,
+0,
+0,
+0,
+0,
+0,
+0,
+0,
+0,
+0,
+0,
+#if PY_VERSION_HEX >= 0x030400a1
+0,
+#endif
+#if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
+0,
+#endif
+#if __PYX_NEED_TP_PRINT_SLOT
+0,
+#endif
+#if PY_VERSION_HEX >= 0x030C0000
+0,
+#endif
+#if PY_VERSION_HEX >= 0x030d00A4
+0,
+#endif
+#if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
+0,
+#endif
+};
+#endif
+static int __pyx_CyFunction_init(PyObject *module) {
+#if CYTHON_USE_TYPE_SPECS
+__pyx_CyFunctionType = __Pyx_FetchCommonTypeFromSpec(module, &__pyx_CyFunctionType_spec, NULL);
+#else
+CYTHON_UNUSED_VAR(module);
+__pyx_CyFunctionType = __Pyx_FetchCommonType(&__pyx_CyFunctionType_type);
+#endif
+if (unlikely(__pyx_CyFunctionType == NULL)) {
+return -1;
+}
+return 0;
+}
+static CYTHON_INLINE void *__Pyx_CyFunction_InitDefaults(PyObject *func, size_t size, int pyobjects) {
+__pyx_CyFunctionObject *m = (__pyx_CyFunctionObject *) func;
+m->defaults = PyObject_Malloc(size);
+if (unlikely(!m->defaults))
+return PyErr_NoMemory();
+memset(m->defaults, 0, size);
+m->defaults_pyobjects = pyobjects;
+m->defaults_size = size;
+return m->defaults;
+}
+static CYTHON_INLINE void __Pyx_CyFunction_SetDefaultsTuple(PyObject *func, PyObject *tuple) {
+__pyx_CyFunctionObject *m = (__pyx_CyFunctionObject *) func;
+m->defaults_tuple = tuple;
+Py_INCREF(tuple);
+}
+static CYTHON_INLINE void __Pyx_CyFunction_SetDefaultsKwDict(PyObject *func, PyObject *dict) {
+__pyx_CyFunctionObject *m = (__pyx_CyFunctionObject *) func;
+m->defaults_kwdict = dict;
+Py_INCREF(dict);
+}
+static CYTHON_INLINE void __Pyx_CyFunction_SetAnnotationsDict(PyObject *func, PyObject *dict) {
+__pyx_CyFunctionObject *m = (__pyx_CyFunctionObject *) func;
+m->func_annotations = dict;
+Py_INCREF(dict);
+}
+/* CythonFunction */
+static PyObject *__Pyx_CyFunction_New(PyMethodDef *ml, int flags, PyObject* qualname,
+PyObject *closure, PyObject *module, PyObject* globals, PyObject* code) {
+PyObject *op = __Pyx_CyFunction_Init(
+PyObject_GC_New(__pyx_CyFunctionObject, __pyx_CyFunctionType),
+ml, flags, qualname, closure, module, globals, code
+);
+if (likely(op)) {
+PyObject_GC_Track(op);
+}
+return op;
+}
+/* CLineInTraceback */
+#ifndef CYTHON_CLINE_IN_TRACEBACK
+static int __Pyx_CLineForTraceback(PyThreadState *tstate, int c_line) {
+PyObject *use_cline;
+PyObject *ptype, *pvalue, *ptraceback;
+#if CYTHON_COMPILING_IN_CPYTHON
+PyObject **cython_runtime_dict;
+#endif
+CYTHON_MAYBE_UNUSED_VAR(tstate);
+if (unlikely(!__pyx_cython_runtime)) {
+return c_line;
+}
+__Pyx_ErrFetchInState(tstate, &ptype, &pvalue, &ptraceback);
+#if CYTHON_COMPILING_IN_CPYTHON
+cython_runtime_dict = _PyObject_GetDictPtr(__pyx_cython_runtime);
+if (likely(cython_runtime_dict)) {
+__PYX_PY_DICT_LOOKUP_IF_MODIFIED(
+use_cline, *cython_runtime_dict,
+__Pyx_PyDict_GetItemStr(*cython_runtime_dict, __pyx_n_s_cline_in_traceback))
+} else
+#endif
+{
+PyObject *use_cline_obj = __Pyx_PyObject_GetAttrStrNoError(__pyx_cython_runtime, __pyx_n_s_cline_in_traceback);
+if (use_cline_obj) {
+use_cline = PyObject_Not(use_cline_obj) ? Py_False : Py_True;
+Py_DECREF(use_cline_obj);
+} else {
+PyErr_Clear();
+use_cline = NULL;
+}
+}
+if (!use_cline) {
+c_line = 0;
+(void) PyObject_SetAttr(__pyx_cython_runtime, __pyx_n_s_cline_in_traceback, Py_False);
+}
+else if (use_cline == Py_False || (use_cline != Py_True && PyObject_Not(use_cline) != 0)) {
+c_line = 0;
+}
+__Pyx_ErrRestoreInState(tstate, ptype, pvalue, ptraceback);
+return c_line;
+}
+#endif
+/* CodeObjectCache */
+#if !CYTHON_COMPILING_IN_LIMITED_API
+static int __pyx_bisect_code_objects(__Pyx_CodeObjectCacheEntry* entries, int count, int code_line) {
+int start = 0, mid = 0, end = count - 1;
+if (end >= 0 && code_line > entries[end].code_line) {
+return count;
+}
+while (start < end) {
+mid = start + (end - start) / 2;
+if (code_line < entries[mid].code_line) {
+end = mid;
+} else if (code_line > entries[mid].code_line) {
+start = mid + 1;
+} else {
+return mid;
+}
+}
+if (code_line <= entries[mid].code_line) {
+return mid;
+} else {
+return mid + 1;
+}
+}
+static PyCodeObject *__pyx_find_code_object(int code_line) {
+PyCodeObject* code_object;
+int pos;
+if (unlikely(!code_line) || unlikely(!__pyx_code_cache.entries)) {
+return NULL;
+}
+pos = __pyx_bisect_code_objects(__pyx_code_cache.entries, __pyx_code_cache.count, code_line);
+if (unlikely(pos >= __pyx_code_cache.count) || unlikely(__pyx_code_cache.entries[pos].code_line != code_line)) {
+return NULL;
+}
+code_object = __pyx_code_cache.entries[pos].code_object;
+Py_INCREF(code_object);
+return code_object;
+}
+static void __pyx_insert_code_object(int code_line, PyCodeObject* code_object) {
+int pos, i;
+__Pyx_CodeObjectCacheEntry* entries = __pyx_code_cache.entries;
+if (unlikely(!code_line)) {
+return;
+}
+if (unlikely(!entries)) {
+entries = (__Pyx_CodeObjectCacheEntry*)PyMem_Malloc(64*sizeof(__Pyx_CodeObjectCacheEntry));
+if (likely(entries)) {
+__pyx_code_cache.entries = entries;
+__pyx_code_cache.max_count = 64;
+__pyx_code_cache.count = 1;
+entries[0].code_line = code_line;
+entries[0].code_object = code_object;
+Py_INCREF(code_object);
+}
+return;
+}
+pos = __pyx_bisect_code_objects(__pyx_code_cache.entries, __pyx_code_cache.count, code_line);
+if ((pos < __pyx_code_cache.count) && unlikely(__pyx_code_cache.entries[pos].code_line == code_line)) {
+PyCodeObject* tmp = entries[pos].code_object;
+entries[pos].code_object = code_object;
+Py_DECREF(tmp);
+return;
+}
+if (__pyx_code_cache.count == __pyx_code_cache.max_count) {
+int new_max = __pyx_code_cache.max_count + 64;
+entries = (__Pyx_CodeObjectCacheEntry*)PyMem_Realloc(
+__pyx_code_cache.entries, ((size_t)new_max) * sizeof(__Pyx_CodeObjectCacheEntry));
+if (unlikely(!entries)) {
+return;
+}
+__pyx_code_cache.entries = entries;
+__pyx_code_cache.max_count = new_max;
+}
+for (i=__pyx_code_cache.count; i>pos; i--) {
+entries[i] = entries[i-1];
+}
+entries[pos].code_line = code_line;
+entries[pos].code_object = code_object;
+__pyx_code_cache.count++;
+Py_INCREF(code_object);
+}
+#endif
+/* AddTraceback */
+#include "compile.h"
+#include "frameobject.h"
+#include "traceback.h"
+#if PY_VERSION_HEX >= 0x030b00a6 && !CYTHON_COMPILING_IN_LIMITED_API
+#ifndef Py_BUILD_CORE
+#define Py_BUILD_CORE 1
+#endif
+#include "internal/pycore_frame.h"
+#endif
+#if CYTHON_COMPILING_IN_LIMITED_API
+static PyObject *__Pyx_PyCode_Replace_For_AddTraceback(PyObject *code, PyObject *scratch_dict,
+PyObject *firstlineno, PyObject *name) {
+PyObject *replace = NULL;
+if (unlikely(PyDict_SetItemString(scratch_dict, "co_firstlineno", firstlineno))) return NULL;
+if (unlikely(PyDict_SetItemString(scratch_dict, "co_name", name))) return NULL;
+replace = PyObject_GetAttrString(code, "replace");
+if (likely(replace)) {
+PyObject *result;
+result = PyObject_Call(replace, __pyx_empty_tuple, scratch_dict);
+Py_DECREF(replace);
+return result;
+}
+PyErr_Clear();
+#if __PYX_LIMITED_VERSION_HEX < 0x030780000
+{
+PyObject *compiled = NULL, *result = NULL;
+if (unlikely(PyDict_SetItemString(scratch_dict, "code", code))) return NULL;
+if (unlikely(PyDict_SetItemString(scratch_dict, "type", (PyObject*)(&PyType_Type)))) return NULL;
+compiled = Py_CompileString(
+"out = type(code)(\n"
+"  code.co_argcount, code.co_kwonlyargcount, code.co_nlocals, code.co_stacksize,\n"
+"  code.co_flags, code.co_code, code.co_consts, code.co_names,\n"
+"  code.co_varnames, code.co_filename, co_name, co_firstlineno,\n"
+"  code.co_lnotab)\n", "<dummy>", Py_file_input);
+if (!compiled) return NULL;
+result = PyEval_EvalCode(compiled, scratch_dict, scratch_dict);
+Py_DECREF(compiled);
+if (!result) PyErr_Print();
+Py_DECREF(result);
+result = PyDict_GetItemString(scratch_dict, "out");
+if (result) Py_INCREF(result);
+return result;
+}
+#else
+return NULL;
+#endif
+}
+static void __Pyx_AddTraceback(const char *funcname, int c_line,
+int py_line, const char *filename) {
+PyObject *code_object = NULL, *py_py_line = NULL, *py_funcname = NULL, *dict = NULL;
+PyObject *replace = NULL, *getframe = NULL, *frame = NULL;
+PyObject *exc_type, *exc_value, *exc_traceback;
+int success = 0;
+if (c_line) {
+(void) __pyx_cfilenm;
+(void) __Pyx_CLineForTraceback(__Pyx_PyThreadState_Current, c_line);
+}
+PyErr_Fetch(&exc_type, &exc_value, &exc_traceback);
+code_object = Py_CompileString("_getframe()", filename, Py_eval_input);
+if (unlikely(!code_object)) goto bad;
+py_py_line = PyLong_FromLong(py_line);
+if (unlikely(!py_py_line)) goto bad;
+py_funcname = PyUnicode_FromString(funcname);
+if (unlikely(!py_funcname)) goto bad;
+dict = PyDict_New();
+if (unlikely(!dict)) goto bad;
+{
+PyObject *old_code_object = code_object;
+code_object = __Pyx_PyCode_Replace_For_AddTraceback(code_object, dict, py_py_line, py_funcname);
+Py_DECREF(old_code_object);
+}
+if (unlikely(!code_object)) goto bad;
+getframe = PySys_GetObject("_getframe");
+if (unlikely(!getframe)) goto bad;
+if (unlikely(PyDict_SetItemString(dict, "_getframe", getframe))) goto bad;
+frame = PyEval_EvalCode(code_object, dict, dict);
+if (unlikely(!frame) || frame == Py_None) goto bad;
+success = 1;
+bad:
+PyErr_Restore(exc_type, exc_value, exc_traceback);
+Py_XDECREF(code_object);
+Py_XDECREF(py_py_line);
+Py_XDECREF(py_funcname);
+Py_XDECREF(dict);
+Py_XDECREF(replace);
+if (success) {
+PyTraceBack_Here(
+(struct _frame*)frame);
+}
+Py_XDECREF(frame);
+}
+#else
+static PyCodeObject* __Pyx_CreateCodeObjectForTraceback(
+const char *funcname, int c_line,
+int py_line, const char *filename) {
+PyCodeObject *py_code = NULL;
+PyObject *py_funcname = NULL;
+#if PY_MAJOR_VERSION < 3
+PyObject *py_srcfile = NULL;
+py_srcfile = PyString_FromString(filename);
+if (!py_srcfile) goto bad;
+#endif
+if (c_line) {
+#if PY_MAJOR_VERSION < 3
+py_funcname = PyString_FromFormat( "%s (%s:%d)", funcname, __pyx_cfilenm, c_line);
+if (!py_funcname) goto bad;
+#else
+py_funcname = PyUnicode_FromFormat( "%s (%s:%d)", funcname, __pyx_cfilenm, c_line);
+if (!py_funcname) goto bad;
+funcname = PyUnicode_AsUTF8(py_funcname);
+if (!funcname) goto bad;
+#endif
+}
+else {
+#if PY_MAJOR_VERSION < 3
+py_funcname = PyString_FromString(funcname);
+if (!py_funcname) goto bad;
+#endif
+}
+#if PY_MAJOR_VERSION < 3
+py_code = __Pyx_PyCode_New(
+0,
+0,
+0,
+0,
+0,
+0,
+__pyx_empty_bytes, /*PyObject *code,*/
+__pyx_empty_tuple, /*PyObject *consts,*/
+__pyx_empty_tuple, /*PyObject *names,*/
+__pyx_empty_tuple, /*PyObject *varnames,*/
+__pyx_empty_tuple, /*PyObject *freevars,*/
+__pyx_empty_tuple, /*PyObject *cellvars,*/
+py_srcfile,   /*PyObject *filename,*/
+py_funcname,  /*PyObject *name,*/
+py_line,
+__pyx_empty_bytes  /*PyObject *lnotab*/
+);
+Py_DECREF(py_srcfile);
+#else
+py_code = PyCode_NewEmpty(filename, funcname, py_line);
+#endif
+Py_XDECREF(py_funcname);
+return py_code;
+bad:
+Py_XDECREF(py_funcname);
+#if PY_MAJOR_VERSION < 3
+Py_XDECREF(py_srcfile);
+#endif
+return NULL;
+}
+static void __Pyx_AddTraceback(const char *funcname, int c_line,
+int py_line, const char *filename) {
+PyCodeObject *py_code = 0;
+PyFrameObject *py_frame = 0;
+PyThreadState *tstate = __Pyx_PyThreadState_Current;
+PyObject *ptype, *pvalue, *ptraceback;
+if (c_line) {
+c_line = __Pyx_CLineForTraceback(tstate, c_line);
+}
+py_code = __pyx_find_code_object(c_line ? -c_line : py_line);
+if (!py_code) {
+__Pyx_ErrFetchInState(tstate, &ptype, &pvalue, &ptraceback);
+py_code = __Pyx_CreateCodeObjectForTraceback(
+funcname, c_line, py_line, filename);
+if (!py_code) {
+/* If the code object creation fails, then we should clear the
+fetched exception references and propagate the new exception */
+Py_XDECREF(ptype);
+Py_XDECREF(pvalue);
+Py_XDECREF(ptraceback);
+goto bad;
+}
+__Pyx_ErrRestoreInState(tstate, ptype, pvalue, ptraceback);
+__pyx_insert_code_object(c_line ? -c_line : py_line, py_code);
+}
+py_frame = PyFrame_New(
+tstate,            /*PyThreadState *tstate,*/
+py_code,           /*PyCodeObject *code,*/
+__pyx_d,    /*PyObject *globals,*/
+0                  /*PyObject *locals*/
+);
+if (!py_frame) goto bad;
+__Pyx_PyFrame_SetLineNumber(py_frame, py_line);
+PyTraceBack_Here(py_frame);
+bad:
+Py_XDECREF(py_code);
+Py_XDECREF(py_frame);
+}
+#endif
+/* CIntFromPyVerify */
+#define __PYX_VERIFY_RETURN_INT(target_type, func_type, func_value)\
+__PYX__VERIFY_RETURN_INT(target_type, func_type, func_value, 0)
+#define __PYX_VERIFY_RETURN_INT_EXC(target_type, func_type, func_value)\
+__PYX__VERIFY_RETURN_INT(target_type, func_type, func_value, 1)
+#define __PYX__VERIFY_RETURN_INT(target_type, func_type, func_value, exc)\
+{\
+func_type value = func_value;\
+if (sizeof(target_type) < sizeof(func_type)) {\
+if (unlikely(value != (func_type) (target_type) value)) {\
+func_type zero = 0;\
+if (exc && unlikely(value == (func_type)-1 && PyErr_Occurred()))\
+return (target_type) -1;\
+if (is_unsigned && unlikely(value < zero))\
+goto raise_neg_overflow;\
+else\
+goto raise_overflow;\
+}\
+}\
+return (target_type) value;\
+}
+/* CIntFromPy */
+static CYTHON_INLINE int __Pyx_PyInt_As_int(PyObject *x) {
+#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
+#pragma GCC diagnostic push
+#pragma GCC diagnostic ignored "-Wconversion"
+#endif
+const int neg_one = (int) -1, const_zero = (int) 0;
+#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
+#pragma GCC diagnostic pop
+#endif
+const int is_unsigned = neg_one > const_zero;
+#if PY_MAJOR_VERSION < 3
+if (likely(PyInt_Check(x))) {
+if ((sizeof(int) < sizeof(long))) {
+__PYX_VERIFY_RETURN_INT(int, long, PyInt_AS_LONG(x))
+} else {
+long val = PyInt_AS_LONG(x);
+if (is_unsigned && unlikely(val < 0)) {
+goto raise_neg_overflow;
+}
+return (int) val;
+}
+}
+#endif
+if (unlikely(!PyLong_Check(x))) {
+int val;
+PyObject *tmp = __Pyx_PyNumber_IntOrLong(x);
+if (!tmp) return (int) -1;
+val = __Pyx_PyInt_As_int(tmp);
+Py_DECREF(tmp);
+return val;
+}
+if (is_unsigned) {
+#if CYTHON_USE_PYLONG_INTERNALS
+if (unlikely(__Pyx_PyLong_IsNeg(x))) {
+goto raise_neg_overflow;
+} else if (__Pyx_PyLong_IsCompact(x)) {
+__PYX_VERIFY_RETURN_INT(int, __Pyx_compact_upylong, __Pyx_PyLong_CompactValueUnsigned(x))
+} else {
+const digit* digits = __Pyx_PyLong_Digits(x);
+assert(__Pyx_PyLong_DigitCount(x) > 1);
+switch (__Pyx_PyLong_DigitCount(x)) {
+case 2:
+if ((8 * sizeof(int) > 1 * PyLong_SHIFT)) {
+if ((8 * sizeof(unsigned long) > 2 * PyLong_SHIFT)) {
+__PYX_VERIFY_RETURN_INT(int, unsigned long, (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
+} else if ((8 * sizeof(int) >= 2 * PyLong_SHIFT)) {
+return (int) (((((int)digits[1]) << PyLong_SHIFT) | (int)digits[0]));
+}
+}
+break;
+case 3:
+if ((8 * sizeof(int) > 2 * PyLong_SHIFT)) {
+if ((8 * sizeof(unsigned long) > 3 * PyLong_SHIFT)) {
+__PYX_VERIFY_RETURN_INT(int, unsigned long, (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
+} else if ((8 * sizeof(int) >= 3 * PyLong_SHIFT)) {
+return (int) (((((((int)digits[2]) << PyLong_SHIFT) | (int)digits[1]) << PyLong_SHIFT) | (int)digits[0]));
+}
+}
+break;
+case 4:
+if ((8 * sizeof(int) > 3 * PyLong_SHIFT)) {
+if ((8 * sizeof(unsigned long) > 4 * PyLong_SHIFT)) {
+__PYX_VERIFY_RETURN_INT(int, unsigned long, (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
+} else if ((8 * sizeof(int) >= 4 * PyLong_SHIFT)) {
+return (int) (((((((((int)digits[3]) << PyLong_SHIFT) | (int)digits[2]) << PyLong_SHIFT) | (int)digits[1]) << PyLong_SHIFT) | (int)digits[0]));
+}
+}
+break;
+}
+}
+#endif
+#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX < 0x030C00A7
+if (unlikely(Py_SIZE(x) < 0)) {
+goto raise_neg_overflow;
+}
+#else
+{
+int result = PyObject_RichCompareBool(x, Py_False, Py_LT);
+if (unlikely(result < 0))
+return (int) -1;
+if (unlikely(result == 1))
+goto raise_neg_overflow;
+}
+#endif
+if ((sizeof(int) <= sizeof(unsigned long))) {
+__PYX_VERIFY_RETURN_INT_EXC(int, unsigned long, PyLong_AsUnsignedLong(x))
+#ifdef HAVE_LONG_LONG
+} else if ((sizeof(int) <= sizeof(unsigned PY_LONG_LONG))) {
+__PYX_VERIFY_RETURN_INT_EXC(int, unsigned PY_LONG_LONG, PyLong_AsUnsignedLongLong(x))
+#endif
+}
+} else {
+#if CYTHON_USE_PYLONG_INTERNALS
+if (__Pyx_PyLong_IsCompact(x)) {
+__PYX_VERIFY_RETURN_INT(int, __Pyx_compact_pylong, __Pyx_PyLong_CompactValue(x))
+} else {
+const digit* digits = __Pyx_PyLong_Digits(x);
+assert(__Pyx_PyLong_DigitCount(x) > 1);
+switch (__Pyx_PyLong_SignedDigitCount(x)) {
+case -2:
+if ((8 * sizeof(int) - 1 > 1 * PyLong_SHIFT)) {
+if ((8 * sizeof(unsigned long) > 2 * PyLong_SHIFT)) {
+__PYX_VERIFY_RETURN_INT(int, long, -(long) (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
+} else if ((8 * sizeof(int) - 1 > 2 * PyLong_SHIFT)) {
+return (int) (((int)-1)*(((((int)digits[1]) << PyLong_SHIFT) | (int)digits[0])));
+}
+}
+break;
+case 2:
+if ((8 * sizeof(int) > 1 * PyLong_SHIFT)) {
+if ((8 * sizeof(unsigned long) > 2 * PyLong_SHIFT)) {
+__PYX_VERIFY_RETURN_INT(int, unsigned long, (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
+} else if ((8 * sizeof(int) - 1 > 2 * PyLong_SHIFT)) {
+return (int) ((((((int)digits[1]) << PyLong_SHIFT) | (int)digits[0])));
+}
+}
+break;
+case -3:
+if ((8 * sizeof(int) - 1 > 2 * PyLong_SHIFT)) {
+if ((8 * sizeof(unsigned long) > 3 * PyLong_SHIFT)) {
+__PYX_VERIFY_RETURN_INT(int, long, -(long) (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
+} else if ((8 * sizeof(int) - 1 > 3 * PyLong_SHIFT)) {
+return (int) (((int)-1)*(((((((int)digits[2]) << PyLong_SHIFT) | (int)digits[1]) << PyLong_SHIFT) | (int)digits[0])));
+}
+}
+break;
+case 3:
+if ((8 * sizeof(int) > 2 * PyLong_SHIFT)) {
+if ((8 * sizeof(unsigned long) > 3 * PyLong_SHIFT)) {
+__PYX_VERIFY_RETURN_INT(int, unsigned long, (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
+} else if ((8 * sizeof(int) - 1 > 3 * PyLong_SHIFT)) {
+return (int) ((((((((int)digits[2]) << PyLong_SHIFT) | (int)digits[1]) << PyLong_SHIFT) | (int)digits[0])));
+}
+}
+break;
+case -4:
+if ((8 * sizeof(int) - 1 > 3 * PyLong_SHIFT)) {
+if ((8 * sizeof(unsigned long) > 4 * PyLong_SHIFT)) {
+__PYX_VERIFY_RETURN_INT(int, long, -(long) (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
+} else if ((8 * sizeof(int) - 1 > 4 * PyLong_SHIFT)) {
+return (int) (((int)-1)*(((((((((int)digits[3]) << PyLong_SHIFT) | (int)digits[2]) << PyLong_SHIFT) | (int)digits[1]) << PyLong_SHIFT) | (int)digits[0])));
+}
+}
+break;
+case 4:
+if ((8 * sizeof(int) > 3 * PyLong_SHIFT)) {
+if ((8 * sizeof(unsigned long) > 4 * PyLong_SHIFT)) {
+__PYX_VERIFY_RETURN_INT(int, unsigned long, (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
+} else if ((8 * sizeof(int) - 1 > 4 * PyLong_SHIFT)) {
+return (int) ((((((((((int)digits[3]) << PyLong_SHIFT) | (int)digits[2]) << PyLong_SHIFT) | (int)digits[1]) << PyLong_SHIFT) | (int)digits[0])));
+}
+}
+break;
+}
+}
+#endif
+if ((sizeof(int) <= sizeof(long))) {
+__PYX_VERIFY_RETURN_INT_EXC(int, long, PyLong_AsLong(x))
+#ifdef HAVE_LONG_LONG
+} else if ((sizeof(int) <= sizeof(PY_LONG_LONG))) {
+__PYX_VERIFY_RETURN_INT_EXC(int, PY_LONG_LONG, PyLong_AsLongLong(x))
+#endif
+}
+}
+{
+int val;
+int ret = -1;
+#if PY_VERSION_HEX >= 0x030d00A6 && !CYTHON_COMPILING_IN_LIMITED_API
+Py_ssize_t bytes_copied = PyLong_AsNativeBytes(
+x, &val, sizeof(val), Py_ASNATIVEBYTES_NATIVE_ENDIAN | (is_unsigned ? Py_ASNATIVEBYTES_UNSIGNED_BUFFER | Py_ASNATIVEBYTES_REJECT_NEGATIVE : 0));
+if (unlikely(bytes_copied == -1)) {
+} else if (unlikely(bytes_copied > (Py_ssize_t) sizeof(val))) {
+goto raise_overflow;
+} else {
+ret = 0;
+}
+#elif PY_VERSION_HEX < 0x030d0000 && !(CYTHON_COMPILING_IN_PYPY || CYTHON_COMPILING_IN_LIMITED_API) || defined(_PyLong_AsByteArray)
+int one = 1; int is_little = (int)*(unsigned char *)&one;
+unsigned char *bytes = (unsigned char *)&val;
+ret = _PyLong_AsByteArray((PyLongObject *)x,
+bytes, sizeof(val),
+is_little, !is_unsigned);
+#else
+PyObject *v;
+PyObject *stepval = NULL, *mask = NULL, *shift = NULL;
+int bits, remaining_bits, is_negative = 0;
+int chunk_size = (sizeof(long) < 8) ? 30 : 62;
+if (likely(PyLong_CheckExact(x))) {
+v = __Pyx_NewRef(x);
+} else {
+v = PyNumber_Long(x);
+if (unlikely(!v)) return (int) -1;
+assert(PyLong_CheckExact(v));
+}
+{
+int result = PyObject_RichCompareBool(v, Py_False, Py_LT);
+if (unlikely(result < 0)) {
+Py_DECREF(v);
+return (int) -1;
+}
+is_negative = result == 1;
+}
+if (is_unsigned && unlikely(is_negative)) {
+Py_DECREF(v);
+goto raise_neg_overflow;
+} else if (is_negative) {
+stepval = PyNumber_Invert(v);
+Py_DECREF(v);
+if (unlikely(!stepval))
+return (int) -1;
+} else {
+stepval = v;
+}
+v = NULL;
+val = (int) 0;
+mask = PyLong_FromLong((1L << chunk_size) - 1); if (unlikely(!mask)) goto done;
+shift = PyLong_FromLong(chunk_size); if (unlikely(!shift)) goto done;
+for (bits = 0; bits < (int) sizeof(int) * 8 - chunk_size; bits += chunk_size) {
+PyObject *tmp, *digit;
+long idigit;
+digit = PyNumber_And(stepval, mask);
+if (unlikely(!digit)) goto done;
+idigit = PyLong_AsLong(digit);
+Py_DECREF(digit);
+if (unlikely(idigit < 0)) goto done;
+val |= ((int) idigit) << bits;
+tmp = PyNumber_Rshift(stepval, shift);
+if (unlikely(!tmp)) goto done;
+Py_DECREF(stepval); stepval = tmp;
+}
+Py_DECREF(shift); shift = NULL;
+Py_DECREF(mask); mask = NULL;
+{
+long idigit = PyLong_AsLong(stepval);
+if (unlikely(idigit < 0)) goto done;
+remaining_bits = ((int) sizeof(int) * 8) - bits - (is_unsigned ? 0 : 1);
+if (unlikely(idigit >= (1L << remaining_bits)))
+goto raise_overflow;
+val |= ((int) idigit) << bits;
+}
+if (!is_unsigned) {
+if (unlikely(val & (((int) 1) << (sizeof(int) * 8 - 1))))
+goto raise_overflow;
+if (is_negative)
+val = ~val;
+}
+ret = 0;
+done:
+Py_XDECREF(shift);
+Py_XDECREF(mask);
+Py_XDECREF(stepval);
+#endif
+if (unlikely(ret))
+return (int) -1;
+return val;
+}
+raise_overflow:
+PyErr_SetString(PyExc_OverflowError,
+"value too large to convert to int");
+return (int) -1;
+raise_neg_overflow:
+PyErr_SetString(PyExc_OverflowError,
+"can't convert negative value to int");
+return (int) -1;
+}
+/* CIntFromPy */
+static CYTHON_INLINE long __Pyx_PyInt_As_long(PyObject *x) {
+#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
+#pragma GCC diagnostic push
+#pragma GCC diagnostic ignored "-Wconversion"
+#endif
+const long neg_one = (long) -1, const_zero = (long) 0;
+#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
+#pragma GCC diagnostic pop
+#endif
+const int is_unsigned = neg_one > const_zero;
+#if PY_MAJOR_VERSION < 3
+if (likely(PyInt_Check(x))) {
+if ((sizeof(long) < sizeof(long))) {
+__PYX_VERIFY_RETURN_INT(long, long, PyInt_AS_LONG(x))
+} else {
+long val = PyInt_AS_LONG(x);
+if (is_unsigned && unlikely(val < 0)) {
+goto raise_neg_overflow;
+}
+return (long) val;
+}
+}
+#endif
+if (unlikely(!PyLong_Check(x))) {
+long val;
+PyObject *tmp = __Pyx_PyNumber_IntOrLong(x);
+if (!tmp) return (long) -1;
+val = __Pyx_PyInt_As_long(tmp);
+Py_DECREF(tmp);
+return val;
+}
+if (is_unsigned) {
+#if CYTHON_USE_PYLONG_INTERNALS
+if (unlikely(__Pyx_PyLong_IsNeg(x))) {
+goto raise_neg_overflow;
+} else if (__Pyx_PyLong_IsCompact(x)) {
+__PYX_VERIFY_RETURN_INT(long, __Pyx_compact_upylong, __Pyx_PyLong_CompactValueUnsigned(x))
+} else {
+const digit* digits = __Pyx_PyLong_Digits(x);
+assert(__Pyx_PyLong_DigitCount(x) > 1);
+switch (__Pyx_PyLong_DigitCount(x)) {
+case 2:
+if ((8 * sizeof(long) > 1 * PyLong_SHIFT)) {
+if ((8 * sizeof(unsigned long) > 2 * PyLong_SHIFT)) {
+__PYX_VERIFY_RETURN_INT(long, unsigned long, (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
+} else if ((8 * sizeof(long) >= 2 * PyLong_SHIFT)) {
+return (long) (((((long)digits[1]) << PyLong_SHIFT) | (long)digits[0]));
+}
+}
+break;
+case 3:
+if ((8 * sizeof(long) > 2 * PyLong_SHIFT)) {
+if ((8 * sizeof(unsigned long) > 3 * PyLong_SHIFT)) {
+__PYX_VERIFY_RETURN_INT(long, unsigned long, (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
+} else if ((8 * sizeof(long) >= 3 * PyLong_SHIFT)) {
+return (long) (((((((long)digits[2]) << PyLong_SHIFT) | (long)digits[1]) << PyLong_SHIFT) | (long)digits[0]));
+}
+}
+break;
+case 4:
+if ((8 * sizeof(long) > 3 * PyLong_SHIFT)) {
+if ((8 * sizeof(unsigned long) > 4 * PyLong_SHIFT)) {
+__PYX_VERIFY_RETURN_INT(long, unsigned long, (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
+} else if ((8 * sizeof(long) >= 4 * PyLong_SHIFT)) {
+return (long) (((((((((long)digits[3]) << PyLong_SHIFT) | (long)digits[2]) << PyLong_SHIFT) | (long)digits[1]) << PyLong_SHIFT) | (long)digits[0]));
+}
+}
+break;
+}
+}
+#endif
+#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX < 0x030C00A7
+if (unlikely(Py_SIZE(x) < 0)) {
+goto raise_neg_overflow;
+}
+#else
+{
+int result = PyObject_RichCompareBool(x, Py_False, Py_LT);
+if (unlikely(result < 0))
+return (long) -1;
+if (unlikely(result == 1))
+goto raise_neg_overflow;
+}
+#endif
+if ((sizeof(long) <= sizeof(unsigned long))) {
+__PYX_VERIFY_RETURN_INT_EXC(long, unsigned long, PyLong_AsUnsignedLong(x))
+#ifdef HAVE_LONG_LONG
+} else if ((sizeof(long) <= sizeof(unsigned PY_LONG_LONG))) {
+__PYX_VERIFY_RETURN_INT_EXC(long, unsigned PY_LONG_LONG, PyLong_AsUnsignedLongLong(x))
+#endif
+}
+} else {
+#if CYTHON_USE_PYLONG_INTERNALS
+if (__Pyx_PyLong_IsCompact(x)) {
+__PYX_VERIFY_RETURN_INT(long, __Pyx_compact_pylong, __Pyx_PyLong_CompactValue(x))
+} else {
+const digit* digits = __Pyx_PyLong_Digits(x);
+assert(__Pyx_PyLong_DigitCount(x) > 1);
+switch (__Pyx_PyLong_SignedDigitCount(x)) {
+case -2:
+if ((8 * sizeof(long) - 1 > 1 * PyLong_SHIFT)) {
+if ((8 * sizeof(unsigned long) > 2 * PyLong_SHIFT)) {
+__PYX_VERIFY_RETURN_INT(long, long, -(long) (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
+} else if ((8 * sizeof(long) - 1 > 2 * PyLong_SHIFT)) {
+return (long) (((long)-1)*(((((long)digits[1]) << PyLong_SHIFT) | (long)digits[0])));
+}
+}
+break;
+case 2:
+if ((8 * sizeof(long) > 1 * PyLong_SHIFT)) {
+if ((8 * sizeof(unsigned long) > 2 * PyLong_SHIFT)) {
+__PYX_VERIFY_RETURN_INT(long, unsigned long, (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
+} else if ((8 * sizeof(long) - 1 > 2 * PyLong_SHIFT)) {
+return (long) ((((((long)digits[1]) << PyLong_SHIFT) | (long)digits[0])));
+}
+}
+break;
+case -3:
+if ((8 * sizeof(long) - 1 > 2 * PyLong_SHIFT)) {
+if ((8 * sizeof(unsigned long) > 3 * PyLong_SHIFT)) {
+__PYX_VERIFY_RETURN_INT(long, long, -(long) (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
+} else if ((8 * sizeof(long) - 1 > 3 * PyLong_SHIFT)) {
+return (long) (((long)-1)*(((((((long)digits[2]) << PyLong_SHIFT) | (long)digits[1]) << PyLong_SHIFT) | (long)digits[0])));
+}
+}
+break;
+case 3:
+if ((8 * sizeof(long) > 2 * PyLong_SHIFT)) {
+if ((8 * sizeof(unsigned long) > 3 * PyLong_SHIFT)) {
+__PYX_VERIFY_RETURN_INT(long, unsigned long, (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
+} else if ((8 * sizeof(long) - 1 > 3 * PyLong_SHIFT)) {
+return (long) ((((((((long)digits[2]) << PyLong_SHIFT) | (long)digits[1]) << PyLong_SHIFT) | (long)digits[0])));
+}
+}
+break;
+case -4:
+if ((8 * sizeof(long) - 1 > 3 * PyLong_SHIFT)) {
+if ((8 * sizeof(unsigned long) > 4 * PyLong_SHIFT)) {
+__PYX_VERIFY_RETURN_INT(long, long, -(long) (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
+} else if ((8 * sizeof(long) - 1 > 4 * PyLong_SHIFT)) {
+return (long) (((long)-1)*(((((((((long)digits[3]) << PyLong_SHIFT) | (long)digits[2]) << PyLong_SHIFT) | (long)digits[1]) << PyLong_SHIFT) | (long)digits[0])));
+}
+}
+break;
+case 4:
+if ((8 * sizeof(long) > 3 * PyLong_SHIFT)) {
+if ((8 * sizeof(unsigned long) > 4 * PyLong_SHIFT)) {
+__PYX_VERIFY_RETURN_INT(long, unsigned long, (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
+} else if ((8 * sizeof(long) - 1 > 4 * PyLong_SHIFT)) {
+return (long) ((((((((((long)digits[3]) << PyLong_SHIFT) | (long)digits[2]) << PyLong_SHIFT) | (long)digits[1]) << PyLong_SHIFT) | (long)digits[0])));
+}
+}
+break;
+}
+}
+#endif
+if ((sizeof(long) <= sizeof(long))) {
+__PYX_VERIFY_RETURN_INT_EXC(long, long, PyLong_AsLong(x))
+#ifdef HAVE_LONG_LONG
+} else if ((sizeof(long) <= sizeof(PY_LONG_LONG))) {
+__PYX_VERIFY_RETURN_INT_EXC(long, PY_LONG_LONG, PyLong_AsLongLong(x))
+#endif
+}
+}
+{
+long val;
+int ret = -1;
+#if PY_VERSION_HEX >= 0x030d00A6 && !CYTHON_COMPILING_IN_LIMITED_API
+Py_ssize_t bytes_copied = PyLong_AsNativeBytes(
+x, &val, sizeof(val), Py_ASNATIVEBYTES_NATIVE_ENDIAN | (is_unsigned ? Py_ASNATIVEBYTES_UNSIGNED_BUFFER | Py_ASNATIVEBYTES_REJECT_NEGATIVE : 0));
+if (unlikely(bytes_copied == -1)) {
+} else if (unlikely(bytes_copied > (Py_ssize_t) sizeof(val))) {
+goto raise_overflow;
+} else {
+ret = 0;
+}
+#elif PY_VERSION_HEX < 0x030d0000 && !(CYTHON_COMPILING_IN_PYPY || CYTHON_COMPILING_IN_LIMITED_API) || defined(_PyLong_AsByteArray)
+int one = 1; int is_little = (int)*(unsigned char *)&one;
+unsigned char *bytes = (unsigned char *)&val;
+ret = _PyLong_AsByteArray((PyLongObject *)x,
+bytes, sizeof(val),
+is_little, !is_unsigned);
+#else
+PyObject *v;
+PyObject *stepval = NULL, *mask = NULL, *shift = NULL;
+int bits, remaining_bits, is_negative = 0;
+int chunk_size = (sizeof(long) < 8) ? 30 : 62;
+if (likely(PyLong_CheckExact(x))) {
+v = __Pyx_NewRef(x);
+} else {
+v = PyNumber_Long(x);
+if (unlikely(!v)) return (long) -1;
+assert(PyLong_CheckExact(v));
+}
+{
+int result = PyObject_RichCompareBool(v, Py_False, Py_LT);
+if (unlikely(result < 0)) {
+Py_DECREF(v);
+return (long) -1;
+}
+is_negative = result == 1;
+}
+if (is_unsigned && unlikely(is_negative)) {
+Py_DECREF(v);
+goto raise_neg_overflow;
+} else if (is_negative) {
+stepval = PyNumber_Invert(v);
+Py_DECREF(v);
+if (unlikely(!stepval))
+return (long) -1;
+} else {
+stepval = v;
+}
+v = NULL;
+val = (long) 0;
+mask = PyLong_FromLong((1L << chunk_size) - 1); if (unlikely(!mask)) goto done;
+shift = PyLong_FromLong(chunk_size); if (unlikely(!shift)) goto done;
+for (bits = 0; bits < (int) sizeof(long) * 8 - chunk_size; bits += chunk_size) {
+PyObject *tmp, *digit;
+long idigit;
+digit = PyNumber_And(stepval, mask);
+if (unlikely(!digit)) goto done;
+idigit = PyLong_AsLong(digit);
+Py_DECREF(digit);
+if (unlikely(idigit < 0)) goto done;
+val |= ((long) idigit) << bits;
+tmp = PyNumber_Rshift(stepval, shift);
+if (unlikely(!tmp)) goto done;
+Py_DECREF(stepval); stepval = tmp;
+}
+Py_DECREF(shift); shift = NULL;
+Py_DECREF(mask); mask = NULL;
+{
+long idigit = PyLong_AsLong(stepval);
+if (unlikely(idigit < 0)) goto done;
+remaining_bits = ((int) sizeof(long) * 8) - bits - (is_unsigned ? 0 : 1);
+if (unlikely(idigit >= (1L << remaining_bits)))
+goto raise_overflow;
+val |= ((long) idigit) << bits;
+}
+if (!is_unsigned) {
+if (unlikely(val & (((long) 1) << (sizeof(long) * 8 - 1))))
+goto raise_overflow;
+if (is_negative)
+val = ~val;
+}
+ret = 0;
+done:
+Py_XDECREF(shift);
+Py_XDECREF(mask);
+Py_XDECREF(stepval);
+#endif
+if (unlikely(ret))
+return (long) -1;
+return val;
+}
+raise_overflow:
+PyErr_SetString(PyExc_OverflowError,
+"value too large to convert to long");
+return (long) -1;
+raise_neg_overflow:
+PyErr_SetString(PyExc_OverflowError,
+"can't convert negative value to long");
+return (long) -1;
+}
+/* CIntToPy */
+static CYTHON_INLINE PyObject* __Pyx_PyInt_From_int(int value) {
+#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
+#pragma GCC diagnostic push
+#pragma GCC diagnostic ignored "-Wconversion"
+#endif
+const int neg_one = (int) -1, const_zero = (int) 0;
+#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
+#pragma GCC diagnostic pop
+#endif
+const int is_unsigned = neg_one > const_zero;
+if (is_unsigned) {
+if (sizeof(int) < sizeof(long)) {
+return PyInt_FromLong((long) value);
+} else if (sizeof(int) <= sizeof(unsigned long)) {
+return PyLong_FromUnsignedLong((unsigned long) value);
+#ifdef HAVE_LONG_LONG
+} else if (sizeof(int) <= sizeof(unsigned PY_LONG_LONG)) {
+return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG) value);
+#endif
+}
+} else {
+if (sizeof(int) <= sizeof(long)) {
+return PyInt_FromLong((long) value);
+#ifdef HAVE_LONG_LONG
+} else if (sizeof(int) <= sizeof(PY_LONG_LONG)) {
+return PyLong_FromLongLong((PY_LONG_LONG) value);
+#endif
+}
+}
+{
+unsigned char *bytes = (unsigned char *)&value;
+#if !CYTHON_COMPILING_IN_LIMITED_API && PY_VERSION_HEX >= 0x030d00A4
+if (is_unsigned) {
+return PyLong_FromUnsignedNativeBytes(bytes, sizeof(value), -1);
+} else {
+return PyLong_FromNativeBytes(bytes, sizeof(value), -1);
+}
+#elif !CYTHON_COMPILING_IN_LIMITED_API && PY_VERSION_HEX < 0x030d0000
+int one = 1; int little = (int)*(unsigned char *)&one;
+return _PyLong_FromByteArray(bytes, sizeof(int),
+little, !is_unsigned);
+#else
+int one = 1; int little = (int)*(unsigned char *)&one;
+PyObject *from_bytes, *result = NULL;
+PyObject *py_bytes = NULL, *arg_tuple = NULL, *kwds = NULL, *order_str = NULL;
+from_bytes = PyObject_GetAttrString((PyObject*)&PyLong_Type, "from_bytes");
+if (!from_bytes) return NULL;
+py_bytes = PyBytes_FromStringAndSize((char*)bytes, sizeof(int));
+if (!py_bytes) goto limited_bad;
+order_str = PyUnicode_FromString(little ? "little" : "big");
+if (!order_str) goto limited_bad;
+arg_tuple = PyTuple_Pack(2, py_bytes, order_str);
+if (!arg_tuple) goto limited_bad;
+if (!is_unsigned) {
+kwds = PyDict_New();
+if (!kwds) goto limited_bad;
+if (PyDict_SetItemString(kwds, "signed", __Pyx_NewRef(Py_True))) goto limited_bad;
+}
+result = PyObject_Call(from_bytes, arg_tuple, kwds);
+limited_bad:
+Py_XDECREF(kwds);
+Py_XDECREF(arg_tuple);
+Py_XDECREF(order_str);
+Py_XDECREF(py_bytes);
+Py_XDECREF(from_bytes);
+return result;
+#endif
+}
+}
+/* CIntToPy */
+static CYTHON_INLINE PyObject* __Pyx_PyInt_From_long(long value) {
+#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
+#pragma GCC diagnostic push
+#pragma GCC diagnostic ignored "-Wconversion"
+#endif
+const long neg_one = (long) -1, const_zero = (long) 0;
+#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
+#pragma GCC diagnostic pop
+#endif
+const int is_unsigned = neg_one > const_zero;
+if (is_unsigned) {
+if (sizeof(long) < sizeof(long)) {
+return PyInt_FromLong((long) value);
+} else if (sizeof(long) <= sizeof(unsigned long)) {
+return PyLong_FromUnsignedLong((unsigned long) value);
+#ifdef HAVE_LONG_LONG
+} else if (sizeof(long) <= sizeof(unsigned PY_LONG_LONG)) {
+return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG) value);
+#endif
+}
+} else {
+if (sizeof(long) <= sizeof(long)) {
+return PyInt_FromLong((long) value);
+#ifdef HAVE_LONG_LONG
+} else if (sizeof(long) <= sizeof(PY_LONG_LONG)) {
+return PyLong_FromLongLong((PY_LONG_LONG) value);
+#endif
+}
+}
+{
+unsigned char *bytes = (unsigned char *)&value;
+#if !CYTHON_COMPILING_IN_LIMITED_API && PY_VERSION_HEX >= 0x030d00A4
+if (is_unsigned) {
+return PyLong_FromUnsignedNativeBytes(bytes, sizeof(value), -1);
+} else {
+return PyLong_FromNativeBytes(bytes, sizeof(value), -1);
+}
+#elif !CYTHON_COMPILING_IN_LIMITED_API && PY_VERSION_HEX < 0x030d0000
+int one = 1; int little = (int)*(unsigned char *)&one;
+return _PyLong_FromByteArray(bytes, sizeof(long),
+little, !is_unsigned);
+#else
+int one = 1; int little = (int)*(unsigned char *)&one;
+PyObject *from_bytes, *result = NULL;
+PyObject *py_bytes = NULL, *arg_tuple = NULL, *kwds = NULL, *order_str = NULL;
+from_bytes = PyObject_GetAttrString((PyObject*)&PyLong_Type, "from_bytes");
+if (!from_bytes) return NULL;
+py_bytes = PyBytes_FromStringAndSize((char*)bytes, sizeof(long));
+if (!py_bytes) goto limited_bad;
+order_str = PyUnicode_FromString(little ? "little" : "big");
+if (!order_str) goto limited_bad;
+arg_tuple = PyTuple_Pack(2, py_bytes, order_str);
+if (!arg_tuple) goto limited_bad;
+if (!is_unsigned) {
+kwds = PyDict_New();
+if (!kwds) goto limited_bad;
+if (PyDict_SetItemString(kwds, "signed", __Pyx_NewRef(Py_True))) goto limited_bad;
+}
+result = PyObject_Call(from_bytes, arg_tuple, kwds);
+limited_bad:
+Py_XDECREF(kwds);
+Py_XDECREF(arg_tuple);
+Py_XDECREF(order_str);
+Py_XDECREF(py_bytes);
+Py_XDECREF(from_bytes);
+return result;
+#endif
+}
+}
+/* FormatTypeName */
+#if CYTHON_COMPILING_IN_LIMITED_API
+static __Pyx_TypeName
+__Pyx_PyType_GetName(PyTypeObject* tp)
+{
+PyObject *name = __Pyx_PyObject_GetAttrStr((PyObject *)tp,
+__pyx_n_s_name_2);
+if (unlikely(name == NULL) || unlikely(!PyUnicode_Check(name))) {
+PyErr_Clear();
+Py_XDECREF(name);
+name = __Pyx_NewRef(__pyx_n_s__68);
+}
+return name;
+}
+#endif
+/* FastTypeChecks */
+#if CYTHON_COMPILING_IN_CPYTHON
+static int __Pyx_InBases(PyTypeObject *a, PyTypeObject *b) {
+while (a) {
+a = __Pyx_PyType_GetSlot(a, tp_base, PyTypeObject*);
+if (a == b)
+return 1;
+}
+return b == &PyBaseObject_Type;
+}
+static CYTHON_INLINE int __Pyx_IsSubtype(PyTypeObject *a, PyTypeObject *b) {
+PyObject *mro;
+if (a == b) return 1;
+mro = a->tp_mro;
+if (likely(mro)) {
+Py_ssize_t i, n;
+n = PyTuple_GET_SIZE(mro);
+for (i = 0; i < n; i++) {
+if (PyTuple_GET_ITEM(mro, i) == (PyObject *)b)
+return 1;
+}
+return 0;
+}
+return __Pyx_InBases(a, b);
+}
+static CYTHON_INLINE int __Pyx_IsAnySubtype2(PyTypeObject *cls, PyTypeObject *a, PyTypeObject *b) {
+PyObject *mro;
+if (cls == a || cls == b) return 1;
+mro = cls->tp_mro;
+if (likely(mro)) {
+Py_ssize_t i, n;
+n = PyTuple_GET_SIZE(mro);
+for (i = 0; i < n; i++) {
+PyObject *base = PyTuple_GET_ITEM(mro, i);
+if (base == (PyObject *)a || base == (PyObject *)b)
+return 1;
+}
+return 0;
+}
+return __Pyx_InBases(cls, a) || __Pyx_InBases(cls, b);
+}
+#if PY_MAJOR_VERSION == 2
+static int __Pyx_inner_PyErr_GivenExceptionMatches2(PyObject *err, PyObject* exc_type1, PyObject* exc_type2) {
+PyObject *exception, *value, *tb;
+int res;
+__Pyx_PyThreadState_declare
+__Pyx_PyThreadState_assign
+__Pyx_ErrFetch(&exception, &value, &tb);
+res = exc_type1 ? PyObject_IsSubclass(err, exc_type1) : 0;
+if (unlikely(res == -1)) {
+PyErr_WriteUnraisable(err);
+res = 0;
+}
+if (!res) {
+res = PyObject_IsSubclass(err, exc_type2);
+if (unlikely(res == -1)) {
+PyErr_WriteUnraisable(err);
+res = 0;
+}
+}
+__Pyx_ErrRestore(exception, value, tb);
+return res;
+}
+#else
+static CYTHON_INLINE int __Pyx_inner_PyErr_GivenExceptionMatches2(PyObject *err, PyObject* exc_type1, PyObject *exc_type2) {
+if (exc_type1) {
+return __Pyx_IsAnySubtype2((PyTypeObject*)err, (PyTypeObject*)exc_type1, (PyTypeObject*)exc_type2);
+} else {
+return __Pyx_IsSubtype((PyTypeObject*)err, (PyTypeObject*)exc_type2);
+}
+}
+#endif
+static int __Pyx_PyErr_GivenExceptionMatchesTuple(PyObject *exc_type, PyObject *tuple) {
+Py_ssize_t i, n;
+assert(PyExceptionClass_Check(exc_type));
+n = PyTuple_GET_SIZE(tuple);
+#if PY_MAJOR_VERSION >= 3
+for (i=0; i<n; i++) {
+if (exc_type == PyTuple_GET_ITEM(tuple, i)) return 1;
+}
+#endif
+for (i=0; i<n; i++) {
+PyObject *t = PyTuple_GET_ITEM(tuple, i);
+#if PY_MAJOR_VERSION < 3
+if (likely(exc_type == t)) return 1;
+#endif
+if (likely(PyExceptionClass_Check(t))) {
+if (__Pyx_inner_PyErr_GivenExceptionMatches2(exc_type, NULL, t)) return 1;
+} else {
+}
+}
+return 0;
+}
+static CYTHON_INLINE int __Pyx_PyErr_GivenExceptionMatches(PyObject *err, PyObject* exc_type) {
+if (likely(err == exc_type)) return 1;
+if (likely(PyExceptionClass_Check(err))) {
+if (likely(PyExceptionClass_Check(exc_type))) {
+return __Pyx_inner_PyErr_GivenExceptionMatches2(err, NULL, exc_type);
+} else if (likely(PyTuple_Check(exc_type))) {
+return __Pyx_PyErr_GivenExceptionMatchesTuple(err, exc_type);
+} else {
+}
+}
+return PyErr_GivenExceptionMatches(err, exc_type);
+}
+static CYTHON_INLINE int __Pyx_PyErr_GivenExceptionMatches2(PyObject *err, PyObject *exc_type1, PyObject *exc_type2) {
+assert(PyExceptionClass_Check(exc_type1));
+assert(PyExceptionClass_Check(exc_type2));
+if (likely(err == exc_type1 || err == exc_type2)) return 1;
+if (likely(PyExceptionClass_Check(err))) {
+return __Pyx_inner_PyErr_GivenExceptionMatches2(err, exc_type1, exc_type2);
+}
+return (PyErr_GivenExceptionMatches(err, exc_type1) || PyErr_GivenExceptionMatches(err, exc_type2));
+}
+#endif
+/* CheckBinaryVersion */
+static unsigned long __Pyx_get_runtime_version(void) {
+#if __PYX_LIMITED_VERSION_HEX >= 0x030B00A4
+return Py_Version & ~0xFFUL;
+#else
+const char* rt_version = Py_GetVersion();
+unsigned long version = 0;
+unsigned long factor = 0x01000000UL;
+unsigned int digit = 0;
+int i = 0;
+while (factor) {
+while ('0' <= rt_version[i] && rt_version[i] <= '9') {
+digit = digit * 10 + (unsigned int) (rt_version[i] - '0');
+++i;
+}
+version += factor * digit;
+if (rt_version[i] != '.')
+break;
+digit = 0;
+factor >>= 8;
+++i;
+}
+return version;
+#endif
+}
+static int __Pyx_check_binary_version(unsigned long ct_version, unsigned long rt_version, int allow_newer) {
+const unsigned long MAJOR_MINOR = 0xFFFF0000UL;
+if ((rt_version & MAJOR_MINOR) == (ct_version & MAJOR_MINOR))
+return 0;
+if (likely(allow_newer && (rt_version & MAJOR_MINOR) > (ct_version & MAJOR_MINOR)))
+return 1;
+{
+char message[200];
+PyOS_snprintf(message, sizeof(message),
+"compile time Python version %d.%d "
+"of module '%.100s' "
+"%s "
+"runtime version %d.%d",
+(int) (ct_version >> 24), (int) ((ct_version >> 16) & 0xFF),
+__Pyx_MODULE_NAME,
+(allow_newer) ? "was newer than" : "does not match",
+(int) (rt_version >> 24), (int) ((rt_version >> 16) & 0xFF)
+);
+return PyErr_WarnEx(NULL, message, 1);
+}
+}
+/* FunctionImport */
+#ifndef __PYX_HAVE_RT_ImportFunction_3_0_11
+#define __PYX_HAVE_RT_ImportFunction_3_0_11
+static int __Pyx_ImportFunction_3_0_11(PyObject *module, const char *funcname, void (**f)(void), const char *sig) {
+PyObject *d = 0;
+PyObject *cobj = 0;
+union {
+void (*fp)(void);
+void *p;
+} tmp;
+d = PyObject_GetAttrString(module, (char *)"__pyx_capi__");
+if (!d)
+goto bad;
+cobj = PyDict_GetItemString(d, funcname);
+if (!cobj) {
+PyErr_Format(PyExc_ImportError,
+"%.200s does not export expected C function %.200s",
+PyModule_GetName(module), funcname);
+goto bad;
+}
+if (!PyCapsule_IsValid(cobj, sig)) {
+PyErr_Format(PyExc_TypeError,
+"C function %.200s.%.200s has wrong signature (expected %.500s, got %.500s)",
+PyModule_GetName(module), funcname, sig, PyCapsule_GetName(cobj));
+goto bad;
+}
+tmp.p = PyCapsule_GetPointer(cobj, sig);
+*f = tmp.fp;
+if (!(*f))
+goto bad;
+Py_DECREF(d);
+return 0;
+bad:
+Py_XDECREF(d);
+return -1;
+}
+#endif
+/* InitStrings */
+#if PY_MAJOR_VERSION >= 3
+static int __Pyx_InitString(__Pyx_StringTabEntry t, PyObject **str) {
+if (t.is_unicode | t.is_str) {
+if (t.intern) {
+*str = PyUnicode_InternFromString(t.s);
+} else if (t.encoding) {
+*str = PyUnicode_Decode(t.s, t.n - 1, t.encoding, NULL);
+} else {
+*str = PyUnicode_FromStringAndSize(t.s, t.n - 1);
+}
+} else {
+*str = PyBytes_FromStringAndSize(t.s, t.n - 1);
+}
+if (!*str)
+return -1;
+if (PyObject_Hash(*str) == -1)
+return -1;
+return 0;
+}
+#endif
+static int __Pyx_InitStrings(__Pyx_StringTabEntry *t) {
+while (t->p) {
+#if PY_MAJOR_VERSION >= 3
+__Pyx_InitString(*t, t->p);
+#else
+if (t->is_unicode) {
+*t->p = PyUnicode_DecodeUTF8(t->s, t->n - 1, NULL);
+} else if (t->intern) {
+*t->p = PyString_InternFromString(t->s);
+} else {
+*t->p = PyString_FromStringAndSize(t->s, t->n - 1);
+}
+if (!*t->p)
+return -1;
+if (PyObject_Hash(*t->p) == -1)
+return -1;
+#endif
+++t;
+}
+return 0;
+}
+#include <string.h>
+static CYTHON_INLINE Py_ssize_t __Pyx_ssize_strlen(const char *s) {
+size_t len = strlen(s);
+if (unlikely(len > (size_t) PY_SSIZE_T_MAX)) {
+PyErr_SetString(PyExc_OverflowError, "byte string is too long");
+return -1;
+}
+return (Py_ssize_t) len;
+}
+static CYTHON_INLINE PyObject* __Pyx_PyUnicode_FromString(const char* c_str) {
+Py_ssize_t len = __Pyx_ssize_strlen(c_str);
+if (unlikely(len < 0)) return NULL;
+return __Pyx_PyUnicode_FromStringAndSize(c_str, len);
+}
+static CYTHON_INLINE PyObject* __Pyx_PyByteArray_FromString(const char* c_str) {
+Py_ssize_t len = __Pyx_ssize_strlen(c_str);
+if (unlikely(len < 0)) return NULL;
+return PyByteArray_FromStringAndSize(c_str, len);
+}
+static CYTHON_INLINE const char* __Pyx_PyObject_AsString(PyObject* o) {
+Py_ssize_t ignore;
+return __Pyx_PyObject_AsStringAndSize(o, &ignore);
+}
+#if __PYX_DEFAULT_STRING_ENCODING_IS_ASCII || __PYX_DEFAULT_STRING_ENCODING_IS_DEFAULT
+#if !CYTHON_PEP393_ENABLED
+static const char* __Pyx_PyUnicode_AsStringAndSize(PyObject* o, Py_ssize_t *length) {
+char* defenc_c;
+PyObject* defenc = _PyUnicode_AsDefaultEncodedString(o, NULL);
+if (!defenc) return NULL;
+defenc_c = PyBytes_AS_STRING(defenc);
+#if __PYX_DEFAULT_STRING_ENCODING_IS_ASCII
+{
+char* end = defenc_c + PyBytes_GET_SIZE(defenc);
+char* c;
+for (c = defenc_c; c < end; c++) {
+if ((unsigned char) (*c) >= 128) {
+PyUnicode_AsASCIIString(o);
+return NULL;
+}
+}
+}
+#endif
+*length = PyBytes_GET_SIZE(defenc);
+return defenc_c;
+}
+#else
+static CYTHON_INLINE const char* __Pyx_PyUnicode_AsStringAndSize(PyObject* o, Py_ssize_t *length) {
+if (unlikely(__Pyx_PyUnicode_READY(o) == -1)) return NULL;
+#if __PYX_DEFAULT_STRING_ENCODING_IS_ASCII
+if (likely(PyUnicode_IS_ASCII(o))) {
+*length = PyUnicode_GET_LENGTH(o);
+return PyUnicode_AsUTF8(o);
+} else {
+PyUnicode_AsASCIIString(o);
+return NULL;
+}
+#else
+return PyUnicode_AsUTF8AndSize(o, length);
+#endif
+}
+#endif
+#endif
+static CYTHON_INLINE const char* __Pyx_PyObject_AsStringAndSize(PyObject* o, Py_ssize_t *length) {
+#if __PYX_DEFAULT_STRING_ENCODING_IS_ASCII || __PYX_DEFAULT_STRING_ENCODING_IS_DEFAULT
+if (
+#if PY_MAJOR_VERSION < 3 && __PYX_DEFAULT_STRING_ENCODING_IS_ASCII
+__Pyx_sys_getdefaultencoding_not_ascii &&
+#endif
+PyUnicode_Check(o)) {
+return __Pyx_PyUnicode_AsStringAndSize(o, length);
+} else
+#endif
+#if (!CYTHON_COMPILING_IN_PYPY && !CYTHON_COMPILING_IN_LIMITED_API) || (defined(PyByteArray_AS_STRING) && defined(PyByteArray_GET_SIZE))
+if (PyByteArray_Check(o)) {
+*length = PyByteArray_GET_SIZE(o);
+return PyByteArray_AS_STRING(o);
+} else
+#endif
+{
+char* result;
+int r = PyBytes_AsStringAndSize(o, &result, length);
+if (unlikely(r < 0)) {
+return NULL;
+} else {
+return result;
+}
+}
+}
+static CYTHON_INLINE int __Pyx_PyObject_IsTrue(PyObject* x) {
+int is_true = x == Py_True;
+if (is_true | (x == Py_False) | (x == Py_None)) return is_true;
+else return PyObject_IsTrue(x);
+}
+static CYTHON_INLINE int __Pyx_PyObject_IsTrueAndDecref(PyObject* x) {
+int retval;
+if (unlikely(!x)) return -1;
+retval = __Pyx_PyObject_IsTrue(x);
+Py_DECREF(x);
+return retval;
+}
+static PyObject* __Pyx_PyNumber_IntOrLongWrongResultType(PyObject* result, const char* type_name) {
+__Pyx_TypeName result_type_name = __Pyx_PyType_GetName(Py_TYPE(result));
+#if PY_MAJOR_VERSION >= 3
+if (PyLong_Check(result)) {
+if (PyErr_WarnFormat(PyExc_DeprecationWarning, 1,
+"__int__ returned non-int (type " __Pyx_FMT_TYPENAME ").  "
+"The ability to return an instance of a strict subclass of int is deprecated, "
+"and may be removed in a future version of Python.",
+result_type_name)) {
+__Pyx_DECREF_TypeName(result_type_name);
+Py_DECREF(result);
+return NULL;
+}
+__Pyx_DECREF_TypeName(result_type_name);
+return result;
+}
+#endif
+PyErr_Format(PyExc_TypeError,
+"__%.4s__ returned non-%.4s (type " __Pyx_FMT_TYPENAME ")",
+type_name, type_name, result_type_name);
+__Pyx_DECREF_TypeName(result_type_name);
+Py_DECREF(result);
+return NULL;
+}
+static CYTHON_INLINE PyObject* __Pyx_PyNumber_IntOrLong(PyObject* x) {
+#if CYTHON_USE_TYPE_SLOTS
+PyNumberMethods *m;
+#endif
+const char *name = NULL;
+PyObject *res = NULL;
+#if PY_MAJOR_VERSION < 3
+if (likely(PyInt_Check(x) || PyLong_Check(x)))
+#else
+if (likely(PyLong_Check(x)))
+#endif
+return __Pyx_NewRef(x);
+#if CYTHON_USE_TYPE_SLOTS
+m = Py_TYPE(x)->tp_as_number;
+#if PY_MAJOR_VERSION < 3
+if (m && m->nb_int) {
+name = "int";
+res = m->nb_int(x);
+}
+else if (m && m->nb_long) {
+name = "long";
+res = m->nb_long(x);
+}
+#else
+if (likely(m && m->nb_int)) {
+name = "int";
+res = m->nb_int(x);
+}
+#endif
+#else
+if (!PyBytes_CheckExact(x) && !PyUnicode_CheckExact(x)) {
+res = PyNumber_Int(x);
+}
+#endif
+if (likely(res)) {
+#if PY_MAJOR_VERSION < 3
+if (unlikely(!PyInt_Check(res) && !PyLong_Check(res))) {
+#else
+if (unlikely(!PyLong_CheckExact(res))) {
+#endif
+return __Pyx_PyNumber_IntOrLongWrongResultType(res, name);
+}
+}
+else if (!PyErr_Occurred()) {
+PyErr_SetString(PyExc_TypeError,
+"an integer is required");
+}
+return res;
+}
+static CYTHON_INLINE Py_ssize_t __Pyx_PyIndex_AsSsize_t(PyObject* b) {
+Py_ssize_t ival;
+PyObject *x;
+#if PY_MAJOR_VERSION < 3
+if (likely(PyInt_CheckExact(b))) {
+if (sizeof(Py_ssize_t) >= sizeof(long))
+return PyInt_AS_LONG(b);
+else
+return PyInt_AsSsize_t(b);
+}
+#endif
+if (likely(PyLong_CheckExact(b))) {
+#if CYTHON_USE_PYLONG_INTERNALS
+if (likely(__Pyx_PyLong_IsCompact(b))) {
+return __Pyx_PyLong_CompactValue(b);
+} else {
+const digit* digits = __Pyx_PyLong_Digits(b);
+const Py_ssize_t size = __Pyx_PyLong_SignedDigitCount(b);
+switch (size) {
+case 2:
+if (8 * sizeof(Py_ssize_t) > 2 * PyLong_SHIFT) {
+return (Py_ssize_t) (((((size_t)digits[1]) << PyLong_SHIFT) | (size_t)digits[0]));
+}
+break;
+case -2:
+if (8 * sizeof(Py_ssize_t) > 2 * PyLong_SHIFT) {
+return -(Py_ssize_t) (((((size_t)digits[1]) << PyLong_SHIFT) | (size_t)digits[0]));
+}
+break;
+case 3:
+if (8 * sizeof(Py_ssize_t) > 3 * PyLong_SHIFT) {
+return (Py_ssize_t) (((((((size_t)digits[2]) << PyLong_SHIFT) | (size_t)digits[1]) << PyLong_SHIFT) | (size_t)digits[0]));
+}
+break;
+case -3:
+if (8 * sizeof(Py_ssize_t) > 3 * PyLong_SHIFT) {
+return -(Py_ssize_t) (((((((size_t)digits[2]) << PyLong_SHIFT) | (size_t)digits[1]) << PyLong_SHIFT) | (size_t)digits[0]));
+}
+break;
+case 4:
+if (8 * sizeof(Py_ssize_t) > 4 * PyLong_SHIFT) {
+return (Py_ssize_t) (((((((((size_t)digits[3]) << PyLong_SHIFT) | (size_t)digits[2]) << PyLong_SHIFT) | (size_t)digits[1]) << PyLong_SHIFT) | (size_t)digits[0]));
+}
+break;
+case -4:
+if (8 * sizeof(Py_ssize_t) > 4 * PyLong_SHIFT) {
+return -(Py_ssize_t) (((((((((size_t)digits[3]) << PyLong_SHIFT) | (size_t)digits[2]) << PyLong_SHIFT) | (size_t)digits[1]) << PyLong_SHIFT) | (size_t)digits[0]));
+}
+break;
+}
+}
+#endif
+return PyLong_AsSsize_t(b);
+}
+x = PyNumber_Index(b);
+if (!x) return -1;
+ival = PyInt_AsSsize_t(x);
+Py_DECREF(x);
+return ival;
+}
+static CYTHON_INLINE Py_hash_t __Pyx_PyIndex_AsHash_t(PyObject* o) {
+if (sizeof(Py_hash_t) == sizeof(Py_ssize_t)) {
+return (Py_hash_t) __Pyx_PyIndex_AsSsize_t(o);
+#if PY_MAJOR_VERSION < 3
+} else if (likely(PyInt_CheckExact(o))) {
+return PyInt_AS_LONG(o);
+#endif
+} else {
+Py_ssize_t ival;
+PyObject *x;
+x = PyNumber_Index(o);
+if (!x) return -1;
+ival = PyInt_AsLong(x);
+Py_DECREF(x);
+return ival;
+}
+}
+static CYTHON_INLINE PyObject * __Pyx_PyBool_FromLong(long b) {
+return b ? __Pyx_NewRef(Py_True) : __Pyx_NewRef(Py_False);
+}
+static CYTHON_INLINE PyObject * __Pyx_PyInt_FromSize_t(size_t ival) {
+return PyInt_FromSize_t(ival);
+}
+/* #### Code section: utility_code_pragmas_end ### */
+#ifdef _MSC_VER
+#pragma warning( pop )
+#endif
+/* #### Code section: end ### */
+#endif /* Py_PYTHON_H */

Mercurial > repos > rliterman > csp2

comparison CSP2/CSP2_env/env-d9b9114564458d9d-741b3de822f2aaca6c6caa4325c4afce/lib/python3.8/site-packages/pysam/libcfaidx.c @ 68:5028fdace37b